CN114100520B - Preparation equipment and preparation process for preparing diclofenac sodium delayed-release preparation through membrane control - Google Patents
Preparation equipment and preparation process for preparing diclofenac sodium delayed-release preparation through membrane control Download PDFInfo
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- CN114100520B CN114100520B CN202111388028.3A CN202111388028A CN114100520B CN 114100520 B CN114100520 B CN 114100520B CN 202111388028 A CN202111388028 A CN 202111388028A CN 114100520 B CN114100520 B CN 114100520B
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- 238000002360 preparation method Methods 0.000 title claims abstract description 108
- 229960001193 diclofenac sodium Drugs 0.000 title claims abstract description 31
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 title claims abstract description 31
- 230000003111 delayed effect Effects 0.000 title claims abstract description 30
- 239000012528 membrane Substances 0.000 title claims abstract description 16
- 238000003860 storage Methods 0.000 claims abstract description 73
- 238000005192 partition Methods 0.000 claims abstract description 8
- 230000000712 assembly Effects 0.000 claims abstract description 4
- 238000000429 assembly Methods 0.000 claims abstract description 4
- 230000001105 regulatory effect Effects 0.000 claims description 32
- 239000004615 ingredient Substances 0.000 claims description 17
- 238000009826 distribution Methods 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000003825 pressing Methods 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 238000005054 agglomeration Methods 0.000 claims description 4
- 230000002776 aggregation Effects 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 230000000149 penetrating effect Effects 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 230000000694 effects Effects 0.000 description 4
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010002556 Ankylosing Spondylitis Diseases 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J4/00—Feed or outlet devices; Feed or outlet control devices
- B01J4/001—Feed or outlet devices as such, e.g. feeding tubes
- B01J4/007—Feed or outlet devices as such, e.g. feeding tubes provided with moving parts
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2204/00—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices
- B01J2204/002—Aspects relating to feed or outlet devices; Regulating devices for feed or outlet devices the feeding side being of particular interest
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
Abstract
The invention relates to the technical field of processing of diclofenac sodium delayed-release preparations, in particular to a preparation device for preparing the diclofenac sodium delayed-release preparation by membrane control and a preparation process thereof, comprising a preparation box, wherein the upper surface of the preparation box is provided with a pair of support plates symmetrically distributed between each other, the opposite surfaces of the support plates are provided with support beams, two support beams are horizontally and symmetrically arranged, and a feeding component is slidably arranged; the feeding assembly comprises a storage box, adjusting assemblies are symmetrically arranged on two sides of the storage box, a partition plate is arranged at the center of the storage box, the partition plate divides the inside of the storage box into two parts, and adjusting pipes are slidably arranged at the bottoms of the two parts. The preparation equipment and the preparation process for preparing the diclofenac sodium delayed-release preparation by the membrane control are reasonable in design, optimize production operation, improve preparation quality and efficiency, and can be widely popularized.
Description
Technical Field
The invention relates to the technical field of processing of diclofenac sodium delayed-release preparations, in particular to a preparation device for preparing a diclofenac sodium delayed-release preparation by membrane control and a preparation process thereof.
Background
The diclofenac sodium belongs to a non-steroidal anti-inflammatory drug, and has obvious analgesic, anti-inflammatory and antipyretic effects. The composition has analgesic, antiinflammatory, and antipyretic effects by inhibiting prostaglandin synthesis. Therefore, the traditional Chinese medicine belongs to one of typical representative medicines of anti-inflammatory analgesic medicines, and is often used for treating various kinds of light, moderate, acute and chronic pains in orthopedics, such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and the like.
In the existing production process of the diclofenac sodium delayed release preparation, the production equipment is required to be subjected to reaction processing for adding ingredients, the existing material adding process is complex in pouring mode of the ingredients, the working efficiency is slow, the production process of the equipment is complex, and the use requirement cannot be met.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a preparation device for preparing a diclofenac sodium delayed-release preparation by membrane control and a preparation process thereof.
The technical scheme adopted for solving the technical problems is as follows: the preparation equipment for preparing the diclofenac sodium delayed-release preparation by membrane control and the preparation process thereof comprise a preparation box, wherein the upper surface of the preparation box is provided with a pair of support plates which are symmetrically distributed with each other, the opposite surfaces of the support plates are provided with support beams, two support beams are horizontally and symmetrically arranged, and a feeding component is slidably arranged;
The feeding assembly comprises a storage box, adjusting assemblies are symmetrically arranged on two sides of the storage box, a partition plate is arranged in the middle of the inside of the storage box, the inside of the storage box is divided into two parts by the partition plate, adjusting pipes are slidably arranged at the bottoms of the two parts, and a plurality of conveying holes spliced with the adjusting pipes are symmetrically distributed on the upper surface of the preparation box in pairs;
The inside of preparation case includes two separately independent cavities, and the puddler is all installed to the inside of every cavity, and the puddler links to each other with the fixed first motor that sets up on the preparation case outer wall.
Preferably, the upper surface of storage case articulates there are two flip, the bottom surface bilateral symmetry of storage case has still connect a pair of mounting panel, runs through on the mounting panel and is equipped with the actuating lever, the actuating lever links to each other with the second motor of fixed mounting on the mounting panel, the one end and the gear fixed connection that the second motor was kept away from to the actuating lever.
Preferably, the regulating pipe activity sets up in the storage tank bottom, the protrusion is equipped with a plurality of tooth pieces on the outer wall of regulating pipe, tooth piece and gear engagement, the inside of storage tank is stretched into at the top of regulating pipe, the inside bottom of storage tank still is equipped with the restriction pipe, restriction pipe and storage tank fixed connection, restriction pipe and regulating pipe activity grafting.
Preferably, the discharge gate has been seted up on the flow-limiting pipe lateral wall, the outer wall of adjusting tube is laminated with the inner wall of flow-limiting pipe, the one end of top pipe wall fixed connection connecting rod of flow-limiting pipe, the other end and the dog fixed connection of connecting rod, the connecting rod is L shape structure and passes the pipe wall of flow-limiting pipe, the dog slides between the outer wall of flow-limiting pipe and the inner wall of storage box.
Preferably, the adjusting part comprises an outer tube, a limiting rod and a pull rod, the outer tube is sleeved outside the supporting beam in a sliding mode, the outer tube is symmetrically distributed on two sides of the storage box and fixedly connected with the storage box, the limiting rod is installed in the outer tube in a penetrating mode, the limiting rod is elastically connected with the outer tube, one end of the limiting rod extends into the outer tube, and the other end of the limiting rod is located outside the outer tube and one end of the pull rod is symmetrically welded on two side walls of the outer tube.
Preferably, the inner wall of the outer tube is horizontally provided with a moving groove at the upper end and the lower end of the limiting rod inserted, one end of the limiting rod is fixedly connected with the surface of the limiting rod facing the moving groove, and the other end of the moving rod extends into the inner wall of the moving groove and is fixedly connected with a spring fixedly arranged in the moving groove.
Preferably, the inside of storage box still is equipped with the anti-blocking subassembly that staggers the distribution, anti-blocking subassembly include with storage box inner wall fixed connection's bracing piece, with bracing piece elastic connection's fixed plate, the inside of fixed plate still is equipped with the net board, be equipped with the pivot of inserting inside the bracing piece on the face of fixed plate orientation bracing piece, pivot and bracing piece rotate and are connected and are equipped with the torsional spring between, bracing piece and storage box's inner wall fixed connection.
A preparation method of a preparation device for preparing a diclofenac sodium delayed-release preparation by membrane control comprises the following steps:
S1, adding preparation raw materials required by a diclofenac sodium delayed release preparation into a plurality of storage boxes respectively according to different specification distributions, opening a flip cover to carry out feeding, dividing the interior of the preparation box into two chambers for hot processing or normal temperature processing, moving the required dosing box to the position right above the preparation box, pulling a pull rod, driving a limiting rod to move towards the outer part of an outer pipe, enabling the limiting rod to be originally spliced with a slot on a supporting beam, sliding the outer pipe after leaving, loosening the pull rod after the outer pipe drives the storage box to move to a required position, and reinserting the limiting rod into the slot to limit the limiting rod by resetting a spring;
S2, after the position of the storage box is regulated, the second motor can be started, the second motor drives the gear to rotate, the gear and the tooth block on the outer wall of the regulating pipe are matched with each other to move downwards until the regulating pipe penetrates into the conveying hole, at the moment, along with the downward movement of the regulating pipe, the connecting rod drives the stop block to synchronously move with the regulating pipe, the stop block moves to the lower part of the discharge hole, ingredients in the storage box enter the regulating pipe along the discharge hole to enter the preparation box, the second motor can be reversely driven after the feeding is completed, the regulating pipe rises, and then the stop block resets and slides to the upper part of the discharge hole to stop discharging;
S3, when ingredients in the storage box are added towards the preparation box, the fixing plate is pressed downwards by downward traction force, but the elastic connection of the fixing plate and the supporting rod can enable the fixing plate to rise after pressing downwards, the fixing plate is enabled to swing in a reciprocating mode along with continuous flowing of the ingredients, the ingredients are enabled to be scattered more evenly, the ingredients cannot be blocked by agglomeration, the stirring reaction of the diclofenac sodium delayed preparation is carried out in the preparation box, and a finished product is taken out from the preparation box after the completion.
The beneficial effects of the invention are as follows: according to the preparation equipment and the preparation process of the membrane control preparation diclofenac sodium delayed release preparation, disclosed by the invention, when the preparation box is processed through the arrangement of the feeding component, manual addition is not needed, the preparation box can be automatically added according to the requirement, the production of the diclofenac sodium delayed release preparation is assisted, the production operation is optimized, the compactness of the working procedure is improved, the consumption of manual labor is reduced, high operation efficiency is realized, the high-efficiency effect is achieved, the preparation equipment and the preparation process of the preparation diclofenac sodium delayed release preparation are more convenient and rapid to carry out batching conversion according to different production requirements by virtue of the arrangement of the regulating component, the storage box can be rapidly moved, so that the preparation can be carried out in high efficiency regardless of normal-temperature processing or thermal processing, the operation is convenient and rapid, the synchronous operation of feeding and production is carried out, the shutdown is not needed or the operation power is reduced, the production efficiency of the diclofenac sodium delayed release preparation is ensured, the practicability is strong, the conveying smoothness of the batching is improved when the preparation box is fed through the arrangement of the anti-blocking component, the possibility of material agglomeration blocking is reduced, the membrane control preparation equipment and the preparation process of the diclofenac sodium delayed release preparation is reasonable in design, the production quality and the preparation process is optimized, and the preparation quality and the popularization efficiency are improved.
Drawings
The invention will be further described with reference to the drawings and examples.
FIG. 1 is a schematic diagram of the overall structure of the present invention;
FIG. 2 is a schematic structural view of a charging assembly;
FIG. 3 is a schematic view of the bottom structure of the tank;
FIG. 4 is a schematic structural view of an adjustment assembly;
FIG. 5 is a schematic view of the internal structure of the storage tank;
Fig. 6 is a schematic structural view of the anti-blocking assembly.
In the figure: 1. a charging assembly; 2. preparing a box; 3. a delivery hole; 4. a first motor; 5. a support plate; 6. a support beam; 7. an adjustment assembly; 8. a flip cover; 9. a storage tank; 10. a second motor; 11. a driving rod; 12. a gear; 13. an adjusting tube; 14. a storage bin; 15. tooth blocks; 16. an outer tube; 17. a flow limiting pipe; 18. a stop block; 19. a discharge port; 20. a connecting rod; 21. a moving groove; 22. a pull rod; 23. a limit rod; 24. a spring; 25. a moving rod; 26. an anti-blocking assembly; 27. a fixing plate; 28. a grid plate; 29. a rotating shaft; 30. and (5) supporting the rod.
Detailed Description
The invention is further described in connection with the following detailed description in order to make the technical means, the creation characteristics, the achievement of the purpose and the effect of the invention easy to understand.
As shown in fig. 1-6, the preparation equipment for preparing the diclofenac sodium delayed-release preparation by using the membrane control and the preparation process thereof disclosed by the invention comprise a preparation box 2, wherein a pair of support plates 5 symmetrically distributed between each other are arranged on the upper surface of the preparation box 2, support beams 6 are arranged on the opposite surfaces of the support plates 5, two support beams 6 are horizontally and symmetrically arranged, and a feeding assembly 1 is slidably arranged;
The feeding assembly 1 comprises a storage box 14, wherein adjusting assemblies 7 are symmetrically arranged on two sides of the storage box 14, a partition plate is arranged in the middle of the inside of the storage box 14, the inside of the storage box 14 is divided into two parts by the partition plate, adjusting pipes 13 are slidably arranged at the bottoms of the two parts, and a plurality of conveying holes 3 which are spliced with the adjusting pipes 13 are symmetrically distributed on the upper surface of the preparation box 2 in pairs;
The inside of preparation case 2 includes two separately independent cavities, and the puddler is all installed to the inside of every cavity, and the puddler links to each other with the fixed first motor 4 that sets up on the outer wall of preparation case 2, movable groove 21 has been seted up at gag lever post 23 male upper and lower both ends level on the inner wall of outer tube 16, the one end of fixed connection movable rod 25 on the face of gag lever post 23 orientation movable groove 21, the other end of movable rod 25 stretches into the inner wall of movable groove 21 and with the fixed spring 24 fixed connection that sets up inside movable groove 21.
The inside of storage case 14 still is equipped with the anti-blocking subassembly 26 that staggers the distribution of the pair, anti-blocking subassembly 26 include with storage case 14 inner wall fixed connection's bracing piece 30, with bracing piece 30 elastic connection's fixed plate 27, the inside of fixed plate 27 still is equipped with the grid plate 28, be equipped with the pivot 29 that inserts inside bracing piece 30 on the face of fixed plate 27 towards bracing piece 30, pivot 29 and bracing piece 30 rotate and are connected and are equipped with the torsional spring between, bracing piece 30 and storage case 14's inner wall fixed connection.
The upper surface of storage case 14 articulates there are two flip 8, the bottom face bilateral symmetry of storage case 14 has still connect a pair of mounting panel, runs through on the mounting panel and is equipped with actuating lever 11, actuating lever 11 links to each other with the second motor 10 of fixed mounting on the mounting panel, the one end that actuating lever 11 kept away from second motor 10 and gear 12 fixed connection start second motor 10, second motor 10 drive gear 12 rotates, gear 12 cooperates the downshift position with the tooth piece 15 on the governing tube 13 outer wall.
The regulating pipe 13 is movably arranged at the bottom of the storage box 14, a plurality of tooth blocks 15 are arranged on the outer wall of the regulating pipe 13 in a protruding mode, the tooth blocks 15 are meshed with the gears 12, the top of the regulating pipe 13 stretches into the storage box 14, a flow limiting pipe 17 is further arranged at the bottom end of the storage box 14, the flow limiting pipe 17 is fixedly connected with the storage box 14, the flow limiting pipe 17 is movably inserted into the regulating pipe 13, the connecting rod 20 drives the stop block 18 to synchronously displace with the regulating pipe 13 along with downward movement of the regulating pipe 13, and the stop block 18 moves to the lower portion of the discharge hole 19.
The discharging hole 19 is formed in the side wall of the flow limiting pipe 17, the outer wall of the adjusting pipe 13 is attached to the inner wall of the flow limiting pipe 17, one end of a connecting rod 20 is fixedly connected to the pipe wall of the top end of the flow limiting pipe 17, the other end of the connecting rod 20 is fixedly connected with a baffle 18, the connecting rod 20 is of an L-shaped structure and penetrates through the pipe wall of the flow limiting pipe 17, the baffle 18 slides between the outer wall of the flow limiting pipe 17 and the inner wall of the storage box 14, raw materials for preparing the diclofenac sodium delayed-release preparation are distributed according to different specifications, the raw materials are respectively added into the storage boxes 14, and the flip 8 is opened to feed the materials.
The adjusting component 7 comprises an outer tube 16, a limiting rod 23 and a pull rod 22, wherein the outer tube 16 is slidably sleeved outside the supporting beam 6, the outer tube 16 is symmetrically distributed on two sides of the storage box 14 and fixedly connected with the storage box 14, the limiting rod 23 is installed in the outer tube 16 in a penetrating mode, the limiting rod 23 is elastically connected with the outer tube 16, one end of the limiting rod 23 extends into the outer tube 16, and the other end of the limiting rod is located outside the outer tube 16 and symmetrically welded with one end of the pull rod 22 on two side walls.
A preparation method of a preparation device for preparing a diclofenac sodium delayed-release preparation by membrane control comprises the following steps:
S1, adding preparation raw materials required by a diclofenac sodium delayed release preparation into a plurality of storage boxes 14 respectively according to different specification distributions, opening a flip cover 8 to carry out feeding, dividing the interior of a preparation box 2 into two chambers for hot working or normal temperature working, moving the required dosing box to the position right above the preparation box 2, pulling a pull rod 22, driving a limiting rod 23 to move towards the outside of an outer tube 16 by the pull rod 22, enabling the limiting rod 23 to be originally spliced with a slot on a supporting beam 6, sliding the outer tube 16 after the limiting rod 23 leaves, loosening the pull rod 22 after the outer tube 16 drives the storage boxes 14 to move to a required position, and reinserting the limiting rod 23 into the slot to limit the supporting beam 6 through the reset of a spring 24;
S2, after the position of the storage box 14 is regulated, the second motor 10 can be started, the second motor 10 drives the gear 12 to rotate, the gear 12 and the tooth block 15 on the outer wall of the regulating pipe 13 are matched with each other to move downwards until the regulating pipe 13 penetrates through the inside of the conveying hole 3, at the moment, along with the downward movement of the regulating pipe 13, the connecting rod 20 drives the stop block 18 to synchronously displace with the regulating pipe 13, the stop block 18 moves to the lower part of the discharge hole 19, ingredients in the storage box 14 enter the inside of the regulating pipe 13 along the discharge hole 19 so as to enter the inside of the preparation box 2, and after the feeding is completed, the second motor 10 can be reversely driven, so that the regulating pipe 13 rises, and then the stop block 18 resets and slides to the upper part of the discharge hole 19 so as to stop discharging;
s3, when ingredients in the storage box 14 are added towards the preparation box 2, the fixing plate 27 is pressed down by downward traction force, but the elastic connection of the fixing plate 27 and the supporting rod 30 enables the fixing plate 27 to rise after pressing down, the fixing plate 27 is enabled to swing in a reciprocating mode along with continuous flowing and pressing of the ingredients, the ingredients are enabled to be scattered more evenly, the ingredients cannot be blocked by agglomeration, the stirring reaction of the diclofenac sodium delayed release preparation is carried out in the preparation box 2, and a finished product is taken out from the preparation after completion.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (5)
1. The preparation equipment for preparing the diclofenac sodium delayed-release preparation by membrane control comprises a preparation box (2), and is characterized in that: the upper surface of the preparation box (2) is provided with a pair of support plates (5) which are symmetrically distributed among each other, the opposite surfaces of the support plates (5) are provided with support beams (6), the two support beams (6) are horizontally and symmetrically arranged, and the feeding components (1) are slidably arranged;
The feeding assembly (1) comprises a storage box (14), regulating assemblies (7) are symmetrically arranged on two sides of the storage box (14), a partition plate is arranged in the middle of the inside of the storage box (14), the inside of the storage box (14) is divided into two parts by the partition plate, regulating pipes (13) are slidably arranged at the bottoms of the two parts, and a plurality of conveying holes (3) which are spliced with the regulating pipes (13) are symmetrically distributed on the upper surface of the preparation box (2);
The inside of the preparation box (2) comprises two independent chambers, and each chamber is internally provided with a stirring rod which is connected with a first motor (4) fixedly arranged on the outer wall of the preparation box (2);
The upper surface of the storage box (14) is hinged with two flip covers (8), two sides of the bottom end surface of the storage box (14) are symmetrically connected with a pair of mounting plates, a driving rod (11) is arranged on the mounting plates in a penetrating mode, the driving rod (11) is connected with a second motor (10) fixedly arranged on the mounting plates, and one end, far away from the second motor (10), of the driving rod (11) is fixedly connected with a gear (12);
The regulating pipe (13) is movably arranged at the bottom of the storage box (14), a plurality of tooth blocks (15) are arranged on the outer wall of the regulating pipe (13) in a protruding mode, the tooth blocks (15) are meshed with the gears (12), the top of the regulating pipe (13) stretches into the storage box (14), a flow limiting pipe (17) is further arranged at the bottom end of the inside of the storage box (14), the flow limiting pipe (17) is fixedly connected with the storage box (14), and the flow limiting pipe (17) is movably connected with the regulating pipe (13) in a plugging mode;
The utility model discloses a flow limiting device for a liquid storage box, including flow limiting tube (17), outer wall, baffle (18), adjusting tube (13), discharge gate (19) have been seted up on flow limiting tube (17) lateral wall, the outer wall of adjusting tube (13) is laminated with the inner wall of flow limiting tube (17), the top pipe wall fixed connection connecting rod (20) one end of flow limiting tube (17), the other end and the baffle (18) fixed connection of connecting rod (20), connecting rod (20) are L shape structure and pass the pipe wall of flow limiting tube (17), the baffle (18) slides between the outer wall of flow limiting tube (17) and the inner wall of storage box (14).
2. The preparation device for preparing the diclofenac sodium delayed release preparation by membrane control according to claim 1, wherein: the adjusting component (7) comprises an outer tube (16), a limiting rod (23) and a pull rod (22), wherein the outer tube (16) is sleeved outside the supporting beam (6) in a sliding mode, the outer tube (16) is symmetrically distributed on two sides of the storage box (14) and fixedly connected with the storage box (14), the limiting rod (23) is installed in the outer tube (16) in a penetrating mode, the limiting rod (23) is elastically connected with the outer tube (16), one end of the limiting rod (23) extends into the outer tube (16), and the other end of the limiting rod is located outside the outer tube (16) and one end of the pull rod (22) is symmetrically welded on two side walls of the outer tube.
3. The preparation device for preparing the diclofenac sodium delayed release preparation by membrane control according to claim 2, wherein: the inner wall of the outer tube (16) is horizontally provided with moving grooves (21) at the upper end and the lower end of the limiting rod (23) which are inserted, one end of the limiting rod (23) is fixedly connected with one end of a moving rod (25) on the surface of the limiting rod (23) facing the moving grooves (21), and the other end of the moving rod (25) extends into the inner wall of the moving grooves (21) and is fixedly connected with springs (24) fixedly arranged inside the moving grooves (21).
4. The preparation device for preparing the diclofenac sodium delayed release preparation by membrane control according to claim 1, wherein: the inside of storage case (14) still is equipped with anti-blocking assembly (26) of staggered distribution, anti-blocking assembly (26) include with storage case (14) inner wall fixed connection's bracing piece (30), with bracing piece (30) elastic connection's fixed plate (27), the inside of fixed plate (27) still is equipped with grid plate (28), be equipped with on the face of fixed plate (27) towards bracing piece (30) and insert inside pivot (29) of bracing piece (30), pivot (29) are rotated with bracing piece (30) and are connected and are equipped with the torsional spring between, the inner wall fixed connection of bracing piece (30) and storage case (14).
5. A method for preparing a film-controlled preparation device for preparing a diclofenac sodium delayed release preparation according to any one of claims 1-4, wherein: the method comprises the following steps:
S1, adding preparation raw materials required by a diclofenac sodium delayed release preparation into a plurality of storage boxes (14) respectively according to different specification distributions, opening a flip (8) to carry out feeding, dividing the interior of a preparation box (2) into two chambers for hot working or normal temperature working, moving the required dosing box to the position right above the preparation box (2), pulling a pull rod (22), driving a limit rod (23) to move towards the outer part of an outer tube (16) by the pull rod (22), inserting the limit rod (23) into a slot on a supporting beam (6), sliding the outer tube (16) after leaving, loosening the pull rod (22) after the outer tube (16) drives the storage boxes (14) to move to a required position, and reinserting the limit rod (23) into the slot to limit with the supporting beam (6) through the reset of a spring (24);
S2, after the position of the storage box (14) is adjusted, the second motor (10) can be started, the second motor (10) drives the gear (12) to rotate, the gear (12) is matched with the tooth block (15) on the outer wall of the adjusting pipe (13) to move downwards until the adjusting pipe (13) penetrates through the inside of the conveying hole (3), at the moment, along with the downward movement of the adjusting pipe (13), the connecting rod (20) drives the stop block (18) to synchronously displace with the adjusting pipe (13), the stop block (18) moves to the lower part of the discharge hole (19), ingredients in the storage box (14) enter the inside of the adjusting pipe (13) along the discharge hole (19) so as to enter the inside of the preparation box (2), and after the feeding is completed, the second motor (10) can be reversely driven, so that the lifting position of the adjusting pipe (13) is further reset and the stop block (18) slides to the upper part of the discharge hole (19) to block the discharge hole;
S3, when ingredients in the storage box (14) are added towards the preparation box (2), the fixing plate (27) is pressed down by downward traction force, but the elastic connection of the fixing plate (27) and the supporting rod (30) can enable the fixing plate (27) to rise after pressing down, the fixing plate (27) is enabled to swing in a reciprocating mode along with continuous flowing and pressing of the ingredients, the ingredients are enabled to be scattered more evenly, the ingredients cannot be blocked by agglomeration, the stirring reaction of the diclofenac sodium delayed preparation is carried out in the preparation box (2), and a finished product is taken out from the preparation inside after the completion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111388028.3A CN114100520B (en) | 2021-11-22 | 2021-11-22 | Preparation equipment and preparation process for preparing diclofenac sodium delayed-release preparation through membrane control |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111388028.3A CN114100520B (en) | 2021-11-22 | 2021-11-22 | Preparation equipment and preparation process for preparing diclofenac sodium delayed-release preparation through membrane control |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114100520A CN114100520A (en) | 2022-03-01 |
| CN114100520B true CN114100520B (en) | 2024-07-02 |
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Family Applications (1)
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| CN111635492A (en) * | 2020-07-02 | 2020-09-08 | 浙江汇翔化学工业有限公司 | Production process of polycarboxylate superplasticizer |
| CN112275216A (en) * | 2020-10-14 | 2021-01-29 | 太仓中化环保化工有限公司 | Accurate feeding equipment for multiple chemical reaction material ratios |
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| CN212283667U (en) * | 2019-12-12 | 2021-01-05 | 北京马赫天诚科技有限公司 | Three-dimensional storehouse type semi-automatic batching device |
| CN211358559U (en) * | 2019-12-16 | 2020-08-28 | 常州市丰迪制漆有限公司 | Mixing apparatus for chemical production that can automatic ratio |
| CN213050479U (en) * | 2020-08-13 | 2021-04-27 | 甘肃京兰水泥有限公司 | Preparation and feeding device of cement grinding aid |
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| CN111635492A (en) * | 2020-07-02 | 2020-09-08 | 浙江汇翔化学工业有限公司 | Production process of polycarboxylate superplasticizer |
| CN112275216A (en) * | 2020-10-14 | 2021-01-29 | 太仓中化环保化工有限公司 | Accurate feeding equipment for multiple chemical reaction material ratios |
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