CN114184798A

CN114184798A - Sample image analyzer

Info

Publication number: CN114184798A
Application number: CN202010960882.1A
Authority: CN
Inventors: 苏晓冬; 周慕昭; 李乐昌
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2020-09-14
Filing date: 2020-09-14
Publication date: 2022-03-15

Abstract

A sample image analyser, comprising: detection platform for bear the weight of the slide that awaits measuring is in order to detect, detection platform has the slide that is used for accepting the slide that awaits measuring and puts the position, one side that the position was put to the slide has first slide fixing device, is used for fixing the slide that awaits measuring on the position is placed to the slide, first slide fixing device orientation first bulge has on the lateral wall that the position was placed to the slide, first bulge produces horizontal and vertical downward direction effort in order to compress tightly the slide that awaits measuring on the position is placed to the slide, the opposite side that the position was placed to the slide has stop device, stop device produce at least with first slide fixing device is relative effort on the horizontal direction, be used for with the slide restriction that awaits measuring is in the position is placed to the slide. The analyzer can be stable fix the slide to be measured at the slide placing position, prevent the slide perk, make the analyzer result of shooing more accurate.

Description

Sample image analyzer

Technical Field

The application relates to the field of medical equipment, in particular to a sample image analyzer.

Background

In a specimen analysis system, it is often necessary to perform image analysis on a specimen, for example, to take an image of the specimen (e.g., blood) on a specimen slide (e.g., a blood smear), and perform analysis using the taken image, so as to obtain a corresponding detection result. When the image is shot, the slide to be detected needs to be fixed at a slide placing position on the detection platform. The conventional slide fixing device adopts a mode of fixing a slide to be detected from the side surface, but the slide fixing device only has horizontal clamping force, so that the possibility of tilting the slide exists, and the photographed image is inaccurate or cannot be finished.

Disclosure of Invention

The present invention has been made to solve the above problems. According to an aspect of the present invention, there is provided a sample image analyser, the analyser comprising:

the slide loading device is used for loading the slide to be detected to the detection platform;

the detection platform is used for bearing the slide to be detected for detection and is provided with a slide placing position for receiving the slide to be detected,

one side of the slide placing position is provided with a first slide fixing device used for fixing a slide to be detected on the slide placing position, the side wall of the first slide fixing device facing the slide placing position is provided with a first convex part, the first convex part generates horizontal and vertical downward acting force to press the slide to be detected on the slide placing position,

the other side of the slide placing position is provided with a limiting device, and the limiting device at least generates an acting force which is opposite to the first slide fixing device in the horizontal direction and is used for limiting the slide to be detected at the slide placing position; and

and the imaging device is used for shooting the sample in the slide to be detected on the slide placing position.

In one embodiment, an included angle formed by at least one side wall of the first protruding part and the slide to be tested is an acute angle.

In one embodiment, the first fixing device further has an arc-shaped first guide member for guiding the slide to be tested to the slide placing position.

In one embodiment, the first slide holding device is movable, and has a first fixing position on a movement track, and the first protruding part presses the slide to be tested on the slide placing position at the first fixing position.

In one embodiment, the limiting device comprises a second slide fixing device, and the side wall of the second slide fixing device facing the slide placing position is provided with a second protruding part which generates horizontal and vertical downward acting force to press the slide to be tested on the slide placing position.

In one embodiment, the first slide holding device and the second slide holding device are located at an end near an entrance of the slide placing position into which the slide to be tested is introduced.

In one embodiment, an included angle formed by at least one side wall of the second protruding part and the slide to be tested is an acute angle.

In one embodiment, the second slide holding device further has a second guide member having an arc shape for guiding the slide to be tested to the slide placing position.

In one embodiment, the second slide holding device is movable, and has a second fixing position on the movement track, and the second protruding part presses the slide to be tested on the slide placing position at the second fixing position.

In one embodiment, the second slide holding device is fixed, the first slide holding device is movable, and the movement track of the first slide holding device has a first fixing position where the first projecting member presses the slide to be measured on the slide placing position.

When carrying out sample image shooting, the fixed slide that awaits measuring that above-mentioned sample image analyzer's first slide fixing device can stabilize, the firm slide that awaits measuring that compresses tightly of the power that the protruding part of first slide fixing device produced horizontal and vertical direction prevents the slide perk that awaits measuring makes the shooting result more accurate.

Drawings

The above and other objects, features and advantages of the present invention will become more apparent by describing in more detail embodiments of the present invention with reference to the attached drawings. The accompanying drawings are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings, like reference numbers generally represent like parts or steps.

FIG. 1 is a block diagram of a sample image analyzer according to an embodiment of the present disclosure;

FIG. 2 is a schematic diagram of a sample image analyzer for loading a slide to be tested according to an embodiment of the present application;

FIG. 3 is a schematic view of another structure of a specimen image analyzer for loading a slide to be tested according to an embodiment of the present application;

FIG. 4 is a schematic view of another structure of a specimen image analyzer for loading a slide to be tested according to an embodiment of the present application;

fig. 5 is a side view of a specimen image analyzer and an enlarged schematic view of a first slide holding device and a second slide holding device in an embodiment of the present application.

Detailed Description

The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. Wherein like elements in different embodiments are numbered with like associated elements. In the following description, numerous details are set forth in order to provide a better understanding of the present application. However, those skilled in the art will readily recognize that some of the features may be omitted or replaced with other elements, materials, methods in different instances. In some instances, certain operations related to the present application have not been shown or described in detail in order to avoid obscuring the core of the present application from excessive description, and it is not necessary for those skilled in the art to describe these operations in detail, so that they may be fully understood from the description in the specification and the general knowledge in the art.

Furthermore, the features, operations, or characteristics described in the specification may be combined in any suitable manner to form various embodiments. Also, the various steps or actions in the method descriptions may be transposed or transposed in order, as will be apparent to one of ordinary skill in the art. Thus, the various sequences in the specification and drawings are for the purpose of describing certain embodiments only and are not intended to imply a required sequence unless otherwise indicated where such sequence must be followed.

The numbering of the components as such, e.g., "first", "second", etc., is used herein only to distinguish the objects as described, and does not have any sequential or technical meaning. The term "connected" and "coupled" when used in this application, unless otherwise indicated, includes both direct and indirect connections (couplings).

The present application provides a specimen image analyzer which is mainly used for analyzing a specimen on a specimen slide, for example, a blood specimen on a blood smear, to assist a doctor in diagnosis and treatment. Of course, the sample includes, but is not limited to, blood, which may also be other substances secreted by or present inside the human body.

Referring to fig. 1 and 2, in one embodiment, the specimen image analyzer 1000 includes a slide loading device 100, a slide moving device 200, and an imaging device 300. The slide moving device 200 includes a detection platform 210 and a driving mechanism (not shown) for driving the detection platform 210 to move relative to the imaging device 300, the detection platform 210 is used for carrying the slide 800 to be detected for detection, and the detection platform 210 has a slide placing position for receiving the slide 800 to be detected. The slide loading device 100 is used for loading the slide 800 to be tested to the detection platform 210. The imaging device 300 is used for shooting a sample in a slide 800 to be tested positioned on the slide placing position. The specimen image analyzer 1000 further includes an image analyzing device 500 for analyzing the taken image of the specimen slide.

Referring to fig. 1 and 2, in one embodiment, the imaging device 300 includes a camera set 310 and a lens set 320, and is used for photographing cells in a sample smeared on a sample slide. Generally, the lens group 320 may include a first objective lens 321 and a second objective lens 322. The first objective lens may be, for example, a 10-fold objective lens, and the second objective lens may be, for example, a 100-fold objective lens. Lens group 320 may also include a third objective lens 323, which may be, for example, a 40 x objective lens. Lens group 320 may also include an adapter or eyepiece.

In addition, in some embodiments, the specimen image analyzer 1000 further includes a slide recovery device 400, a slide gripping device 600, and an identification device 700. The slide recovery device 400 is used for receiving the sample slide after the shooting work is completed, for example, the shot sample slide is sent to the slide recovery device 400 for storage, so as to be operated later. The recognition device 700 is used for recognizing the identity information of the sample slide, and the slide clamping device 600 is used for clamping the sample slide from the recognition device 700 onto the slide moving device 200 for detection.

Generally, when the slide shooting is performed, a slide to be tested needs to be fixed on a detection platform so as to complete the image shooting. Therefore, in order to complete image shooting, the slide to be detected needs to be stably fixed on the detection platform, and the tilting of the slide to be detected affects the slide shooting effect, which may cause shooting failure.

In view of this problem, referring to fig. 3 to 5, in an embodiment of the present application, one side of the slide placing position is provided with a first slide fixing device 330 for fixing a slide 800 to be tested on the slide placing position, a side wall of the first slide fixing device 330 facing the slide placing position is provided with a first protruding part 331, and the first protruding part 331 applies horizontal and vertical downward force to press the slide 800 to be tested on the slide placing position. The other side of the slide placing position is provided with a limiting device 340, and the limiting device 340 at least generates an acting force opposite to the first slide fixing device 330 in the horizontal direction and is used for limiting the slide 800 to be tested at the slide placing position. The other side of the slide placing position is the side opposite to the side of the slide placing position, mainly in order to generate a force opposite to the first slide holding device 330 at least in the horizontal direction.

Referring to fig. 5, the first protruding part 331 may be integrally formed with the first slide holding device 330, or may be separately provided from the first slide holding device 330, as long as the first protruding part 331 and the first slide holding device 330 cooperate to press the slide 800 to be tested on the slide placing position. Preferably, an included angle formed by at least one side wall of the first protruding part 331 and the slide 800 to be tested is an acute angle. Preferably, at least one side wall of the first protruding part 331 forms an included angle of 30 ° to 60 ° with the slide 800 to be tested. In one embodiment, the first slide holder 330 is integrally formed with the first protruding part 331, the first protruding part 331 is a part protruding from the first slide holder 330, the included angle formed by the side wall of the first protruding part 331 and the slide 800 to be tested is an acute angle, and the first protruding part 331 presses the slide 800 to be tested with horizontal and vertical downward force. In one embodiment, the first projection member 331 is provided separately from the first slide holder 330. The shape of the first protruding part 331 may be a triangle, a circle, a diamond, or the like, and the surface of the first protruding part 331 contacting the slide 800 to be tested may be a slope, a circular arc, or the like, as long as the force in the horizontal and vertical downward directions can be generated.

The first protruding part 331 is set to be capable of generating force in horizontal and vertical downward directions, so that the slide 800 to be tested can be well fixed at the slide placing position, and the first protruding part 331 can generate vertical downward force in the vertical direction, so that the slide to be tested can be effectively prevented from tilting.

Referring to fig. 3 and 4, the limiting device 340 may be a groove disposed on the detection platform 210, or may be another protruding component disposed on the other side of the slide placing position, as long as it can generate at least a force opposite to the first slide fixing device 330 in the horizontal direction, and the main purpose of the limiting device is to limit the slide 800 to be detected on the slide placing position.

Referring to fig. 3-5, the first slide retaining device 330 can be fixed or movable. The first slide retaining device 330 can be fixedly mounted to the testing platform 210, or can be fixedly mounted to other components. In one embodiment, the first slide holding device 330 is movable, the first slide holding device 330 is mounted on the testing platform 210, and has a first fixing position on the movement track of the first slide holding device 330, and the first projection member 331 presses the slide 800 to be tested on the slide placing position at the first fixing position. The first protruding part 331 can slide to the first fixing position and can also translate to the first fixing position. In one embodiment, the first slide holder 330 is mounted to the testing platform 210 by a torsion spring. In one embodiment, the testing platform 210 has a hole therein, the first slide holder 330 is mounted to the testing platform 210 via a pivot shaft, and the first slide holder 330 is pivoted to the first holding position. In one embodiment, the testing platform 210 has a slide track thereon, the first slide holder 330 is mounted on the slide track, and the first slide holder 330 slides to the first holding position.

Referring to fig. 4, the first slide fixing device 330 further has a first guide member 332 having an arc shape, and the first guide member 332 is used for guiding the slide 800 to be tested to the slide placing position. The first guide member 332 can be integrally formed with the first slide holder 330 or can be provided separately from the first slide holder 330. When the slide 800 to be tested is loaded to the inspection stage 210, the slide 800 to be tested is fed to the slide placing position via the first guide member 332.

Referring to fig. 3 to 5, the position limiting device 340 includes a second slide holder 341. The limiting device 340 may only include the second slide fixing device 341, or may be composed of the second slide fixing device 341 and other limiting components, or may be composed of two second slide fixing devices 341 to form the limiting device 340, and the final purpose is to stably fix the slide 800 to be tested at the slide placing position.

Referring to fig. 5, in an embodiment of the present application, the second slide holder 341 has a second protrusion 3411 on a side wall facing the slide placing position, and the second protrusion 3411 applies a horizontal and vertical downward force to press the slide 800 to be tested on the slide placing position.

Referring to fig. 5, the second protrusion parts 3411 may be integrally formed with the second slide holder 341 or may be separately provided from the second slide holder 341, as long as the second protrusion parts 3411 and the second slide holder 341 cooperate with each other to press the slide 800 to be tested on the slide placement position. Preferably, an included angle formed by at least one side wall of the second protrusion part 3411 and the slide 800 to be tested is an acute angle. Preferably, at least one side wall of the second protrusion part 3411 forms an angle of 30 ° to 60 ° with the slide 800 to be tested. In one embodiment, the second slide holder 341 is integrally formed with the second protrusion part 3411, the second protrusion part 3411 is a portion of the second slide holder 341 protruding, an included angle formed between a side wall of the second protrusion part 3411 and the slide 800 to be tested is an acute angle, and the second protrusion part 3411 presses the slide 800 to be tested with horizontal and vertical downward forces. In one embodiment, the second projection member 3411 is provided separately from the second slide holding device 341. The shape of the second protrusion member 3411 may be a triangle, a circle, a diamond, or the like, and the surface of the second protrusion member 3411 contacting the slide 800 to be tested may be a slope, a circular arc, or the like, as long as the force in the horizontal and vertical downward direction can be generated.

The second projection parts 3411 are arranged so that the force generated in the horizontal and vertical downward directions can well fix the slide 800 to be tested at the slide placing position. The vertical downward force generated by the second projection member 3411 cooperates with the vertical downward force generated by the first projection 331 to further stably fix the slide 800 to be tested at the slide placing position. Particularly, the first slide fixing device 330, the limiting device 340 composed of other components, and the limiting device 340 of the second slide fixing device 341 cooperate together to form a stable three-point stress model, which is more beneficial to fixing the slide 800 to be tested. In one embodiment, a stable three-point force model can also be formed by the first slide holder 330 and the two second slide holders 341 cooperating with each other. In one embodiment, a bump may be provided on the second slide holder 341 to facilitate three-point stressing.

Referring to fig. 3 to 5, the second slide holder 341 may be fixed or movable. The second slide holder 341 may be fixedly mounted on the testing platform 210, or may be fixedly mounted on another component. In one embodiment, the second slide holder 341 is movable, the second slide holder 341 is mounted on the testing platform 210, and has a second fixing position on the motion trajectory of the second slide holder 341, and the second protrusion parts 3411 press the slide 800 to be tested on the slide placing position at the second fixing position. The second protrusion 3411 may be slid to the second fixing position or translated to the second fixing position. In one embodiment, the second slide holder 341 is mounted to the testing platform 210 by a torsion spring. In one embodiment, the testing platform 210 has a hole therein, the second slide holder 341 is mounted to the testing platform 210 by a rotating shaft, and the second slide holder 341 is rotated to the second fixing position. In one embodiment, the testing platform 210 has a slide track thereon, the second slide holder 341 is mounted on the slide track, and the second slide holder 341 is slid to the second fixed position.

In one embodiment of the present application, the first slide holding device 330 is movable and the second slide holding device 341 is stationary. In one embodiment, the first slide holder 330 is mounted to the testing platform 210 via a torsion spring and the second slide holder 341 is fixedly mounted to the testing platform 210. In one embodiment of the present application, both the first slide holding device 330 and the second slide holding device 341 are movable. In one embodiment of the present application, the first slide holder 330 and the second slide holder 341 are stationary.

Referring to fig. 4, the second slide holding device 341 further has a second guide member 3412 having an arc shape, and the second guide member 3412 is used to guide the slide 800 to be tested to the slide placing position. The second guide member 3412 may be integrally formed with the second slide holder 341 or may be provided separately from the second slide holder 341. When the slide 800 to be tested is introduced, the slide 800 to be tested is guided by the second guide part 3412 of the second slide holder 341, the first guide part 332 of the first slide holder 330 engages with the second guide part 3412, and the slide loading apparatus 100 pushes the slide 800 to be tested into the slide placing position. The first guide part 332 and the second guide part 3412 form a horn shape from the inside to the outside.

In one embodiment, the first slide holding device 330 and the second slide holding device 341 are located near an end of the slide 800 to be tested that is introduced into the slide placement site inlet. The first slide holding device 330 and the second slide holding device 341 are provided at one end of the entrance of the slide placing position to facilitate the pressing of the slide 800 to be tested at the start of the slide introduction. The first slide holding device 330 and the second slide holding device 341 are located in the slide bar code region of the slide 800 to be tested, and do not affect the detectable range of the slide 800 to be tested.

In the sample image analyzer of the present embodiment, since the first slide fixing device 330 has the first protruding part 331, the first protruding part 331 generates horizontal and vertical downward acting forces, and can stably press the slide 800 to be tested, thereby preventing the slide 800 to be tested from being lifted. Further, the specimen image analyzer has a second slide holding device 341, and the second projection member 3411 of the second slide holding device 341 also generates a downward force in the horizontal and vertical directions, and further presses the slide 800 to be measured, and particularly the second projection member 3411 also generates a downward force in the vertical direction. Under the cooperation of the first slide fixing device 330 and the second slide fixing device 341, the slide can be prevented from being tilted, so that the image taken by the sample image analyzer is accurate.

The above description is only for the specific embodiment of the present invention or the description thereof, and the protection scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and the changes or substitutions should be covered within the protection scope of the present invention. The protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A sample image analyzer, characterized in that the analyzer comprises:

2. The analyzer according to claim 1, wherein at least one side wall of said first projection member forms an acute angle with said slide to be tested.

3. The analyzer according to claim 1, wherein said first holding means further has a first guide member having an arc shape for guiding said slide to be tested to said slide placing position.

4. The analyzer according to any one of claims 1 to 3 wherein said first slide holding means is movable, said first slide holding means having a first holding position on its trajectory of movement in which said first projecting member presses against a slide to be measured on said slide seating position.

5. The analyzer of claim 1, wherein the stop means comprises a second slide holding device having a second projection member on a side wall thereof facing the slide placing position, the second projection member exerting horizontal and vertically downward directed forces to press the slide to be tested on the slide placing position.

6. The analyzer of claim 5, wherein said first slide holding device and said second slide holding device are located at an end proximate to an entrance of said slide placement site into which said slide to be tested is introduced.

7. The analyzer according to claim 5 wherein at least one side wall of said second projection member forms an acute angle with said slide to be tested.

8. The analyzer according to claim 5 wherein said second slide holding means further has a second guide member having an arcuate shape for guiding said slide to be tested to said slide placing position.

9. The analyzer according to any one of claims 5 to 8 wherein said second slide holding means is movable, said second slide holding means having a second holding position on its trajectory of movement in which said second projection member presses against the slide to be tested on said slide resting position.

10. The analyzer as claimed in any one of claims 5 to 8 wherein said second slide holding means is stationary and said first slide holding means is movable, said first slide holding means having a first stationary position on its trajectory of movement in which said first projecting member presses against a slide to be tested on said slide receiving position.