CN114174305A - 用于治疗癌症的官能化的金卡宾萘醌络合物 - Google Patents

用于治疗癌症的官能化的金卡宾萘醌络合物 Download PDF

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Publication number
CN114174305A
CN114174305A CN202080050300.4A CN202080050300A CN114174305A CN 114174305 A CN114174305 A CN 114174305A CN 202080050300 A CN202080050300 A CN 202080050300A CN 114174305 A CN114174305 A CN 114174305A
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substituted
compound
alkyl
alkoxy
alkylamino
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English (en)
Chinese (zh)
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J·L·塞斯勒
S·森
J·F·阿拉姆布拉
Z·崔
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University of Texas System
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/12—Gold compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/10—Silver compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202080050300.4A 2019-05-22 2020-05-22 用于治疗癌症的官能化的金卡宾萘醌络合物 Pending CN114174305A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962851187P 2019-05-22 2019-05-22
US62/851187 2019-05-22
PCT/US2020/034415 WO2020237225A1 (en) 2019-05-22 2020-05-22 Functionalized gold carbene naphthoquinone complexes for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
CN114174305A true CN114174305A (zh) 2022-03-11

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CN202080050300.4A Pending CN114174305A (zh) 2019-05-22 2020-05-22 用于治疗癌症的官能化的金卡宾萘醌络合物

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Country Link
US (1) US12577262B2 (https=)
EP (1) EP3972981A4 (https=)
JP (1) JP2022532801A (https=)
KR (1) KR20220024123A (https=)
CN (1) CN114174305A (https=)
AU (1) AU2020279478A1 (https=)
CA (1) CA3140716A1 (https=)
IL (1) IL288176A (https=)
MX (1) MX2021014195A (https=)
SG (1) SG11202112856QA (https=)
WO (1) WO2020237225A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102821849A (zh) * 2010-03-02 2012-12-12 圣安德鲁斯大学董事会 金络合物
US20130026453A1 (en) * 2011-07-29 2013-01-31 Klaus Kunze Methods of Polymerizing Silanes and Cyclosilanes Using N-Heterocyclic Carbenes, Metal Complexes Having N-Heterocyclic Carbene Ligands, and Lanthanide Compounds
CN104220441A (zh) * 2012-02-13 2014-12-17 百时美施贵宝公司 烯二炔化合物、其缀合物及其用途和方法
WO2019006327A1 (en) * 2017-06-30 2019-01-03 Board Of Regents, The University Of Texas System OR-CARBENE COMPLEXES CONTAINING NAPHTOQUINONE AND METHODS OF USE

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170129911A1 (en) 2015-11-10 2017-05-11 Massachusetts Institute Of Technology Complexes comprising a platinum compound and an immune checkpoint inhibitor and related methods

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102821849A (zh) * 2010-03-02 2012-12-12 圣安德鲁斯大学董事会 金络合物
US20130026453A1 (en) * 2011-07-29 2013-01-31 Klaus Kunze Methods of Polymerizing Silanes and Cyclosilanes Using N-Heterocyclic Carbenes, Metal Complexes Having N-Heterocyclic Carbene Ligands, and Lanthanide Compounds
CN104220441A (zh) * 2012-02-13 2014-12-17 百时美施贵宝公司 烯二炔化合物、其缀合物及其用途和方法
WO2019006327A1 (en) * 2017-06-30 2019-01-03 Board Of Regents, The University Of Texas System OR-CARBENE COMPLEXES CONTAINING NAPHTOQUINONE AND METHODS OF USE

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HISASHI OHARA等: "Effect of chelating ring size in catalytic ketone hydrogenation: facile synthesis of ruthenium(II) precatalysts containing an N-heterocyclic carbene with a primary amine donor for ketone hydrogenation and a DFT study of mechanisms", 《DALTON TRANS.》, vol. 41, 23 May 2012 (2012-05-23), pages 8799 *
LUCA BOSELLI等: "Synthesis, structures, and selective toxicity to cancer cells of gold(I) complexes involving N-heterocyclic carbene ligands", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》, vol. 85, 24 July 2014 (2014-07-24), pages 89 *
QI LIU等: "Tunable Multicolor Phosphorescence of Crystalline Polymeric Complex Salts with Metallophilic Backbones", 《ANGEW. CHEM. INT. ED.》, vol. 57, 25 April 2018 (2018-04-25), pages 6279 - 6283 *
R. MCCALL等: "Dual targeting of the cancer antioxidant network with 1, 4-naphthoquinone fused Gold(I) Nheterocyclic carbene complexes", 《CHEM. SCI.》, vol. 8, 21 July 2017 (2017-07-21), pages 5920 *
TOBIAS DIEHL等: "Synthesis of hydroxyl-functionalized N-heterocyclic carbene gold(I) complexes and peptide conjugates", 《DALTON TRANS》, vol. 46, 9 February 2017 (2017-02-09), pages 2989 *

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Publication number Publication date
EP3972981A4 (en) 2023-05-24
CA3140716A1 (en) 2020-11-26
KR20220024123A (ko) 2022-03-03
EP3972981A1 (en) 2022-03-30
US12577262B2 (en) 2026-03-17
AU2020279478A1 (en) 2021-12-09
WO2020237225A1 (en) 2020-11-26
IL288176A (en) 2022-01-01
JP2022532801A (ja) 2022-07-19
MX2021014195A (es) 2022-02-21
SG11202112856QA (en) 2021-12-30
US20220340601A1 (en) 2022-10-27

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Application publication date: 20220311