CN114062005A - Sampling device for freeze-drying machine - Google Patents
Sampling device for freeze-drying machine Download PDFInfo
- Publication number
- CN114062005A CN114062005A CN202111360338.4A CN202111360338A CN114062005A CN 114062005 A CN114062005 A CN 114062005A CN 202111360338 A CN202111360338 A CN 202111360338A CN 114062005 A CN114062005 A CN 114062005A
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- Prior art keywords
- sampling
- freeze
- thief rod
- sampling device
- flange
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- 238000005070 sampling Methods 0.000 title claims abstract description 53
- 238000004108 freeze drying Methods 0.000 title claims abstract description 10
- 239000003814 drug Substances 0.000 claims abstract description 42
- 239000000463 material Substances 0.000 claims abstract description 26
- 238000007789 sealing Methods 0.000 claims abstract description 16
- 210000000078 claw Anatomy 0.000 claims description 20
- 239000011521 glass Substances 0.000 claims description 9
- 229910000831 Steel Inorganic materials 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 229940127557 pharmaceutical product Drugs 0.000 claims description 4
- 239000010959 steel Substances 0.000 claims description 4
- 210000001503 joint Anatomy 0.000 claims description 3
- 238000001035 drying Methods 0.000 abstract description 18
- 238000000034 method Methods 0.000 abstract description 4
- 238000009434 installation Methods 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000009777 vacuum freeze-drying Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000010836 blood and blood product Substances 0.000 description 1
- 229940125691 blood product Drugs 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The invention discloses a sampling device for a freeze-drying machine, which is arranged on a freeze-drying machine, and comprises: a sealing part which is arranged on the freeze dryer and is used for sealing; a grasping portion mounted on the sealing portion for grasping; and install in the lower part of snatching the position for hold the material position that connects of sample, at the whole freeze-drying process of medicine, under the condition of the vacuum environment in not destroying the drying cabinet, and can take out the medicine bottle from the drying cabinet the inside when guaranteeing to take out medicine structure and quality, thereby carry out experimental study.
Description
Technical Field
The invention relates to a sampling device for a freeze-drying machine.
Background
The freeze dryer is originated from the vacuum freeze drying technology in the 20 th of the 19 th century, and enters the 21 st century, and the vacuum freeze drying technology is widely applied to the fields except for the fields of medicines, biological products, foods, blood products and active substances.
Because the market is more and more to the demand of new medicine at present, the freeze dryer pharmacy sampling device structure is also very crucial to the development of new medicine and the earlier stage experiment of medicine, in research and experimentation, need constantly take out the medicine from the drying cabinet in each stage and observe and study, if random taking, can destroy the vacuum environment in the drying cabinet, thereby pollute other medicines easily, and the medicine that takes out also needs strict protection, need carry out in the drying cabinet and press and fill in the back and just can take out, otherwise can lead to the experiment to be disturbed by external factor, make data inaccurate.
Disclosure of Invention
The invention aims to provide a sampling device for a freeze-drying machine, which can be used for taking out a medicine bottle from a drying box while ensuring the structure and quality of the medicine to be taken out in the whole freeze-drying process of the medicine without damaging the vacuum environment in the drying box, thereby carrying out experimental research.
The technical scheme for realizing the purpose is as follows: a sampling device for a lyophilized machine, mounted on a lyophilizer, said sampling device comprising:
a sealing part which is arranged on the freeze dryer and is used for sealing;
a grasping portion mounted on the sealing portion for grasping; and
and the material receiving part is arranged at the lower part of the grabbing part and is used for containing samples.
Preferably: the freeze dryer includes: the equipment gate, equipment sheet layer and the medicine bottle of taking the plug, the equipment sheet layer install in the back at the equipment gate, the medicine bottle of taking the plug is placed in on the equipment sheet layer.
Preferably: the sealing part comprises a butt flange, and the butt flange is in butt joint with a reserved flange on the equipment gate through a bolt.
Preferably: snatch the position including semi-automatic sampling claw, thief rod handle, get hopper and ball assembly, rotate the ball assembly install in on the flange, the one end of thief rod is connected the thief rod handle, the other end of thief rod passes rotate the ball assembly with the back of semi-automatic sampling claw links to each other, be provided with a steel wire warp in the semi-automatic sampling claw the thief rod internal connection the thief rod handle, get the hopper install in flange's back just is located the below of thief rod.
Preferably: connect the material position to include conveying pipeline, receiver and sample ball valve, the conveying pipeline is located the below of ball subassembly is rotated and one end with get the hopper intercommunication, the other end of conveying pipeline is connected the one end of sample ball valve, the other end of sample ball valve is connected with the receiver.
Preferably: and an observation sight glass is arranged on the butt flange, and the height of the observation sight glass is consistent with that of the sampling rod.
Preferably: the material receiver and the sampling ball valve are detachably connected.
The invention has the beneficial effects that: through the installation flange, be convenient for guarantee the inside vacuum of drying cabinet, so as to guarantee that the medicine is not contaminated, through the semi-automatic claw of taking a sample of installation, the thief rod handle, get hopper and ball subassembly, be convenient for open and closed through thief rod handle control claw, thereby press the medicine bottle on the plug, and can carry out snatching of medicine bottle, through the installation conveying pipeline, receiver and sample ball valve, be convenient for when receiving the sample, guarantee that the vacuum environment in the drying cabinet is not destroyed, observe the sight glass through the installation, be convenient for observe the state that the thief claw snatched at the in-process of snatching of being convenient for, adopt to dismantle with the sample ball valve through setting up the receiver and be connected, be convenient for pull down the receiver after closing the ball valve, when not destroying the drying cabinet internal environment, take out sample medicine bottle, the convenience is improved.
Drawings
FIG. 1 is a schematic overall view of a sampling device for lyophilized pharmaceutical products of the present invention;
FIG. 2 is a rear view of a sampling device for use in a lyophilized machine of the present invention;
fig. 3 is a schematic view of the connection of the components on the counterflange of the invention.
Reference numerals: 1. an equipment gate; 2. an equipment board layer; 3. a medicine bottle with a rubber plug; 4. a semi-automatic sampling claw; 5. a sampling rod; 6. a material taking hopper; 7. a rotating ball assembly; 8. butting flanges; 9. a sampling ball valve; 10. a material receiver; 11. a thief rod handle; 12. an observation sight glass; 13. a delivery pipe.
Detailed Description
The technical scheme of the invention is clearly and completely described in the following with reference to the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance.
The invention will be further explained with reference to the drawings.
Example one
When taking out the medicine in the drying cabinet, if take at will, can lead to the vacuum environment in the drying cabinet to be destroyed to make the medicine contaminated, the medicine that takes out in addition also receives external factors to pollute easily, leads to the content error production of experiment and research, makes the medicine quality reduce, refers to and shows 1 to 3, a sampling device for freeze-drying machine installs on the freeze dryer, and sampling device includes: the device comprises a sealing part, a grabbing part and a material receiving part, wherein the sealing part is arranged on the freeze dryer and used for sealing; the grabbing part is arranged on the sealing part and used for grabbing; the material receiving part is arranged at the lower part of the grabbing part and used for containing samples.
The freeze dryer includes: the equipment gate 1, the equipment sheet layer 2 and the medicine bottle 3 of taking the plug, equipment sheet layer 2 installs in the back of equipment gate 1, and the medicine bottle 3 of taking the plug is placed on equipment sheet layer 2.
The sealing part comprises a butt flange 8, the butt flange 8 is in butt joint with a reserved flange on the equipment gate 1 through bolts, so that the vacuum inside the drying box is convenient to ensure, and the medicines are not polluted.
Snatch the position and include semi-automatic sampling claw 4, thief rod 5, thief rod handle 11, get hopper 6 and rolling ball subassembly 7, rolling ball subassembly 7 is installed on flange 8, thief rod handle 11 is connected to thief rod 5's one end, thief rod 5's the other end passes and rotates ball subassembly 7 and semi-automatic sampling claw 4's back and links to each other, be provided with a steel wire through thief rod 5 internal connection thief rod handle 11 in semi-automatic sampling claw 4, get hopper 6 and install in flange 8's back and be located thief rod 5's below, be convenient for through opening and the closure of thief rod handle control claw, thereby press the medicine bottle with the plug, and can carry out snatching of medicine bottle.
Connect the material position to include conveying pipeline 13, receiver 10 and sample ball valve 9, conveying pipeline 13 is located the below of ball subassembly 7 and one end and gets hopper 6 intercommunication, and the one end of sample ball valve 9 is connected to the other end of conveying pipeline 13, and the other end of sample ball valve 9 is connected with receiver 10, is convenient for when receiving the sample, guarantees that the vacuum environment in the drying cabinet is not destroyed.
An observation sight glass 12 is arranged on the butt flange 8, the height of the observation sight glass 12 is consistent with that of the sampling rod 5, and the grasping state of the sampling claw can be conveniently observed in the grasping process.
The material receiver 10 and the sampling ball valve 9 are detachably connected, so that the material receiver can be conveniently detached after the ball valve is closed, the internal environment of the drying oven is not damaged, the sample medicine bottle is taken out, and the convenience is improved while the internal environment of the drying oven is not damaged.
The working principle is as follows: firstly, observing the state of a semi-automatic sampling claw 4 through an observation sight glass 12, selecting a proper sample, adjusting the position of the semi-automatic sampling claw 4 by controlling a sampling rod 5, operating a sampling rod handle 11 to control the semi-automatic sampling claw 4 to open and close through a steel wire to tightly press the rubber plug of a sample rubber-plug-carrying medicine bottle 3, then controlling the semi-automatic sampling claw 4 to grasp the rubber-plug-carrying medicine bottle 3, moving the rubber-plug-carrying medicine bottle 3 to the upper part of a material taking hopper 6, loosening the semi-automatic sampling claw 4, dropping the rubber-plug-carrying medicine bottle 3 into the material taking hopper 6, then dropping the rubber plug-carrying medicine bottle 3 downwards into a material conveying pipe 13, then opening a sampling ball valve 9 to enable the rubber-plug-carrying medicine bottle 3 to drop into a material receiver 10 through the sampling ball valve 9, then closing the sampling ball valve 9, detaching the material receiver 10 from the lower part of the sampling ball valve 9, taking out the rubber plug-carrying medicine bottle 3 therein, namely taking out the sample, wherein the structure can be used under the condition of not damaging the vacuum environment in a drying box, and can take out the medicine bottle from the drying cabinet when guaranteeing to take out medicine structure and quality to experimental study carries out.
The above embodiments are provided only for illustrating the present invention and not for limiting the present invention, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present invention, and therefore all equivalent technical solutions should also fall within the scope of the present invention, and should be defined by the claims.
Claims (7)
1. The utility model provides a sampling device for freeze-drying machine medicine, installs on the freeze-dryer which characterized in that: the sampling device comprises:
a sealing part which is arranged on the freeze dryer and is used for sealing;
a grasping portion mounted on the sealing portion for grasping; and
and the material receiving part is arranged at the lower part of the grabbing part and is used for containing samples.
2. A sampling device according to claim 1 for use in a lyophilized machine, wherein: the freeze dryer includes: the device comprises a device gate (1), a device plate layer (2) and medicine bottles (3) with rubber plugs, wherein the device plate layer (2) is installed on the back face of the device gate (1), and the medicine bottles (3) with rubber plugs are placed on the device plate layer (2).
3. A sampling device according to claim 2 for use in a freeze-dried pharmaceutical machine, wherein: the sealing part comprises a butt flange (8), and the butt flange (8) is in butt joint with a reserved flange on the equipment gate (1) through bolts.
4. A sampling device according to claim 3 for use in a freeze-dried pharmaceutical machine, wherein: snatch the position including semi-automatic sampling claw (4), thief rod (5), thief rod handle (11), get hopper (6) and ball assembly (7) rotate ball assembly (7) install in on flange (8), the one end of thief rod (5) is connected thief rod handle (11), the other end of thief rod (5) passes revolve ball assembly (7) with the back of semi-automatic sampling claw (4) links to each other, be provided with a steel wire warp in semi-automatic sampling claw (4) thief rod (5) internal connection thief rod handle (11), thief hopper (6) install in flange (8) the back and be located the below of thief rod (5).
5. A sampling device according to claim 4 for use in lyophilized pharmaceutical products, wherein: the material receiving part comprises a material conveying pipe (13), a material receiver (10) and a sampling ball valve (9), wherein the material conveying pipe (13) is connected to the front end of the butt flange (8) and penetrates through the butt flange (8) to be communicated with the material taking hopper (6); the material conveying pipe (13) is located below the rotating ball assembly (7), the other end of the material conveying pipe (13) is connected with one end of the sampling ball valve (9), and the other end of the sampling ball valve (9) is connected with the material receiver (10).
6. A sampling device according to claim 4 for use in lyophilized pharmaceutical products, wherein: an observation sight glass (12) is installed on the butt flange (8), and the height of the observation sight glass (12) is consistent with that of the sampling rod (5).
7. A sampling device according to claim 5 for use in lyophilized pharmaceutical products, wherein: the material receiver (10) is detachably connected with the sampling ball valve (9).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111360338.4A CN114062005A (en) | 2021-11-17 | 2021-11-17 | Sampling device for freeze-drying machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111360338.4A CN114062005A (en) | 2021-11-17 | 2021-11-17 | Sampling device for freeze-drying machine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114062005A true CN114062005A (en) | 2022-02-18 |
Family
ID=80273247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111360338.4A Pending CN114062005A (en) | 2021-11-17 | 2021-11-17 | Sampling device for freeze-drying machine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114062005A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116539374A (en) * | 2023-07-05 | 2023-08-04 | 精华制药集团南通有限公司 | Portable sampling device for industrial pharmacy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201285206Y (en) * | 2008-10-30 | 2009-08-05 | 上海舒博拉尼制药设备有限公司 | Full-automatic online sampling apparatus of freeze drying machine |
| CN102692339A (en) * | 2012-06-19 | 2012-09-26 | 上海共和真空技术有限公司 | Freezing sampling device |
| CN204594726U (en) * | 2014-12-30 | 2015-08-26 | 楚天科技股份有限公司 | A kind of freeze drying box on-line period device |
-
2021
- 2021-11-17 CN CN202111360338.4A patent/CN114062005A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201285206Y (en) * | 2008-10-30 | 2009-08-05 | 上海舒博拉尼制药设备有限公司 | Full-automatic online sampling apparatus of freeze drying machine |
| CN102692339A (en) * | 2012-06-19 | 2012-09-26 | 上海共和真空技术有限公司 | Freezing sampling device |
| CN204594726U (en) * | 2014-12-30 | 2015-08-26 | 楚天科技股份有限公司 | A kind of freeze drying box on-line period device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116539374A (en) * | 2023-07-05 | 2023-08-04 | 精华制药集团南通有限公司 | Portable sampling device for industrial pharmacy |
| CN116539374B (en) * | 2023-07-05 | 2023-10-10 | 精华制药集团南通有限公司 | Portable sampling device for industrial pharmacy |
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