CN114222754A - A型肉毒杆菌毒素复合物、其配制剂和使用方法 - Google Patents
A型肉毒杆菌毒素复合物、其配制剂和使用方法 Download PDFInfo
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- CN114222754A CN114222754A CN202080028618.2A CN202080028618A CN114222754A CN 114222754 A CN114222754 A CN 114222754A CN 202080028618 A CN202080028618 A CN 202080028618A CN 114222754 A CN114222754 A CN 114222754A
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Abstract
本发明涉及A型肉毒杆菌毒素复合物、其配制剂和使用方法。本发明提供了一种A型肉毒杆菌毒素复合物,其包含HA70组分、HA17组分、HA33组分、NTNH组分和BoNT/A1组分,其中所述肉毒杆菌毒素复合物具有740‑790kDa的分子量。与现有的肉毒杆菌毒素复合物相比,本发明的肉毒杆菌毒素复合物的分子量更小,安全性更高,且具有相当的治疗效果。
Description
PCT国内申请,说明书已公开。
Claims (21)
- PCT国内申请,权利要求书已公开。
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CN (2) | CN114222754A (zh) |
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IL314995A (en) * | 2022-02-15 | 2024-10-01 | Merz Pharma Gmbh & Co Kgaa | Liquid botulinum toxin formulation and its uses |
WO2024049286A1 (ko) * | 2022-09-02 | 2024-03-07 | (주)메디톡스 | 내성 발현이 감소된 보툴리눔 독소 제제 및 이와 관련된 방법 |
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US8187612B2 (en) * | 1993-12-28 | 2012-05-29 | Allergan, Inc. | Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle |
WO2005035730A2 (en) * | 2003-10-07 | 2005-04-21 | Allergan, Inc. | Dna sequences of the botulinum neurotoxin complex of type a-hall (allergan) strain |
SG10202100698QA (en) | 2008-12-31 | 2021-02-25 | Revance Therapeutics Inc | Injectable Botulinum Toxin Formulations |
CN113056478A (zh) * | 2018-12-21 | 2021-06-29 | 一般财团法人阪大微生物病研究会 | 肉毒毒素的制造方法 |
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2021
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Non-Patent Citations (7)
Title |
---|
DESIRÉE A.等: "Molecular Assembly of Botulinum Neurotoxin Progenitor Complexes", 《PNAS》 * |
NCBI REFERENCE SEQUENCE:WP_003356711.1: "hemagglutinin[Clostridium botulinum]", 《GENBANK》 * |
NCBI REFERENCE SEQUENCE:WP_011948507.1: "botulinum neurotoxin hemagglutinin HA70 subunit[Clostridium botulinum]", 《GENBANK》 * |
NCBI REFERENCE SEQUENCE:WP_011948510.1: "non-toxic nonhemagglutinin NTNH[Clostridium botulinum]", 《GENBANK》 * |
NCBI REFERENCE SEQUENCE:WP_011948511.1: "botulinum neurotoxin type A [Clostridium botulinum]", 《GENBANK》 * |
PDB:4LO0_A: "Chain A, HA-33", 《GENBANK》 * |
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NZ780855A (en) | 2023-06-30 |
BR112021024058A2 (pt) | 2022-10-11 |
US20220257730A1 (en) | 2022-08-18 |
MX2021014486A (es) | 2022-01-04 |
SA521430958B1 (ar) | 2024-02-22 |
AU2020440362B2 (en) | 2023-02-16 |
SG11202111282SA (en) | 2021-11-29 |
CN116041452A (zh) | 2023-05-02 |
EP3932938A1 (en) | 2022-01-05 |
WO2021195968A1 (zh) | 2021-10-07 |
KR20220003061A (ko) | 2022-01-07 |
KR20230146125A (ko) | 2023-10-18 |
JP7328714B2 (ja) | 2023-08-17 |
AU2020440362A1 (en) | 2021-11-04 |
EP3932938A4 (en) | 2022-11-30 |
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