CN114194435B - Filling method for preventing liquid medicine from foaming - Google Patents
Filling method for preventing liquid medicine from foaming Download PDFInfo
- Publication number
- CN114194435B CN114194435B CN202111642059.7A CN202111642059A CN114194435B CN 114194435 B CN114194435 B CN 114194435B CN 202111642059 A CN202111642059 A CN 202111642059A CN 114194435 B CN114194435 B CN 114194435B
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- Prior art keywords
- filling
- foaming
- needle
- liquid medicine
- medicine
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
- B65B3/12—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/18—Controlling escape of air from containers or receptacles during filling
Abstract
The invention discloses a filling method for preventing liquid medicine from foaming, which comprises the following steps: s1, aligning: the filling needle is aligned with the bottle mouth below; s2, inserting pins: the filling needle is inserted into the bottle body, and the distance L between the filling needle and the bottom of the bottle is less than or equal to 3mm; s3, filling: the filling pump fills medicine for a period of time t at an acceleration a 1 Then the constant speed V is used for filling the medicine for a period of time t 2 ，V＝at 1 The method comprises the steps of carrying out a first treatment on the surface of the In the process of filling medicine, the filling needle and the liquid level rise synchronously. The filling method for preventing the liquid medicine from foaming can prevent the liquid medicine from foaming.
Description
Technical Field
The invention relates to the technical field of food and medicine packaging mechanical equipment, in particular to a filling method for preventing liquid medicine from foaming.
Background
The different liquid medicine characteristics differ in the degree of foaming during filling. For freeze-dried products, bubbles can adhere to the periphery of the bottle wall, and a circle of honeycomb holes can be formed after freeze-drying, so that the product appearance is affected. For the hydro-acupuncture product, the general filling amount is equivalent to the bottle capacity, and the bubble easily contacts the plug during the filling, influences the product leakproofness, and even some bubbles can emerge the bottleneck, influence the sterility of product.
Through research, the foaming of the liquid medicine is mainly concentrated in two stages, namely, the first stage: a filling stage, in which the liquid medicine is extruded by a filling pump and sprayed out from a needle filling port, and a large amount of bubbles are generated at the moment of contacting the bottle bottom; second,: in the filling process, the stage is mainly influenced by the change of the liquid level, and as the liquid medicine is continuously filled, the liquid level rises, the impact degree of the liquid medicine changes, and bubbles are generated. The existing filling method is difficult to prevent the liquid medicine from foaming.
Disclosure of Invention
The invention aims to solve the technical problem of overcoming the defects of the prior art and providing a filling method capable of preventing liquid medicine from foaming.
In order to solve the technical problems, the invention adopts the following technical scheme:
a filling method for preventing foaming of a liquid medicine, comprising the steps of:
s1, aligning: the filling needle is aligned with the bottle mouth below;
s2, inserting pins: the filling needle is inserted into the bottle body, and the distance L between the filling needle and the bottom of the bottle is less than or equal to 3mm;
s3, filling: the filling pump firstly fills medicine for a time period t1 at an acceleration a, and then fills medicine for a time period t2 at a constant speed V, wherein V=at 1; in the process of filling medicine, the filling needle and the liquid level rise synchronously.
As a further improvement of the above technical scheme:
the a is less than or equal to 150rpm, and the V is less than or equal to 200rpm/s.
The a=50 rpm, v=150 rpm/s.
The t2 is more than or equal to 2.1s.
The t2=2.4 s.
The bottle filling amount is 6.74g.
The l=3 mm.
The bottle body continuously runs at a constant speed along the conveying line, and the filling needle runs forward synchronously with the bottle body below during filling.
The filling needles are arranged in a plurality, each filling needle is arranged side by side along the conveying line, and each filling needle is filled synchronously.
Compared with the prior art, the invention has the advantages that:
in the filling method for preventing the liquid medicine from foaming, in the starting stage, a filling pump firstly fills the liquid medicine at the acceleration a for a time period t1, and the filling speed is gradually increased, so that the injection of the liquid medicine at the outlet of a filling needle is reduced, and the quantity of bubbles generated by instant contact with the bottom of a bottle is reduced; in the filling process, the constant-speed V filling time length t2 is used, and in the filling process, the filling needle is lifted while filling, and the filling needle and the liquid level are lifted synchronously, so that the impact degree of the liquid medicine in the filling process is balanced, and the generation of bubbles is prevented. The filling method can prevent the liquid medicine from foaming.
The filling method for preventing the liquid medicine from foaming has the advantages that the pump speed is 150rpm, the acceleration is 50rpm/s, the filling time is 2.4 seconds, the filling is smooth, and no bubbles are generated.
Drawings
Fig. 1 is a schematic illustration of the filling of a single filling needle of the filling method of the present invention for preventing foaming of a medical fluid.
Fig. 2 is an operation view of a filling pump of the filling method for preventing foaming of a medical fluid according to the present invention.
Fig. 3 is a schematic illustration of the filling of the parallel drainage and irrigation needle of the filling method of preventing foaming of the medical fluid of the present invention.
The reference numerals in the drawings denote:
1. filling needles; 2. a bottle body; 3. and (5) conveying a line.
Detailed Description
The invention will be described in further detail with reference to the drawings and the specific examples.
Embodiment one:
fig. 1 and 2 show an embodiment of the liquid medicine foaming prevention filling method of the present invention, which comprises the steps of:
s1, aligning: the filling needle 1 is aligned with the bottle mouth below;
s2, inserting pins: the filling needle 1 is inserted into the bottle body 2, and the distance L between the filling needle and the bottle bottom is less than or equal to 3mm;
s3, filling: as shown in fig. 2, the filling pump fills the medicine for a time period t1 at an acceleration a, and then fills the medicine for a time period t2 at a constant speed V, v=at1; in the process of filling medicine, the filling needle and the liquid level rise synchronously.
In the filling stage, the filling pump firstly fills the medicine at the acceleration a for a time period t1, and the filling speed is gradually increased, so that the injection of the medicine liquid at the outlet of the filling needle 1 is reduced, and the air bubble quantity generated by instant contact with the bottle bottom is reduced; in the filling process, the constant-speed V is used for filling the medicine for a time period t2, and in the filling process, the filling needle 1 is lifted while filling, and the filling needle 1 and the liquid level are lifted synchronously, so that the impact degree of the medicine liquid in the filling process is balanced, and the generation of bubbles is prevented. The filling method can prevent the liquid medicine from foaming.
The filling method can eliminate the generation of bubbles in the filling stage by reducing the speed and the acceleration of the filling pump, reduce the impact of liquid medicine in the filling process by the lifting of the filling needle 1, and prolong the filling time by adjusting the operation curve of the filling pump, thereby preventing the liquid medicine from foaming on the premise of ensuring the productivity.
In this example, a is 150rpm or less and V is 200rpm/s or less.
In this example, a=50 rpm, v=150 rpm/s.
In this example, t2 is not less than 2.1s.
In this embodiment, t2=2.4 s.
In this example, the bottle 2 was filled in an amount of 6.74g.
In this embodiment, l=3 mm.
The speed and the acceleration of the filling pump are regulated to the most reasonable state, so that the impact of liquid medicine can be effectively relieved. For example, 6.74g is filled, the pump speed is 200rpm, the acceleration is 150rpm/s, the filling time is 2.1 seconds, but the liquid medicine splashes obviously at the beginning of the filling, and the foaming is serious; by adjusting the pump speed to 150rpm, the acceleration to 50rpm/s, the filling time to 2.4 seconds, the filling is smooth, and no bubbles are generated.
In this embodiment, the bottle body 2 runs continuously at a constant speed along the conveying line 3, and the filling needle 1 runs forward with the bottle body 2 below during filling. Specifically, the bottle body 2 runs continuously at a constant speed along the conveying line 3; the filling needle 1 is arranged on a needle frame, the needle frame is driven by two servo motors, and can perform horizontal following movement and vertical lifting movement, and the filling action is completed in a coordinated manner in two directions.
In the alignment step: as shown in fig. 1, the bottle body 2 is at the position of B1, and the filling needle 1 is kept at the bottle mouth and aligned with the center of the bottle mouth; because the bottle body 2 moves at a uniform speed on the conveying line 3, and the needle frame accelerates from rest to alignment with the bottle mouth, the filling needle 1 reaches the same speed as the bottle body 2 in the horizontal direction through the acceleration stage at the position B1; when the bottle body 2 reaches the position B2, the filling needle 1 is inserted into a position 3mm away from the bottle bottom, and the filling pump is started according to the matched speed and acceleration, so that the speed and acceleration are reduced as much as possible to prevent bubbles; the bottle body 2 is positioned at the position B3-B5, the filling pump is used for continuously filling, and the filling needle 1 is synchronously lifted along with the continuous lifting of the liquid level, and the distance between the filling needle and the liquid level is always kept at 3mm; when the bottle body 2 reaches the position B6, the following filling stroke is prolonged to ensure the productivity in order to compensate the time of low-speed starting loss; when the bottle body 2 reaches the position B7, filling is completed, and the filling needle 1 is lifted to a position above the bottle mouth; finally, the filling needle 1 returns to the initial position in the horizontal direction and waits for the filling in the next period.
In order to prevent bubbles from being generated by the change of the liquid level in the filling process, the filling needle 1 and the liquid level rise are completely synchronous, and the distance of 3mm above the liquid level is always kept.
In order to maintain the normal production speed and to strive for more filling time, the distance that the filling needle 1 moves along with the bottle body 2 can be lengthened, as shown in the following table one,
list one
By following the distance, the filling time was increased by 0.3 seconds. The increased filling time can compensate the filling time of reducing the acceleration and speed loss in the filling stage, thereby achieving the purpose of preventing foaming and ensuring the productivity.
The filling method has no bubble generation in the filling process, prevents the bubble generation and ensures normal productivity.
Embodiment two:
fig. 3 shows another embodiment of the filling method for preventing foaming of a liquid medicine according to the present invention, in which a plurality of filling needles 1 are provided, each filling needle 1 is arranged side by side along a conveying line 3, and each filling needle 1 is filled synchronously, and the filling step is the same as that of the first embodiment. Each filling needle 1 is arranged on the needle frame and synchronously moves forwards and backwards, so that the production efficiency is improved.
While the invention has been described in terms of preferred embodiments, it is not intended to be limiting. Many possible variations and modifications of the disclosed technology can be made by anyone skilled in the art, or equivalent embodiments with equivalent variations can be made, without departing from the scope of the invention. Therefore, any simple modification, equivalent variation and modification of the above embodiments according to the technical substance of the present invention shall fall within the scope of the technical solution of the present invention.
Claims (8)
1. A filling method for preventing liquid medicine from foaming is characterized in that: the method comprises the following steps:
s1, aligning: the filling needle (1) is aligned with the bottle mouth below;
s2, inserting pins: the filling needle (1) is inserted into the bottle body (2) and is separated from the bottle bottom by L which is less than or equal to 3mm;
s3, filling: the filling pump fills medicine for a period of time t at an acceleration a 1 Then the constant speed V is used for filling the medicine for a period of time t 2 ，V=at 1 The method comprises the steps of carrying out a first treatment on the surface of the In the process of filling medicine, the filling needle and the liquid level rise synchronously; the a is less than or equal to 150rpm, and the V is less than or equal to 200rpm/s.
2. The filling method for preventing foaming of a liquid medicine according to claim 1, wherein: the a=50 rpm, v=150 rpm/s.
3. The filling method for preventing foaming of a liquid medicine according to claim 1, wherein: the t is 2 ≥2.1s。
4. A filling method for preventing foaming of a medical fluid according to claim 3, wherein: the t is 2 =2.4s。
5. The filling method for preventing foaming of a liquid medicine according to claim 1, wherein: the filling amount of the bottle body (2) is 6.74g.
6. The filling method for preventing foaming of a liquid medicine according to claim 1, wherein: the l=3 mm.
7. The filling method for preventing foaming of a medical fluid according to any one of claims 1 to 6, wherein: the bottle body (2) continuously runs at a constant speed along the conveying line (3), and the filling needle (1) synchronously runs forward with the bottle body (2) below during filling.
8. The filling method for preventing foaming of a medical fluid according to any one of claims 1 to 6, wherein: the filling needles (1) are arranged in a plurality, the filling needles (1) are arranged side by side along the conveying line (3), and the filling needles (1) are filled synchronously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111642059.7A CN114194435B (en) | 2021-12-29 | 2021-12-29 | Filling method for preventing liquid medicine from foaming |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111642059.7A CN114194435B (en) | 2021-12-29 | 2021-12-29 | Filling method for preventing liquid medicine from foaming |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114194435A CN114194435A (en) | 2022-03-18 |
| CN114194435B true CN114194435B (en) | 2023-09-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111642059.7A Active CN114194435B (en) | 2021-12-29 | 2021-12-29 | Filling method for preventing liquid medicine from foaming |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206788A (en) * | 1977-11-24 | 1980-06-10 | Kao Soap Co., Ltd. | Method for controlling filling rate in filling machine |
| CN101734594A (en) * | 2009-12-09 | 2010-06-16 | 广州达意隆包装机械股份有限公司 | Needle tube type filling machine and filling method thereof |
| CN202346734U (en) * | 2011-11-16 | 2012-07-25 | 甘庆潜 | Variable-speed fixed-liquid-level type filling machine |
| CN203921235U (en) * | 2014-05-27 | 2014-11-05 | 苏州柏德纳科技有限公司 | Anti-bubble swirl type filling liquid mechanism |
| CN113682508A (en) * | 2021-08-31 | 2021-11-23 | 楚天科技股份有限公司 | Filling method for enabling filling needle to rise synchronously with liquid level |
-
2021
- 2021-12-29 CN CN202111642059.7A patent/CN114194435B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4206788A (en) * | 1977-11-24 | 1980-06-10 | Kao Soap Co., Ltd. | Method for controlling filling rate in filling machine |
| CN101734594A (en) * | 2009-12-09 | 2010-06-16 | 广州达意隆包装机械股份有限公司 | Needle tube type filling machine and filling method thereof |
| CN202346734U (en) * | 2011-11-16 | 2012-07-25 | 甘庆潜 | Variable-speed fixed-liquid-level type filling machine |
| CN203921235U (en) * | 2014-05-27 | 2014-11-05 | 苏州柏德纳科技有限公司 | Anti-bubble swirl type filling liquid mechanism |
| CN113682508A (en) * | 2021-08-31 | 2021-11-23 | 楚天科技股份有限公司 | Filling method for enabling filling needle to rise synchronously with liquid level |
Non-Patent Citations (1)
| Title |
|---|
| 黄勇军.《伺服泵高速灌装的流体分析与研究》.2012,第30-34页. * |
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| CN114194435A (en) | 2022-03-18 |
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