CN114112919B - Optical flow cell assembly, optical detection device and sample analysis device - Google Patents
Optical flow cell assembly, optical detection device and sample analysis device Download PDFInfo
- Publication number
- CN114112919B CN114112919B CN202010898259.8A CN202010898259A CN114112919B CN 114112919 B CN114112919 B CN 114112919B CN 202010898259 A CN202010898259 A CN 202010898259A CN 114112919 B CN114112919 B CN 114112919B
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- Prior art keywords
- sheath flow
- flow chamber
- optical
- glue
- chamber base
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- 230000003287 optical effect Effects 0.000 title claims abstract description 132
- 238000001514 detection method Methods 0.000 title claims abstract description 22
- 239000003292 glue Substances 0.000 claims abstract description 118
- 239000012530 fluid Substances 0.000 claims abstract description 20
- 239000000853 adhesive Substances 0.000 claims description 32
- 230000001070 adhesive effect Effects 0.000 claims description 32
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 238000004026 adhesive bonding Methods 0.000 abstract description 4
- 238000007711 solidification Methods 0.000 abstract description 2
- 230000008023 solidification Effects 0.000 abstract description 2
- 210000004027 cell Anatomy 0.000 description 21
- 230000000903 blocking effect Effects 0.000 description 18
- 239000000523 sample Substances 0.000 description 11
- 238000000034 method Methods 0.000 description 7
- 239000000084 colloidal system Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920000297 Rayon Polymers 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000005304 optical glass Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000011112 process operation Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B11/00—Connecting constructional elements or machine parts by sticking or pressing them together, e.g. cold pressure welding
- F16B11/006—Connecting constructional elements or machine parts by sticking or pressing them together, e.g. cold pressure welding by gluing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
Abstract
An optical flow cell assembly, an optical detection device, and a sample analysis device are disclosed. The optical flow chamber assembly comprises a sheath flow chamber base and an optical sheath flow chamber arranged on the sheath flow chamber base, wherein a sheath flow channel is arranged in the optical sheath flow chamber, a fluid channel is arranged in the sheath flow chamber base, and the fluid channel is communicated with the sheath flow channel; one end of the sheath flow chamber base, which is close to the optical sheath flow chamber, is provided with a glue clamping structure; the sheath flow chamber base is bonded with the optical sheath flow chamber through glue, and the glue is also integrally filled in the glue clamping structure. Through set up the card glue structure in the periphery of sheath flow chamber base, the optical flow chamber subassembly that this application provided is after glue bonding fixed sheath flow chamber base and optical sheath flow chamber, and glue still fills in the card glue structure, therefore glue after the solidification forms the joint structure with sheath flow chamber base to can prevent effectively that the fixed connection state of sheath flow chamber base and optical sheath flow chamber from damaging because of glue and sheath flow chamber base come unstuck.
Description
Technical Field
The present application relates to the field of sample detection technology, and in particular, to an optical flow cell assembly, an optical detection device, and a sample analysis device.
Background
In an optical flow chamber component of sample analysis equipment, the degree of thermal expansion and shrinkage between metal parts such as a viscose glue and a sheath flow chamber base is different due to the difference of process methods during gluing and the factors of temperature and cold non-uniformity on the optical flow chamber component, and the degumming phenomenon is easy to occur under the long-time working condition, so that the optical flow chamber component is damaged and scrapped, and the service life of the optical flow chamber component is greatly influenced.
Disclosure of Invention
The application mainly provides an optical flow chamber component, an optical detection device and sample analysis equipment to solve the problem that the adhesive is easy to degum with sheath flow chamber base and makes the optical flow chamber component damage under the operating mode such as expend with heat and contract with cold.
In order to solve the technical problems, one technical scheme adopted by the application is as follows: an optical flow cell assembly is provided. The optical flow chamber assembly comprises a sheath flow chamber base and an optical sheath flow chamber arranged on the sheath flow chamber base, wherein a sheath flow channel is arranged in the optical sheath flow chamber, a fluid channel is arranged in the sheath flow chamber base, and the fluid channel is communicated with the sheath flow channel; one end of the sheath flow chamber base, which is close to the optical sheath flow chamber, is provided with a glue clamping structure; the sheath flow chamber base is bonded with the optical sheath flow chamber through glue, and the glue is also integrally filled in the glue clamping structure.
In some embodiments, a first mounting plane is provided at the bottom of the optical sheath flow chamber, a mounting portion is provided at the top of the sheath flow chamber base, and the first mounting plane is fixed to the mounting portion.
In some embodiments, the mounting portion is a second mounting plane provided at a top of the sheath flow chamber base, the second mounting plane abutting the first mounting plane.
In some embodiments, the mounting portion is a mounting groove provided at the top of the sheath flow chamber base, and the first mounting plane is provided in the mounting groove and abuts against a bottom plane of the mounting groove.
In some embodiments, the first mounting plane has an area that is less than or equal to an area of a bottom plane of the mounting groove.
In some embodiments, the adhesive blocking structure comprises a blocking groove which is annularly arranged on the periphery of the top of the sheath flow chamber base, and the glue is coated on the bottom of the optical sheath flow chamber and is filled in the blocking groove.
In some embodiments, the adhesive blocking structure further comprises an adhesive flowing hole arranged on the sheath flow chamber base, and the adhesive flowing hole is communicated with the mounting part and the clamping groove.
In some embodiments, the adhesive blocking structure comprises a protrusion arranged on the periphery of the sheath flow chamber base, and the glue coats the bottom of the optical sheath flow chamber and extends to the lower side of the protrusion.
In order to solve the technical problems, another technical scheme adopted by the application is as follows: an optical detection device is provided. The optical detection device comprises a light emitting component, a light receiving component and the optical flow chamber component, wherein the light emitting component emits light to the optical sheath flow chamber, and the light receiving component receives the light passing through the optical sheath flow chamber.
In order to solve the technical problems, another technical scheme adopted by the application is as follows: a sample analysis apparatus is provided. The sample analysis device comprises an optical detection arrangement as described above.
The beneficial effects of this application are: unlike the prior art, the present application discloses an optical flow cell assembly, an optical detection device and a sample analysis device. Through set up the card glue structure in the periphery of sheath flow chamber base to after sheath flow chamber base and optical sheath flow chamber pass through glue bonding, this glue still integrative fills in card glue structure, with fixed sheath flow chamber base and optical sheath flow chamber, and the glue after solidifying still forms the joint structure with the card glued structure, thereby even glue and sheath flow chamber base come off after, glue can also not break away from with sheath flow chamber base, the risk that optical sheath flow chamber drops from sheath flow chamber base because of glue comes off has effectively been reduced, therefore the optical flow chamber subassembly that this application provided is not only through the self characteristic of glue to bond fixed sheath flow chamber base and optical sheath flow chamber, and still utilize glue after solidifying to form the joint structure with sheath flow chamber base, can prevent effectively that the situation that destroys the fixed connection state of sheath flow chamber base and optical sheath flow chamber because of glue and sheath flow chamber base comes off.
Drawings
For a clearer description of embodiments of the present application or of the solutions of the prior art, the drawings that are required to be used in the description of the embodiments or of the prior art will be briefly described, it being apparent that the drawings in the description below are only some embodiments of the present application, and that other drawings may be obtained, without inventive effort, by a person skilled in the art from these drawings, in which:
FIG. 1 is a schematic diagram of an embodiment of an optical flow cell assembly provided herein;
FIG. 2 is a schematic view of the configuration of an optical sheath flow cell in the optical flow cell assembly of FIG. 1;
FIG. 3 is a schematic view of a first cross-sectional configuration of a sheath flow chamber mount in the optical flow chamber assembly of FIG. 1;
FIG. 4 is a second cross-sectional schematic view of a sheath flow chamber mount in the optical flow chamber assembly of FIG. 1;
FIG. 5 is a schematic axial side view of the sheath flow chamber base of FIG. 4;
FIG. 6 is a third schematic view of the sheath flow chamber base of FIG. 1;
FIG. 7 is a fourth schematic view of the sheath flow chamber base of FIG. 1;
fig. 8 is a schematic view of a fifth construction of the sheath flow chamber base of fig. 1.
Detailed Description
The following description of the technical solutions in the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.
The terms "first," "second," "third," and the like in the embodiments of the present application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second", and "a third" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those listed steps or elements but may include other steps or elements not listed or inherent to such process, method, article, or apparatus.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly appreciate that the embodiments described herein may be combined with other embodiments.
Referring to fig. 1, fig. 1 is a schematic diagram of an optical flow cell assembly according to an embodiment of the present application.
The optical flow cell assembly 100 is used to create a sheath flow as the test fluid passes therethrough to facilitate counting of the test fluid and the like.
The optical flow cell assembly 100 comprises a sheath flow cell base 10 and an optical sheath flow cell 20, the optical sheath flow cell 20 is connected with the sheath flow cell base 10, wherein the sheath flow cell base 10 is provided with a fluid channel 12, the optical sheath flow cell 20 is provided with a sheath flow channel 22, the sheath flow channel 22 is communicated with the fluid channel 12, and a detection liquid sequentially flows through the fluid channel 12 and the sheath flow channel 22 and forms a sheath flow when flowing through the sheath flow channel 22.
Wherein the sheath flow chamber base 10 is further adapted to be coupled to other devices for receiving a test fluid; the optical sheath flow chamber 20 is made of transparent and stable materials such as optical glass or quartz, so that cells in the optical sheath flow chamber 20 under the restriction of sheath liquid can pass through the laser detection area in a single row, and higher detection sensitivity and measurement accuracy can be obtained.
In this application, sheath flow chamber mount 10 and optical sheath flow chamber 20 are connected by glue 30.
Specifically, as shown in fig. 1 and 3, the sheath flow chamber base 10 includes a mounting plate 11 and a column 13 disposed on one side of the mounting plate 11, a fluid channel 12 penetrates through the mounting plate 11 and the column 13, a mounting portion 14 is disposed at the top of the column 13 facing away from the mounting plate 11, the fluid channel 12 communicates with the mounting portion 14, and a blocking structure 15 is disposed on an outer side wall of one end of the column 13 near the optical sheath flow chamber 20.
The mounting plate 11 is used for being connected with other devices, and one end of the optical sheath flow chamber 20 is arranged at the mounting part 14 and is communicated with the fluid channel 12, and then the optical sheath flow chamber is bonded by glue 30, and the glue 30 is also integrally filled in the adhesive structure 15, after the glue 30 is solidified, the optical sheath flow chamber 20 is fixedly connected with the sheath flow chamber base 10, and meanwhile, the glue 30 and the adhesive structure 15 form a clamping structure.
Alternatively, the sheath flow chamber base 10 may be generally cylindrical, and the sheath flow chamber base 10 may be of other shapes, which is not limited in this application.
Referring to fig. 1 to 3, a first mounting plane 23 is provided at the bottom of the optical sheath flow chamber 20, and the first mounting plane 23 is fixed to the mounting portion 14. Specifically, the first mounting plane 23 abuts against the mounting portion 14, the glue 30 is applied to an outer side surface of a joint between the optical sheath flow chamber 20 and the mounting portion 14, so as to fix the first mounting plane 23 to the mounting portion 14 after the glue 30 is solidified, and the glue 30 adhering the sheath flow chamber base 10 and the optical sheath flow chamber 20 is integrally filled in the adhesive structure 15, in other words, the glue 30 adhering the sheath flow chamber base 10 and the optical sheath flow chamber 20 and the glue 30 filling in the adhesive structure 15 are mutually connected.
The first mounting plane 23 and the mounting portion 14 are abutted with each other, that is, no glue coating is performed between the first mounting plane 23 and the mounting portion 14, so as to avoid that the glue 30 permeates into the sheath flow channel 22 or the fluid channel 12, and influences the detection of the optical sheath flow chamber 20, or blocks the sheath flow channel 22 and the fluid channel 12.
Alternatively, as shown in fig. 2, the mounting portion 14 may be a second mounting plane 140 disposed on the top of the sheath flow chamber base 10, where the second mounting plane 140 abuts against the first mounting plane 23, that is, no glue coating is performed between the first mounting plane 23 and the second mounting plane 140, and the glue 30 coats the outer sidewall of the optical sheath flow chamber 20 and a portion of the second mounting plane 140 that does not contact the first mounting plane 23, so that the glue 30 is prevented from penetrating into the sheath flow channel 22 or the fluid channel 12, and the detection of the optical sheath flow chamber 20 is affected.
Optionally, as shown in fig. 3, the mounting portion 14 is a mounting groove 142 disposed at the top of the sheath flow chamber base 10, and the first mounting plane 23 is disposed in the mounting groove 142 and abuts against a bottom plane of the mounting groove 142, that is, no glue coating is performed between the first mounting plane 23 and the bottom plane of the mounting groove 142, so as to avoid the glue 30 from penetrating into the sheath flow channel 22 or the fluid channel 12.
Wherein the area of the first mounting plane 23 is less than or equal to the area of the bottom plane of the mounting groove 142. When the area of the first mounting plane 23 is smaller than the area of the bottom plane of the mounting groove 142, the glue 30 can also fill the gap between the outer periphery of the optical sheath flow chamber 20 and the side wall of the mounting groove 421, which is beneficial to increasing the glue filling amount and facilitating the bonding fixation. When the area of the first mounting plane 23 is equal to the area of the bottom plane of the mounting groove 142, one end of the optical sheath flow chamber 20 is embedded in the mounting groove 142, so that the connection and fixation of the optical sheath flow chamber 20 and the sheath flow chamber base 10 are facilitated.
In this embodiment, referring to fig. 1 and 5, one end of the optical sheath flow chamber 20 is disposed in the mounting groove 142, and the sheath flow channel 22 is aligned with and communicated with the fluid channel 12, the glue 30 fills the space around the optical sheath flow chamber 20 in the mounting groove 142, and the glue 30 is further adhered to the adhesive blocking structure 15.
In the first embodiment, as shown in fig. 1 and 5, the adhesive blocking structure 15 includes a blocking groove 150 around the top of the sheath flow chamber base 10, the glue 30 is integrally filled in the mounting groove 142 and the blocking groove 150, and forms a blocking structure with the blocking groove 150 after solidification, so that even if the solidified glue 30 is subjected to long-time thermal expansion and contraction and other working conditions and slightly adheres to the sheath flow chamber base 10, the glue 30 can not separate from the sheath flow chamber base 10, and the risk that the optical sheath flow chamber 20 falls off from the sheath flow chamber base 10 due to the glue 30 degumming is effectively reduced.
Specifically, the glue 30 wraps the bottom of the optical sheath flow chamber 20 and the top of the sheath flow chamber base 10 and is integrally filled in the clamping groove 150, so that after the glue 30 is solidified, a clamping structure is formed between a part of the glue 30 filled in the clamping groove 150 and the clamping groove 150, and even if the glue 30 is degummed, the glue 30 and the column 13 can be prevented from being separated, and the risk that the optical sheath flow chamber 20 falls off from the sheath flow chamber base 10 due to the degummed glue 30 is reduced.
Optionally, the adhesive structure 15 may further include a plurality of clamping grooves 150 axially disposed along the column 13, and the glue 30 is integrally filled in the mounting groove 14 and the plurality of clamping grooves 150, and forms a clamping structure with the plurality of clamping grooves 150.
Alternatively, the adhesive structure 15 includes a plurality of grooves disposed on the outer sidewall of the cylinder 13, the glue 30 is integrally filled in the mounting groove 14 and the plurality of grooves, and the glue 30 and the grooves form a clamping structure.
In the second embodiment, referring to fig. 1 and 6, the adhesive blocking structure 15 further includes an adhesive flowing hole 152 disposed on the column 13, the adhesive flowing hole 152 is communicated with the mounting portion 12 and the adhesive blocking slot 150, the adhesive 30 is integrally coated on the bottom of the optical sheath flow chamber 20 and fills the adhesive blocking slot 150 and the adhesive flowing hole 152, and a firmer blocking structure is formed, so that the risk that the adhesive 30 falls off from the sheath flow chamber base 10 is reduced.
The number of glue flow holes 152 may be 1, 2 or 3, etc., without limitation.
Specifically, the glue 30 wraps the end of the cylinder 13 and fills the clamping groove 150 and the glue flowing hole 152, so that after the glue 30 is solidified, the glue filled in the clamping groove 150 and the glue flowing hole 152 and the glue wrapped on the periphery of the cylinder 13 form an annular structure to be firmly connected with the cylinder 13, thereby effectively preventing the glue 30 from falling off from the sheath flow chamber base 10.
Optionally, referring to fig. 7, the outer side wall of the column 13 is provided with a groove 154, the groove 154 is communicated with the clamping groove 152 and extends to the end of the column 13 provided with the mounting groove 14, the colloid 30 is integrally filled in the mounting groove 14, the groove 154 and the clamping groove 150, and the end of the column 13 does not need to be wrapped, so that the process operation difficulty of coating the colloid 30 is reduced and the coating amount of the colloid is reduced. The grooves 154 may be provided in plurality along the axial direction of the cylinder 13 and uniformly distributed on the outer circumference of the cylinder 30.
Still further, the adhesive clamping structure 15 may include the clamping groove 150, the adhesive flowing hole 152 and the groove 154, and the adhesive 30 is integrally filled in the mounting groove 14, the adhesive flowing hole 152, the groove 154 and the clamping groove 150.
In the third embodiment, referring to fig. 8, the adhesive blocking structure 15 includes a protrusion 156 disposed on the outer periphery of the sheath flow chamber base 10, the protrusion 156 may be annular and disposed around the outer periphery of the cylinder 13, or a plurality of columnar protrusions 153 are distributed around the outer periphery of the cylinder 13 along the circumference of the cylinder 13, the glue 30 is coated on the bottom of the optical sheath flow chamber 20 and extends to the lower side of the protrusion 156, i.e. the glue 30 also wraps the protrusion 156, so that after the glue 30 is solidified, a blocking structure is formed with the protrusion 156, thereby effectively preventing the glue 30 from falling off from the sheath flow chamber base 10.
Further, the adhesive clamping structure 15 may further include the features of the clamping groove 150, the adhesive flowing hole 152 or the groove 154 in the above embodiment, and further, the combination of the protrusion 156 and the features of the clamping groove 150, the adhesive flowing hole 152 or the groove 154 may form a more firm clamping structure with the glue 30, so that the risk of the optical sheath flow chamber 20 falling off from the sheath flow chamber base 10 due to the adhesive 30 is avoided even if the solidified glue 30 is not tightly adhered and degummed.
According to the optical flow chamber assembly 100, after the sheath flow chamber base 10 is adhered to the optical sheath flow chamber 20 through glue, the glue 30 is integrally filled into the glue clamping structure 15 to fix the sheath flow chamber base 10 and the optical sheath flow chamber 20, and the solidified glue 30 and the glue clamping structure 15 form a clamping structure, so that even if the glue 30 is degummed with the sheath flow chamber base 10, the glue 30 can not be separated from the sheath flow chamber base 10, and the risk that the optical sheath flow chamber 20 falls off from the sheath flow chamber base 10 due to the degumping of the glue 30 is effectively reduced, and therefore, the optical flow chamber assembly 100 provided by the application not only adheres to the sheath flow chamber base 10 and the optical sheath flow chamber 20 through the self characteristics of the glue 30, but also utilizes the solidified glue 30 and the sheath flow chamber base 10 to form the clamping structure, and can effectively prevent the condition that the fixed connection state of the sheath flow chamber base 10 and the optical sheath flow chamber is damaged due to the degumping of the glue 30 and the sheath flow chamber base 10.
Further, the end of the optical sheath flow chamber 20 facing the sheath flow chamber base 10 is provided with a glue fixing structure, the glue fixing structure can be a ring groove, at least one ring groove is arranged at the end of the optical sheath flow chamber 20, and the glue 30 is further filled in the ring groove, so that after the glue 30 is solidified, a clamping structure is formed with the ring groove, and the optical sheath flow chamber 20 and the glue 30 can be prevented from being separated even if the glue 30 and the optical sheath flow chamber 20 are degummed, and therefore, the optical sheath flow chamber assembly 100 provided by the application can ensure that the optical sheath flow chamber 20 and the sheath flow chamber base 10 are fixedly connected even if the glue 30 and the sheath flow chamber base 10 are degummed, and can prevent the optical sheath flow chamber 20 and the sheath flow chamber base 10 from falling off due to the degumping of the glue 30.
The glue fixing structure can also be a convex column, the convex column is arranged at the end part of the optical sheath flow chamber 20 in a surrounding way, or a plurality of convex columns are uniformly distributed at the end part of the optical sheath flow chamber 20, and the glue 30 also wraps the convex column, so that after the glue 30 is solidified, the glue 30 and the convex column form a clamping structure, and the situation that the glue 30 is separated from the optical sheath flow chamber 20 is effectively avoided.
Based on this, the present application further provides an optical detection device, which includes a light emitting component, a light receiving component and an optical flow cell component 100 as described above, where the light emitting component emits light to the optical sheath flow cell 20, and the light receiving component receives the light after passing through the optical sheath flow cell 20, so as to perform cell detection on the detection liquid flowing through the sheath flow channel 22.
Based on this, the present application also provides a sample analysis device comprising an optical detection arrangement as described above. The sample analysis equipment is used for detecting biological samples to analyze and obtain biological indexes, and provides basis for clinical diagnosis of medical staff, so that the medical staff can accurately diagnose the cause of the patient.
Unlike the prior art, the present application discloses an optical flow cell assembly, an optical detection device and a sample analysis device. Through set up the card glue structure in the periphery of sheath flow chamber base to after sheath flow chamber base and optical sheath flow chamber pass through glue bonding, this glue still integrative fills in card glue structure, with fixed sheath flow chamber base and optical sheath flow chamber, and the glue after solidifying still forms the joint structure with the card glued structure, thereby even glue and sheath flow chamber base come off after, glue can also not break away from with sheath flow chamber base, the risk that optical sheath flow chamber drops from sheath flow chamber base because of glue comes off has effectively been reduced, therefore the optical flow chamber subassembly that this application provided is not only through the self characteristic of glue to bond fixed sheath flow chamber base and optical sheath flow chamber, and still utilize glue after solidifying to form the joint structure with sheath flow chamber base, can prevent effectively that the situation that destroys the fixed connection state of sheath flow chamber base and optical sheath flow chamber because of glue and sheath flow chamber base comes off.
The foregoing description is only exemplary embodiments of the present application and is not intended to limit the scope of the present application, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present application, or direct or indirect application in other related technical fields are included in the scope of the present application.
Claims (10)
1. An optical flow chamber assembly is characterized by comprising a sheath flow chamber base and an optical sheath flow chamber arranged on the sheath flow chamber base, wherein a sheath flow channel is arranged in the optical sheath flow chamber, a fluid channel is arranged in the sheath flow chamber base, and the fluid channel is communicated with the sheath flow channel; a glue clamping structure is arranged at one end of the sheath flow chamber base, which is close to the optical sheath flow chamber;
the sheath flow chamber base is bonded with the optical sheath flow chamber through glue, and the glue is also integrally filled in the glue clamping structure;
the sheath flow chamber base comprises a mounting plate and a cylinder arranged on one side of the mounting plate, the top of the sheath flow chamber base is provided with a mounting part, the mounting part is a mounting groove arranged on the top of the sheath flow chamber base, the adhesive clamping structure comprises a clamping groove arranged on the periphery of the top of the sheath flow chamber base in a surrounding mode, a plurality of grooves are formed in the outer side wall of the cylinder and are communicated with the clamping groove and extend to the end portion of the cylinder, which is provided with the mounting groove, the grooves are arranged along the axial direction of the cylinder and evenly distributed on the periphery of the cylinder, and the mounting groove, the grooves and the clamping groove are integrally filled with glue.
2. The optical flow cell assembly of claim 1 wherein a bottom of the optical sheath flow cell is provided with a first mounting plane, the first mounting plane being secured to the mounting portion.
3. The optical flow cell assembly of claim 2 wherein the mounting portion is a second mounting plane disposed on top of the sheath flow cell mount, the second mounting plane abutting the first mounting plane.
4. The optical flow cell assembly of claim 2 wherein the first mounting plane is disposed within the mounting groove and abuts a bottom plane of the mounting groove.
5. The optical flow cell assembly of claim 4 wherein an area of the first mounting plane is less than or equal to an area of a bottom plane of the mounting groove.
6. The optical flow cell assembly of claim 3 or 4 wherein the glue is wrapped around the bottom of the optical sheath flow cell and fills the slot.
7. The optical flow cell assembly of claim 6 wherein the snap-fit structure further comprises a glue flow hole disposed on the sheath flow cell base, the glue flow hole communicating the mounting portion and the snap-fit groove.
8. The optical flow cell assembly of claim 3 or 4 wherein the glue retaining structure comprises a protrusion disposed on the periphery of the sheath flow cell base, the glue coating the bottom of the optical sheath flow cell and extending to the underside of the protrusion.
9. An optical detection device, comprising a light emitting assembly, a light receiving assembly and an optical flow cell assembly according to any one of claims 1 to 8, wherein the light emitting assembly emits light to the optical sheath flow cell, and the light receiving assembly receives the light after passing through the optical sheath flow cell.
10. A sample analysis device, characterized in that it comprises an optical detection arrangement according to claim 9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010898259.8A CN114112919B (en) | 2020-08-31 | 2020-08-31 | Optical flow cell assembly, optical detection device and sample analysis device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010898259.8A CN114112919B (en) | 2020-08-31 | 2020-08-31 | Optical flow cell assembly, optical detection device and sample analysis device |
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| Publication Number | Publication Date |
|---|---|
| CN114112919A CN114112919A (en) | 2022-03-01 |
| CN114112919B true CN114112919B (en) | 2024-04-05 |
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| CN202010898259.8A Active CN114112919B (en) | 2020-08-31 | 2020-08-31 | Optical flow cell assembly, optical detection device and sample analysis device |
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