CN114080181A - 用于生理系统干扰的神经调节技术 - Google Patents

用于生理系统干扰的神经调节技术 Download PDF

Info

Publication number
CN114080181A
CN114080181A CN202080048471.3A CN202080048471A CN114080181A CN 114080181 A CN114080181 A CN 114080181A CN 202080048471 A CN202080048471 A CN 202080048471A CN 114080181 A CN114080181 A CN 114080181A
Authority
CN
China
Prior art keywords
energy
concentration
subject
target region
glucose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080048471.3A
Other languages
English (en)
Chinese (zh)
Inventor
克里斯托弗·迈克尔·普莱奥
维多利亚·尤金妮亚·科特罗
杰弗里·迈克尔·阿舍
约翰·弗莱德里克·格拉夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Electric Co
Original Assignee
General Electric Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Electric Co filed Critical General Electric Co
Publication of CN114080181A publication Critical patent/CN114080181A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
    • A61B5/0051—Detecting, measuring or recording by applying mechanical forces or stimuli by applying vibrations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/416—Evaluating particular organs or parts of the immune or lymphatic systems the spleen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/4244—Evaluating particular parts, e.g. particular organs liver
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4222—Evaluating particular parts, e.g. particular organs
    • A61B5/425—Evaluating particular parts, e.g. particular organs pancreas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6823—Trunk, e.g., chest, back, abdomen, hip
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0536—Preventing neurodegenerative response or inflammatory reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0004—Applications of ultrasound therapy
    • A61N2007/0021—Neural system treatment
    • A61N2007/0026—Stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0073—Ultrasound therapy using multiple frequencies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N2007/0078—Ultrasound therapy with multiple treatment transducers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Optics & Photonics (AREA)
  • Endocrinology (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Surgical Instruments (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
CN202080048471.3A 2019-04-30 2020-06-19 用于生理系统干扰的神经调节技术 Pending CN114080181A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16/399,692 US11426610B2 (en) 2019-04-30 2019-04-30 Neuromodulation techniques for perturbation of physiological systems
PCT/US2020/038665 WO2020223741A2 (fr) 2019-04-30 2020-06-19 Techniques de neuromodulation pour perturbation de systèmes physiologiques

Publications (1)

Publication Number Publication Date
CN114080181A true CN114080181A (zh) 2022-02-22

Family

ID=71083670

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080048471.3A Pending CN114080181A (zh) 2019-04-30 2020-06-19 用于生理系统干扰的神经调节技术

Country Status (5)

Country Link
US (2) US11426610B2 (fr)
EP (1) EP3962598A4 (fr)
JP (1) JP2022536025A (fr)
CN (1) CN114080181A (fr)
WO (2) WO2020222217A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022180184A1 (fr) * 2021-02-24 2022-09-01 Indigo Diabetes Nv Système de surveillance de santé en continu
CA3227424A1 (fr) * 2021-07-27 2023-02-02 The Regents Of The University Of California Detection de signaux neuronaux de reponses immunitaires

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6615081B1 (en) 1998-10-26 2003-09-02 Birinder R. Boveja Apparatus and method for adjunct (add-on) treatment of diabetes by neuromodulation with an external stimulator
US7323296B2 (en) 2004-10-01 2008-01-29 Yuanhong Ma Method and index for diagnosing insulin resistance
CN102149428B (zh) 2008-07-14 2015-07-08 代理并代表亚利桑那州立大学的亚利桑那董事会 使用超声用于调节细胞活性的方法和装置
US20130184728A1 (en) 2011-11-29 2013-07-18 David J. Mishelevich Ultrasound Neuromodulation for Diagnosis and Other-Modality Preplanning
US8235897B2 (en) 2010-04-27 2012-08-07 A.D. Integrity Applications Ltd. Device for non-invasively measuring glucose
WO2015069446A1 (fr) 2013-11-06 2015-05-14 Towe Bruce C Modulation induite par ultrasons de niveaux de glycémie
WO2016072875A1 (fr) * 2014-11-03 2016-05-12 Glaxosmithkline Intellectual Property Development Limited Dispositif de neuromodulation
US20160236012A1 (en) 2015-02-18 2016-08-18 The George Washington University a Congressionally Chartered Not-for-Profit Corporation Ultrasound stimulation of pancreatic beta cells
US20170100605A1 (en) 2015-05-15 2017-04-13 Ohio State Innovation Foundation Systems and methods of improving an immune disorder
EP3439736A1 (fr) 2016-04-04 2019-02-13 General Electric Company Techniques de neuromodulation
WO2018022902A1 (fr) * 2016-07-27 2018-02-01 The Trustees Of Columbia University In The City Of New York Procédés et systèmes de modulation de nerfs périphériques utilisant des ultrasons focalisés
AU2017348440C1 (en) * 2016-10-31 2023-07-20 General Electric Company Techniques for neuromodulation

Also Published As

Publication number Publication date
US20200346043A1 (en) 2020-11-05
EP3962598A2 (fr) 2022-03-09
WO2020222217A1 (fr) 2020-11-05
EP3962598A4 (fr) 2023-05-10
US20220362587A1 (en) 2022-11-17
WO2020223741A2 (fr) 2020-11-05
JP2022536025A (ja) 2022-08-12
WO2020223741A3 (fr) 2020-12-10
US11426610B2 (en) 2022-08-30

Similar Documents

Publication Publication Date Title
US20220362587A1 (en) Neuromodulation techniques for perturbation of physiological systems
US11911634B2 (en) Neuromodulation energy application techniques
JP7404254B2 (ja) 超音波ニューロモジュレーション技術
JP2023058664A (ja) ニューロモジュレーション技術
US20230218276A1 (en) Delivery of therapeutic neuromodulation
US11771368B2 (en) Rapid assessment of microcirculation in patients to realize closed-loop systems
US20230226380A1 (en) Noninvasive tissue displacement control and monitoring for neuromodulation
CN114786770A (zh) 多束神经调节技术
US20190261912A1 (en) System and methods for identifying or assessing inflammatory bowel disease or gut inflammation
US12029577B2 (en) Neuromodulation to target glucose transporter and/or incretin pathways
US20220175306A1 (en) Neuromodulation to target glucose transporter and/or incretin pathways
US20240226609A1 (en) Neuromodulation techniques

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination