CN114224345A - Integrated multi-channel stepping electrode support and manufacturing method thereof - Google Patents
Integrated multi-channel stepping electrode support and manufacturing method thereof Download PDFInfo
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- CN114224345A CN114224345A CN202111554554.2A CN202111554554A CN114224345A CN 114224345 A CN114224345 A CN 114224345A CN 202111554554 A CN202111554554 A CN 202111554554A CN 114224345 A CN114224345 A CN 114224345A
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- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
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Abstract
The invention discloses an integrated multi-channel stepping electrode support and a manufacturing method thereof, wherein the integrated multi-channel stepping electrode support comprises a first connecting plate, a lifting mechanism and an electrode array, wherein the first connecting plate is connected with a second connecting plate at intervals; the lifting mechanism is arranged between the first connecting plate and the second connecting plate; the electrode array penetrates through silicon tube through holes formed in the first connecting plate and the second connecting plate; the electrode array is connected with the lifting mechanism, and the lifting mechanism drives the electrode array to move along the axial direction of the electrode array. The invention has the advantages of no unstable and nonparallel structure in the manufacturing process and low cost. The structure of the integrated two-layer plate replaces a three-layer plate structure in the prior art, so that a structural model is simplified, the weight is reduced, and the accuracy degree and the integration degree of the structure are greatly improved. The electrode support mechanism is a two-layer electrode support mechanism with high integration degree, the whole structure is a whole, and screws can directly enter the first connecting plate to be clamped, so that the surface is smoother.
Description
Technical Field
The invention belongs to the field of medical test devices, and relates to an integrated multi-channel stepping electrode support and a manufacturing method thereof.
Background
The human brain is composed of approximately 100 hundred million neurons interconnected by synapses into complex functional networks, and is one of the most complex organs of the human body. At present, people still have low level of cognition on the functional mechanism of the brain, and the research on the function of the brain also becomes one of the hotspots of the current international scientific research.
In the free activity of conscious animals, the activity rule of the group neurons in each relevant brain region of the brain is an important research field at the forefront of neuroscience in recent years. In-vivo multi-channel electrophysiological technology is an important means for recording neural activity, and can observe the activity state of target brain area neurons in a waking and freely-moving state, so that recorded neuron signals are consistent with those in a normal physiological state, and researchers usually adopt the combination of electrophysiology and behaviourology to explore the correlation between brain area activity and behaviour. But the in-vivo multichannel electrophysiological technology relates to a plurality of important technical links such as design and manufacture of an electrode cap, chronic electrode surgical implantation, multichannel real-time data acquisition, single neuron discharge cluster analysis and the like.
In the prior art, a research on a physiological newspaper of a problem group of Endoconcha teachers in Linglong of university of east China, a multichannel in-vivo recording technology, namely a mouse propelled micro-electrode array cap manufacturing and implanting operation. In this article, the problem group of the lin longyear teacher designed an electrode cap with a micro-propulsion device, which can adjust the position of the recording electrode in the vertical direction in the brain at any time. After the electrode is implanted into the brain of an animal, the position of the electrode can still push the recording electrode to deeper brain tissue, so that more neurons can be recorded in the experiment. The electrode cap introduced in the article is of a hollow structure and small in size, can be pushed slightly by adopting mechanical driving, can be slightly modified and can be used for recording other brain areas. The electrode support introduced by the Linlongnian teacher needs more materials in the manufacturing process of an electrode cap, and needs an electrode support plate (PCB fiberboard), a square copper rod, a screw, a nut, epoxy resin, 502 glue and the like. And the manufacturing process is complex, and details and attention need to be paid, so that the micro operation is completed, and the parallel of the PCB fiberboards is ensured, so that the mechanical driving feasibility of the electrode bracket is ensured.
The prior art has the following disadvantages:
firstly, the manufacturing process is difficult and tedious, a PCB needs to be customized in advance, the time period is long, and each support needs to be manually assembled. The process of plugging the copper cylinder into the hole of the PCB is very difficult, and the manufacturer can easily hurt himself by mistake when using tools. The bracket has long manufacturing time and needs to be provided with epoxy resin glue to be smeared at the joint of the copper column and the PCB to be heated and air-dried.
Secondly, the integration degree of the manual electrode support is low, the precision is poor, all the plates may not be parallel to each other, and unnecessary influence is generated on the experimental result.
And thirdly, the supporting columns are made of metal copper columns, so that the weight of the support can be increased, and the burden is added to the mice in the experiment. And the existing structure has three layers, and is difficult to assemble.
Disclosure of Invention
The invention aims to solve the problems in the prior art and provides an integrated multi-channel stepping electrode support and a manufacturing method thereof. The invention has high integration degree and can have a backstop function on the screw.
In order to achieve the purpose, the invention adopts the following technical scheme to realize the purpose:
an integrated multi-channel steppable electrode holder comprising:
the first connecting plates are connected with second connecting plates at intervals;
the lifting mechanism is arranged between the first connecting plate and the second connecting plate;
the electrode array penetrates through silicon tube through holes formed in the first connecting plate and the second connecting plate; the electrode array is connected with the lifting mechanism, and the lifting mechanism drives the electrode array to move along the axial direction of the electrode array.
The invention further improves the following steps:
the first connecting plate is connected with the second connecting plate through a plurality of supporting columns.
The first connecting plate, the second connecting plate and the support columns are of an integrated structure manufactured through 3D printing.
The lifting mechanism comprises a screw and a nut sleeved on the screw; the first connecting plate is provided with a first screw mounting hole, and the second connecting plate is provided with a second screw mounting hole; the screw extends into the second screw mounting hole from the first screw mounting hole; a step is arranged in the first screw mounting hole, a screw cap is embedded into the first screw mounting hole, and the screw cap is clamped on the step in the first screw mounting hole; the nut is fixedly connected with the electrode array.
The top surface of the screw cap is not higher than the upper surface of the first connecting plate.
The limiting groove is formed in the first connecting plate and communicated with the first screw mounting hole, the limiting groove is in sliding fit with the limiting block, the limiting block slides into the first screw mounting hole from the limiting groove, the screw cap and the step are clamped, and axial displacement of the screw is limited.
The electrode array comprises a plurality of bundled silicon tubes, and each silicon tube is internally provided with an electrode wire; a first silicon tube through hole is formed in the first connecting plate, and a second silicon tube through hole is formed in the second connecting plate; the silicon tubes extend into the first silicon tube through hole and penetrate out of the second silicon tube through hole, and the silicon tubes between the first silicon tube through hole and the second silicon tube through hole are connected with the nuts.
The electrode array is bonded with the nut through AB glue.
The first connecting plate is provided with a first clamping piece mounting hole, and the second connecting plate is provided with a second clamping piece mounting hole; the clamping iron wire extends into the second clamping piece mounting hole from the first clamping piece mounting hole; the centre gripping iron wire passes through gluey fixed connection with first holder mounting hole and second holder mounting hole.
A method for manufacturing an integrated multi-channel stepping electrode support comprises the following steps:
manufacturing a first connecting plate, a second connecting plate and a plurality of support columns of an integrated structure by adopting a 3D printing method;
placing a nut between the first screw mounting hole and the second screw mounting hole, extending a screw from the first screw mounting hole, and matching the screw with the nut in a threaded manner, and finally extending the bottom of the screw into the second screw mounting hole, wherein the nut is attached to the step of the first screw mounting hole;
sliding the limiting block into the limiting groove, extending into the first screw mounting hole, and clamping the screw cap and the step;
inserting the electrode wire into the silicon tubes, binding the silicon tubes together, and extending into the silicon tubes from the through holes of the first silicon tube and extending out from the through holes of the second silicon tube;
fixedly connecting the nut with a plurality of bundled silicon tubes;
and the clamping iron wire penetrates through the first clamping piece mounting hole and extends into the second clamping piece mounting hole, and the clamping iron wire is fixedly connected with the first clamping piece mounting hole and the second clamping piece mounting hole.
Compared with the prior art, the invention has the following beneficial effects:
the invention has convenient manufacture, does not need to configure epoxy resin glue, does not need to customize a PCB, does not have the state of unstable and nonparallel structure in the manufacturing process and has low cost. The structure of the integrated two-layer plate replaces a three-layer plate structure in the prior art, so that a structural model is simplified, the weight is reduced, and the accuracy degree and the integration degree of the structure are greatly improved. The electrode support mechanism is a two-layer electrode support mechanism with high integration degree, the whole structure is a whole, and screws can directly enter the first connecting plate to be clamped, so that the surface is smoother.
Furthermore, the screw cap is provided with the limiting block and the limiting groove, and the screw cap can be pushed towards the direction of the first screw mounting hole after the screw is threaded down, so that the limiting block in the limiting groove is positioned at the upper end of the screw cap, and the screw cap plays a role in preventing the screw from moving upwards. The structure can completely replace the function of the existing third layer cover plate, save materials, reduce weight and greatly improve the integration degree.
Furthermore, the first connecting plate, the second connecting plate and the support columns are designed through 3D shape modeling software and manufactured through 3D printing. By using the 3D printing technology, the printing equipment can be manufactured in batches, and each printing equipment does not need to be manufactured manually, so that the time and the energy are saved.
Furthermore, the invention achieves the maximum parallel degree within the error allowable range of the machine in the printing process, the precision is far higher than the parallel precision in manual manufacturing, the manufacturing is integrated, all parts are not required to be fixed by glue, and the brand-new structure only needs two layers of plates to replace the original three-layer plate structure effect, so that the invention is more integrated and lighter.
Further, the invention adopts the light-cured material to perform 3D printing, and the total mass of the printing is less than half of the mass of the replaced part.
Drawings
In order to more clearly explain the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention, and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a schematic view of the overall structure of the present invention.
Fig. 2 is a front view of the present invention.
Fig. 3 is a left side view of fig. 2.
Fig. 4 is a top view of fig. 2.
Wherein: 1-a first connecting plate, 2-a second connecting plate, 3-a first screw mounting hole, 4-a first silicon tube through hole, 5-a first clamping piece mounting hole, 6-a second screw mounting hole, 7-a second silicon tube through hole, 8-a second clamping piece mounting hole, 9-a support column, 10-a limiting groove and 11-a limiting block.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.
In the description of the embodiments of the present invention, it should be noted that if the terms "upper", "lower", "horizontal", "inner", etc. are used for indicating the orientation or positional relationship based on the orientation or positional relationship shown in the drawings or the orientation or positional relationship which is usually arranged when the product of the present invention is used, the description is merely for convenience and simplicity, and the indication or suggestion that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and thus, cannot be understood as limiting the present invention. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.
Furthermore, the term "horizontal", if present, does not mean that the component is required to be absolutely horizontal, but may be slightly inclined. For example, "horizontal" merely means that the direction is more horizontal than "vertical" and does not mean that the structure must be perfectly horizontal, but may be slightly inclined.
In the description of the embodiments of the present invention, it should be further noted that unless otherwise explicitly stated or limited, the terms "disposed," "mounted," "connected," and "connected" should be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
The invention is described in further detail below with reference to the accompanying drawings:
referring to fig. 1-4, the embodiment of the invention discloses an integrated multi-channel stepping electrode support, which comprises a first connecting plate 1, a lifting mechanism and an electrode array. The first connecting plates 1 are connected with second connecting plates 2 at intervals; the first connecting plate 1 is connected with the second connecting plate 2 through a plurality of supporting columns 9. First connecting plate 1, second connecting plate 2 and a plurality of support column 9 are the integral type structure of making through 3D printing.
The lifting mechanism is arranged between the first connecting plate 1 and the second connecting plate 2; the lifting mechanism comprises a screw and a nut sleeved on the screw; a first screw mounting hole 3 is formed in the first connecting plate 1, and a second screw mounting hole 6 is formed in the second connecting plate 2; the screw extends into the second screw mounting hole 6 from the first screw mounting hole 3; a step is arranged in the first screw mounting hole 3, a screw cap is embedded into the first screw mounting hole 3, and the screw cap is clamped on the step in the first screw mounting hole 3; the nut is fixedly connected with the electrode array. The top surface of the screw cap is not higher than the upper surface of the first connection plate 1. The first connecting plate 1 is provided with a limiting groove 10, the limiting groove 10 is communicated with the first screw mounting hole 3, the limiting groove 10 is in sliding fit with the limiting block 11, and the limiting block 11 slides into the first screw mounting hole 3 from the limiting groove 10 to clamp a screw cap and a step and limit axial displacement of a screw.
The limiting block 11 is of a strip structure with a trapezoidal section or a strip structure with a convex section, and the section of the limiting groove 10 is the same as that of the limiting block 11.
The electrode array penetrates through silicon tube through holes formed in the first connecting plate 1 and the second connecting plate 2; the electrode array is connected with the lifting mechanism, and the lifting mechanism drives the electrode array to move along the axial direction of the electrode array. The electrode array comprises a plurality of bundled silicon tubes, and each silicon tube is internally provided with an electrode wire; a first silicon tube through hole 4 is formed in the first connecting plate 1, and a second silicon tube through hole 7 is formed in the second connecting plate 2; the silicon tubes extend into the first silicon tube through hole 4 and penetrate out of the second silicon tube through hole 7, and the silicon tubes between the first silicon tube through hole 4 and the second silicon tube through hole 7 are connected with the nuts. The electrode array is bonded with the nut through AB glue.
A first clamping piece mounting hole 5 is formed in the first connecting plate 1, and a second clamping piece mounting hole 8 is formed in the second connecting plate 2; the clamping iron wire extends into the second clamping piece mounting hole 8 from the first clamping piece mounting hole 5; the centre gripping iron wire passes through gluey fixed connection with first holder mounting hole 5 and second holder mounting hole 8.
The embodiment of the invention also discloses a manufacturing method of the integrated multi-channel stepping electrode support, which comprises the following steps:
and 6, enabling the clamping iron wire to penetrate through the first clamping piece mounting hole 5 and stretch into the second clamping piece mounting hole 8, and fixedly connecting the clamping iron wire with the first clamping piece mounting hole 5 and the second clamping piece mounting hole 8.
After the manufacturing is finished, the screw is screwed, and the silicon tube can be driven to synchronously act.
Through practical use, the electrode bracket can replace an electrode bracket manually made by people, and a complete in-vivo multi-channel stepping electrode to be used for chronic electrode implantation operation can be made. Meanwhile, the invention can be used for manufacturing a plurality of brain area electrode supports, and can also be extended to other electrophysiological signal recording, such as field potential recording of a plurality of brain areas, and the like, so that a plurality of field potential recording electrodes can be simultaneously arranged.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An integrated multi-channel steppable electrode holder, comprising:
the connecting device comprises first connecting plates (1), wherein the first connecting plates (1) are connected with second connecting plates (2) at intervals;
the lifting mechanism is arranged between the first connecting plate (1) and the second connecting plate (2);
the electrode array penetrates through silicon tube through holes formed in the first connecting plate (1) and the second connecting plate (2); the electrode array is connected with the lifting mechanism, and the lifting mechanism drives the electrode array to move along the axial direction of the electrode array.
2. Integrated multichannel steppable electrode holder according to claim 1, wherein the first connection plate (1) is connected to the second connection plate (2) by a number of support columns (9).
3. The integrated multichannel steppable electrode holder of claim 2, wherein said first connection plate (1), second connection plate (2) and support posts (9) are a one-piece structure made by 3D printing.
4. The integrated multi-channel steppable electrode holder of claim 1, wherein the lifting mechanism includes a screw and a nut that is sleeved on the screw; a first screw mounting hole (3) is formed in the first connecting plate (1), and a second screw mounting hole (6) is formed in the second connecting plate (2); the screw extends into the second screw mounting hole (6) from the first screw mounting hole (3); a step is arranged in the first screw mounting hole (3), a screw cap is embedded into the first screw mounting hole (3), and the screw cap is clamped on the step in the first screw mounting hole (3); the nut is fixedly connected with the electrode array.
5. The integrated multi-channel steppable electrode holder of claim 4, wherein a top surface of said screw cap is not higher than an upper surface of the first connection plate (1).
6. The integrated multichannel stepping electrode support according to claim 4, wherein a limiting groove (10) is formed in the first connecting plate (1), the limiting groove (10) is communicated with the first screw mounting hole (3), the limiting groove (10) is in sliding fit with the limiting block (11), and the limiting block (11) slides into the first screw mounting hole (3) from the limiting groove (10) to clamp a screw cap and a step to limit axial displacement of a screw.
7. The integrated multi-channel steppable electrode holder of claim 4, wherein the electrode array comprises a plurality of silicon tubes bundled together, one wire electrode being disposed within each silicon tube; a first silicon tube through hole (4) is formed in the first connecting plate (1), and a second silicon tube through hole (7) is formed in the second connecting plate (2); the silicon tubes extend into the first silicon tube through hole (4) and penetrate out of the second silicon tube through hole (7), and the silicon tubes between the first silicon tube through hole (4) and the second silicon tube through hole (7) are connected with the nuts.
8. The integrated multi-channel steppable electrode holder of claim 7, wherein said electrode array is bonded to a nut by an AB glue.
9. The integrated multichannel stepping electrode support as claimed in claim 1, wherein the first connecting plate (1) is provided with a first clamping member mounting hole (5), and the second connecting plate (2) is provided with a second clamping member mounting hole (8); the clamping iron wire extends into the second clamping piece mounting hole (8) from the first clamping piece mounting hole (5); the centre gripping iron wire is connected through gluing fixedly with first holder mounting hole (5) and second holder mounting hole (8).
10. A method of making an integrated multi-channel steppable electrode support according to any one of claims 1-9, comprising the steps of:
manufacturing a first connecting plate (1), a second connecting plate (2) and a plurality of supporting columns (9) which are of an integrated structure by adopting a 3D printing method;
the method comprises the following steps that a nut is placed between a first screw mounting hole (3) and a second screw mounting hole (6), the screw extends into the first screw mounting hole (3) and is in threaded fit with the nut, and finally the bottom of the screw extends into the second screw mounting hole (6) and a screw cap is attached to a step of the first screw mounting hole (3);
sliding the limiting block (11) into the limiting groove (10) and extending into the first screw mounting hole (3) to clamp the screw cap and the step tightly;
inserting the electrode wire into the silicon tubes, binding the silicon tubes together, extending into the silicon tubes from the first silicon tube through holes (4) and extending out from the second silicon tube through holes (7);
fixedly connecting the nut with a plurality of bundled silicon tubes;
the clamping iron wire penetrates through the first clamping piece mounting hole (5) and stretches into the second clamping piece mounting hole (8), and the clamping iron wire is fixedly connected with the first clamping piece mounting hole (5) and the second clamping piece mounting hole (8).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111554554.2A CN114224345A (en) | 2021-12-17 | 2021-12-17 | Integrated multi-channel stepping electrode support and manufacturing method thereof |
| PCT/CN2022/137517 WO2023109641A1 (en) | 2021-12-17 | 2022-12-08 | Integrated multi-channel stepping electrode stent and manufacturing method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111554554.2A CN114224345A (en) | 2021-12-17 | 2021-12-17 | Integrated multi-channel stepping electrode support and manufacturing method thereof |
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| CN114224345A true CN114224345A (en) | 2022-03-25 |
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| CN202111554554.2A Pending CN114224345A (en) | 2021-12-17 | 2021-12-17 | Integrated multi-channel stepping electrode support and manufacturing method thereof |
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| WO (1) | WO2023109641A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023109641A1 (en) * | 2021-12-17 | 2023-06-22 | 深圳先进技术研究院 | Integrated multi-channel stepping electrode stent and manufacturing method therefor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2135548A1 (en) * | 2008-06-18 | 2009-12-23 | Universiteit van Amsterdam | Microdrive for use in neurophysiological research of animals |
| CN203195686U (en) * | 2013-04-16 | 2013-09-18 | 中国科学院昆明动物研究所 | Bidirectional microelectrode propeller and microelectrode |
| CN104367319A (en) * | 2014-11-05 | 2015-02-25 | 中国科学院深圳先进技术研究院 | Electrode device for chronic recording |
| CN106618563A (en) * | 2016-11-09 | 2017-05-10 | 中国人民解放军第三军医大学 | Light reusable microelectrode propeller and embedding method thereof |
| CN113274027B (en) * | 2021-06-17 | 2022-07-05 | 复旦大学 | In-vivo multichannel electroencephalogram signal recording device |
| CN114305427A (en) * | 2021-12-06 | 2022-04-12 | 中国科学院深圳先进技术研究院 | But marching type electrode support of integration |
| CN216777083U (en) * | 2021-12-17 | 2022-06-21 | 深圳先进技术研究院 | But multichannel marching type electrode support of integration |
| CN114224345A (en) * | 2021-12-17 | 2022-03-25 | 深圳先进技术研究院 | Integrated multi-channel stepping electrode support and manufacturing method thereof |
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2021
- 2021-12-17 CN CN202111554554.2A patent/CN114224345A/en active Pending
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2022
- 2022-12-08 WO PCT/CN2022/137517 patent/WO2023109641A1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023109641A1 (en) * | 2021-12-17 | 2023-06-22 | 深圳先进技术研究院 | Integrated multi-channel stepping electrode stent and manufacturing method therefor |
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