CN114225982A - Diaphragm type micro-fluidic control device - Google Patents
Diaphragm type micro-fluidic control device Download PDFInfo
- Publication number
- CN114225982A CN114225982A CN202111539891.4A CN202111539891A CN114225982A CN 114225982 A CN114225982 A CN 114225982A CN 202111539891 A CN202111539891 A CN 202111539891A CN 114225982 A CN114225982 A CN 114225982A
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- CN
- China
- Prior art keywords
- chip substrate
- control device
- channel
- gravure
- chip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000758 substrate Substances 0.000 claims abstract description 36
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 4
- 239000012530 fluid Substances 0.000 abstract description 12
- 238000007689 inspection Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001488 breeding effect Effects 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000012214 genetic breeding Methods 0.000 description 1
- 238000010353 genetic engineering Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The invention relates to a chip for a fluid control device, in particular to a diaphragm type micro-fluidic control device which comprises a chip substrate and a channel intaglio plate, wherein a flexible film tightly attached to the chip substrate is arranged between the chip substrate and the channel intaglio plate, and grooves are arranged on the surfaces of the channel intaglio plate corresponding to the chip substrate.
Description
Technical Field
The invention relates to a chip for a fluid control device, in particular to a diaphragm type microfluidic control device.
Background
The micro-fluidic system realizes the addition, movement, convergence, uniform mixing, separation, collection and other fluid control of micro (micro-liter to nano-upgrade) fluid inside a chip (an independent device for carrying fluid and realizing fluid control) through a proper device, and combines heating, optical inspection, biological or chemical modification and reagent pre-embedding, completes corresponding reaction inside the chip and obtains a detection result, thereby becoming the popular technology in various fields of current biomedical treatment, molecular diagnosis, environmental monitoring, genetic engineering, breeding and the like.
The microfluidic control device in the prior art generally comprises a chip, but the microfluidic chip in the prior art is provided with a groove for fluid to flow on a chip substrate, so that a process flow for processing the groove is required for chip processing, and the chip is disposable, so that the chip processing ratio is high, and the inspection cost is increased.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a diaphragm type microfluidic control device which is simple in fluid carrier structure, good in sealing performance and simple to process.
In order to solve the technical problems, the invention provides the following technical scheme:
a diaphragm type microfluidic control device comprises a chip substrate and a channel intaglio, wherein a flexible film tightly attached to the chip substrate is arranged between the chip substrate and the channel intaglio, and grooves are formed in the surfaces of the channel intaglio corresponding to the chip substrate.
Preferably, the gravure groove is provided with an exhaust hole.
Preferably, a filling opening is arranged above the chip substrate.
Preferably, an upper pressure plate is arranged above the chip substrate, and the upper pressure plate is provided with a filling groove corresponding to the filling port.
Preferably, the grooves on the grooved intaglio comprise a liquid injection zone and a mixing zone.
Preferably, the grooves on the gravure channel further comprise a check zone.
The diaphragm type microfluidic control device comprises a chip substrate and a channel intaglio plate, wherein a flexible film tightly attached to the chip substrate is arranged between the chip substrate and the channel intaglio plate, and grooves are formed in the surfaces of the channel intaglio plate corresponding to the chip substrate. When the flexible film is used, fluid is arranged between the chip substrate and the flexible film, the chip substrate and the channel intaglio plate are pressed together, and the fluid between the flexible film and the chip substrate flows to a corresponding place along the groove on the channel intaglio plate according to setting because the groove is arranged on one surface of the channel intaglio plate corresponding to the chip substrate.
The technical scheme is that the groove intaglio is provided with an exhaust hole. The vent hole can vent gas in the groove during use.
The filling port is arranged above the chip substrate in the technical scheme. Fluid is injected between the chip substrate and the flexible membrane from the fill port.
According to the technical scheme, the upper pressure plate is arranged above the chip substrate, the upper pressure plate is provided with the filling groove corresponding to the filling port, and the upper pressure plate and the groove intaglio plate are matched to press the chip and the groove intaglio plate more tightly.
The groove on the groove intaglio plate in the technical scheme comprises a liquid injection area, a mixing area and an inspection area, and the groove intaglio plate can be selected and used according to needs.
According to the diaphragm type microfluidic control device, the grooves are arranged externally, and the gravure of the grooves is reused, so that the fluid grooves do not need to be processed on the chip, the chip substrate only needs to be a flat plate, the processing cost of the microfluidic chip is reduced, and the inspection and culture cost is reduced.
On the basis of the common knowledge in the field, the above-mentioned preferred conditions can be combined arbitrarily to obtain the embodiment of the invention.
Drawings
Fig. 1 is a schematic structural view of a diaphragm-type microfluidic control device according to the present embodiment;
FIG. 2 is a schematic structural diagram of a gravure groove of the present technology;
FIG. 3 is another schematic structural view of a gravure groove of the present embodiment;
FIG. 4 is another schematic structural view of a gravure groove of the present technology;
FIG. 5 is another schematic structural view of a gravure groove of the present embodiment;
fig. 6 is another schematic structural view of a gravure groove of the present embodiment.
1-an upper pressing plate; 2-filling port; 3-a chip substrate; 4-a flexible film; 5-a channel gravure; 6-air exhaust hole; 7-a groove; 8-a liquid injection zone; 9-a mixing zone; 10-inspection area.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention are further described in detail below with reference to the accompanying drawings in the embodiments of the present invention.
Example 1
As shown in fig. 1, a diaphragm type microfluidic control device includes a chip substrate 3 and a trench intaglio 5, a flexible film 4 closely attached to the chip substrate 3 is disposed between the chip substrate 3 and the trench intaglio 5, and a trench 7 is disposed on a surface of the trench intaglio 5 corresponding to the chip substrate 3.
Preferably, the gravure 5 is provided with an exhaust hole 6.
Preferably, the filling port 2 is provided above the chip substrate 3.
Preferably, an upper pressure plate 1 is arranged above the chip substrate 3, and the upper pressure plate 1 is provided with a filling groove corresponding to the filling port 2.
The gravure 5 of the present embodiment is configured as the gravure shown in fig. 2, and includes a liquid injection region 8, a mixing region 9, and a check region 10.
Example 2:
the present embodiment is different from embodiment 1 in that the gravure of the present embodiment is provided as the gravure of fig. 3, and includes a liquid injection region and a mixing region.
Example 3:
the present embodiment is different from embodiment 1 in that the gravure of the present embodiment is provided as the gravure of fig. 4.
Example 4:
the present embodiment is different from embodiment 1 in that the gravure of the present embodiment is provided as the gravure of fig. 5.
Example 5:
the present embodiment is different from embodiment 1 in that the gravure of the present embodiment is provided as the gravure of fig. 6.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (6)
1. A diaphragm type micro-fluidic control device is characterized by comprising a chip substrate and a channel gravure plate, wherein a flexible film tightly attached to the chip substrate is arranged between the chip substrate and the channel gravure plate, and grooves are formed in the surfaces of the channel gravure plate, which correspond to the chip substrate.
2. The membrane-based microfluidic control device of claim 1, wherein the grooved intaglio is provided with vent holes.
3. The membrane-type microfluidic control device according to claim 1, wherein a filling port is provided above the chip substrate.
4. The diaphragm microfluidic control device of claim 1, wherein an upper platen is disposed above the chip substrate, and the upper platen is provided with a filling groove corresponding to the filling port.
5. The membrane-based microfluidic control device of claim 1, wherein the grooves on the grooved intaglio comprise a liquid injection zone and a mixing zone.
6. The membrane-based microfluidic control device of claim 5, wherein the groove on the grooved gravure further comprises a check zone.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111539891.4A CN114225982A (en) | 2021-12-16 | 2021-12-16 | Diaphragm type micro-fluidic control device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111539891.4A CN114225982A (en) | 2021-12-16 | 2021-12-16 | Diaphragm type micro-fluidic control device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114225982A true CN114225982A (en) | 2022-03-25 |
Family
ID=80756804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111539891.4A Pending CN114225982A (en) | 2021-12-16 | 2021-12-16 | Diaphragm type micro-fluidic control device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114225982A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1880329A (en) * | 2005-06-13 | 2006-12-20 | 中国科学院电子学研究所 | Reversible packaging micro fluent chip for separating and purifying biological sample |
| CN102337207A (en) * | 2011-10-18 | 2012-02-01 | 中国科学院苏州纳米技术与纳米仿生研究所 | Microfluidic microbe two-dimensional suspension culture chip |
| CN104096608A (en) * | 2014-07-21 | 2014-10-15 | 东南大学 | Separated type automatic micron-size particle assembling and sorting device and manufacturing method thereof |
| US20170326552A1 (en) * | 2014-11-26 | 2017-11-16 | Imec Vzw | Compact Fluid Analysis Device and Method to Fabricate |
| CN113769807A (en) * | 2021-10-29 | 2021-12-10 | 青岛全诊生物技术有限公司 | Diaphragm type micro-fluidic control device |
-
2021
- 2021-12-16 CN CN202111539891.4A patent/CN114225982A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1880329A (en) * | 2005-06-13 | 2006-12-20 | 中国科学院电子学研究所 | Reversible packaging micro fluent chip for separating and purifying biological sample |
| CN102337207A (en) * | 2011-10-18 | 2012-02-01 | 中国科学院苏州纳米技术与纳米仿生研究所 | Microfluidic microbe two-dimensional suspension culture chip |
| CN104096608A (en) * | 2014-07-21 | 2014-10-15 | 东南大学 | Separated type automatic micron-size particle assembling and sorting device and manufacturing method thereof |
| US20170326552A1 (en) * | 2014-11-26 | 2017-11-16 | Imec Vzw | Compact Fluid Analysis Device and Method to Fabricate |
| CN113769807A (en) * | 2021-10-29 | 2021-12-10 | 青岛全诊生物技术有限公司 | Diaphragm type micro-fluidic control device |
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| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20230612 Address after: 16 / F, 127 Guotong Road, Yangpu District, Shanghai 200082 Applicant after: Shanghai Weijing Instrument Co.,Ltd. Address before: 266000 household 101, building 3, No. 20, Zhuzhou Road, Laoshan District, Qingdao City, Shandong Province Applicant before: Qingdao Quanxian Biotechnology Co.,Ltd. |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220325 |