CN114209978A - Electric field generating device, electric field generating apparatus, and electric field control method - Google Patents

Electric field generating device, electric field generating apparatus, and electric field control method Download PDF

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CN114209978A
CN114209978A CN202210158141.0A CN202210158141A CN114209978A CN 114209978 A CN114209978 A CN 114209978A CN 202210158141 A CN202210158141 A CN 202210158141A CN 114209978 A CN114209978 A CN 114209978A
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electric field
time period
target biological
biological tissue
controlling
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衷兴华
周丽波
汪龙
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Hangzhou Vena Anke Medical Technology Co ltd
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Hangzhou Vena Anke Medical Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0492Patch electrodes

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Abstract

The embodiment of the application provides an electric field generating device, equipment and an electric field control method. The electric field generating apparatus includes: an electric field generator for electrically connecting with at least two electrode patches; the control unit is electrically connected with the electric field generator and is used for controlling the electric field generator to output a first voltage signal to the target biological tissue through each electrode patch in a first time period so as to form an electric field; controlling the target biological tissue not to form an electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is disposed on one of the electrode patches. According to the temperature information acquisition method and device, the target biological tissue is controlled not to form the electric field in the second time period, the temperature information of each temperature sensor is acquired, and when the control unit acquires the temperature information, the target biological tissue does not form the electric field, so that the measurement accuracy of the temperature sensors cannot be interfered, and the acquired temperature information is more accurate.

Description

Electric field generating device, electric field generating apparatus, and electric field control method
Technical Field
The present application relates to the field of pulse technology, and in particular, to an electric field generating apparatus, an electric field generating device, and an electric field control method.
Background
At present, an electric field generating device based on a pulse technology can be used for treating tumors, the electric field generating device can act on a human body through at least one group of electrode patch pairs, the electrode patch pairs are oppositely arranged on target biological tissues, and alternating voltage is applied to the electrode patch pairs, so that an electric field for treating the tumors is generated between the electrode patch pairs. The electrode patch is generally provided with a temperature sensor for detecting the temperature of target biological tissues and avoiding injury caused by overhigh temperature.
However, when the electric field generating device outputs a voltage signal to the target biological tissue to form an electric field, the data fluctuation monitored by the temperature sensor is large, so that the accuracy of the temperature information acquired by the electric field generating device is low.
Disclosure of Invention
The application provides an electric field generating device, equipment and a control method of an electric field aiming at the defects of the existing mode, and aims to solve the technical problem that the accuracy of temperature information acquired by the electric field generating device is low in the prior art.
In a first aspect, an embodiment of the present application provides an electric field generating apparatus, including:
an electric field generator for electrically connecting with at least two electrode patches;
the control unit is electrically connected with the electric field generator and is used for controlling the electric field generator to output a first voltage signal to the target biological tissue through each electrode patch in a first time period so as to form an electric field; controlling the target biological tissue not to form an electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is disposed on one of the electrode patches.
In one possible implementation manner, the control unit is further configured to control the electric field generator to stop outputting the first voltage signal during a second time period; alternatively, the first and second electrodes may be,
the electric field generating device also comprises a switch unit, the switch unit comprises at least two switch modules, and each switch module is used for controlling the connection and disconnection of the electric field generator and one electrode patch;
and the control unit is also used for controlling the switch modules to be switched off in a second time period so as to stop outputting the first voltage signal output by the electric field generator to the target biological tissue.
In one possible implementation manner, the electric field generating device further includes: an alarm unit;
and the control unit is electrically connected with the alarm unit and is also used for controlling the alarm unit to send out alarm information when the temperature value corresponding to at least one piece of temperature information is greater than the designed temperature value.
In one possible implementation manner, the control unit is further configured to control the target biological tissue not to form the electric field in a third time period after the second time period when the temperature value corresponding to the at least one piece of temperature information is greater than the design temperature value; and/or, during a first time period, controlling the electric field generator to output a second voltage signal; the second voltage signal has a lower voltage value and/or frequency than the first voltage signal.
In one possible implementation, the electric field generating device further includes at least one of:
the first time period and the second time period are set at intervals;
the duration of the second time period is 100 milliseconds to 300 milliseconds.
The waveform of the first voltage signal is at least one of: sinusoidal waveforms, bipolar pulse waveforms, unipolar pulse waveforms.
In a second aspect, an embodiment of the present application provides an electric field generating apparatus, including: at least two electrode patches, at least one temperature sensor and an electric field generating device as in the first aspect;
each electrode patch is electrically connected with the electric field generator through a lead, and is attached to the target biological tissue according to a design mode;
each temperature sensor is electrically connected with the control unit and used for sending temperature information to the control unit.
In one possible implementation, a switch module is provided on the lead connecting each electrode patch and the electric field generator.
In a third aspect, an embodiment of the present application further provides a method for controlling an electric field, including:
in a first time period, controlling the electric field generator to output a first voltage signal to the target biological tissue through each electrode patch so as to form an electric field;
controlling the target biological tissue not to form an electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is disposed on one of the electrode patches.
In a fourth aspect, an embodiment of the present application further provides a device for controlling an electric field, including:
the control module is used for controlling the electric field generator to output a first voltage signal to the target biological tissue through each electrode patch in a first time period so as to form an electric field; controlling the target biological tissue not to form an electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is disposed on one of the electrode patches.
In a fifth aspect, the present application further provides a computer-readable storage medium for storing computer instructions, which when executed on an electric field generation apparatus, implement the electric field control method according to the third aspect.
The beneficial technical effects brought by the technical scheme provided by the embodiment of the application comprise:
the control unit of the electric field generating device can control the electric field generator to output the first voltage signal in the first time period, control the target biological tissue to not form an electric field in the second time period, and acquire the temperature information of each temperature sensor, so that when the control unit acquires the temperature information, the target biological tissue does not form an electric field, the accuracy of the temperature sensors cannot be interfered, and the acquired temperature information is more accurate.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
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The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic structural diagram of an electric field generating apparatus according to an embodiment of the present disclosure;
fig. 2 is a schematic structural diagram of an electric field generating apparatus according to an embodiment of the present disclosure;
FIG. 3 is a schematic structural diagram of another electric field generating apparatus provided in the embodiments of the present application;
FIG. 4 is a schematic structural diagram of another electric field generating apparatus according to an embodiment of the present disclosure;
FIG. 5 is a timing diagram of a first voltage signal output by the electric field generating device according to the embodiment of the present disclosure;
fig. 6 is a flowchart of a method for controlling an electric field according to an embodiment of the present disclosure.
Reference numerals:
10-an electric field generating device;
100-an electric field generating device, 110-an electric field generator, 120-a control unit, 130-a switch unit and 140-an alarm unit;
200-electrode patch;
300-temperature sensor.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" or "coupled" to another element, it can be directly connected or coupled to the other element or intervening elements may also be present. Further, "connected" or "coupled" as used herein may include wirelessly connected or wirelessly coupled. As used herein, the term "and/or" includes all or any element and all combinations of one or more of the associated listed items.
It has been found that since 1980, electric fields have become popular in biological and medical fields, including killing of microorganisms, cell fusion, gene transformation, and tumor therapy. YoramPati et al discovered in 2004 that alternating AC electric fields with low electric field strength of 1V/cm-2V/cm and medium and low frequency (100-300 KHZ) can selectively inhibit tumor cell proliferation. With the research on the action mechanism of tumor treatment electric fields (TTF), TTF has many potential advantages as a new tumor treatment method compared with conventional surgery and radiotherapy and chemotherapy.
At present, the mechanism of action of TTF is primarily to interfere with mitosis, which destroys cancer cells. If an uneven external electric field is applied in the mitosis process of the cancer cells, microtubules consisting of polar molecules are subjected to reversal polarization in the early mitosis stage and move along the direction of stronger field intensity, so that the microtubules cannot be gathered into spindle threads, and the mitosis of the cancer cells is stopped; meanwhile, when the direction of the applied external electric field force line is parallel to the long axis of the dividing cell, the density of the electric field force line and cytoplasm at the narrow mitotic groove of the cell at the end stage of mitosis is highest, and under the action of coulomb force, the cell membrane at the mitotic groove is cracked and cannot divide two complete new cancer cells.
At present, a TTF technology-based tumor therapy apparatus mainly acts on a human body by means of at least one set of electrode patch pairs, the electrode patch pairs are oppositely arranged on a target biological tissue, and a target therapy electric field is generated between the electrode patch pairs by applying an alternating voltage to the electrode patches. In TTF treatment, the contact part of the electrode patch and the skin can be heated along with the enhancement of the field intensity, and the human body can be injured due to overhigh temperature, so that the detection of the temperature of the target biological tissue acted by the electrode patch is very important. The existing electrode patch is provided with a temperature sensor for detecting the temperature of the electrode patch acting on the surface of a human body.
However, it was found that during the operation of TTF, the data fluctuation monitored by the temperature sensor on the electrode patch is a bit large, and the specific data information is shown in table one.
Table one:
Figure 957786DEST_PATH_IMAGE001
according to the information shown in table one, the existing electric field generating device collects temperature information during operation, and does not have the second time period t2 when the electric field at the target biological tissue is 0. The fluctuation of the Temperature value corresponding to the Temperature information acquired by the four NTC (negative Temperature Coefficient sensor) Temperature sensors is large, so that the Temperature acquired by the Temperature sensors is not accurate, the Temperature information acquired by the electric field generating device is not accurate, and the treatment effect of the electric field generating device is required.
The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.
An embodiment of the present application provides an electric field generating apparatus, and referring to fig. 1, the electric field generating apparatus 100 includes: an electric field generator 110 and a control unit 120.
Referring to fig. 1 and 2, the electric field generator 110 is configured to be electrically connected to at least two electrode patches 200, and each of the temperature sensors 300 is disposed on one of the electrode patches 200. The electrode patch 200 and the temperature sensor 300 are the structure of the electric field generating device 10 shown in fig. 2, and are further described in detail in the following description of the electric field generating device 10.
Referring to fig. 1 and 2, the control unit 120 is electrically connected to the electric field generator 110, and the control unit 120 is configured to control the electric field generator 110 to output a first voltage signal to the target biological tissue through each electrode patch 200 during a first time period to form an electric field; in the second time period, the electric field is not formed at the target biological tissue, and the temperature information of each temperature sensor 300 is acquired.
The control unit 120 of the embodiment of the application can control the electric field generator 110 to output the first voltage signal in the first time period, and control the target biological tissue to not form an electric field in the second time period, so as to obtain the temperature information of each temperature sensor 300, so that when the control unit 120 obtains the temperature information, the target biological tissue does not form an electric field, so that the precision of the temperature sensors 300 is not disturbed, and the obtained temperature information is more accurate.
Alternatively, the target biological tissue may be a tissue such as a tumor, a lesion, a cancer cell, etc., which is an ablation target of the pulsed electric field, and the electrode patch 200 may be attached to the surface of the human body to form an electric field at the target biological tissue.
Optionally, in a first time period, the electric field generator 110 is controlled to output a first voltage signal to the target biological tissue through each electrode patch 200, and the electric field generator 110 is in a working state and continuously outputs a pulse signal to the target biological tissue to treat the target biological tissue.
Optionally, in the second time period, the target biological tissue is controlled not to form an electric field, that is, the first voltage signal of the electric field generator 110 stops being output to the target biological tissue, the voltage difference between the electrode patches is 0, and the target biological tissue has no electric field, so that the accuracy of the temperature sensor is not affected, the control unit 120 obtains accurate temperature information, and accordingly, corresponding control is performed based on the temperature information, and the treatment effect of the electric field generating device 100 is ensured.
In some embodiments, the control unit 120 is further configured to control the electric field generator 110 to stop outputting the first voltage signal during the second time period.
Alternatively, the control unit 120 may directly control the electric field generator 110 not to output the first voltage signal for the second period of time, so that there is no electric field at the target biological tissue.
Alternatively, the control signal output by the control unit 120 to the electric field generator 110 is a PWM (Pulse Width Modulation) signal.
Optionally, referring to fig. 3, the electric field generating device 100 further includes a switching unit 130, and the switching unit 130 includes at least two switching modules, each of which is used for controlling the electric field generator 110 to be connected to and disconnected from one of the electrode patches 200.
Optionally, the first end and the second end of each switch module are electrically connected to the electric field generator 110 and one electrode patch 200, respectively, and the control end of the switch module is electrically connected to the control unit 120.
Alternatively, the switching unit 130 may have only one switching module, and the electric field generator 110 is controlled to be connected to and disconnected from all the electrode patches 200 by one switching module. I.e. the first end and the second end of the switch module, are electrically connected to the electric field generator 110 and all the electrode patches 200, respectively, and the control end of the switch module is electrically connected to the control unit 120.
Optionally, referring to fig. 3, the control unit 120 is further configured to control each of the switch modules to be turned off during the second time period, so that the first voltage signal output by the electric field generator 110 stops being output to the target biological tissue.
Optionally, the switch module includes a mos transistor (metal oxide semiconductor field effect transistor), a source and a drain of the mos transistor are respectively used as the first end and the second end of the switch module, or a source and a drain of the mos transistor are respectively used as the second end and the first end of the switch module; and the grid electrode of the mos tube is used as the control end of the switch module.
Optionally, the switch module may also be an intelligent switch, and is disposed on a path through which the electric field generator 110 is electrically connected to the electrode patch 200, and the on/off of the intelligent switch is controlled by the control unit 120 to control the electric field generator 110 and the electrode patch 200 to be electrically connected, so as to control the first voltage signal output by the electric field generator 110 to be output to the target biological tissue or stop being output to the target biological tissue.
In some embodiments, referring to fig. 4, the electric field generating apparatus 100 further includes: an alarm unit 140.
The control unit 120 is electrically connected to the alarm unit 140, and the control unit 120 is further configured to control the alarm unit 140 to send out alarm information when a temperature value corresponding to at least one piece of temperature information is greater than a designed temperature value.
Alternatively, the alarm information may be an audio alarm, or may be alarm information displayed on the display screen of the electric field generation apparatus 100.
Optionally, in the embodiment of the present application, the alarm unit 140 may send an alarm when the temperature of the target biological tissue is too high, so as to avoid damage to the target biological tissue.
In some embodiments, the control unit 120 is further configured to control the electric field not to be formed at the target biological tissue for a third time period after the second time period when the at least one temperature information corresponds to a temperature value greater than the design temperature value.
Optionally, the electric field generating device 100 is further provided with a third time period between the second time period and the next first time period, and is configured to not form an electric field at the target biological tissue, so that the temperature at the target biological tissue is naturally reduced, and the target biological tissue is prevented from being damaged due to continuous high temperature, and the treatment effect is not affected.
Optionally, the control unit 120 is further configured to control the electric field generator 110 to output a second voltage signal during the first time period; the second voltage signal has a lower voltage value and/or frequency than the first voltage signal.
Optionally, in the embodiment of the present application, when the temperature value corresponding to at least one piece of temperature information is greater than the design temperature value, the voltage signal is reduced, that is, the second voltage signal is output, so that the damage to the target biological tissue can be further ensured.
In some embodiments, the electric field generating apparatus 100, further comprises at least one of:
the first time period and the second time period are set at intervals;
the duration of the second time period is 100 milliseconds to 300 milliseconds.
The waveform of the first voltage signal is at least one of: sinusoidal waveforms, bipolar pulse waveforms, unipolar pulse waveforms.
Optionally, specific embodiments of the first time period and the second time period may be designed in advance according to actual situations.
Optionally, the first voltage signal is a pulse signal, and the voltage, the frequency and the waveform of the pulse signal can be set according to actual needs.
Alternatively, referring to fig. 5, a timing chart of the output of a first voltage signal is shown, an abscissa t represents time, an ordinate v represents voltage, t1 represents a first period, t2 represents a second period, and a period t2 is provided between adjacent periods t 1. The first voltage signal shown in fig. 5 is a bipolar pulse waveform, that is, a positive pulse waveform and a negative pulse waveform, where the positive pulse waveform has a positive voltage and a stepped voltage, and the negative pulse waveform has a negative voltage and a stepped voltage.
Through further tests, temperature information which can be collected based on the electric field generating device 100 of the embodiment of the present application is shown in the following table two.
Table two:
Figure 409627DEST_PATH_IMAGE002
comparing the data in the table two and the table one, it can be seen that the range of variation of the temperature value corresponding to each temperature information obtained by the electric field generating apparatus 100 in the embodiment of the present application is not large, the difference between the actual temperature value obtained by the mercury thermometer test is not large, and the accuracy is high.
An embodiment of the present application provides an electric field generating apparatus, and referring to fig. 2, the electric field generating apparatus 10 includes: at least two electrode patches 200, at least one temperature sensor 300 and an electric field generating device 100 of any embodiment of the present application.
Each electrode patch 200 is electrically connected to the electric field generator 110 through a lead, and each electrode patch 200 is attached to a target biological tissue in a designed manner.
Each temperature sensor 300 is electrically connected to the control unit 120 for transmitting temperature information to the control unit 120.
Alternatively, as shown in fig. 2 to 4, one temperature sensor 300 may be disposed in each electrode patch 200, and one temperature sensor 300 may be disposed in a part of the electrode patches 200 in all the electrode patches 200.
Alternatively, the temperature sensor 300 may be an NTC temperature sensor, and the temperature sensor 300 may also employ other temperature measuring elements including thermistors.
Alternatively, the electrode patches 200 may be adhered to the surface of the human body by a conductive medical gel, and the respective electrode patches 200 may be held at the designed positions on the surface of the human body by an adhesive tape to form an electric field at the target biological tissue.
Alternatively, the electrode patches 200 are provided in pairs, and the alternating electric field generated at the target biological tissue can be adjusted by adjusting the arrangement positions of the electrode patches 200 at the target biological tissue.
Alternatively, the temperature sensor 300 and the control unit 120 may be electrically connected by wireless communication, for example, wireless communication may be implemented by any one of bluetooth, 3G (3 rd-Generation wireless telephone technology, third Generation wireless telephone technology), LTE (Long Term Evolution), 5G, WIFI (wireless fidelity), zigbee-beam protocol, UWB (ultra wide band), and NFC (near field communication).
In some embodiments, a switch module is provided on each wire connecting each electrode patch 200 to the electric field generator 110.
Optionally, the switch module includes a mos transistor (metal oxide semiconductor field effect transistor), a source and a drain of the mos transistor are respectively used as the first end and the second end of the switch module, or a source and a drain of the mos transistor are respectively used as the second end and the first end of the switch module; and the grid electrode of the mos tube is used as the control end of the switch module.
Optionally, the switch module may also be an intelligent switch, and is disposed on a path through which the electric field generator 110 is electrically connected to the electrode patch 200, and the on/off of the intelligent switch is controlled by the control unit 120 to control the electric field generator 110 and the electrode patch 200 to be electrically connected, so as to control the first voltage signal output by the electric field generator 110 to be output to the target biological tissue or stop being output to the target biological tissue.
Alternatively, referring to fig. 3, a schematic of the structure of an electric field generating device, an electric field generator 110, is shown. The electric field generating device 100 further comprises a switching unit 130, wherein the switching unit 130 comprises at least two switching modules, and each switching module is used for controlling the connection and disconnection of the electric field generator 110 and one electrode patch 200. The switching unit 130 may have only one switching module, and the electric field generator 110 is controlled to be connected to and disconnected from all the electrode patches 200 by one switching module.
Alternatively, referring to fig. 3, which shows a schematic structural diagram of an electric field generating device, the electric field generating apparatus 100 further includes: an alarm unit 140. The control unit 120 is electrically connected to the alarm unit 140, and the control unit 120 is further configured to control the alarm unit 140 to send out alarm information when a temperature value corresponding to at least one piece of temperature information is greater than a designed temperature value.
Based on the same inventive concept, the embodiment of the present application further provides a method for controlling an electric field, as shown in fig. 6, the method for controlling an electric field includes: step S601 to step S602.
S601, in a first time period, controlling the electric field generator 110 to output a first voltage signal to the target biological tissue through each electrode patch 200 to form an electric field.
Alternatively, the control method of the electric field is applied to the electric field generating apparatus 100, and is executed by the control unit 120.
Optionally, during the first time period, the control unit 120 controls the electric field generator 110 to output a first voltage signal to the target biological tissue through each electrode patch 200 to form an electric field.
S602, in a second time period, controlling the target biological tissue not to form an electric field, and acquiring temperature information of each temperature sensor 300; each temperature sensor 300 is provided on one electrode patch 200.
Alternatively, the control unit 120 controls not to form an electric field at the target biological tissue and acquires temperature information of each temperature sensor 300 during the second period.
Optionally, the control method of the electric field further comprises: and controlling the electric field generator 110 to stop outputting the first voltage signal in the second time period.
Alternatively, the control unit 120 controls the electric field generator 110 to stop outputting the first voltage signal during the second period.
Optionally, the control method of the electric field further comprises: and in a second time period, controlling all the switch modules to be switched off so that the first voltage signal output by the electric field generator 110 stops being output to the target biological tissue.
Alternatively, during the second time period, the control unit 120 controls each of the switch modules to be turned off, so that the first voltage signal output by the electric field generator 110 stops being output to the target biological tissue.
Optionally, the control method of the electric field further comprises: when the temperature value corresponding to at least one temperature information is greater than the designed temperature value, the control alarm unit 140 sends out alarm information.
Optionally, when the temperature value corresponding to at least one piece of temperature information is greater than the design temperature value, the control unit 120 controls the alarm unit 140 to send out alarm information.
Optionally, the control method of the electric field further comprises: and when the temperature value corresponding to the at least one piece of temperature information is larger than the design temperature value, controlling the target biological tissue not to form the electric field in a third time period after the second time period.
Optionally, when the temperature value corresponding to the at least one temperature information is greater than the design temperature value, the control unit 120 controls the target biological tissue not to form the electric field during a third time period after the second time period.
Optionally, the control method of the electric field further comprises: when the temperature value corresponding to at least one piece of temperature information is greater than the design temperature value, controlling the electric field generator 110 to output a second voltage signal in a first time period; the second voltage signal has a lower voltage value and/or frequency than the first voltage signal.
Optionally, when the temperature value corresponding to the at least one piece of temperature information is greater than the design temperature value, the control unit 120 controls the electric field generator 110 to output the second voltage signal in the first time period.
Based on the same inventive concept, the embodiment of the present application further provides a control device of an electric field, including:
the control module is used for controlling the electric field generator 110 to output a first voltage signal to the target biological tissue through each electrode patch 200 in a first time period so as to form an electric field; controlling the target biological tissue not to form an electric field and acquiring temperature information of each temperature sensor 300 in a second time period; each temperature sensor 300 is provided on one electrode patch 200.
Alternatively, the control module may implement the function of the control unit 120 correspondingly.
Optionally, the control module is configured to control the electric field generator 110 to stop outputting the first voltage signal during the second time period.
Optionally, the control module is configured to control each of the switch modules to be turned off during the second time period, so that the first voltage signal output by the electric field generator 110 stops being output to the target biological tissue.
Optionally, the control module is configured to control the alarm unit 140 to send out alarm information when a temperature value corresponding to at least one piece of temperature information is greater than a design temperature value.
Optionally, the control module is configured to control no electric field to be formed at the target biological tissue in a third time period after the second time period when the temperature value corresponding to the at least one piece of temperature information is greater than the design temperature value.
Optionally, the control module is configured to control the electric field generator 110 to output a second voltage signal in a first time period when the temperature value corresponding to the at least one piece of temperature information is greater than the design temperature value.
Based on the same inventive concept, the present application further provides a computer-readable storage medium, which is used for storing computer instructions, and when the computer instructions are executed on the electric field generation device 10, the method for controlling an electric field according to any embodiment of the present application is implemented.
It should be noted that the computer readable medium of the present application can be a computer readable signal medium or a computer readable storage medium or any combination of the two. A computer readable storage medium may be, for example, but not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, apparatus, or device, or any combination of the foregoing. More specific examples of the computer readable storage medium may include, but are not limited to: an electrical connection having one or more wires, a portable computer diskette, a hard disk, a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disc read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination of the foregoing.
In embodiments of the present application, a computer readable storage medium may be any tangible medium that can contain, or store a program for use by or in connection with an instruction execution system, apparatus, or device. In this application, however, a computer readable signal medium may include a propagated data signal with computer readable program code embodied therein, for example, in baseband or as part of a carrier wave. Such a propagated data signal may take many forms, including, but not limited to, electro-magnetic, optical, or any suitable combination thereof. A computer readable signal medium may also be any computer readable medium that is not a computer readable storage medium and that can communicate, propagate, or transport a program for use by or in connection with an instruction execution system, apparatus, or device. Program code embodied on a computer readable medium may be transmitted using any appropriate medium, including but not limited to: electrical wires, optical cables, RF (radio frequency), etc., or any suitable combination of the foregoing.
The computer-readable medium of the embodiments of the present application may be embodied in an electronic device; or may be present alone without being incorporated into the electronic device.
Those of skill in the art will appreciate that the various operations, methods, steps in the processes, acts, or solutions discussed in this application can be interchanged, modified, combined, or eliminated. Further, other steps, measures, or schemes in various operations, methods, or flows that have been discussed in this application can be alternated, altered, rearranged, broken down, combined, or deleted. Further, steps, measures, schemes in the prior art having various operations, methods, procedures disclosed in the present application may also be alternated, modified, rearranged, decomposed, combined, or deleted.
In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing the present application and simplifying the description, but do not indicate or imply that the referred device or element must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the present application.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.
It should be understood that, although the steps in the flowcharts of the figures are shown in order as indicated by the arrows, the steps are not necessarily performed in order as indicated by the arrows. The steps are not performed in the exact order shown and may be performed in other orders unless explicitly stated herein. Moreover, at least a portion of the steps in the flow chart of the figure may include multiple sub-steps or multiple stages, which are not necessarily performed at the same time, but may be performed at different times, which are not necessarily performed in sequence, but may be performed alternately or alternately with other steps or at least a portion of the sub-steps or stages of other steps.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, several modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.

Claims (10)

1. An electric field generating apparatus, comprising:
an electric field generator for electrically connecting with at least two electrode patches;
the control unit is electrically connected with the electric field generator and is used for controlling the electric field generator to output a first voltage signal to target biological tissues through each electrode patch in a first time period so as to form an electric field; controlling the target biological tissue not to form the electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is arranged on one electrode patch.
2. The electric field generating device according to claim 1, wherein the control unit is further configured to control the electric field generator to stop outputting the first voltage signal for a second time period; alternatively, the first and second electrodes may be,
the electric field generating device also comprises a switch unit, the switch unit comprises at least two switch modules, and each switch module is used for controlling the connection and disconnection of the electric field generator and one electrode patch;
the control unit is further configured to control each of the switch modules to be turned off in a second time period, so that the first voltage signal output by the electric field generator stops being output to the target biological tissue.
3. The electric field generating apparatus according to claim 1, further comprising: an alarm unit;
the control unit is electrically connected with the alarm unit and is also used for controlling the alarm unit to send out alarm information when at least one temperature value corresponding to the temperature information is greater than a designed temperature value.
4. The electric field generating apparatus according to claim 2, wherein the control unit is further configured to control the electric field not to be formed at the target biological tissue for a third time period after the second time period when the temperature value corresponding to at least one of the temperature information is greater than the design temperature value; and/or, during a first time period, controlling the electric field generator to output a second voltage signal; the voltage value and/or frequency of the second voltage signal is lower than the first voltage signal.
5. The electric field generating apparatus according to claim 1, further comprising at least one of:
the first time period and the second time period are set at intervals;
the duration of the second time period is 100-300 milliseconds;
the waveform of the first voltage signal is at least one of: sinusoidal waveforms, bipolar pulse waveforms, unipolar pulse waveforms.
6. An electric field generating apparatus, comprising: at least two electrode patches, at least one temperature sensor and an electric field generating device according to any one of claims 1-5;
each electrode patch is electrically connected with the electric field generator through a lead, and is attached to a target biological tissue according to a design mode;
and each temperature sensor is electrically connected with the control unit and used for sending the temperature information to the control unit.
7. The electric field generating apparatus according to claim 6, wherein a switching module is provided on a lead wire connecting each of the electrode patches and the electric field generator.
8. A method of controlling an electric field, comprising:
in a first time period, controlling the electric field generator to output a first voltage signal to the target biological tissue through each electrode patch so as to form an electric field;
controlling the target biological tissue not to form the electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is arranged on one electrode patch.
9. A control device for an electric field, comprising:
the control module is used for controlling the electric field generator to output a first voltage signal to the target biological tissue through each electrode patch in a first time period so as to form an electric field; controlling the target biological tissue not to form the electric field in a second time period, and acquiring temperature information of each temperature sensor; each temperature sensor is arranged on one electrode patch.
10. A computer-readable storage medium, characterized in that it is used to store computer instructions for implementing the method for controlling an electric field according to claim 8, when said computer instructions are run on an electric field generating device.
CN202210158141.0A 2022-02-21 2022-02-21 Electric field generating device, electric field generating apparatus, and electric field control method Pending CN114209978A (en)

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Application publication date: 20220322