CN114129679A - Calcium tablet special for children and preparation method thereof - Google Patents
Calcium tablet special for children and preparation method thereof Download PDFInfo
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- CN114129679A CN114129679A CN202010918027.4A CN202010918027A CN114129679A CN 114129679 A CN114129679 A CN 114129679A CN 202010918027 A CN202010918027 A CN 202010918027A CN 114129679 A CN114129679 A CN 114129679A
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 69
- 239000011575 calcium Substances 0.000 title claims abstract description 69
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 69
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 18
- 239000006228 supernatant Substances 0.000 claims abstract description 17
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 241000572565 Alpinia oxyphylla Species 0.000 claims abstract description 9
- 244000268590 Euryale ferox Species 0.000 claims abstract description 9
- 235000006487 Euryale ferox Nutrition 0.000 claims abstract description 9
- 230000008569 process Effects 0.000 claims abstract description 9
- 235000013305 food Nutrition 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 6
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 6
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 6
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 6
- 235000010580 Psophocarpus tetragonolobus Nutrition 0.000 claims abstract description 6
- 241000046198 Triteleia hyacinthina Species 0.000 claims abstract description 6
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 6
- 210000000582 semen Anatomy 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 4
- 240000008669 Hedera helix Species 0.000 claims abstract description 3
- 210000002421 cell wall Anatomy 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims abstract description 3
- 238000000605 extraction Methods 0.000 claims description 18
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 238000002386 leaching Methods 0.000 claims description 5
- 239000011344 liquid material Substances 0.000 claims description 5
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 4
- 229940069978 calcium supplement Drugs 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 3
- 239000001110 calcium chloride Substances 0.000 claims description 3
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 3
- 239000001506 calcium phosphate Substances 0.000 claims description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 3
- 235000011010 calcium phosphates Nutrition 0.000 claims description 3
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 3
- ZQBZAOZWBKABNC-UHFFFAOYSA-N [P].[Ca] Chemical compound [P].[Ca] ZQBZAOZWBKABNC-UHFFFAOYSA-N 0.000 claims description 2
- 238000005119 centrifugation Methods 0.000 claims description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims 1
- 206010006956 Calcium deficiency Diseases 0.000 abstract description 9
- 230000001502 supplementing effect Effects 0.000 abstract description 4
- 241000196324 Embryophyta Species 0.000 abstract 2
- 235000018927 edible plant Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000037182 bone density Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 238000012795 verification Methods 0.000 description 6
- 229930003316 Vitamin D Natural products 0.000 description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 4
- 239000011710 vitamin D Substances 0.000 description 4
- 235000019166 vitamin D Nutrition 0.000 description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 description 4
- 229940046008 vitamin d Drugs 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 238000000874 microwave-assisted extraction Methods 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 210000002436 femur neck Anatomy 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 101150044508 key gene Proteins 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000009456 molecular mechanism Effects 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000005374 Poisoning Diseases 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000001727 glucose Nutrition 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 235000021056 liquid food Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Aiming at the current situation of calcium deficiency of children, the life big data is utilized to determine the core gene target point of calcium deficiency of children, and then the network pharmacology big data is utilized to screen and obtain the medicine-food homologous plant formula for supplementing calcium to children, and the medicine-food homologous plant formula is prepared from the following raw materials in parts by weight: 5-30 parts of dried orange peel, 5-30 parts of Chinese yam, 5-40 parts of white hyacinth bean, 3-20 parts of sharpleaf galangal fruit, 5-35 parts of gordon euryale seed and 6-25 parts of rhizoma polygonati, and is prepared by matching with food raw materials containing 800mg of calcium in 400-plus materials according to the following method: s1 micronizing pericarpium Citri Reticulatae, rhizoma Dioscoreae, semen lablab album, fructus Alpinae Oxyphyllae, semen euryales, and rhizoma Polygonati, breaking cell wall, and extracting functional components; centrifuging the S2 extract to obtain supernatant; s3, concentrating the supernatant, and mixing with the calcium raw material superfine powder; s4 granulating, performing aseptic treatment, and preparing the calcium tablet special for children according to the standard tablet process. The calcium tablet is designed according to life big data, is prepared from medicinal and edible plant raw materials, and has simple preparation method.
Description
Technical Field
The invention relates to a calcium tablet special for children and a preparation method thereof.
Background
The children are in the stage of rapid growth of bodies, and need a large amount of calcium for building bones and muscles, so the demand of calcium is very large, and the viscera of the children are delicate and tender in the development stage, the qi of the body is not filled, the healthy viscera function is not formed, the deficiency of the kidney, the spleen and the lung qi often appears, and the characteristics of delicate and tender lung, frequent insufficiency of the spleen and frequent deficiency of the kidney are shown. The absorption and utilization of calcium are limited, and calcium deficiency easily occurs.
At present, the most common method for supplementing calcium for children is to take calcium supplementing products. However, the existing calcium supplement products are only added with exogenous calcium (or added with vitamin D), which is to supplement calcium, and the exogenous calcium is only added under the condition that the absorption and transformation mechanism of calcium and the special physiological characteristics of children are not completely understood, and other necessary conditions of calcium absorption are neglected, so that the absorption amount of calcium is far less than the daily requirement of calcium, and the situation that only calcium is not absorbed is caused. And the expert committee of vitamin D discipline group of the calcium deficiency committee of the chinese college of senior citizens pointed out: "the following dosing method has proven ineffective, or ineffective and the risk of poisoning increases, and therefore the use of active vitamin D formulations" is not recommended [ china journal of calcium deficiency 2014, volume 20, phase 9.
Chinese patent CN201210422523.6 discloses a calcium preparation, its preparation method and application, the formulation is composed of calcium salt, vitamin D, vitamin K, mannitol and glucose. Chinese patent CN200910082672.0 discloses a micro-emulsion calcium preparation, a preparation method and application thereof, wherein a micro-emulsion structure is used as a carrier of a calcium source, and vitamins, lecithin and sorbitol are used in a matching manner. The calcium supplement products are only designed from the calcium absorption angle, and do not supplement calcium according to the physiological characteristics and molecular mechanism of children, so that the problem of calcium deficiency of children cannot be fundamentally solved. The most suitable medicine formula is not screened from a molecular mechanism causing calcium deficiency of children, and the scientificity and the effectiveness are lacked.
In addition, the addition amount of calcium in the beverage specified in national food safety standard of food nutrition enhancer use (GB 14880-2012) is 160-1350 mg/kg, the daily consumption of the domestic calcium preparation related liquid food is about 100mL at present, the maximum addition amount of calcium limited by laws and regulations is only 135 mg, the requirement that the daily calcium intake of children is 1200 and 1500 mg/day is far less, the calcium supplementing effect on children is very little, and other types of foods have the problem.
Disclosure of Invention
Aiming at the defects, the invention starts with a cause mechanism aiming at the calcium deficiency of children, utilizes a life big data technology to excavate a key gene target point of the calcium deficiency of the children, finds a key compound for regulating and controlling the key gene target point through a network pharmacological system tool, and screens a medicine-food homologous traditional Chinese medicine to form a traditional Chinese medicine formula for promoting the calcium supplement of the children, wherein the traditional Chinese medicine formula is prepared from the following raw materials in parts by weight: 5-30 parts of dried orange peel, 5-30 parts of Chinese yam, 5-40 parts of white hyacinth bean, 3-20 parts of sharpleaf galangal fruit, 5-35 parts of gordon euryale seed and 6-25 parts of rhizoma polygonati, and the food raw materials containing 400-800mg of calcium are matched for use, and the preparation method comprises the following steps: s1 mixing pericarpium Citri Reticulatae, rhizoma Dioscoreae, semen lablab album, fructus Alpinae Oxyphyllae, semen euryales, and rhizoma Polygonati in proportion, micronizing, breaking cell wall, and extracting functional components; centrifuging the S2 extract to obtain supernatant; s3, concentrating the supernatant, and mixing with the calcium raw material superfine powder; s4 granulating, performing aseptic treatment, and preparing the calcium tablet special for children according to the standard tablet process.
Preferably, the agitation leaching parameters are: the liquid-material ratio is 5-12, the extraction temperature is 90-boiling, the extraction time is 0.5-2 hours, and the extraction times are 1-2 times.
Preferably, the extracting solution is phosphate solution, so that the pH value of the extracting system is maintained to be stable, and the calcium-phosphorus ratio can be adjusted to improve the calcium absorption efficiency.
Preferably, the supernatant is obtained using a continuous centrifugation technique, preferably a tube centrifuge.
Preferably, the calcium is a calcium-containing material prescribed in food safety laws, such as calcium carbonate, calcium chloride, calcium phosphate, and the like.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A calcium tablet special for children and a preparation method thereof, the specific steps are as follows: s1 mixing the following raw materials: 5 parts of dried orange peel, 5 parts of Chinese yam, 5 parts of white hyacinth bean, 3 parts of sharpleaf galangal fruit, 5 parts of gordon euryale seed and 6 parts of rhizoma polygonati are subjected to superfine grinding and then are fully mixed; s2 stirring and leaching, wherein the specific parameters are as follows: 0.1M phosphate solution (pH7.0), liquid-material ratio of 5, extraction temperature of 90 deg.C, extraction time of 0.5 hr, extraction frequency of 2 times, and microwave-assisted extraction to accelerate dissolution, wherein the extraction adopts tubular centrifuge to obtain supernatant, and rotation speed of 16000 rpm takes supernatant; s3, after vacuum concentration, the supernatant is fully mixed with calcium carbonate micropowder containing 400mg of calcium; s4, granulating according to a standard granulation process, carrying out aseptic treatment, and preparing the calcium tablet special for children according to a tablet standard process.
Example 2
A calcium tablet special for children and a preparation method thereof, the specific steps are as follows: s1 mixing the following raw materials: 30 parts of dried orange peel, 30 parts of Chinese yam, 40 parts of white hyacinth bean, 20 parts of sharpleaf galangal fruit, 35 parts of gordon euryale seed and 25 parts of rhizoma polygonati are subjected to superfine grinding and then mixed; s2 stirring and leaching, wherein the specific parameters are as follows: 0.2M phosphate solution (pH7.0), liquid-material ratio of 12, boiling extraction at extraction temperature, extraction time of 2 hours, extraction times of 1 time, accelerated dissolution by using microwave-assisted extraction technology, obtaining supernatant by using a tubular centrifuge, and taking the supernatant at a rotation speed of 16000 rpm; s3, mixing the supernatant with calcium chloride micropowder containing 800mg of calcium after vacuum concentration; s4, granulating according to a standard granulation process, carrying out aseptic treatment, and preparing the calcium tablet special for children according to a tablet standard process.
Example 3
A calcium tablet special for children and a preparation method thereof, the specific steps are as follows: s1 mixing the following raw materials: 10 parts of dried orange peel, 10 parts of Chinese yam, 10 parts of white hyacinth bean, 10 parts of sharpleaf galangal fruit, 10 parts of gordon euryale seed and 10 parts of rhizoma polygonati are subjected to superfine grinding and then mixed; s2 stirring and leaching, wherein the specific parameters are as follows: extracting with pure water at a liquid-material ratio of 7, an extraction temperature of 90 deg.C, an extraction time of 1 hr, and an extraction frequency of 2 times, accelerating dissolution by using microwave-assisted extraction technology, obtaining supernatant by using a tubular centrifuge, and obtaining supernatant at a rotation speed of 16000 rpm; s3, after vacuum concentration, the supernatant is fully mixed with calcium carbonate containing 600mg of calcium and calcium phosphate micro powder containing 200mg of calcium; s4, granulating according to a standard granulation process, carrying out aseptic treatment, and preparing the calcium tablet special for children according to a tablet standard process.
Clinical validation
Example 1, example 2, and example 3 were all clinically validated according to the following methods:
method (A)
Inclusion criteria for 1 case
Children 1-5 years old; the patients were tested voluntarily, and the medicine was taken on time and the doctor was given a double-visit at regular intervals.
2 exclusion criteria
If the medicine is not taken according to the regulation, the curative effect can not be judged; insufficient data and the like affecting the judgment of curative effect or safety.
3 clinical verification
The calcium tablet taken alone by a child is taken as a control group, and the calcium tablet taken in the embodiment is taken as a verification group, wherein the calcium tablets are taken by 20 cases respectively. The taking method comprises the following steps: calcium tablet for children is taken 3 times a day according to the instruction; the calcium tablet of the embodiment of the invention is 2 tablets per time and 3 times a day; the administration is continued for 3 months.
Bone density measurement: the bone density of lumbar vertebrae L2-4 and left femoral neck Wards triangle of each group of patients is measured by a dual-energy X-ray bone density measuring instrument before and after taking (after 3 months).
The statistical method adopts SPSS 20.0 statistical software to perform data analysis, the measurement data is expressed by x +/-s, the comparison adopts t test, and the counting data comparison adopts x 2 test. P <0.05 indicates that the difference is statistically significant.
(II) verification result
Example 1 comparison of bone Density before and after administration (g/cm)3,Mean±SD）
Example 2 comparison of bone Density before and after administration (g/cm)3,Mean±SD）
Example 3 comparison of bone Density before and after administration (g/cm)3,Mean±SD）
The clinical verification result shows that: after the control group and the verification group are taken for 3 months, the bone density of lumbar vertebra and femoral neck is improved to different degrees. The calcium tablet of the invention has better effect on relieving osteoporosis in lactation than the calcium preparation of the control group, wherein the water average of the calcium tablet of the verification group of the example 2 for improving the bone density is higher than that of the examples 1 and 3, and the example 2 is a better formula proportion and a preparation process of the calcium tablet of the invention.
Any combination of the summary of the invention and the detailed description of the invention section above, including the description of the invention, is not intended to be limiting in any way and does not describe all aspects of the combination for the sake of brevity. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The special calcium tablet for children and the preparation method thereof are characterized in that the raw materials are mixed according to the following parts by weight: the food raw material containing 400-plus 800mg calcium, 5-30 parts of dried orange peel, 5-30 parts of Chinese yam, 5-40 parts of white hyacinth bean, 3-20 parts of sharpleaf galangal fruit, 5-35 parts of gordon euryale seed and 6-25 parts of rhizoma polygonati are prepared according to the following method: s1 micronizing pericarpium Citri Reticulatae, rhizoma Dioscoreae, semen lablab album, fructus Alpinae Oxyphyllae, semen euryales, and rhizoma Polygonati, breaking cell wall, and extracting functional components; centrifuging the S2 extract to obtain supernatant; s3, concentrating the supernatant, and mixing with the calcium raw material superfine powder; s4 granulating, performing aseptic treatment, and preparing the calcium tablet special for children according to the standard tablet process.
2. The calcium tablet special for children as claimed in claim 1, wherein the stirring and leaching parameters are as follows: the liquid-material ratio is 5-12, the extraction temperature is 90-boiling, the extraction time is 0.5-2 hours, and the extraction times are 1-2 times.
3. The children calcium tablet and the preparation method thereof according to claim 1, wherein the extract is preferably phosphate solution, the pH value of the extraction system is stabilized, and the calcium-phosphorus ratio of the calcium tablet is adjusted to promote the calcium absorption and utilization efficiency.
4. The children specific calcium tablet and the preparation method thereof according to claim 1, wherein the supernatant is obtained by a continuous centrifugation technology, preferably a tube centrifuge.
5. The calcium tablet as claimed in claim 1, wherein the calcium is a calcium-containing material such as calcium carbonate, calcium chloride, calcium phosphate, etc. prescribed in food safety law.
6. Protecting the special calcium tablet for children prepared by the method and application in calcium supplement for children.
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| CN1209285A (en) * | 1998-08-19 | 1999-03-03 | 韩国庆 | Health-care food |
| CN104623478A (en) * | 2015-01-23 | 2015-05-20 | 广州中医药大学 | Medicine for regulating spleen-deficiency syndrome type intestinal bacilli illness and preparation method thereof |
| CN108938989A (en) * | 2018-10-22 | 2018-12-07 | 河南中医药大学 | It is a kind of treat osteoporosis cover fennel essence bone-building up powder |
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2020
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|---|---|---|---|---|
| CN1209285A (en) * | 1998-08-19 | 1999-03-03 | 韩国庆 | Health-care food |
| CN104623478A (en) * | 2015-01-23 | 2015-05-20 | 广州中医药大学 | Medicine for regulating spleen-deficiency syndrome type intestinal bacilli illness and preparation method thereof |
| CN108938989A (en) * | 2018-10-22 | 2018-12-07 | 河南中医药大学 | It is a kind of treat osteoporosis cover fennel essence bone-building up powder |
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| "补钙之前打个问号", 中国矿业报, pages 1 * |
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