CN114081449A - Hela liver cancer detection device based on model mouse and use method thereof - Google Patents
Hela liver cancer detection device based on model mouse and use method thereof Download PDFInfo
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- CN114081449A CN114081449A CN202111407661.2A CN202111407661A CN114081449A CN 114081449 A CN114081449 A CN 114081449A CN 202111407661 A CN202111407661 A CN 202111407661A CN 114081449 A CN114081449 A CN 114081449A
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- 238000001514 detection method Methods 0.000 title claims abstract description 101
- 201000007270 liver cancer Diseases 0.000 title claims abstract description 32
- 208000014018 liver neoplasm Diseases 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 16
- 239000000523 sample Substances 0.000 claims abstract description 52
- 238000012360 testing method Methods 0.000 claims abstract description 5
- 210000004185 liver Anatomy 0.000 claims description 13
- 230000000694 effects Effects 0.000 claims description 6
- 230000033001 locomotion Effects 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 206010039491 Sarcoma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
- A61B5/4222—Evaluating particular parts, e.g. particular organs
- A61B5/4244—Evaluating particular parts, e.g. particular organs liver
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2503/00—Evaluating a particular growth phase or type of persons or animals
- A61B2503/40—Animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/006—Appliances for supporting or fettering animals for operative purposes with leg or foot restraining means
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Abstract
The invention discloses a hela liver cancer detection device based on a model mouse and a using method thereof, relates to the technical field of liver cancer detection, and aims to solve the problems that the existing equipment for liver cancer detection is not suitable for the model mouse, has certain limitation in research, cannot be operated in a better targeted manner, and is low in using flexibility. Transparent detection cover both sides are provided with the fly leaf, are provided with the connecting rod that three equidistance distributes in the transparent detection cover, and three connecting rod lower extreme is provided with the circular arc slide rail, swing joint has the slide in the circular arc slide rail, and slide lower extreme swing joint has the needle file, and swing joint has the test probe in the needle file, transparent detection cover lower extreme fixedly connected with base is provided with movable platform in the base, and the platform comprises upper and lower two parts, and the platform upper surface is provided with four elastic cords, and base one side fixed mounting has the display screen.
Description
Technical Field
The invention relates to the technical field of liver cancer detection, in particular to a hela liver cancer detection device based on a model mouse and a using method thereof.
Background
Liver cancer, a malignant tumor of the liver, can be divided into primary and secondary types. The primary liver malignant tumor originates from the epithelium or mesenchymal tissue of the liver, the former is called primary liver cancer, which is a highly-developed malignant tumor with great harm in China; the latter is called sarcoma, and is less common than primary liver cancer. Secondary or metastatic liver cancer refers to the invasion of malignant tumors of multiple organ origins in the whole body to the liver.
At present, in the process of early examination and treatment research of liver cancer, targeted clinical research can be carried out through a model mouse, the existing equipment for detecting liver cancer is not suitable for the model mouse, certain limitation exists in the research, better targeted operation cannot be carried out, and meanwhile, the use flexibility of the existing equipment is low.
Disclosure of Invention
The invention aims to provide a hela liver cancer detection device based on a model mouse and a using method thereof, and aims to solve the problems that the equipment for liver cancer detection in the background technology is not suitable for the model mouse, has certain limitations in research, cannot be operated in a better targeted manner, and is low in using flexibility of the existing equipment.
In order to achieve the purpose, the invention provides the following technical scheme: the utility model provides a hela liver cancer detection device and application method based on model mouse, includes the transparent detection cover, transparent detection cover both sides are provided with the fly leaf, be provided with the connecting rod that three equidistance distributes in the transparent detection cover, it is three the connecting rod lower extreme is provided with the circular arc slide rail, swing joint has the slide in the circular arc slide rail, slide lower extreme swing joint has the needle file, swing joint has the test probe in the needle file, transparent detection cover lower extreme fixedly connected with base, be provided with movable platform in the base, and the platform comprises upper and lower two parts, the platform upper surface is provided with four elastic cords, base one side fixed mounting has the display screen.
Through adopting above-mentioned technical scheme, be convenient for separately operate the increase functionality with two upper and lower parts of platform divide into, for detection operation increases the accuracy, set up the flexibility ratio that the circular arc slide rail can adjust the increase structure according to detecting the angle needs, interchangeable testing probe can be according to different demands and transfer the change detection instrument, the elastic cord can be fixed the mouse and avoid excessively struggling on the platform and increase the degree of difficulty for detection operation.
Further, be provided with the controller in the base, set up first recess in the base, the platform is located first recess, be provided with two jacking equipment one in the platform the latter half, two jacking equipment one controls the lift activity of the first half of platform.
Through adopting above-mentioned technical scheme, the first half activity of jacking equipment control platform to increase the flexibility ratio of equipment.
Further, the slide moves from side to side through the arc guide rail in the circular arc slide rail, install jacking equipment two in the slide, jacking equipment two control needle file's lift activity.
Through adopting above-mentioned technical scheme, the position of the steerable slide of the interior arc guide rail of circular arc slide rail, and the steerable test probe's of jacking equipment two position.
Further, both sides of the platform are provided with sliding blocks, both sides of the base are provided with driving screw rods, and the driving screw rods are movably connected with the sliding blocks.
By adopting the technical scheme, the lead screw is driven to drive the sliding block to move back and forth, so that the position of a mouse is controlled.
Further, four elastic cord one side all is provided with the fixed plate, four the fixed plate is fixed with the platform upper surface, four elastic cord lower surface one side all is provided with the magic and pastes two, the platform upper surface is provided with four magic and pastes one, four the magic is pasted one and is pasted two bonding connections with the magic.
Through adopting above-mentioned technical scheme, the viscidity that magic was pasted one and is pasted two can be fixed the mouse and avoid influencing the operation on the detection process on the platform.
Furthermore, a sliding groove is formed in the lower end of the needle seat, a second groove is formed in the sliding groove, two cylinders are arranged in the second groove, clamping sleeves are arranged at the front ends of the cylinders, the surfaces of the clamping sleeves are uneven and are made of rubber, and the clamping sleeves are movably connected with the detection probe.
Through adopting above-mentioned technical scheme, the detection probe is fixed at the second recess under the clamping effect of clutch collar, and because clutch collar is the unsmooth improvement stability of effectual increase resistance in rubber material surface.
A hela liver cancer detection device based on a model mouse and a using method of the device comprise the following steps:
step 1: firstly, a model mouse to be tested is placed above a platform, and then four elastic belts are wound around four limbs of the mouse and adhered with a first magic tape through a second magic tape below to adjust the elasticity of the model mouse, so that the mouse lies on the platform;
step 2: the platform moves forwards in the first groove to the position below the transparent detection cover under the action of the sliding blocks on the two sides and the driving screw rod, fine adjustment is carried out according to the position of the detection probe, the platform is stopped after being adjusted to the position below the detection probe, and then the upper half part of the platform is lifted under the action of the first lifting device, so that the position of the liver of the mouse is close to the detection probe;
and step 3: before detection, the corresponding detection probe can be clamped into the second groove of the needle base, the detection probe is clamped by the clamping sleeve in the second groove, and a proper detection probe can be selected as required during detection each time;
and 4, step 4: at the moment, the detection probe is adjusted to a proper required angle in the arc slide rail through the arc guide rail, and meanwhile, the needle seat enables the detection probe to be penetrated into the body of the mouse to detect or sample the liver under the control of the lifting device II, so that medical value is provided for liver cancer research.
Compared with the prior art, the invention has the beneficial effects that:
1. this hela liver cancer detection device based on model mouse and application method thereof is convenient for part operation increase functionality about divideing into the platform, for detection operation increases the accuracy, sets up the flexibility ratio that the circular arc slide rail can adjust the increase structure according to the detection angle needs, and replaceable detecting probe can transfer the change detection instrument according to different demands, and the elastic cord can be fixed the mouse and avoid too struggling for the detection operation increase the degree of difficulty.
2. According to the hela liver cancer detection device based on the model mouse and the use method thereof, the detection probe is fixed on the second groove under the clamping action of the clamping sleeve, and the clamping sleeve is made of rubber materials, so that the surface unevenness can be effectively increased, and the stability is improved.
Drawings
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic diagram of a platform structure according to the present invention;
FIG. 3 is a schematic view of the structure of the needle holder of the present invention;
FIG. 4 is a schematic representation of the elastic band structure of the present invention;
FIG. 5 is a schematic diagram of the system of the present invention.
In the figure: 1. a transparent detection cover; 2. a movable plate; 3. a connecting rod; 4. a circular arc slide rail; 5. a slide base; 6. a needle seat; 7. detecting the probe; 8. a base; 9. a platform; 10. elastic bands; 11. a display screen; 12. a controller; 13. a first groove; 14. lifting equipment I; 15. a second lifting device; 16. a slider; 17. driving the screw rod; 18. a fixing plate; 19. sticking a magic tape I; 20. a second magic tape; 21. a chute; 22. a second groove; 23. a cylinder; 24. and (5) clamping sleeves.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Referring to fig. 1, 2 and 5, an embodiment of the present invention is: a hela liver cancer detection device based on a model mouse and a using method thereof comprise a transparent detection cover 1, wherein two sides of the transparent detection cover 1 are provided with movable plates 2, three connecting rods 3 which are distributed equidistantly are arranged in the transparent detection cover 1, the lower ends of the three connecting rods 3 are provided with arc slide rails 4, slide seats 5 are movably connected in the arc slide rails 4, the lower ends of the slide seats 5 are movably connected with needle seats 6, detection probes 7 are movably connected in the needle seats 6, the lower end of the transparent detection cover 1 is fixedly connected with a base 8, a movable platform 9 is arranged in the base 8, the platform 9 consists of an upper part and a lower part, the upper surface of the platform 9 is provided with four elastic bands 10, one side of the base 8 is fixedly provided with a display screen 11, the base 8 is internally provided with a controller 12, the base 8 is internally provided with a first groove 13, the platform 9 is positioned in the first groove 13, and the lower half part of the platform 9 is provided with two lifting devices 14, two lifting devices I14 control the lifting movement of the upper half part of the platform 9, the slide carriage 5 moves left and right through an arc-shaped guide rail in the arc-shaped slide rail 4, a lifting device II 15 is installed in the slide carriage 5, the lifting movement of the needle seat 6 is controlled by the lifting device II 15, both sides of the platform 9 are provided with sliders 16, both sides of the base 8 are provided with driving lead screws 17, the two driving lead screws 17 are movably connected with the sliders 16, the platform 9 is divided into an upper part and a lower part, the separation operation is convenient, the functionality is increased, the accuracy is increased for the detection operation, the arc-shaped slide rail 4 is arranged, the flexibility of the structure can be adjusted and increased according to the detection angle, the detection tools can be adjusted and replaced according to different requirements by the replaceable detection probes 7, the elastic band 10 can fix the mouse on the platform 9 to avoid excessive struggling to increase the difficulty for the detection operation, and the lifting device I14 controls the movement of the upper half part of the platform 9, thereby increase the flexibility ratio of equipment, the steerable slide 5 position of the controllable slide rail of the interior arc guide rail of circular arc slide rail 4, and the steerable detection probe 7 position of jacking equipment two 15.
Referring to fig. 3, a sliding groove 21 is formed at the lower end of the needle base 6, a second groove 22 is formed in the sliding groove 21, two cylinders 23 are arranged in the second groove 22, clamping sleeves 24 are arranged at the front ends of the two cylinders 23, the surfaces of the two cylinders are uneven and made of rubber, the two clamping sleeves 24 are movably connected with the detection probe 7, the detection probe 7 is fixed in the second groove 22 under the clamping effect of the clamping sleeves 24, and the clamping sleeves 24 are made of rubber, and the surfaces of the clamping sleeves are uneven, so that resistance can be effectively increased, and stability is improved.
Referring to fig. 4, one side of each of the four elastic bands 10 is provided with a fixing plate 18, the four fixing plates 18 are fixed on the upper surface of the platform 9, one side of each of the lower surfaces of the four elastic bands 10 is provided with a second hook and loop fastener 20, the upper surface of the platform 9 is provided with a first hook and loop fastener 19, the first hook and loop fasteners 19 and the second hook and loop fastener 20 are adhered to each other, and the adhesion of the first hook and loop fastener 19 and the second hook and loop fastener 20 can fix the mouse on the platform 9 to avoid affecting the operation in the detection process.
A hela liver cancer detection device based on a model mouse and a using method of the device comprise the following steps:
step 1: firstly, a model mouse to be tested is placed above a platform 9, and then four elastic bands 10 are respectively wound around four limbs of the mouse and adhered with a first magic tape 19 through a second magic tape 20 at the lower part to adjust the elasticity, so that the mouse lies on the platform 9;
step 2: the platform 9 moves forwards in the first groove 13 to the position below the transparent detection cover 1 under the action of the sliding blocks 16 and the driving screw rods 17 on the two sides, fine adjustment is carried out according to the position of the detection probe 7, the platform is adjusted to the position below the detection probe 7 and then stopped, and the upper half part of the platform 9 is lifted under the action of the lifting device I14, so that the position of the liver of the mouse is close to the detection probe 7;
and 3, step 3: before detection, the corresponding detection probe 7 can be clamped into the second groove 22 of the needle base 6, the detection probe 7 is clamped by the clamping sleeve 24 in the second groove 22, and a proper detection probe 7 can be selected as required during detection each time;
and 4, step 4: at the moment, the detection probe 7 is adjusted to a proper required angle in the arc slide rail 4 through the arc guide rail, and meanwhile, the needle seat 6 enables the detection probe 7 to penetrate into the body of the mouse to detect or sample the liver under the control of the second lifting device 15, so that medical value is provided for liver cancer research.
The working principle is as follows: firstly, a model mouse to be tested is placed above a platform 9, in order to avoid accidents in the detection process, four elastic bands 10 are respectively wound around four limbs of the mouse and wound around the four limbs through a second magic tape 20 below to be adhered with a first magic tape 19 to adjust the tightness, so that the mouse lies on the platform 9, at the moment, the platform 9 moves forwards in a first groove 13 to the lower part of a transparent detection cover 1 under the action of sliders 16 and driving screw rods 17 on two sides, fine adjustment is carried out according to the position of a detection probe 7, the platform is adjusted to the lower part of the detection probe 7 and then stops, the upper half part of the platform 9 is lifted under the action of a first lifting device 14, the liver of the mouse is close to the detection probe 7, the corresponding detection probe 7 can be clamped into a second groove 22 of a needle base 6 before detection, the detection probe 7 is clamped by a clamping sleeve 24 in the second groove 22, and the appropriate detection probe 7 can be selected as required during detection each time, at the moment, the detection probe 7 is adjusted to a proper required angle in the arc slide rail 4 through the arc guide rail, and meanwhile, the needle seat 6 enables the detection probe 7 to penetrate into the body of the mouse to detect or sample the liver under the control of the second lifting device 15, so that medical value is provided for liver cancer research.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (7)
1. The utility model provides a hela liver cancer detection device based on model mouse, includes transparent detection cover (1), its characterized in that: transparent detection cover (1) both sides are provided with fly leaf (2), be provided with connecting rod (3) that three equidistance distributes in transparent detection cover (1), it is three connecting rod (3) lower extreme is provided with circular arc slide rail (4), swing joint has slide (5) in circular arc slide rail (4), slide (5) lower extreme swing joint has needle file (6), swing joint has test probe (7) in needle file (6), transparent detection cover (1) lower extreme fixedly connected with base (8), be provided with movable platform (9) in base (8), and platform (9) comprise upper and lower two parts, platform (9) upper surface is provided with four elastic cord (10), base (8) one side fixed mounting has display screen (11).
2. The device for detecting hela liver cancer based on model mouse as claimed in claim 1, wherein: be provided with controller (12) in base (8), first recess (13) have been seted up in base (8), platform (9) are located first recess (13), be provided with two jacking equipment one (14), two in the platform (9) the latter half of jacking equipment one (14) the lift activity of control platform (9) upper half.
3. The device for detecting hela liver cancer based on model mouse as claimed in claim 1, wherein: the slide (5) moves left and right through an arc-shaped guide rail in the arc-shaped slide rail (4), a second lifting device (15) is installed in the slide (5), and the second lifting device (15) controls the lifting movement of the needle seat (6).
4. The device for detecting hela liver cancer based on model mouse as claimed in claim 1, wherein: both sides of the platform (9) are provided with sliding blocks (16), both sides of the base (8) are provided with driving screw rods (17), and the driving screw rods (17) are movably connected with the sliding blocks (16).
5. The device for detecting hela liver cancer based on model mouse as claimed in claim 1, wherein: four elastic cord (10) one side all is provided with fixed plate (18), four fixed plate (18) fixed with platform (9) upper surface, four elastic cord (10) lower surface one side all is provided with the magic and pastes two (20), platform (9) upper surface is provided with four magic and pastes one (19), four the magic is pasted one (19) and is pasted two (20) adhesion with the magic and connect.
6. The device for detecting hela liver cancer based on model mouse as claimed in claim 1, wherein: the needle file is characterized in that a sliding groove (21) is formed in the lower end of the needle base (6), a second groove (22) is formed in the sliding groove (21), two cylinders (23) are arranged in the second groove (22), the front ends of the cylinders (23) are provided with clamping sleeves (24), the surfaces of the clamping sleeves (24) are uneven and are made of rubber, and the clamping sleeves (24) are movably connected with the detection probes (7).
7. A hela liver cancer detection device based on a model mouse and a using method thereof are characterized by comprising the following steps:
step 1: firstly, a model mouse to be tested is placed above a platform (9), and then four elastic bands (10) are wound around four limbs of the mouse and are adhered with a magic tape I (19) through a magic tape II (20) at the lower part to adjust the elasticity, so that the mouse lies on the platform (9) flatly;
step 2: the platform (9) moves forwards in the first groove (13) to the position below the transparent detection cover (1) under the action of the sliding blocks (16) on the two sides and the driving screw rod (17), fine adjustment is carried out according to the position of the detection probe (7), the platform is adjusted to the position below the detection probe (7) and then stopped, and the upper half part of the platform (9) is lifted under the action of the lifting device I (14), so that the position of the liver of a mouse is close to the detection probe (7);
and step 3: before detection, the corresponding detection probe (7) can be clamped into the second groove (22) of the needle seat (6), the detection probe (7) is clamped by the clamping sleeve (24) in the second groove (22), and a proper detection probe (7) can be selected according to requirements during detection each time;
and 4, step 4: at this moment, the detection probe (7) is adjusted to a proper required angle in the arc slide rail (4) through the arc guide rail, meanwhile, the needle seat (6) enables the detection probe (7) to be pierced into the mouse body under the control of the second lifting device (15) to detect the liver or sample the liver, and the movable plates (2) on the two sides of the transparent detection cover (1) can be opened manually to perform auxiliary operation, so that medical value is provided for liver cancer research.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111407661.2A CN114081449A (en) | 2021-11-24 | 2021-11-24 | Hela liver cancer detection device based on model mouse and use method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111407661.2A CN114081449A (en) | 2021-11-24 | 2021-11-24 | Hela liver cancer detection device based on model mouse and use method thereof |
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| CN114081449A true CN114081449A (en) | 2022-02-25 |
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| CN202111407661.2A Pending CN114081449A (en) | 2021-11-24 | 2021-11-24 | Hela liver cancer detection device based on model mouse and use method thereof |
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