CN114174323B - 新的癌抗原和方法 - Google Patents

新的癌抗原和方法 Download PDF

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Publication number
CN114174323B
CN114174323B CN202080049064.4A CN202080049064A CN114174323B CN 114174323 B CN114174323 B CN 114174323B CN 202080049064 A CN202080049064 A CN 202080049064A CN 114174323 B CN114174323 B CN 114174323B
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cancer
polypeptide
cells
seq
nucleic acid
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CN114174323A (zh
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G·卡西奥蒂斯
G·扬
J·阿蒂格
F·马里诺
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Enara Biology Ltd
Francis Crick Institute Ltd
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Enara Biology Ltd
Francis Crick Institute Ltd
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CN202080049064.4A 2019-07-05 2020-07-03 新的癌抗原和方法 Active CN114174323B (zh)

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PCT/GB2020/051594 WO2021005339A1 (en) 2019-07-05 2020-07-03 Novel cancer antigens and methods

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BR112021006941A2 (pt) 2018-10-19 2021-08-31 The Francis Crick Institute Limited Antígenos de câncer inovadores e métodos
TW202241925A (zh) 2021-01-15 2022-11-01 德商英麥提克生物技術股份有限公司 用於不同類型癌症免疫治療的hla展示肽
US20250054576A1 (en) 2021-12-17 2025-02-13 Evaxion Biotech A/S Personalized cancer therapy targeting normally non-expressed sequences
WO2025202937A1 (en) 2024-03-26 2025-10-02 BioNTech SE Cancer vaccines

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602854A (zh) * 2015-12-11 2018-09-28 伊玛提克斯生物技术有限公司 用于多种癌症免疫治疗的新型肽和肽组合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002515734A (ja) 1996-01-02 2002-05-28 カイロン コーポレイション 遺伝子改変された樹状細胞により媒介される免疫刺激
US6770456B1 (en) 1998-07-29 2004-08-03 Ludwig Institute For Cancer Research Endogenous retrovirus tumor associated nucleic acids and antigens
US20020015998A1 (en) 2000-04-06 2002-02-07 Gabriel Vogeli Novel G protein-coupled receptors
US7193069B2 (en) * 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
EP1586330A1 (en) 2004-04-16 2005-10-19 Georg-August-Universität Göttingen Vaccination against malignant melanoma
DK1871391T3 (da) 2005-03-30 2012-04-16 Viroxis Endogen retrovirus og proteiner, der kodes af env som target for cancerbehandling
AT502292B1 (de) 2005-05-11 2010-04-15 Avir Green Hills Biotechnology Melanomdiagnose
US8921050B2 (en) 2006-03-17 2014-12-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods of diagnosing renal cell carcinoma
US20080019979A1 (en) 2006-05-22 2008-01-24 Feng Wang-Johanning HERV-K Antigens, Antibodies, and Methods
US20100120627A1 (en) * 2006-08-02 2010-05-13 Abdelmajid Belouchi Genemap of the human genes associated with psoriasis
WO2009026116A2 (en) * 2007-08-16 2009-02-26 Genizon Biosciences, Inc. Genemap of the human genes associated with longevity
GB201521746D0 (en) * 2015-12-10 2016-01-27 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers
CR20180551A (es) * 2016-04-21 2019-02-12 Immatics Biotechnologies Gmbh Inmunoterapia contra el melanoma y otros tipos de cáncer
US10384736B2 (en) * 2016-07-13 2019-08-20 Marcelo A. Pizarro Dual oscillating cycle saddle and support system

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602854A (zh) * 2015-12-11 2018-09-28 伊玛提克斯生物技术有限公司 用于多种癌症免疫治疗的新型肽和肽组合物

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