CN114225800A - Liquid preparation ultrafiltration device - Google Patents
Liquid preparation ultrafiltration device Download PDFInfo
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- CN114225800A CN114225800A CN202111510762.2A CN202111510762A CN114225800A CN 114225800 A CN114225800 A CN 114225800A CN 202111510762 A CN202111510762 A CN 202111510762A CN 114225800 A CN114225800 A CN 114225800A
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- liquid preparation
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- 239000007788 liquid Substances 0.000 title claims abstract description 243
- 238000000108 ultra-filtration Methods 0.000 title claims abstract description 226
- 238000002360 preparation method Methods 0.000 title claims abstract description 148
- 238000009826 distribution Methods 0.000 claims abstract description 37
- 238000004891 communication Methods 0.000 claims abstract description 33
- 239000012530 fluid Substances 0.000 claims abstract description 19
- 238000002156 mixing Methods 0.000 claims description 25
- 239000012528 membrane Substances 0.000 claims description 23
- 238000001514 detection method Methods 0.000 claims description 20
- 238000003756 stirring Methods 0.000 claims description 13
- 238000003760 magnetic stirring Methods 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 7
- 230000008859 change Effects 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 10
- 239000000126 substance Substances 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/18—Apparatus therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/20—Accessories; Auxiliary operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/22—Controlling or regulating
Abstract
The invention relates to a liquid preparation ultrafiltration device, which comprises: the liquid preparation equipment comprises a liquid preparation electrical connecting assembly and a liquid preparation pipeline; the ultrafiltration equipment comprises an ultrafiltration electrical connecting assembly and an ultrafiltration pipeline, the liquid preparation electrical connecting assembly is electrically connected with the ultrafiltration electrical connecting assembly in a switching and connecting mode, and the liquid preparation pipeline is in fluid communication with the ultrafiltration pipeline in a switching and connecting mode; a connection means by which the liquid dispensing apparatus and the ultrafiltration apparatus are detachably mechanically connected. When the liquid distribution electrical connecting assembly is electrically connected with the ultrafiltration electrical connecting assembly, the liquid distribution pipeline is connected with the ultrafiltration pipeline to communicate the fluid, and the liquid distribution equipment and the ultrafiltration equipment are mechanically connected through the connecting device, the two equipment can be combined for use; when the liquid preparation electrical connecting assembly is electrically disconnected with the ultrafiltration electrical connecting assembly, the liquid preparation pipeline is disconnected with the ultrafiltration pipeline, and the liquid preparation equipment and the ultrafiltration equipment are mechanically disconnected through the connecting device, the two equipment can be used independently.
Description
Technical Field
The invention relates to the technical field of biological pharmaceutical equipment, in particular to a liquid preparation ultrafiltration device.
Background
In the biopharmaceutical process, the liquid preparation system and the ultrafiltration system are not separated from each unit operation in the upstream process and the downstream process. The general liquid preparation equipment and the ultrafiltration equipment are used independently, the required equipment configuration quantity is large, the occupied space is large, the production line management is not facilitated, and the resource waste is caused.
Disclosure of Invention
Therefore, it is necessary to provide a liquid preparation ultrafiltration device aiming at the problem of combined use of liquid preparation equipment and ultrafiltration equipment.
A fluid-dispensing ultrafiltration device, the fluid-dispensing ultrafiltration device comprising:
the liquid preparation equipment comprises a liquid preparation electrical connecting assembly and a liquid preparation pipeline;
the ultrafiltration equipment comprises an ultrafiltration electrical connecting assembly and an ultrafiltration pipeline, the liquid preparation electrical connecting assembly is electrically connected with the ultrafiltration electrical connecting assembly in a switching and connecting mode, and the liquid preparation pipeline is in fluid communication with the ultrafiltration pipeline in a switching and connecting mode;
a connection means by which the liquid dispensing apparatus and the ultrafiltration apparatus are detachably mechanically connected.
In one embodiment, the liquid preparation device further comprises a liquid preparation control system and a liquid preparation assembly, the liquid preparation control system is connected with the liquid preparation assembly, the liquid preparation electrical connection assembly is arranged on the liquid preparation control system, the liquid preparation pipeline is connected with the liquid preparation assembly, and the liquid preparation assembly is used for containing and stirring the prepared liquid; and/or the presence of a gas in the gas,
the ultrafiltration equipment further comprises an ultrafiltration control system and an ultrafiltration component, wherein the ultrafiltration control system is connected with the ultrafiltration component, the ultrafiltration electrical connection component is arranged in the ultrafiltration control system, the ultrafiltration pipeline is connected with the ultrafiltration component, and the ultrafiltration component is used for purifying the configured liquid.
In one embodiment, the connecting device comprises a signal identification part, the liquid preparation equipment is plugged with the ultrafiltration equipment through the connecting device, and the signal identification part is used for detecting the connection state and feeding back a signal to the ultrafiltration control system.
In one embodiment, the liquid preparation electrical connection assembly comprises a first power interface, a first network communication interface and a first signal connection interface, the ultrafiltration electrical connection assembly comprises a second power interface, a power supply interface, a second network communication interface and a second signal connection interface, the second power interface is used for being connected with a power supply, the first power interface is connected with the power supply interface, the first network communication interface is connected with the second network communication interface, and the first signal connection interface is connected with the second signal connection interface so as to electrically connect the liquid preparation equipment with the ultrafiltration equipment; or the first power interface is used for being connected with a power supply, the first network communication interface is disconnected with the second network communication interface, and the first signal connection interface is disconnected with the second signal connection interface, so that the liquid preparation equipment is electrically disconnected with the ultrafiltration equipment.
In one embodiment, the liquid dispensing assembly comprises: the liquid mixing device comprises a liquid mixing bag, a liquid mixing box, a weighing module, a magnetic stirring module, a liquid mixing detection assembly and a detection electrode interface, wherein the liquid mixing bag is arranged in the liquid mixing box and is used for containing liquid to be mixed; the liquid distribution box is connected with the weighing module, and the weighing module is used for measuring the total amount change of the prepared liquid in the liquid distribution bag; the bottom in the liquid preparation box is provided with a magnetic stirring module for uniformly stirring and mixing the prepared liquid; the liquid preparation detection assembly is arranged in the liquid preparation box and used for detecting the state of the prepared liquid; the detection electrode interface is used for connecting external equipment.
In one embodiment, the magnetic stirring module comprises a stirring pump and a blade, the blade is arranged in the liquid distribution box, and the stirring pump is connected with the blade.
In one embodiment, the ultrafiltration pipeline comprises an ultrafiltration section pipeline, a reflux section pipeline and a permeation section pipeline, the ultrafiltration assembly comprises a membrane pump set, a pressure sensor, a flow meter, a pinch valve and an ultrafiltration membrane package, the ultrafiltration section pipeline, the reflux section pipeline and the permeation section pipeline are all connected with the ultrafiltration membrane package, and the membrane pump set, the pressure sensor, the flow meter and the pinch valve are all arranged on the ultrafiltration section pipeline.
In one embodiment, one end of the liquid distribution pipeline is connected with the return section pipeline, and the other end of the liquid distribution pipeline is connected with the ultrafiltration section pipeline through the liquid distribution box; the backflow section pipeline further comprises a backflow pinch valve, and the permeation section pipeline further comprises a permeation pinch valve.
In one embodiment, the diaphragm pump group comprises a first diaphragm pump and a second diaphragm pump, the first diaphragm pump is arranged at one end of the ultrafiltration section pipeline close to the liquid distribution pipeline, and the second diaphragm pump is arranged at one end of the ultrafiltration section pipeline close to the ultrafiltration membrane.
In one embodiment, the ultrafiltration module further comprises a backflow detection module, wherein the backflow detection module is arranged on the backflow section pipeline and used for detecting the liquid state of the backflow section pipeline.
According to the liquid preparation ultrafiltration device, the liquid preparation electrical connecting assembly and the ultrafiltration electrical connecting assembly can be electrically connected in an on-off manner, the liquid preparation pipeline can be in fluid communication with the ultrafiltration pipeline in an on-off manner, the liquid preparation equipment and the ultrafiltration equipment are detachably and mechanically connected through the connecting device, when the liquid preparation electrical connecting assembly is electrically connected with the ultrafiltration electrical connecting assembly, the liquid preparation pipeline is connected with the ultrafiltration pipeline so that the fluid is communicated, and the liquid preparation equipment and the ultrafiltration equipment are mechanically connected through the connecting device, the liquid preparation equipment and the ultrafiltration equipment can be combined for use to form liquid preparation ultrafiltration integrated equipment, at the moment, the liquid preparation system becomes a prepositive process of an ultrafiltration system, and the convenient and rapid combined application of two sets of systems is realized; when the liquid preparation electrical connecting assembly is electrically disconnected with the ultrafiltration electrical connecting assembly, the liquid preparation pipeline is disconnected with the ultrafiltration pipeline, and the liquid preparation equipment and the ultrafiltration equipment are mechanically disconnected through the connecting device, the liquid preparation equipment and the ultrafiltration equipment can be independently used, so that the dual-purpose machine is realized. The liquid preparation ultrafiltration device can reduce the configuration quantity of production line equipment, improve the utilization rate of the equipment and reduce the operation cost.
Drawings
FIG. 1 is a schematic structural view of a liquid preparation ultrafiltration device;
fig. 2 is a schematic structural diagram of the connecting device.
Description of reference numerals:
100. liquid preparation equipment; 110. a liquid preparation bag; 120. a liquid preparation system control cabinet; 130. a liquid distribution box; 140. detecting an electrode interface; 150. an electrode support frame; 160. a weighing module; 170. a magnetic stirring module;
200. ultrafiltration equipment; 210. a second diaphragm pump; 220. a pressure sensor; 230. a flow meter; 240. a pinch valve; 250. an ultrafiltration membrane package; 260. a backflow detection component; 270. a touch screen; 280. a control box;
300. a connecting device;
1. connecting the female head; 2. connecting a male head; 21. a plug-in part; 3. inserting a guide sleeve; 4. a guiding square cylinder; 5. a locking member; 51. a contact block; 6. a spring; 7. a fixed cover; 71. a limiting plane; 72. a first guide sleeve; 73. a second guide sleeve; 8. a top cover; 81. a limiting bump; 9. a position sensor; 10. a circlip is provided.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like as used herein are for illustrative purposes only and do not denote a unique embodiment.
Referring to fig. 1, fig. 1 shows a schematic structural diagram of a fluid distribution ultrafiltration device in an embodiment of the invention. An embodiment of the present invention provides a liquid preparation ultrafiltration device, including: the liquid preparation equipment 100, the liquid preparation equipment 100 comprises a liquid preparation electrical connection assembly and a liquid preparation pipeline; the ultrafiltration equipment 200, the ultrafiltration equipment 200 comprises an ultrafiltration electrical connection assembly and an ultrafiltration pipeline, the liquid preparation electrical connection assembly and the ultrafiltration electrical connection assembly can be electrically connected in a connection and disconnection manner, and the liquid preparation pipeline and the ultrafiltration pipeline can be in fluid communication in a connection and disconnection manner; the connecting means 300, the liquid dispensing apparatus 100 and the ultrafiltration apparatus 200 are detachably mechanically connected by the connecting means 300. In the liquid preparation ultrafiltration device, the liquid preparation electrical connection assembly and the ultrafiltration electrical connection assembly can be electrically connected in a connection and disconnection manner, the liquid preparation pipeline and the ultrafiltration pipeline can be in fluid communication in a connection and disconnection manner, the liquid preparation equipment 100 and the ultrafiltration equipment 200 are detachably and mechanically connected through the connection device 300, when the liquid preparation electrical connection assembly is electrically connected with the ultrafiltration electrical connection assembly, the liquid preparation pipeline and the ultrafiltration pipeline are connected to enable the fluid to be communicated, and the liquid preparation equipment 100 and the ultrafiltration equipment 200 are mechanically connected through the connection device 300, the liquid preparation equipment 100 and the ultrafiltration equipment 200 can be combined for use to form liquid preparation ultrafiltration integrated equipment, at the moment, the liquid preparation system becomes a prepositive process of an ultrafiltration system, and the convenient and rapid combined application of the two systems is realized; when the liquid preparation electrical connection assembly is electrically disconnected from the ultrafiltration electrical connection assembly, the liquid preparation pipeline is disconnected from the ultrafiltration pipeline, and the liquid preparation equipment 100 and the ultrafiltration equipment 200 are mechanically disconnected through the connection device 300, the liquid preparation equipment 100 and the ultrafiltration equipment 200 can be used independently, so that the dual-purpose of one machine is realized. The liquid preparation ultrafiltration device can reduce the configuration quantity of production line equipment, improve the utilization rate of the equipment and reduce the operation cost.
Preferably, in this embodiment, the liquid dispensing apparatus 100 further includes a liquid dispensing control system and a liquid dispensing assembly, the liquid dispensing control system is connected to the liquid dispensing assembly, the liquid dispensing electrical connection assembly is disposed in the liquid dispensing control system, the liquid dispensing pipeline is connected to the liquid dispensing assembly, and the liquid dispensing assembly is used for containing and stirring a liquid to be dispensed; and/or, the ultrafiltration apparatus 200 further comprises an ultrafiltration control system and an ultrafiltration component, the ultrafiltration control system is connected with the ultrafiltration component, the ultrafiltration electrical connection component is arranged in the ultrafiltration control system, the ultrafiltration pipeline is connected with the ultrafiltration component, and the ultrafiltration component is used for purifying the configured liquid. The liquid preparation control system is used for controlling the liquid preparation assembly, the ultrafiltration control system is used for controlling the ultrafiltration assembly, when the liquid preparation electrical connection assembly is disconnected with the ultrafiltration electrical connection assembly, the electric power connection between the liquid preparation equipment 100 and the ultrafiltration equipment 200 is disconnected, and the liquid preparation equipment 100 and the ultrafiltration equipment 200 can be used independently; when the liquid preparation electrical connection assembly is connected with the ultrafiltration electrical connection assembly, the electric power communication between the liquid preparation equipment 100 and the ultrafiltration equipment 200 is realized, and further, the liquid preparation equipment 100 and the ultrafiltration equipment 200 share one control system, specifically, the liquid preparation equipment 100 and the ultrafiltration equipment 200 can share the ultrafiltration control system.
Further, the connection device 300 comprises a signal recognition component, the liquid preparation device 100 is plugged with the ultrafiltration device 200 through the connection device 300, and the signal recognition component is used for detecting the connection state and feeding back a signal to the ultrafiltration control system. After the liquid preparation device 100 is mechanically plugged into the ultrafiltration device 200 through the connection device 300, the physical connection between the liquid preparation device 100 and the ultrafiltration device 200 is locked, specifically, referring to fig. 2, fig. 2 shows a schematic structural diagram of the connection device 300, and the connection device 300 includes: the connecting female head 1 is provided with a cavity, the end part of the connecting female head 1 is provided with an inserting through hole communicated with the cavity, and the side part of the connecting female head 1 is provided with an opening communicated with the cavity; the male connector 2 is connected, the male connector 2 comprises an inserting part 21, the inserting part 21 is inserted into the cavity through an inserting through hole, and the inserting part 21 is provided with a through limiting hole; self-lock device, self-lock device include retaining member 5, retaining member 5 are used for with the trompil cooperation of pegging graft to through inserting the trompil and spacing grafting cooperation in spacing hole, will connect female head 1 and connect the locking of public head 2. The self-locking device further comprises a fixed cover 7, a top cover 8 and an elastic check ring 10, the fixed cover 7 is fixed in the opening, a cover hole communicated with the opening is formed in the fixed cover 7, the locking part 5 comprises a contact block 51, a transmission rod and an elastic part, the contact block 51 is located at the end part of the transmission rod, the transmission rod is movably inserted in the cover hole and the opening, so that the contact block 51 can be inserted in the limiting hole, the elastic part is assembled on the transmission rod and elastically abutted between the contact block 51 and the fixed cover 7, the locking part 5 is elastically connected with the fixed cover 7 through the elastic part, and the top cover 8 is connected with the transmission rod through the elastic check ring 10; fixed lid 7 is equipped with first uide bushing 72 and the second uide bushing 73 that intercommunication lid hole and interconnect, the outer wall of first uide bushing 72 is equipped with spacing plane 71, top cap 8 is equipped with the first shoulder hole and the second shoulder hole of connection, the internal face in first shoulder hole is equipped with spacing lug 81, first shoulder hole so that spacing lug 81 and the spacing butt of spacing plane 71 can be located to first uide bushing 72 cover, or first shoulder hole so that spacing lug 81 and the spacing butt of the terminal surface of first uide bushing 72 can be located to second uide bushing 73 cover.
When the connecting device 300 is used, the female connector 1 is connected with the liquid distribution equipment 100, the male connector 2 is connected with the ultrafiltration equipment 200, the inserting part 21 connected with the male connector 2 is pushed into a cavity of the female connector 1 through the connecting through hole, the inserting part 21 is contacted with the contact block 51 of the locking part 5 and jacks up the contact block 51, the male connector 2 is continuously pushed until the contact block 51 falls into the limiting hole of the inserting part 21, and the inserting and locking of the female connector 1 and the male connector 2 are realized. Through fixed lid 7 and elastic component mating reaction, prevent that retaining member 5 from deviating from spacing hole, realize connecting the auto-lock. Top cap 8 passes through circlip 10 and realizes holding to the location to retaining member 5 to can rotate for retaining member 5, when needing the disconnection, mention top cap 8, retaining member 5 removes to the direction of keeping away from spacing hole along with top cap 8, realizes the unblock. When the limiting convex block 81 slides upwards to the end surface of the first guide sleeve 72 relative to the limiting plane 71, the top cover 8 is rotated, so that the limiting convex block 81 is abutted and limited on the end surface of the first guide sleeve 72 to keep an unlocking state, the male connector 2 is conveniently pushed out, and the female connector 1 and the male connector 2 are disconnected. By adopting the connecting device 300, the female connector is connected with the liquid preparation device 100, the male connector is connected with the ultrafiltration device 200, then the female connector is connected with the male connector to be locked, so that the quick connection self-locking of the liquid preparation device 100 and the ultrafiltration device 200 can be realized, the operation is simple, the connection is reliable, the requirement of the combined use of the two devices can be met, and the liquid preparation and ultrafiltration integrated machine can be separated by unlocking the connecting device 300, so that the dual-purpose of one machine is realized.
Further, the ultrafiltration control system further comprises a monitoring system and a control system of the whole liquid preparation ultrafiltration equipment, wherein the monitoring system is used for receiving a connection state signal of the liquid preparation equipment 100 and the ultrafiltration equipment 200 and switching the ultrafiltration control system into the control system of the whole liquid preparation ultrafiltration equipment. After the liquid preparation device 100 is mechanically inserted and locked with the ultrafiltration device 200 through the connecting device 300, the signal recognition component detects the connection state and feeds back a signal to the monitoring system, the monitoring system enters the control system of the liquid preparation ultrafiltration device 200 and switches the operation interface, the liquid preparation device 100 and the ultrafiltration device 200 share one control system, and the liquid preparation system becomes a pre-process of the ultrafiltration system, so that the combined use of the two devices is realized.
Optionally, the signal recognition component is a position sensor for detecting the connection state of the ultrafiltration device and feeding back a position signal to the ultrafiltration control system.
Furthermore, the liquid preparation electrical connection assembly comprises a first power interface, a first network communication interface and a first signal connection interface, the ultrafiltration electrical connection assembly comprises a second power interface, a power supply interface, a second network communication interface and a second signal connection interface, the second power interface is used for being connected with a power supply, the first power interface is connected with the power supply interface, the first network communication interface is connected with the second network communication interface, the first signal connection interface is connected with the second signal connection interface, so that the liquid preparation device 100 is electrically connected with the ultrafiltration device 200, the electric power communication, the network communication interface communication and the signal communication between the liquid preparation device 100 and the ultrafiltration device 200 are realized, and further the liquid preparation device 100 and the ultrafiltration device 200 share one control system, and particularly, the liquid preparation device 100 and the ultrafiltration device 200 can share the ultrafiltration control system; or, the first power interface is used for being connected with a power supply, the first network communication interface is disconnected with the second network communication interface, the first signal connection interface is disconnected with the second signal connection interface, so that the liquid preparation equipment 100 is electrically disconnected with the ultrafiltration equipment 200, the power connection, the network communication interface and the signal connection of the liquid preparation equipment 100 and the ultrafiltration equipment 200 are disconnected, and the liquid preparation equipment 100 and the ultrafiltration equipment 200 can be used independently.
Specifically, the connection between the second power supply interface and the power supply, the connection between the first power supply interface and the power supply interface, the connection between the first network communication interface and the second network communication interface, and the connection between the first signal connection interface and the second signal connection interface are all connected through an aviation connector, so that the liquid preparation equipment 100 is electrically connected with the ultrafiltration equipment 200, and when the connection is disconnected, the interfaces can be sealed by using a sealing cover plate.
Preferably, in one embodiment, the liquid dispensing assembly comprises: the liquid mixing device comprises a liquid mixing bag 110, a liquid mixing box 130, a weighing module 160, a magnetic stirring module 170, a liquid mixing detection assembly and a detection electrode interface 140, wherein the liquid mixing bag 110 is arranged in the liquid mixing box 130 and is used for containing liquid; the liquid distribution box 130 is connected with the weighing module 160, and the weighing module 160 is used for measuring the total amount change of the prepared liquid in the liquid distribution bag 110; the bottom in the liquid preparation box 130 is provided with a magnetic stirring module 170 for uniformly stirring and mixing the prepared liquid; the liquid preparation detection component is arranged in the liquid preparation tank 130 and is used for detecting the state of the prepared liquid; the detection electrode interface 140 is used for connecting external devices, specifically, for connecting an electrode, a ph probe, a temperature detection probe, and a sampling interface.
Optionally, in this embodiment, the magnetic stirring module 170 includes a stirring pump (not shown), and a paddle (not shown) disposed in the liquid distribution box 130, and the stirring pump is connected to the paddle. The stirring pump drives the paddle to rotate, and liquid in the liquid distribution box is uniformly stirred.
Optionally, the liquid preparation control system further comprises a liquid preparation system control cabinet 120, and the liquid preparation system control cabinet 120 is disposed outside the liquid preparation tank 130 and is used for controlling and operating the liquid preparation apparatus 100 when used alone.
Further, the liquid preparation control system also comprises a temperature control unit for controlling the temperature of the liquid preparation equipment.
Optionally, the liquid distribution bag 110 is a disposable liquid delivery and distribution bag, and the disposable liquid delivery and distribution bag is disposed in the liquid distribution box 130 and can be aseptically isolated from the outside.
Optionally, a handle (not shown) is disposed outside the liquid dispensing box 130 for manually pushing the liquid dispensing apparatus 100, so as to facilitate the movement and use of the liquid dispensing apparatus 100.
Optionally, the liquid distribution assembly further includes an electrode support frame 150, the electrode support frame 150 is opposite to the detection electrode interface 140 and is disposed on the outer surface of the liquid distribution box 130, and the electrode support frame 150 is inclined upward and is installed at an angle of 15 ° with the liquid distribution box 130. The electrode support frame 150 is used for supporting the tail end of the electrode, so that the normal installation position and the use effect are ensured.
Preferably, in one embodiment, the ultrafiltration pipeline includes an ultrafiltration section pipeline, a reflux section pipeline and a permeation section pipeline, the ultrafiltration module includes a membrane pump set, a pressure sensor 220, a flow meter 230, a pinch valve 240 and an ultrafiltration membrane package 250, the ultrafiltration section pipeline, the reflux section pipeline and the permeation section pipeline are all connected with the ultrafiltration membrane package 250, and the membrane pump set, the pressure sensor 220, the flow meter 230 and the pinch valve 240 are all disposed on the ultrafiltration section pipeline. The diaphragm pump set provides flowing power for liquid in the pipe, the pressure sensor 220 is used for detecting pressure in the pipe, the flow meter is used for measuring flow in the pipe, and feedback signals are provided for controlling system flow, specifically, the flow meter 230 is an ultrasonic flow meter, and the pinch valve 240 is used for controlling the circulation or closing of the pipe.
Furthermore, one end of the liquid distribution pipeline is connected with the reflux section pipeline, and the other end of the liquid distribution pipeline is connected with the ultrafiltration section pipeline through the liquid distribution box 130; the return section pipeline also comprises a return pinch valve, and the permeation section pipeline also comprises a permeation pinch valve. The liquid enters the liquid distribution box 130 through the liquid distribution pipeline for preparation and uniform mixing, enters the ultrafiltration membrane package 250 through the ultrafiltration tube chariot after uniform mixing, and separates substances with different molecular weights or other impurities under the action of stable transmembrane pressure, wherein the small molecular substances flow out through the permeation section pipeline, and the rest of the large molecular substances flow back into the liquid distribution box 130 through the backflow section pipeline.
Optionally, the diaphragm pump set includes a first diaphragm pump and a second diaphragm pump 210, the first diaphragm pump is disposed at one end of the ultrafiltration section pipeline close to the liquid distribution pipeline, and the second diaphragm pump 210 is disposed at one end of the ultrafiltration section pipeline close to the ultrafiltration membrane 250. Liquid flows into the liquid distribution pipeline through the first diaphragm pump, enters the liquid distribution box 130 through the liquid distribution pipeline to be uniformly mixed, flows into the ultrafiltration tube chariot through the second diaphragm pump 210 after being uniformly mixed, enters the ultrafiltration membrane package 250 through the ultrafiltration tube chariot, and separates substances with different molecular weights or other impurities under the action of stable transmembrane pressure, wherein small molecular substances flow out through the permeation section pipeline, and other large molecular substances flow back into the liquid distribution box 130 through the backflow section pipeline.
In this embodiment, the ultrafiltration module further includes a backflow detection module 260, and the backflow detection module 260 is disposed on the backflow segment pipeline for detecting a liquid state of the backflow segment pipeline.
Preferably, the backflow detecting assembly 260 includes a conductivity detecting probe, an ultraviolet detecting probe, a temperature detecting probe and a PH detecting probe, and the conductivity detecting probe, the ultraviolet detecting probe, the temperature detecting probe and the PH detecting probe are respectively used for detecting the conditions of the liquid conductivity, the protein concentration, the temperature and the PH of the backflow segment pipeline.
Optionally, the ultrafiltration control system further comprises a control box 280, in order to reduce the volume of the ultrafiltration apparatus 200, the ultrafiltration module and the ultrafiltration tube 36738are arranged on the outer surface of the control box 280, and the upper side of the control box is provided with a touch screen 270, so that human-computer interaction is facilitated.
In the liquid preparation ultrafiltration device, the liquid preparation electrical connection assembly and the ultrafiltration electrical connection assembly can be electrically connected in a connection and disconnection manner, the liquid preparation pipeline and the ultrafiltration pipeline can be in fluid communication in a connection and disconnection manner, the liquid preparation equipment 100 and the ultrafiltration equipment 200 are detachably and mechanically connected through the connection device 300, when the liquid preparation electrical connection assembly is electrically connected with the ultrafiltration electrical connection assembly, the liquid preparation pipeline and the ultrafiltration pipeline are connected to enable the fluid to be communicated, and the liquid preparation equipment 100 and the ultrafiltration equipment 200 are mechanically connected through the connection device 300, the liquid preparation equipment 100 and the ultrafiltration equipment 200 can be combined for use to form liquid preparation ultrafiltration integrated equipment, at the moment, the liquid preparation system becomes a prepositive process of an ultrafiltration system, and the convenient and rapid combined application of the two systems is realized; when the liquid preparation electrical connection assembly is electrically disconnected from the ultrafiltration electrical connection assembly, the liquid preparation pipeline is disconnected from the ultrafiltration pipeline, and the liquid preparation equipment 100 and the ultrafiltration equipment 200 are mechanically disconnected through the connection device 300, the liquid preparation equipment 100 and the ultrafiltration equipment 200 can be used independently, so that the dual-purpose of one machine is realized. The liquid preparation ultrafiltration device can reduce the configuration quantity of production line equipment, improve the utilization rate of the equipment and reduce the operation cost.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, but should be considered as the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above examples only show some embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A fluid dispensing ultrafiltration device, the fluid dispensing ultrafiltration device comprising:
the liquid preparation equipment comprises a liquid preparation electrical connecting assembly and a liquid preparation pipeline;
the ultrafiltration equipment comprises an ultrafiltration electrical connecting assembly and an ultrafiltration pipeline, the liquid preparation electrical connecting assembly is electrically connected with the ultrafiltration electrical connecting assembly in a switching and connecting mode, and the liquid preparation pipeline is in fluid communication with the ultrafiltration pipeline in a switching and connecting mode;
a connection means by which the liquid dispensing apparatus and the ultrafiltration apparatus are detachably mechanically connected.
2. The fluid-dispensing ultrafiltration device according to claim 1, wherein the fluid-dispensing apparatus further comprises a fluid-dispensing control system and a fluid-dispensing assembly, the fluid-dispensing control system is connected with the fluid-dispensing assembly, the fluid-dispensing electrical connection assembly is arranged on the fluid-dispensing control system, the fluid-dispensing pipeline is connected with the fluid-dispensing assembly, and the fluid-dispensing assembly is used for containing and stirring a fluid to be dispensed; and/or the presence of a gas in the gas,
the ultrafiltration equipment further comprises an ultrafiltration control system and an ultrafiltration component, wherein the ultrafiltration control system is connected with the ultrafiltration component, the ultrafiltration electrical connection component is arranged in the ultrafiltration control system, the ultrafiltration pipeline is connected with the ultrafiltration component, and the ultrafiltration component is used for purifying the configured liquid.
3. The ultrafiltration device of claim 1, wherein the connection device comprises a signal recognition component, the liquid preparation equipment is plugged with the ultrafiltration equipment through the connection device, and the signal recognition component is used for detecting the connection state and feeding back a signal to the ultrafiltration control system.
4. The ultrafiltration device of claim 1, wherein the electrical connection assembly comprises a first power interface, a first network communication interface and a first signal connection interface, and the ultrafiltration electrical connection assembly comprises a second power interface, a power supply interface, a second network communication interface and a second signal connection interface, wherein the second power interface is used for connecting with a power supply, the first power interface is connected with the power supply interface, the first network communication interface is connected with the second network communication interface, and the first signal connection interface is connected with the second signal connection interface, so that the fluid preparation equipment is electrically connected with the ultrafiltration equipment; or the first power interface is used for being connected with a power supply, the first network communication interface is disconnected with the second network communication interface, and the first signal connection interface is disconnected with the second signal connection interface, so that the liquid preparation equipment is electrically disconnected with the ultrafiltration equipment.
5. The fluid-dispensing ultrafiltration device of claim 2, wherein the fluid-dispensing assembly comprises: the liquid mixing device comprises a liquid mixing bag, a liquid mixing box, a weighing module, a magnetic stirring module, a liquid mixing detection assembly and a detection electrode interface, wherein the liquid mixing bag is arranged in the liquid mixing box and is used for containing liquid to be mixed; the liquid distribution box is connected with the weighing module, and the weighing module is used for measuring the total amount change of the prepared liquid in the liquid distribution bag; the bottom in the liquid preparation box is provided with a magnetic stirring module for uniformly stirring and mixing the prepared liquid; the liquid preparation detection assembly is arranged in the liquid preparation box and used for detecting the state of the prepared liquid; the detection electrode interface is used for connecting external equipment.
6. The fluid mixing ultrafiltration device of claim 5, wherein the magnetic stirring module comprises a stirring pump and a paddle, wherein the paddle is disposed in the fluid mixing tank, and the stirring pump is connected to the paddle.
7. The liquid preparation ultrafiltration device according to claim 2, wherein the ultrafiltration pipeline comprises an ultrafiltration section pipeline, a reflux section pipeline and a permeation section pipeline, the ultrafiltration assembly comprises a membrane pump set, a pressure sensor, a flow meter, a pinch valve and an ultrafiltration membrane package, the ultrafiltration section pipeline, the reflux section pipeline and the permeation section pipeline are all connected with the ultrafiltration membrane package, and the membrane pump set, the pressure sensor, the flow meter and the pinch valve are all arranged on the ultrafiltration section pipeline.
8. The fluid-dispensing ultrafiltration device according to claim 7, wherein one end of the fluid-dispensing pipeline is connected with the return section pipeline, and the other end of the fluid-dispensing pipeline is connected with the ultrafiltration section pipeline through the fluid-dispensing tank; the backflow section pipeline further comprises a backflow pinch valve, and the permeation section pipeline further comprises a permeation pinch valve.
9. The fluid-dispensing ultrafiltration device of claim 7, wherein the membrane pump set comprises a first membrane pump and a second membrane pump, the first membrane pump is disposed at an end of the ultrafiltration section pipeline close to the fluid-dispensing pipeline, and the second membrane pump is disposed at an end of the ultrafiltration section pipeline close to the ultrafiltration membrane.
10. The fluid-dispensing ultrafiltration device of claim 7, wherein the ultrafiltration module further comprises a backflow detection module disposed in the backflow segment conduit for detecting a fluid condition of the backflow segment conduit.
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| CN202111510762.2A CN114225800A (en) | 2021-12-10 | 2021-12-10 | Liquid preparation ultrafiltration device |
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| CN202111510762.2A CN114225800A (en) | 2021-12-10 | 2021-12-10 | Liquid preparation ultrafiltration device |
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