CN114225441B

CN114225441B - Continuous vacuum spray drying device

Info

Publication number: CN114225441B
Application number: CN202111548042.5A
Authority: CN
Inventors: 陈洁; 张志祥; 王万玺
Original assignee: Keypoint Pharmaceutical Technology Qidong Co ltd
Current assignee: Keypoint Pharmaceutical Technology Qidong Co ltd
Priority date: 2021-12-16
Filing date: 2021-12-16
Publication date: 2023-02-03
Anticipated expiration: 2041-12-16
Also published as: CN114225441A

Abstract

The invention discloses a continuous vacuum spray drying device, wherein a containing cavity is formed in a shell, a support is arranged in the containing cavity, a collecting pot is fixedly arranged on the support, a conical base is fixedly arranged at the bottom of the collecting pot, a rotating hole is formed in the conical base, a rotor is arranged in the collecting pot, one end of the rotor penetrates through the rotating hole and is rotatably connected with the bottom of the containing cavity, a disc is fixedly arranged on the rotor, an air inlet mechanism is fixedly arranged in the collecting pot, a condensing mechanism is embedded in the shell and is electrically connected with the air inlet mechanism, a cover plate is rotatably connected to the shell, an atomizing nozzle is fixedly arranged on the cover plate, and the atomizing nozzle is electrically connected with the air inlet mechanism. According to the continuous vacuum spray drying device provided by the invention, the collecting pot is driven to rotate by the rotor, so that liquid drops continuously roll while being dried, particles with uniform roundness and high height and relative compactness are prepared, and the quality of products is improved.

Description

Continuous vacuum spray drying device

Technical Field

The invention relates to the technical field of drying equipment, in particular to a continuous vacuum spray drying device.

Background

A spray drier for preparing the powdered material from liquid materials such as biologic medicines, food, etc. features that different atomizers are used to spray the solution, emulsion, suspension or water-contained pasty material in hot air to become fine liquid drops, and during the dropping of liquid drops, the water is evaporated to obtain powdered or granular product, so completing both spraying and drying.

Current spray dryer usually adopts in getting into the drying chamber with high temperature air and atomizing concentrate by different shower nozzles, makes high temperature air and atomizing concentrate fully contact, and then makes the mode of the evaporation of being heated of moisture in the atomizing concentrate separate required product from the concentrate, but what this kind of mode obtained is powdered solid product, and the uniformity is relatively poor.

Disclosure of Invention

The invention aims to solve the technical problems that the particle structure obtained by drying the existing spray dryer is loose, particles (nano particles or microspheres) with good roundness and compactness can not be obtained, and the early release of the medicament is not controlled easily. In order to overcome the defects of the prior art, the invention provides a continuous vacuum spray drying device, a collecting pot is driven by a rotor to rotate, so that liquid drops continuously roll while being dried, particles (nano particles or microspheres) with uniform roundness, high height and relative compactness are prepared, and the quality of products is improved.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a continuous vacuum spray drying device which comprises a shell, a collecting pot, a conical base, a rotor, a support, a disc, an air inlet mechanism, a condensing mechanism, a cover plate and an atomizing nozzle.

In a preferred technical scheme of the invention, the rotor comprises a rotating block, a sleeve, a rotating shaft, fan blades, a fastening bolt and a retaining ring, the rotating block is arranged in the collecting pot, the sleeve is inserted in the rotating hole, one end of the sleeve is connected with the rotating shaft in a sliding manner, the other end of the sleeve is fixedly arranged at the center of the rotating block, the rotating shaft is rotatably connected to the bottom of the accommodating cavity, the fastening bolt is arranged in the sleeve, the rotating block is fixedly connected with the rotating shaft through the fastening bolt, more than two fan blades are uniformly and circumferentially arranged on the side surface of the rotating block, the retaining ring is sleeved on the rotating block, and the retaining ring is fixedly connected with the fan blades.

In a preferred technical scheme of the invention, the air inlet mechanism comprises a pressure sensor, a concentration sensor, a PLC controller and an air nozzle, the pressure sensor and the concentration sensor are embedded in the collecting pot, the PLC controller and the air nozzle are fixedly arranged on one side of the shell, one end of the air nozzle extends into the collecting pot, and the pressure sensor, the concentration sensor and the air nozzle are electrically connected with the PLC controller.

In a preferred technical scheme of the invention, the air nozzle is connected with a vacuum extractor.

In a preferred technical scheme of the invention, the air tap is connected with the hot air blower.

In a preferred technical scheme of the invention, a through hole is formed in the bottom of the collection pot, the valve is fixedly arranged at the bottom of the collection pot and is communicated with the through hole, a temporary storage tank is fixedly arranged in the accommodating cavity, one end of the silicone tube is communicated with the temporary storage tank, the other end of the silicone tube extends to the position below the valve, the valve is electrically connected with the PLC, a material outlet is fixedly arranged on the outer side of the shell, and the material outlet is communicated with the temporary storage tank.

In a preferred technical scheme of the invention, spiral grooves are formed in the end face of the disc and the inner surface of the collection pot.

In a preferred technical scheme of the invention, the condensing mechanism comprises a condensing pipe, a hydraulic pump and a cooling liquid tank, the condensing pipe is fixedly arranged on the circumferential direction of the side wall of the accommodating cavity, the cooling liquid tank is embedded in the shell, the condensing pipe is communicated with the cooling liquid tank, and the hydraulic pump is fixedly arranged in the cooling liquid tank.

The invention has the beneficial effects that:

1. in the invention, atomized liquid drops fall on the disc and then rotate at high speed along with the disc, so that the liquid drops and high-temperature air move relatively, and the drying speed of the liquid drops can be accelerated. Meanwhile, the liquid drops move to the inner wall of the collection pot under the action of centrifugal force to further move and dry.

2. According to the invention, the rotor drives the collecting pot to rotate, so that liquid drops continuously roll along the inner wall of the collecting pot while drying, particles with uniform roundness, high height and relative compactness are prepared, and the product quality is improved.

3. In the invention, the spiral grooves are arranged on the inner walls of the disc and the collecting pot to prolong the moving path of liquid drops and improve the drying efficiency.

4. According to the invention, the temporary storage tank is arranged below the collection pot, so that the collected materials can be intermittently conveyed to the material outlet, the vacuum operation state of the equipment is not interfered, and the continuous operation of the equipment is realized.

Drawings

FIG. 1 is a schematic diagram of a continuous vacuum spray drying apparatus according to an embodiment of the present invention;

fig. 2 is an enlarged schematic view at a in fig. 1.

In the figure:

1. a housing; 2. collecting the pan; 3. a conical base; 4. a rotor; 401. rotating the block; 402. a sleeve; 403. A rotating shaft; 404. a fan blade; 405. fastening a bolt; 406. a baffle ring; 5. a support; 6. a disc; 7. an air intake mechanism; 701. a pressure sensor; 702. a concentration sensor; 703. a PLC controller; 704. an air faucet; 8. a condensing mechanism; 801. a condenser tube; 802. a hydraulic pump; 803. a coolant tank; 9. a cover plate; 10. an atomizing nozzle; 11. an accommodating chamber; 12. hole turning; 13. a helical groove; 14. a through hole; 15. a valve; 16. a temporary storage tank; 17. a silicone tube; 18. and (5) material outlet.

Detailed Description

The technical scheme of the invention is further explained by the specific implementation mode in combination with the attached drawings.

As shown in fig. 1-2, an embodiment provides a continuous vacuum spray drying device, which includes a housing 1, a collection pan 2, a conical base 3, a rotor 4, a support 5, a disc 6, an air inlet mechanism 7, a condensation mechanism 8, a cover plate 9, and an atomizing nozzle 10, wherein a containing cavity 11 is formed in the housing 1, the support 5 is disposed in the containing cavity 11, the collection pan 2 is fixedly disposed on the support 5, the conical base 3 is fixedly disposed at the bottom of the collection pan 2, a rotating hole 12 is formed in the conical base 3, the rotor 4 is disposed in the collection pan 2, one end of the rotor 4 penetrates through the rotating hole 12 and is rotatably connected with the bottom of the containing cavity 11, the disc 6 is fixedly disposed on the rotor 4, the air inlet mechanism 7 is fixedly disposed in the collection pan 2, the condensation mechanism 8 is embedded in the housing 1, the condensation mechanism 8 is electrically connected with the air inlet mechanism 7, the cover plate 9 is rotatably connected to the housing 1, the atomizing nozzle 10 is fixedly disposed on the cover plate 9, and the atomizing nozzle 10 is electrically connected with the air inlet mechanism 7. In this embodiment, the disc 6 is clamped on the rotor 4 and is fixedly connected with the rotor 4. The device is wide in applicability and can be used for solid-liquid separation and liquid-liquid separation, when the solid-liquid separation is needed, the air inlet mechanism 7 is started, the condensing mechanism 8 is closed, liquid to be dried is atomized through the atomizing nozzle 10, atomized liquid drops fall on the disc 6, the disc 6 is driven by the rotor 4 to rotate at a high speed, the centrifugal force generated by the rotation of the disc 6 enables the liquid drops to move from the circle center to the circumferential edge and to be fully contacted with high-temperature air introduced by the air inlet mechanism 7 in the moving process, so that a solvent in the liquid drops is evaporated, and a solid product is obtained; after falling into the collection pot 2, the solid product rolls along the inner surface of the collection pot 2 under the action of centrifugal force and rolls continuously in the rolling process, so that particles (microspheres or nanoparticles) with uniform roundness and high height and relative compactness are prepared, and the device is particularly suitable for the preparation process of albumin or polymer coated drug microspheres; when liquid-liquid separation is carried out to needs, start simultaneously mechanism 7 and the condensation mechanism 8 of admitting air, admit air mechanism 7 and let in high-temperature air in to collecting pot 2, high-temperature air with treat that the separation liquid drop carries out the heat exchange for treat that the evaporation of low boiling point liquid in the separation liquid drop is gaseous and along with the air current gets into to holding in the chamber 11, and then becomes liquid recovery again under condensation mechanism 8's effect, high boiling point liquid then still stays in collecting pot 2, thereby realizes the liquid-liquid separation.

Specifically, rotor 4 includes and changes piece 401, sleeve 402, pivot 403, flabellum 404, fastening bolt 405 and fender ring 406, it sets up in collecting pot 2 to change piece 401, sleeve 402 is pegged graft in changeing hole 12, the one end and the pivot 403 sliding connection of sleeve 402, the other end of sleeve 402 sets firmly in changeing piece 401 center, pivot 403 rotates to be connected in and holds the chamber 11 bottom, fastening bolt 405 sets up in sleeve 402, and change piece 401 through fastening bolt 405 and pivot 403 fixed connection, change the even flabellum 404 that has set firmly more than two of 401 side circumference, fender ring 406 cover is located on changeing piece 401, and fender ring 406 and flabellum 404 fixed connection. Through keeping off ring 406, flabellum 404 and commentaries on classics piece 401 and mutually supporting and enclose into a settling groove to make disc 6 can quick joint in settling groove, improved operating personnel's installation rate, and disc 6 can dismantle with settling groove and be connected, made things convenient for staff's maintenance and change process. And change piece 401 through fastening bolt 405 and pivot 403 fixed connection, make operating personnel can be with collecting pot 2 and rotor 4 by holding the intracavity 11 and pull down to can conveniently clean collecting pot 2, improve operating personnel's use and experience.

Specifically, air inlet mechanism 7 includes pressure sensor 701, concentration sensor 702, PLC controller 703 and air cock 704, and pressure sensor 701 and concentration sensor 702 all inlay in collecting 2 inboards in the pot, and 1 one side of casing has set firmly PLC controller 703 and air cock 704, and in the one end of air cock 704 stretched into collection pot 2, pressure sensor 701, concentration sensor 702 and air cock 704 all with PLC controller 703 electric connection. In this embodiment, the model of the pressure sensor 701 is preferably L10E, the model of the concentration sensor 702 is preferably PMS3003, the model of the PLC controller 703 is preferably S7-300, and both the pressure sensor 701 and the concentration sensor 702 are connected with the PLC controller 703 in a wireless transmission manner. The pressure sensor 701 is used for detecting the accumulation amount of the solid products in the collection pot 2, when the height of the solid products is accumulated to a certain set value, the pressure sensor 701 is extruded, the pressure sensor 701 sends a signal to the PLC 703, and the PLC 703 controls the valve 15 to be opened, so that the solid products in the collection pot 2 are discharged; the concentration sensor 702 is used for detecting the concentration of the fog drops to be separated in the collection pot 2 and sending the measured concentration information to the PLC 703, so that the PLC 703 can adjust the liquid spraying speed of the atomizing nozzle 10 and the air inlet speed of the air tap 704 in real time, the drying efficiency and the product quality of the liquid drops are ensured, and the intelligent continuous production is realized. In addition, in order to prevent the solid product from covering the concentration sensor 702 and affecting the monitoring function thereof, the concentration sensor 702 is disposed above the pressure sensor 701 when mounted.

Specifically, in one embodiment, the air nozzle 704 is connected to a vacuumizer, which is used to reduce the air pressure in the collection pan 2, so as to reduce the boiling point of the solvent in the liquid drop, so that the solvent can be evaporated at room temperature, thereby obtaining a solid product and increasing the drying speed of the liquid drop.

In another embodiment, the air nozzle 704 is connected to a hot air blower, which can blow hot air into the collection pot 2, so that the solvent is heated and evaporated to obtain a solid product.

Specifically, collect 2 bottoms of pot and seted up through-hole 14, valve 15 is fixed in and collects 2 bottoms of pot, and valve 15 and through-hole 14 intercommunication, hold the intracavity 11 and still set firmly the jar 16 of keeping in, silicone tube 17's one end and jar 16 intercommunication of keeping in, silicone tube 17's the other end extends to the valve 15 below, valve 15 and PLC controller 703 electric connection, the casing 1 outside still sets firmly material outlet 18, material outlet 18 and jar 16 intercommunication of keeping in. In this embodiment, the one end that silicone tube 17 is close to valve 15 is the bell mouth, conveniently collects granular product. When the amount of the solid products in the collection pot 2 reaches a set value, the PLC 703 controls the rotor 4 to stop rotating, the valve 15 is just positioned right above the silicone tube 17, meanwhile, the PLC 703 controls the valve 15 to be opened, so that the solid products in the collection pot 2 fall into the silicone tube 17 through the through hole 14, then enter the temporary storage tank 16 through the silicone tube 17 for storage, and after the transfer of the solid products in the collection pot 2 is finished, the valve 15 can be closed; when the holding tank 16 is full, the operator can remove the product through the material outlet 18. In addition, valve 15 can prevent to collect in the interior droplet of pot 2 gets into in the jar 16 of keeping in to avoid getting wet the product, influence drying effect, make operating personnel need not repeated drying, improved work efficiency.

Specifically, spiral grooves 13 are formed in the end face of the disc 6 and the inner surface of the collecting pot 2. By providing the spiral groove 13 on the disc 6 and the collection pan 2, the moving path of the liquid droplets can be extended, thereby improving the drying efficiency.

Specifically, the condensing mechanism 8 includes a condensing pipe 801, a hydraulic pump 802 and a coolant tank 803, the condensing pipe 801 is fixedly arranged on the circumferential direction of the side wall of the accommodating cavity 11, the coolant tank 803 is embedded in the housing 1, the condensing pipe 801 is communicated with the coolant tank 803, and the hydraulic pump 802 is further fixedly arranged in the coolant tank 803. During operation, the coolant circulates between the condensation pipe 801 and the coolant tank 803 under the effect of the hydraulic pump 802, so that the temperature in the accommodating cavity 11 is reduced, the evaporated solvent or low-boiling-point liquid can be liquefied again and collected, recycling is facilitated, and resources are saved.

While the invention has been described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the spirit and scope of the invention. The present invention is not to be limited by the specific embodiments disclosed herein, and other embodiments that fall within the scope of the claims of the present application are intended to be within the scope of the present invention.

Claims

1. A continuous vacuum spray drying device is characterized in that: comprises a shell (1), a collecting pot (2), a conical base (3), a rotor (4), a support (5), a disc (6), an air inlet mechanism (7), a condensing mechanism (8), a cover plate (9) and an atomizing nozzle (10), wherein a containing cavity (11) is formed in the shell (1), the support (5) is arranged in the containing cavity (11), the collecting pot (2) is fixedly arranged on the support (5), the conical base (3) is fixedly arranged at the bottom of the collecting pot (2), a rotary hole (12) is formed in the conical base (3), the rotor (4) is arranged in the collecting pot (2), one end of the rotor (4) penetrates through the rotary hole (12) and is rotatably connected with the bottom of the containing cavity (11), the disc (6) is fixedly arranged on the rotor (4), the air inlet mechanism (7) is fixedly arranged in the collecting pot (2), the condensing mechanism (8) is embedded in the shell (1), the condensing mechanism (8) is electrically connected with the air inlet mechanism (7), the cover plate (9) is rotatably connected with the shell (1), the atomizing nozzle (10) is fixedly arranged on one side of the shell (1), the atomizing nozzle (704) and the air inlet mechanism (704), one end of the air nozzle (704) extends into the collecting pot (2), and the air nozzle (704) is connected with the vacuum extractor; and/or the air nozzle (704) is connected with the hot air blower.

2. A continuous vacuum spray drying apparatus according to claim 1, wherein: the rotor (4) comprises a rotating block (401), a sleeve (402), a rotating shaft (403), fan blades (404), fastening bolts (405) and a retaining ring (406), the rotating block (401) is arranged in the collecting pot (2), the sleeve (402) is inserted into the rotating hole (12), one end of the sleeve (402) is connected with the rotating shaft (403) in a sliding mode, the other end of the sleeve (402) is fixedly arranged at the center of the rotating block (401), the rotating shaft (403) is rotatably connected to the bottom of the accommodating cavity (11), the fastening bolts (405) are arranged in the sleeve (402), the rotating block (401) is fixedly connected with the rotating shaft (403) through the fastening bolts (405), more than two fan blades (404) are uniformly and fixedly arranged on the side face of the rotating block (401) in the circumferential direction, the retaining ring (406) is sleeved on the rotating block (401), and the retaining ring (406) is fixedly connected with the fan blades (404).

3. A continuous vacuum spray drying apparatus according to claim 2, wherein: air inlet mechanism (7) still include pressure sensor (701), concentration sensor (702) and PLC controller (703), pressure sensor (701) and concentration sensor (702) all inlay in collect pot (2) inboard, casing (1) one side has set firmly PLC controller (703), pressure sensor (701), concentration sensor (702) and air cock (704) all with PLC controller (703) electric connection.

4. A continuous vacuum spray drying apparatus according to claim 3, wherein: collect pot (2) bottom and seted up through-hole (14), valve (15) set firmly in collecting pot (2) bottom, and valve (15) and through-hole (14) intercommunication, hold still to have set firmly in chamber (11) and keep in jar (16), the one end and the jar (16) intercommunication of keeping in of silicone tube (17), the other end of silicone tube (17) extends to valve (15) below, valve (15) with PLC controller (703) electric connection, casing (1) outside still has set firmly material export (18), material export (18) and jar (16) intercommunication of keeping in.

5. A continuous vacuum spray drying apparatus according to claim 1, wherein: spiral grooves (13) are formed in the end face of the disc (6) and the inner surface of the collecting pot (2).

6. A continuous vacuum spray drying apparatus according to claim 1, wherein: condensation mechanism (8) include condenser pipe (801), hydraulic pump (802) and coolant liquid case (803), it has condenser pipe (801) to hold chamber (11) lateral wall circumference to set firmly, and coolant liquid case (803) inlay in casing (1), and condenser pipe (801) and coolant liquid case (803) intercommunication, still set firmly hydraulic pump (802) in coolant liquid case (803).