CN114076755A - Controllable reference light source for chemiluminescence immunity analyzer - Google Patents

Controllable reference light source for chemiluminescence immunity analyzer Download PDF

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Publication number
CN114076755A
CN114076755A CN202010846965.8A CN202010846965A CN114076755A CN 114076755 A CN114076755 A CN 114076755A CN 202010846965 A CN202010846965 A CN 202010846965A CN 114076755 A CN114076755 A CN 114076755A
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CN
China
Prior art keywords
light source
display panel
reference light
well plate
immunoassay analyzer
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Granted
Application number
CN202010846965.8A
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Chinese (zh)
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CN114076755B (en
Inventor
邓振进
邬鹏程
黄海萍
高飞
曹俐
周阳
姚健
刘向荣
彭明霞
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Hunan Legend Ai Chip Biotechnology Co ltd
Hunan Testing Institute For Medical Devices
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Hunan Legend Ai Chip Biotechnology Co ltd
Hunan Testing Institute For Medical Devices
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Priority to CN202010846965.8A priority Critical patent/CN114076755B/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • G01N21/763Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N2021/0106General arrangement of respective parts
    • G01N2021/0112Apparatus in one mechanical, optical or electronic block

Abstract

The invention discloses an adjustable reference light source for a chemiluminescence immunoassay analyzer, which comprises an integrating cavity body, a display panel, a controller and a light-emitting piece, wherein the integrating cavity body is provided with a light source; the top plate of the integration cavity body is a pore plate, and a plurality of vertical through holes are formed in the pore plate; the integrating cavity body is internally provided with an integrating cavity, each through hole is communicated with the integrating cavity, the display panel is arranged on the pore plate and covers all the through holes on the pore plate, the light-emitting piece is arranged in the integrating cavity, and the controller is used for controlling the light transmittance of the part, corresponding to the position of each through hole, on the display panel; the attenuation sheet is arranged between the pore plate and the display panel; the inner wall of the integration cavity is provided with a diffuse reflection layer; light diffusion gel is arranged in each through hole. The invention has low price and simple and convenient operation, and can provide a stable and continuous reference light source for the calibration or the test of the chemiluminescence immunoassay analyzer.

Description

Controllable reference light source for chemiluminescence immunity analyzer
Technical Field
The invention particularly relates to an adjustable reference light source for a chemiluminescence immunoassay analyzer.
Background
The chemiluminescence immunoassay analyzer has the advantages of small background interference, high sensitivity, high precision, wide detectable range and good stability, can detect trace antigens or antibodies, and has rapidly developed into one of the hottest detection means in the immunodiagnosis field in recent years.
In order to ensure the performance of the chemiluminescence immunoassay analyzer, the chemiluminescence immunoassay analyzer needs to be calibrated or tested frequently.
The light source for the chemiluminescence immunoassay analyzer comprises a pore plate (such as a 96 pore plate), and a plurality of through holes are formed in the pore plate. When the prior art is adopted to calibrate or test the chemiluminescence immunoassay analyzer, a reagent is firstly added into a centrifugal tube, then the centrifugal tube is placed into a target through hole to be calibrated or tested, and finally the reagent is subjected to chemical reaction in the centrifugal tube and emits light on the corresponding target through hole.
The existing methods for calibrating or testing chemiluminescent immunoassay analyzers using reagents have the following disadvantages: the reagent is expensive, the stable luminescence time is short, the reagent needs to be prepared temporarily before use, and the operation steps are complicated.
Disclosure of Invention
The invention aims to provide an adjustable reference light source for a chemiluminescence immunoassay analyzer aiming at the defects of the prior art in the calibration or test of the chemiluminescence immunoassay analyzer by using a reagent, which has the advantages of low price and simple and convenient operation and can provide a stable and continuous reference light source for the calibration or test of the chemiluminescence immunoassay analyzer.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
an adjustable reference light source for a chemiluminescence immunoassay analyzer is structurally characterized by comprising an integrating cavity body, a display panel, a controller and a light-emitting piece; the top plate of the integration cavity body is a pore plate, and a plurality of vertical through holes are formed in the pore plate; the integration cavity is formed in the integration cavity body, each through hole is communicated with the integration cavity, the display panel is arranged on the pore plate and covers all the through holes in the pore plate, the light-emitting piece is arranged in the integration cavity, and the controller is used for controlling the light transmittance of the part, corresponding to the position of each through hole, on the display panel.
By means of the structure, the light-emitting piece emits light, and the light transmittance of the part corresponding to each through hole on the display panel is controlled by the controller: if light is required to be emitted from one or more through hole sites, the light transmittance at the positions of the display panel corresponding to the through holes requiring light emission is set to be 100%, and the light transmittance at the positions of the display panel corresponding to the other through holes not requiring light emission is set to be 0%. In addition, the light transmittance of the display panel at the position corresponding to each through hole is set to be 0-100% so as to control each through hole position to obtain different light emitting values.
Further, still include the decay piece, the decay piece is located between orifice plate and the display panel.
The chemiluminescence immunity analyzer detector is generally a single-photon detector and is very easy to saturate. And a proper attenuation sheet is selected to properly attenuate the light emitted by the light-emitting part, so that the detector of the chemiluminescence immunoassay analyzer can work in an unsaturated area.
Further, the inner wall of the integration cavity is provided with a diffuse reflection layer.
The diffuse reflection layer on the inner wall of the integrating cavity can enable light emitted by the light-emitting piece to be uniformly distributed inside the integrating cavity, and the premise is provided for uniform light emission of the through holes in the pore plate.
Furthermore, each through hole is internally provided with light diffusion gel.
The light diffusing gel in the through hole enables the light transmitted from the integrating cavity to be uniformly dispersed, so that the light emitting characteristic similar to that of the reagent is generated, and the reagent light emission is effectively simulated.
Preferably, the light emitting member is an LED lamp.
Preferably, the LED lamp and the first driving circuit for driving the LED lamp are both mounted on the first side panel of the integrating cavity body.
Preferably, the display panel is an LCD panel.
Preferably, the controller is electrically connected to the display panel through the second driving circuit.
Preferably, the controller and the second driving circuit are mounted on the second side panel of the integrating chamber body.
Preferably, the well plate is a 6-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, a 384-well plate, or a 1536-well plate.
Compared with the prior art, the invention has the advantages of low price and simple and convenient operation, and can provide a stable and continuous reference light source for the calibration or the test of the chemiluminescence immunoassay analyzer.
Drawings
Fig. 1 is a left side view of an embodiment of the present invention.
Fig. 2 is a sectional view a-a of fig. 1.
Fig. 3 is an exploded view of fig. 1.
Fig. 4 is a block diagram of a circuit in which the display panel is located.
Fig. 5 is a schematic structural view of the integrating cavity body.
Fig. 6 is a numbered schematic of a 96-well plate.
The integrated circuit comprises an integration cavity body 1, a hole plate 101, a through hole 1011, an integration cavity 102, a first side panel 103, a second side panel 104, a display panel 2, a controller 3, a setting unit 301, a light emitting element 4, an attenuation sheet 5, a diffuse reflection layer 6, light diffusion gel 7, a first driving circuit 8 and a second driving circuit 9.
Detailed Description
As shown in fig. 1 to 4, the adjustable reference light source for a chemiluminescence immunoassay analyzer comprises an integrating cavity body 1, a display panel 2, a controller 3 and a light emitting element 4; the top plate of the integration cavity body 1 is a pore plate 101, and a plurality of vertical through holes 1011 are formed in the pore plate 101; the well plate 101 is a 6-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, a 384-well plate or a 1536-well plate, and in this embodiment, a 96-well plate is used, so that 96 through holes 1011 are formed in the well plate 101. The integrating cavity body 1 is internally provided with an integrating cavity 102, each through hole 1011 is communicated with the integrating cavity 102, the display panel 2 is arranged on the pore plate 101 and covers all the through holes 1011 on the pore plate 101, the luminous element 4 is arranged in the integrating cavity 102, and the controller 3 is used for controlling the light transmittance of the part of the display panel 2 corresponding to the position of each through hole 1011. The light emitting member 4 emits light, and the controller 3 controls the light transmittance of the portion of the display panel 2 corresponding to the position of each through hole 1011: if light is required to be emitted from one or some of the through holes 1011, the transmittance at the portions of the display panel 2 corresponding to the positions of the through holes 1011 from which light is required to be emitted is set to 100%, and the transmittance at the portions of the display panel 2 corresponding to the positions of the through holes 1011 from which light is not required to be emitted is set to 0%. In addition, the light transmittance of the display panel 2 at the position corresponding to each through hole 1011 can be set to be between 0% and 100% to control the hole position of each through hole 1011 to obtain different light emission values. It can be seen that by controlling the real-time controllable coded luminescence of each well on the 96-well plate 101 through the controller 3, the present invention can provide a stable continuous reference light source for the calibration or test of a chemiluminescent immunoassay analyzer.
The controller 3 is provided with a setting unit 301, and the setting unit 301 is used for setting the light transmittance of the display panel 2 at the positions corresponding to the positions of the through holes 1011 independently.
The controllable reference light source for the chemiluminescence immunoassay analyzer further comprises an attenuation sheet 5, wherein the attenuation sheet 5 is arranged between the pore plate 101 and the display panel 2. The chemiluminescence immunity analyzer detector is generally a single-photon detector and is very easy to saturate. The detector of the chemiluminescence immunoassay analyzer can work in an unsaturated region by selecting a proper attenuation sheet 5 to properly attenuate the light emitted by the luminous element 4.
The inner wall of the integrating cavity 102 is provided with a diffuse reflecting layer 6. The diffuse reflection layer 6 on the inner wall of the integrating cavity 102 can make the light emitted by the light-emitting member 4 uniformly distributed inside the integrating cavity 102, and provides a premise for uniform light emission from the through holes 1011 on the orifice plate 101. The diffuse reflection layer 6 is a magnesium oxide or barium sulfate coating, so that the diffuse reflection layer has a high diffuse reflection coefficient (98%), and after the luminescent part 4 emits light, the light source light is uniformly distributed inside the cavity of the integrating cavity 102 through internal high diffuse reflection.
The light diffusion gel 7 is provided in each through hole 1011. The light diffusing gel 7 has a shape matching the shape of the through hole 1011 and is completely embedded in the through hole 1011. The light diffusing gel 7 within the through hole 1011 causes the light transmitted from the integrating cavity 102 to be uniformly dispersed, thereby producing a light emission characteristic similar to that of the reagent, effectively simulating reagent light emission.
The light diffusion gel 7 can be a commercially available light diffusion gel, or can be prepared by itself according to the prior art. For example, a certain amount of light diffusion agent (such as silicone spherical micropowder) is doped into polydimethylsiloxane, and the mixture is left for 24 hours to solidify to form the light diffusion gel 7.
The luminous element 4 is an LED lamp. The LED lamp and a first driving circuit 8 (including a power supply) for driving the LED lamp are both arranged on the first side panel 103 of the integrating cavity body 1.
The display panel 2 is an LCD panel with a size of 5.7 feet selected to match the size of the 96-well plate 101. The controller 3 is electrically connected to the display panel 2 through the second drive circuit 9. The controller 3 and a second driving circuit 9 (including a power supply) for driving the LCD panel are mounted on the second side panel 104 of the integrating chamber body 1. The mounting structure of the controller 3 and the second driving circuit 9 on the second side panel 104 is not shown in the drawings due to being hidden, but does not affect the understanding and implementation of the present invention by those skilled in the art. In addition, the controller 3 is used to change the light transmittance at a certain position on the display panel 2 through the driving circuit, which also belongs to the prior art, and is not described herein, but does not affect the understanding and implementation of the present invention by those skilled in the art.
The integration cavity body 1 is a cuboid-like body, and the size of the integration cavity body is almost the same as that of the orifice plate 101. A first side panel 103 is detachably arranged on the left side of the integration cavity body 1, and after the LED lamp and the first driving circuit 8 are arranged on the first side panel 103, the first side panel 103 seals the left side of the integration cavity 102; the second side panel 104 is detachably mounted on the right side of the integration cavity body 1, and after the controller 3 and the second driving circuit 9 are mounted on the second side panel 104, the second side panel 104 closes the right side of the integration cavity 102. The top of the integration cavity body 1 is provided with an orifice plate 101. The front panel, the rear panel and the bottom plate of the integral cavity body 1 are all fixed closed panels.
The invention adopts the button battery to supply power, and can ensure smaller structural size.
Fig. 6 is a schematic numbering diagram of a 96-well plate.
The invention can provide stable and continuous programmable regulation reference light source for the calibration or test (such as interference test between holes, channel difference test, stability test, repeatability test, linearity test, difference calibration between platforms, and the like) of the chemiluminescence immunoassay analyzer.
When an inter-hole interference test is performed, for example, when the interference of the D7 hole site on the peripheral hole sites thereof needs to be tested, the transmittance of the display panel 2 at the position corresponding to the D7 hole site is set to 100%, and the transmittance of the display panel 2 at the position corresponding to the peripheral hole site of the D7 hole site is set to 0%, at this time, theoretically, only the D7 hole site should emit light. The detector is used for testing the optical signal of a certain peripheral hole site (such as a hole site C7) of the hole sites D7, if the detector obviously detects the optical signal, the light emission of the hole site D7 influences the detection of the peripheral hole site, and the interference among the holes exists. Conversely, if the detector does not detect the optical signal, then there is no inter-hole interference.
When a channel difference test is performed, for example, when channel differences of several hole sites B2, B7, B11, D2, D7, D11, G2, G7, and G11 need to be tested, the transmittance of the position on the display panel 2 corresponding to the selected hole site is set to 100%, and the transmittance of the position on the display panel 2 corresponding to the other hole sites is set to 0%. The detector is used for testing the luminous values of the hole sites, theoretically, the luminous values of the selected hole sites are basically the same, and if the test results of the hole sites are obviously different, the chemiluminescence immunoassay analyzer is different in result when testing different hole sites, and errors exist among different holes.
When stability and repeatability tests are carried out, for example, when the stability and the repeatability of the D7 hole site need to be tested, the light transmittance of the position, corresponding to the D7 hole site, on the display panel 2 is set according to the required strength, the light transmittance of the positions, corresponding to the rest hole sites except the D7 hole site, on the display panel 2 is set to be 0%, and the repeatability stability of the D7 hole site is verified by repeatedly testing according to the national standard requirements.
When a linear test is performed, for example, when the hole site D7 is tested, the light transmittance of the display panel 2 at the hole site D7 is set to 5, 10, 30, 50, and 70%, and the linear change of the optical signal at the hole site D7 is tested to realize the linear test.
While the present invention has been described with reference to the embodiments shown in the drawings, the present invention is not limited to the embodiments, which are illustrative and not restrictive, and it will be apparent to those skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (10)

1. The utility model provides a chemiluminescence immunoassay appearance is with adjustable and controllable reference light source which characterized in that:
comprises an integrating cavity body (1), a display panel (2), a controller (3) and a luminous piece (4); the top plate of the integrating cavity body (1) is a pore plate (101), and a plurality of vertical through holes (1011) are formed in the pore plate (101); set up integration chamber (102) in integration chamber body (1), each through-hole (1011) all communicates with each other with integration chamber (102), display panel (2) are located on orifice plate (101) and are covered all through-holes (1011) on orifice plate (101), illuminating part (4) are located in integration chamber (102), controller (3) are used for controlling the luminousness of the position that corresponds department with each through-hole (1011) position on display panel (2).
2. The controllable reference light source for a chemiluminescent immunoassay analyzer of claim 1 further comprising an attenuation sheet (5), wherein the attenuation sheet (5) is disposed between the well plate (101) and the display panel (2).
3. The controllable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein the inner wall of the integrating chamber (102) is provided with a diffuse reflective layer (6).
4. The controllable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein each of the through holes (1011) has a light diffusing gel (7) disposed therein.
5. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein the light emitting member (4) is an LED lamp.
6. The controllable reference light source for a chemiluminescent immunoassay analyzer of claim 5 wherein the LED lamp and the first driver circuit (8) for driving the LED lamp are both mounted on the first side panel (103) of the integrating chamber body (1).
7. The controllable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein the display panel (2) is an LCD panel.
8. The controllable reference light source for a chemiluminescent immunoassay analyzer of claim 1 wherein the controller (3) is electrically connected to the display panel (2) through the second driving circuit (9).
9. The adjustable reference light source for a chemiluminescent immunoassay analyzer of claim 8 wherein the controller (3) and the second driving circuit (9) are mounted on the second side panel (104) of the integrating chamber body (1).
10. The controllable reference light source for a chemiluminescent immunoassay analyzer of any one of claims 1 to 9 wherein the well plate (101) is a 6-well plate, a 12-well plate, a 24-well plate, a 48-well plate, a 96-well plate, a 384-well plate or a 1536-well plate.
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