CN114052736B - System and method for evaluating cognitive function - Google Patents
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Abstract
The application discloses an evaluation system and method of cognitive function, the evaluation system of cognitive function includes: a processor for selecting a visual stimulation protocol from a stimulation database; a stimulus presentation device in communication with the processor for presenting a visual stimulus regimen to a user; interaction means for the user to interactively operate in response to the visual stimulus regimen; a data acquisition device for acquiring operational data of the user for interactive operation in response to the visual stimulus program for evaluating a cognitive function of the user, wherein the visual stimulus program comprises: the first stimulation signals are displayed in sequence according to a preset or random sequence, the user is required to perform interactive operation by using the interactive device, and the second stimulation signals are required to perform no interactive operation or different interactive operations by the user.
Description
Technical Field
The present application relates to the field of technical intervention in cognitive function in humans, and more particularly to systems and methods for assessing or screening cognitive function (particularly cognitive function deficits or disorders) in humans.
Background
With the development of human society, the incidence rate of cognitive deficit diseases is higher and higher, and the diseased population is larger and larger, which has formed a serious threat to human health.
In general, cognitive dysfunction mainly includes: perception defects, memory defects, thinking defects, etc., such as, but not limited to: attention Deficit and Hyperactivity Disorder (ADHD), traumatic Brain Injury (TBI), prion disease dementia, parkinson's disease, cerebral amyloid angiopathy, huntington's disease or other neurodegenerative disorders, autism Spectrum Deficit (ASD), sensory Processing Deficit (SPD), mild Cognitive Impairment (MCI), alzheimer's Disease (AD), schizophrenia, depression, anxiety, learning or memory deficit, adult attention deficit, aphasia, agnosia, and the like.
In recent years, with the improvement of medical level, in combination with the rapid development of interdisciplines such as biological information detection technology, artificial intelligence technology, mobile internet technology, communication technology and the like, besides the traditional chemical drug development path, a new path has been developed: "digital medicine" or "digital therapy". The term "digital medicine" or "digital therapy" is generally based on medical, mobile internet, high-speed telecommunication networks, wearable devices, intelligent software and other technical devices, which are used to measure, evaluate and/or intervene in human health based on clinical information data. In the field of cognitive deficit diseases, due to the lack of effective treatment methods, a long-term constant adherence is usually required to gradually obtain a certain curative effect, and the occurrence of a novel digital medicine or digital therapy is at the right moment. Currently, with intensive research in brain science, neuropsychology, etc., attempts have been made to modulate (including but not limited to screening, assessment, training, improvement or promotion) cognitive dysfunction in humans using the above-described "digital drugs" or "digital therapies" as a technological intervention.
However, when the cognitive function is regulated by using the technical intervention means, one problem faced first is how to evaluate the cognitive function of a tested person or user, or evaluate or screen the specific situation of the cognitive function defect of the user, so as to provide sufficient basis for the subsequent targeted provision of the personalized technical intervention scheme.
For example, attention deficit/hyperactivity disorder (attention deficit hyperactivity disorder, hereinafter simply referred to as "ADHD") is a neuropsychiatric cognitive disorder of relatively high current interest, which is often manifested as symptoms such as hyperactivity, impulsivity, and/or lack of attention, oppositional defiance, and the like. ADHD can severely affect a person's cognitive abilities, academia, behavior, mood, and social functions. Moreover, ADHD and anxiety, depression, and oppositional defiant disorder are often co-morbid. ADHD can cause learning disorders and even abuse of addictive substances such as alcohol.
In the technical intervention regulation of ADHD, comprehensive evaluation in aspects of medicine, development, education, psychology and the like is required to be comprehensively considered first to determine whether a subject or user has core symptoms and continuous, common and functional complications thereof.
One conventional approach is cognitive scale analysis. For example, professionals need to interview with a subject or user and their close relatives, review information about the subject or user in learning and life, to comprehensively assess co-existence of mood and/or behavioral disorders. These comprehensive evaluations include, but are not limited to: medical evaluation, such as the birth information of a tested person or user, the conditions of tobacco, alcohol or other substances, perinatal complications or infection, central nervous system infection, head trauma, recurrent otitis media, medication and the like of a parent; developmental and behavioral assessments, such as age at which ADHD core symptoms begin to appear, symptom duration, environment in which symptoms appear, and degree of functional impairment; educational assessment, such as educational assessment, is focused on verifying whether a subject or user has a core symptom of ADHD in an educational environment; auxiliary assessment, such as assessment of speech and language (language or communication disorder), skill training assessment (movement coordination disorder), mental health assessment (mood disorder, anxiety, oppositional defiant disorder, conduct disorder, obsessive-compulsive disorder, post-traumatic stress disorder, adaptation disorder), blood lead level (lead poisoning), thyroid hormone level (thyroid disease), genetic detection and/or genetic counseling (fragile X-chromosome syndrome), overnight polysomnography for children with obstructive sleep apnea syndrome or restless leg syndrome indicative symptoms and/or risk factors, neurologic consultation or EEG (neurological or seizure disorder); co-morbid assessment of ADHD, such as assessment of oppositional defiant disorder, conduct disorder, depression, anxiety disorder, and learning disorder.
In order to collect and obtain this information, it is necessary to design multiple cognitive rating scales to clarify the specific conditions of ADHD present in the subject or user. The screening or evaluation of this cognitive scale analysis is deficient in: too much on human subjectivity. The design, information acquisition and information analysis of the cognitive scale are seriously dependent on subjective cognition of participants, and the objectivity is poor. Moreover, the manner in which such conventional scale analysis is evaluated is subject to a number of interfering factors, such as, for example, possible interfering factors including, but not limited to, intelligence, language, memory, etc., which can cause the test results to be affected by these factors.
Therefore, for the evaluation mode of the conventional scale analysis, since objectivity is poor and it is easily adversely affected by interference factors, it is difficult to accurately and completely reflect the actual condition of a user or a subject in terms of cognitive functions (particularly, attention and executive functions).
In view of this, how to provide a cognitive function evaluation scheme with stronger objectivity and less interference by interference factors, so as to obtain a screening evaluation result of cognitive function with higher accuracy and reliability, which is a technical problem to be solved in the field.
Disclosure of Invention
The evaluation or screening scheme can objectively evaluate and screen the cognitive function by using a technical intervention means, is not easily interfered by interference factors, and can obtain a screening evaluation result of the cognitive function with higher accuracy and reliability.
According to one aspect of the present application, there is provided an evaluation system of cognitive function, the evaluation system of cognitive function comprising: a processor for selecting a stimulation protocol from a stimulation database; a stimulus presentation device in communication with the processor for presenting a stimulus regimen to a user; interaction means for the user to interactively operate in response to the stimulation protocol; a data acquisition device for acquiring operational data of the user for interactive operation in response to the stimulation protocol for assessing cognitive function of the user, wherein the stimulation protocol comprises: the first stimulation signals are displayed in sequence according to a preset or random sequence, the user is required to perform interactive operation by using the interactive device, and the second stimulation signals are required to perform no interactive operation or different interactive operations by the user.
Preferably, the evaluation system comprises an evaluation device in communication with the data acquisition device for receiving the operation data provided by the data acquisition device and evaluating the cognitive function of the user based on the operation data.
Preferably, the evaluation device and the processor are integrally arranged, or the evaluation device and the processor are mutually independent; and/or the evaluation device is communicated with the processor and is used for transmitting the evaluation result of the cognitive function of the user to the processor, and the processor selects an updated stimulation scheme according to the evaluation result.
Preferably, at least two of the stimulus presentation device, the interaction device and the data acquisition device are integrally arranged or are arranged independently of each other.
Preferably, the stimulation signals of the stimulation protocol are visual stimulation signals, auditory stimulation signals, tactile stimulation signals, gustatory stimulation signals, or motor perception stimulation signals.
Preferably, the first stimulus signal and the second stimulus signal are visual stimulus signals, and the graphic features of the first stimulus signal and the graphic features of the second stimulus signal are in an intersection relationship, so as to induce the user to make the same operation.
Preferably, the graphic features of the first stimulus signal and the graphic features of the second stimulus signal are the same in the same overall area displayed in the same stimulus display device.
Preferably, the area of the intersection between the graphic features of the first stimulation signal and the graphic features of the second stimulation signal is greater than or equal to 50%, preferably greater than or equal to 60%, more preferably greater than or equal to 80%, and most preferably between 85% and 95% of the total area of the graphic features of the first stimulation signal or the total area of the graphic features of the second stimulation signal.
Preferably, the overall presentation time of the stimulation regimen is from 5 minutes to 30 minutes, preferably from 8 minutes to 15 minutes, and even more preferably from 9 minutes to 12 minutes.
Preferably, the total number of the first and second stimulation signals of the stimulation protocol is at least 100, preferably 150 to 1000, more preferably 300 to 800, most preferably 500 to 700.
Preferably, the duration of each of the first and second stimulation signals in the stimulation protocol is at least 50 milliseconds, preferably at least 100 milliseconds, more preferably 80-200 milliseconds, and most preferably 100-150 milliseconds.
Preferably, the time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1000 to 3000 milliseconds, preferably 1500-2500 milliseconds, more preferably 1800-2200 milliseconds, most preferably 2000 milliseconds.
Preferably, in the stimulation protocol, n first stimulation signals are displayed consecutively and m second stimulation signals are displayed subsequently; and/or n second stimulus signals are displayed continuously, and m first stimulus signals are displayed subsequently, wherein n is a natural number greater than or equal to 3, and m is 1, 2 or 3.
Preferably, the displaying of the stimulation scheme includes at least two time periods with different frequency ratios of the stimulation signals, and in one displaying time period, the frequency of occurrence of the first stimulation signal is smaller than that of the second stimulation signal; and/or in another presentation period, the number of occurrences of the first stimulus signal is greater than the number of occurrences of the second stimulus signal.
Preferably, in the one display period, the ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 1/5 to 1/2, preferably 1/3 to 1/4; and/or in the further presentation period the ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 2 to 5, preferably 3 to 4. Alternatively, the ratio of the number of occurrences may be a ratio close to a constant.
Preferably, the one presentation time period precedes the other presentation time period; or alternatively, the one presentation time period and the other presentation time period are presented alternately.
Preferably, the operation data of the user performing an interactive operation in response to the stimulation protocol includes at least one of: a) Reaction time; b) The amount of change in reaction time; c) Missing error conditions including the number of times the first or second stimulus signal is missed; d) Misjudging error conditions including the number of interactions that made an error to the first stimulus signal or the second stimulus signal; e) Guessing an error condition: making a false guess for the next stimulus signal results in a missing error or misjudgment error.
Preferably, the evaluation device includes: and the macro evaluation module is used for evaluating the cognitive function of the user according to the overall operation data of the user for the interactive operation of the stimulation scheme.
According to another aspect of the present application, there is also provided a method for evaluating cognitive function, the method for evaluating cognitive function including: selecting a stimulation protocol from a stimulation database; presenting the stimulation regimen to a user; causing the user to interoperate in response to the stimulation protocol; collecting operational data of the user for interactive operation in response to the stimulation protocol for assessing cognitive function of the user, wherein the stimulation protocol comprises: the first stimulation signals are displayed in sequence according to a preset or random sequence, the user is required to perform interactive operation by using the interactive device, and the second stimulation signals are required to perform no interactive operation or different interactive operations by the user.
Preferably, the stimulation signals of the stimulation protocol are visual stimulation signals, auditory stimulation signals, tactile stimulation signals, gustatory stimulation signals, or motor perception stimulation signals.
Preferably, the first stimulus signal and the second stimulus signal are visual stimulus signals, and the graphic features of the first stimulus signal and the graphic features of the second stimulus signal are in an intersection relationship, so as to induce the user to make the same operation.
Preferably, the graphic features of the first stimulus signal and the graphic features of the second stimulus signal are the same in the same overall area displayed in the same stimulus display device.
Preferably, the area of the intersection between the graphic features of the first stimulation signal and the graphic features of the second stimulation signal is greater than or equal to 50%, preferably greater than or equal to 60%, more preferably greater than or equal to 80%, and most preferably between 85% and 95% of the total area of the graphic features of the first stimulation signal or the total area of the graphic features of the second stimulation signal.
Preferably, the overall presentation time of the stimulation regimen is from 5 minutes to 30 minutes, preferably from 8 minutes to 15 minutes, and even more preferably from 9 minutes to 12 minutes.
Preferably, the total number of the first and second stimulation signals of the stimulation protocol is at least 100, preferably 150 to 1000, more preferably 300 to 800, most preferably 500 to 700.
Preferably, the duration of each of the first and second stimulation signals in the stimulation protocol is at least 50 milliseconds, preferably at least 100 milliseconds, more preferably 80-200 milliseconds, and most preferably 100-150 milliseconds.
Preferably, the time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1000 to 3000 milliseconds, preferably 1500-2500 milliseconds, more preferably 1800-2200 milliseconds, most preferably 2000 milliseconds.
Preferably, in the stimulation protocol, n first stimulation signals are displayed consecutively and m second stimulation signals are displayed subsequently; and/or n second stimulus signals are displayed continuously, and m first stimulus signals are displayed subsequently, wherein n is a natural number greater than or equal to 3, and m is 1, 2 or 3.
Preferably, the displaying of the stimulation scheme includes at least two time periods with different frequency ratios of the stimulation signals, and in one displaying time period, the frequency of occurrence of the first stimulation signal is smaller than that of the second stimulation signal; and/or in another presentation period, the number of occurrences of the first stimulus signal is greater than the number of occurrences of the second stimulus signal.
Preferably, in the one display period, the ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 1/5 to 1/2, preferably 1/3 to 1/4; and/or in the further presentation period the ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 2 to 5, preferably 3 to 4.
Preferably, the one presentation time period precedes the other presentation time period; or alternatively, the one presentation time period and the other presentation time period are presented alternately.
Preferably, the operation data of the user performing an interactive operation in response to the stimulation protocol includes at least one of: a) Reaction time; b) The amount of change in reaction time; c) Missing error conditions including the number of times the first or second stimulus signal is missed; d) Misjudging error conditions including the number of interactions that made an error to the first stimulus signal or the second stimulus signal; e) Guessing an error condition: making a false guess for the next stimulus signal results in a missing error or misjudgment error.
Preferably, the evaluation method includes: and evaluating the cognitive function of the user according to the overall operation data of the interactive operation of the user aiming at the stimulation scheme.
According to still another aspect of the present application, there is further provided an application of the system for evaluating cognitive function or the method for evaluating cognitive function in a cognitive function deficiency, where the system for evaluating cognitive function is the system for evaluating cognitive function provided by the present application, and the method for evaluating cognitive function is the method for evaluating cognitive function provided by the present application.
According to still another aspect of the present application, there is also provided an evaluation system of cognitive function, the evaluation system of cognitive function including: a computer host provided with an operating system for selecting a stimulation protocol; a stimulus presentation device in communication with the computer for presenting a stimulus regimen to a user; interaction means for the user to interactively operate in response to the stimulation protocol; a data acquisition means for acquiring operation data of the user performing an interactive operation in response to the stimulus regimen and transmitting the operation data to the computer for evaluating a cognitive function of the user, wherein the computer host has a processing time delay from receiving an instruction to transmitting the stimulus regimen to the stimulus presentation means, the stimulus presentation means has a presentation time delay from receiving the stimulus regimen from the computer host to completing presentation to the user, and the interactive means or the data acquisition means has a acquisition time delay from receiving an operation signal of the user to transmitting the operation signal to the computer host, wherein a total delay of a sum of the processing time delay, the presentation time delay and the acquisition time delay is 0 to 60ms, preferably 0 to 30ms, more preferably 0 to 10ms, still more preferably 0 to 5ms; and/or the error of the total delay is not more than 30ms, preferably not more than 10ms, and even more preferably not more than 1ms; and/or any one of the processing time delay, the presentation time delay and the acquisition time delay is 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, still more preferably 0 to 1ms; and/or any one of the processing time delay, the presentation time delay and the acquisition time delay is a preset fixed value, and the minimum value of the fixed value is zero.
Preferably, the stimulus display device is a display screen; or the stimulation display device, the interaction device and the data acquisition device are integrated into a touch screen; or the interaction device and the data acquisition device are integrated into a keyboard or a mouse; or the stimulation display device is virtual reality or augmented reality equipment, and the interaction device and the data acquisition device are integrated into a handle operation device.
According to a further aspect of the present application there is also provided a computer host for reaction time detection in the field of cognitive functions, the computer host having a processing time delay between the receipt of an instruction and the transmission of a stimulus regimen to the stimulus presentation device, the processing time delay being 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, still more preferably 0 to 1ms.
According to a further aspect of the present application there is also provided a stimulus presentation device for response time detection in the field of cognitive functions, said stimulus presentation device having a presentation time delay between receipt of a stimulus regimen from a computer host and completion of presentation to said user, the presentation time delay being 0 to 30ms, preferably 0-10ms, more preferably 0-5ms, still more preferably 0-1ms. Preferably, the stimulus presentation means is a display screen or a touch screen or a virtual reality or augmented reality device.
According to still another aspect of the present application, there is further provided an interactive terminal for performing reaction time detection in the cognitive function field, where the interactive terminal is configured to allow the user to perform interactive operation in response to a stimulus scheme, collect operation data of the user performing interactive operation in response to the stimulus scheme, and send the operation data to a host computer, and the interactive terminal has a collection time delay between receiving an operation signal of the user and sending the operation signal to the host computer, where the collection time delay is 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, and still more preferably 0 to 1ms. Preferably, the interactive terminal comprises an interactive device and a data acquisition device. Preferably, the interactive terminal is a keyboard and/or a mouse.
According to the technical scheme, the data acquisition device is used for acquiring the operation data of the user in response to the first stimulation signal to be subjected to interactive operation and the second stimulation signal not to be subjected to interactive operation, so that the cognitive function can be objectively evaluated and screened, and the cognitive function is not easily interfered by interference factors, so that the screening and evaluating result of the cognitive function with higher accuracy and reliability can be obtained.
Additional features and advantages of the present application will be set forth in the detailed description which follows.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application, illustrate embodiments of the application and together with the description serve to explain the application. In the drawings:
FIG. 1 is a schematic system architecture diagram of an assessment scheme for cognitive function according to a preferred embodiment of the present application;
FIG. 2 is a schematic diagram of a set of logical relationships between graphical features of a first stimulus signal and graphical features of a second stimulus signal in accordance with a preferred embodiment of the present application;
fig. 3A and 3B are examples of graphical features of a first stimulation signal and graphical features of a second stimulation signal, respectively, according to a preferred embodiment of the present application.
Detailed Description
The technical solutions of the present application will be described in detail below with reference to the accompanying drawings in combination with embodiments. The description or explanation of the technical solutions and the technical features thereof in this application is exemplary or illustrative, and is not intended to limit the protection scope of this application. It will be appreciated by persons skilled in the art that the technical solutions for the present application may be implemented in the same or similar manner as described in the present application, and are not limited to the embodiments specifically described in the present application.
As described in the background, conventional cognitive deficits (even disorders) are mostly qualitatively assessed using screening scales, which are greatly affected by subjective factors of the filling person. Moreover, in the conventional evaluation and screening method, various interference factors such as intelligence, language, educational background and the like exist, which makes it difficult to objectively, accurately and reliably reflect the actual situation of the cognitive function of the user or the subject, especially the actual situation of the attention and/or suppression as the object of the cognitive function, because the screening evaluation result is adversely affected by these interference factors.
For the above conventional screening or evaluation scheme of cognitive functions, as shown in fig. 1, the present application proposes an evaluation system of cognitive functions, where the evaluation system of cognitive functions includes: a processor for selecting a stimulation protocol from a stimulation database; a stimulus presentation device in communication with the processor for presenting a stimulus regimen to a user; interaction means for the user to interactively operate in response to the stimulation protocol; a data acquisition device for acquiring operational data of the user for interactive operation in response to the stimulation protocol for assessing cognitive function of the user, wherein the stimulation protocol comprises: the first stimulation signals are displayed in sequence according to a preset or random sequence, the user is required to perform interactive operation by using the interactive device, and the second stimulation signals are required to perform no interactive operation or different interactive operations by the user.
The stimulation signals of the stimulation protocol are visual stimulation signals, auditory stimulation signals, tactile stimulation signals, gustatory stimulation signals, or motion-sensing stimulation signals (e.g., forward, backward, rotational, acceleration, deceleration, ascending, descending, etc. motion stimulation may be applied to the user). In some embodiments, a combination of the different types of stimulation signals described above is also possible. Based on the different types of stimulation signals, an appropriate stimulation presentation device and/or data acquisition device may be selected. Hereinafter, a visual stimulus signal will be mainly described as an example, but it is understood that this is only exemplary and not limiting to the scope of the present application, and that these applicable embodiments fall within the scope of the present application for other types of stimulus signals (e.g., auditory stimulus signals, tactile stimulus signals, or gustatory stimulus signals, etc.).
The processor may be various devices (such as a control chip), modules or units (such as a CPU) having an information processing function, such as a desktop computer, a notebook computer, a server, a workstation, a smart phone, a tablet computer, etc.; or alternatively, the processor may be a cloud server. In the present application, the processor is provided with a program that realizes the functions described in the present application. The processor may be provided with a storage function or with a memory, or in communication with a separate memory for mutual data interaction, whereby upon evaluation of the cognitive function a stimulation protocol is selected from a stimulation database, suitable for subsequent evaluation and screening of the cognitive function. According to various embodiments, the stimulation database may include a plurality of stimulation protocols, wherein each stimulation protocol is used to evaluate or screen one or more cognition functional subjects.
The stimulation presentation device is in communication with the processor and upon selection of a stimulation protocol by the processor, data information of the stimulation protocol is transmitted to the stimulation presentation device for presentation (e.g., visual) of the stimulation protocol to a user. The stimulus presentation means may be, for example, a display screen, glasses, etc. After the stimulation display device displays the stimulation scheme to the user, the interaction device is used for at least one user to interactively execute or not to interactively execute. According to various embodiments, the interactive apparatus may take many different forms, including, but not limited to, a smart phone, a tablet computer, a notebook computer, a desktop computer, a headset with interactive functions, a display, glasses, an augmented reality device, and a virtual reality device.
The data acquisition device is used for acquiring operation data of the user for performing interactive operation and/or non-interactive operation in response to the stimulation scheme, so as to evaluate the cognitive function of the user. The data acquisition terminals come in a variety of forms including, but not limited to, gyroscopes, accelerometers, speedometers, motion sensors, pressure sensors, optical sensors, audio acquisition devices, video acquisition devices, auditory sensors, vibration sensors, brain scanning or monitoring instruments.
Preferably, the evaluation system comprises an evaluation device in communication with the data acquisition device for receiving the operation data provided by the data acquisition device and evaluating the cognitive function of the user based on the operation data. The evaluation device can be a single device, module or unit with information operation processing function, and the evaluation device and the processor are arranged independently; in some embodiments, the data acquisition device may be integrated with the processor, wherein the data acquisition device is in communication with the processor, such that the operational data is transmitted to the processor, which evaluates and screens the cognitive function of the user.
Preferably, according to the technical solution of the present application, the evaluation solution is an iterative operation. Specifically, the evaluation device is in communication with the processor and is configured to send an evaluation result of the cognitive function of the user to the processor, and the processor selects an updated stimulation regimen according to the evaluation result. Therefore, the technical scheme of the application can adaptively adjust the applied stimulation scheme, so that a screening evaluation result with higher objectivity, accuracy and reliability is made for the cognitive function of the user.
According to different application conditions, at least two of the stimulation display device, the interaction device and the data acquisition device are integrated or are arranged independently of each other. For example, the interactive terminal and the data acquisition terminal may be integrally provided and implemented using the data acquisition function of the interactive terminal. For example, when the tablet personal computer is used as the interaction terminal, the tablet personal computer can be used as the data acquisition terminal, and the operation data of the user can be obtained by acquiring the operation information of the user on the tablet personal computer. For another example, the interaction terminal and the processor can be integrally arranged, and the functions of the data acquisition device, the processor, the interaction device and the stimulation display device can be realized by arranging corresponding application programs for the tablet personal computer. Or as a further alternative embodiment, the interactive terminal, the data acquisition terminal and the stimulation presentation device are at least partially provided independently. For example, the interactive terminal and the stimulus presentation device are smart phones, and the processor is a server in the cloud.
The above-mentioned "terminal" can be understood as a plurality of embodiments according to different application scenarios. For example, the interactive terminal may be a physical terminal, such as the smart phone, the computer, etc. described above; or can also be understood as a software terminal, such as an APP installed on the smart phone, tablet computer, or an application installed on a desktop computer, etc.; or a combination of physical and software terminals.
Thus, when the above-mentioned evaluation system for cognitive functions is used to implement the screening evaluation method, the method includes: selecting a stimulation protocol from a stimulation database; presenting the stimulation regimen to a user; causing the user to interoperate in response to the stimulation protocol; operational data of the user interoperating in response to the stimulation protocol is collected for assessing cognitive function of the user.
In the technical solution of the present application, the key content is the design choice of the stimulation solution. The stimulation regimen includes: a plurality of first stimulus signals and a plurality of second stimulus signals displayed in sequence according to a predetermined or random order, wherein the first stimulus signals are displayed such that the user is required to perform an interactive operation by using the interactive device, and the second stimulus signals are displayed such that the user is not required to perform any interactive operation or perform a different interactive operation (herein, "different" means that the user performs a different interactive operation with respect to the interactive operation performed by the user when the user is in response to the first stimulus signals, and the second stimulus signals are processed).
The first stimulus signal requires the user to perform interactive operation on the interactive device, such as clicking a keyboard or a screen or making a certain action; the second stimulus signal is displayed so as to require the user to do no interaction or to do different interactions. The display sequence of the first stimulation signal and the second stimulation signal can be preset or random. By manipulating the data of the user in response to the first and second stimulus signals, the cognitive function of the user, or certain specific cognitive function objects, such as, inter alia, attention and/or suppression, can be reflected.
In the technical scheme of the application, a first stimulation signal requiring the user to perform interactive operation on the interactive device and a second stimulation signal requiring the user to do no interactive operation (or perform different interactive operations) are arranged to form the visual stimulation scheme. This is because: when a plurality of first stimulus signals (or a plurality of second stimulus signals) are continuously present, the user may be required to continuously react to (or not to, or to do a different interaction with) the continuously present first stimulus signals (or second stimulus signals) in a state where the user is continuously excited to respond to the subsequently present stimulus signals, often with "inertia", tending to react to the same interaction as the previously continuously present first stimulus signals (or second stimulus signals). However, once the second stimulus signal (or the first stimulus signal) that does not require an interactive response is suddenly presented, the user is liable to make a wrong response due to the previous inertial effects. The present application uses the easily occurring erroneous judgment to collect the related operation data, so as to evaluate or screen the cognitive function of the user or the condition of some objects thereof. For example, the false positive error rate is an evaluation parameter for effective impulse suppression capability. For example, statistically speaking, the guessing error rate of healthy people is generally higher than that of ADHD patients according to the demographics of normal models, because healthy people are more prone to form the above-mentioned "inertia", while ADHD patients are less prone to form the above-mentioned "inertia", so that by comparing the operation data of the user with the operation data of normal models, it can be judged whether the cognitive function situation of the user is within the category of healthy people. This will be described hereinafter. The first stimulus signal and the second stimulus signal are preferably visual stimulus signals, and the visual stimulus signals are described herein as examples, but the first stimulus signal and the second stimulus signal are merely exemplary and not limiting the scope of the application, and the first stimulus signal and the second stimulus signal can be applied to other types of stimulus models, and all modifications are within the scope of the application.
Based on this principle, the display order of the plurality of first stimulation signals and the plurality of second stimulation signals may be of a predetermined design or may be random. But preferably, in order to facilitate the formation of said "inertia", n first stimulus signals are displayed consecutively and m second stimulus signals are displayed subsequently in said visual stimulus scheme; and/or n second stimulus signals are displayed continuously, and m first stimulus signals are displayed subsequently, wherein n is a natural number greater than or equal to 3, and m is 1, 2 or 3. After the n stimulus signals are continuously displayed, the purpose is to enable the user to generate 'inertia' in response to the n stimulus signals (the first stimulus signal or the second stimulus signal) which are continuously displayed. The greater the number of identical stimulus signals that are displayed in succession, the greater the "inertia" of the response to the stimulus signals, while the greater the probability of making a false decision for the response to a different stimulus signal that is subsequently abrupt. The above selections of n and m are for illustration only and are not intended to limit the scope of the present application. For example, according to various embodiments, n may be a natural number equal to or greater than 2, and m is 1 or 2; or 1, 2 or 3. The total number of the first and second stimulation signals of the visual stimulation protocol is at least 100, preferably 150 to 1000, more preferably 300 to 800, most preferably 500 to 700.
In the displaying of the visual stimulus scheme, the displaying of the visual stimulus scheme preferably comprises at least two time periods with different frequency ratios of stimulus signals, and in one displaying time period, the frequency of occurrence of the first stimulus signal is smaller than that of the second stimulus signal; and/or in another presentation period, the number of occurrences of the first stimulus signal is greater than the number of occurrences of the second stimulus signal.
Thus, during the one presentation period, the number of occurrences of the first stimulus signal is less than the number of occurrences of the second stimulus signal, and the user is continuously not in operative interaction due to the successive occurrences of the second stimulus signal, thereby being in a low-alertness relaxed state; when the first stimulus signal appears, the response speed is different according to the difference of the concentration degree of the user, and the variation range of the response speed is also different, so that based on the concentration degree, the missing error of the first stimulus signal can generate different operation data according to different users, and the method can be used for evaluating the concentration of the user.
In the other display period, the number of occurrences of the first stimulus signal is greater than the number of occurrences of the second stimulus signal, so that the user is required to continuously respond to the first stimulus signal and keep excited, and the second stimulus signal suddenly appearing after the so-called "inertia" is formed, which may pose a challenge to the user with poor suppression function: the interactive operation is misjudged when the interactive operation is not conducted. Therefore, the false positive error rate is an important parameter for evaluating the impulse suppression ability of the user, and to some extent, the parameter also reflects the concentration of the user.
The one presentation time period and the other presentation time period may have different arrangements. For example, the one presentation time period may precede the other presentation time period; or displaying the another display time period first and then displaying the one display time period; or the one display time period and the other display time period are multiple, and the two display time periods are alternately displayed.
In the one display period, the ratio of the occurrence number of the first stimulation signals to the occurrence number of the second stimulation signals is 1/5 to 1/2, preferably 1/3 to 1/4, so as to adapt to the design requirement of 'inertia' in different working occasions. In the further presentation period, the ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 2 to 5, preferably 3 to 4.
While the above has been described in terms of factors such as the order and number of the first and second stimulation signals displayed in the visual stimulation signals, the preferred embodiment of the present application is not limited thereto, and the visual expression form may be selected.
The graphical information or the graphical features of the first stimulus signal may be completely different from the graphical information or the graphical features of the second stimulus signal, but in this case it is not very easy to induce a misjudgment error or a missing error to the user when performing the evaluation. Thus, preferably, the graphical features of the first stimulus signal and the graphical features of the second stimulus signal are in an intersecting relationship for inducing the same operation by the user. The term "intersection relationship" as used herein refers to a portion of the first stimulus signal having the same graphic characteristics as the graphic characteristics of the second stimulus signal, and a different portion for allowing the user to distinguish between the first stimulus signal and the second stimulus signal, as shown in fig. 2. For example, the first stimulus signal and the second stimulus signal may have the same shape, but different colors; or have the same shape but different sizes, etc. Thus, the selection of the design intersection and the distinction portions may be made for different parameters of the graphical feature. It should be noted that, since the first stimulus signal and the second stimulus signal are not typically presented on the stimulus display device at the same time, the "intersection relationship" as used herein does not refer to the interference portion between the two patterns at the time of display, but rather the same portion therebetween although separately displayed.
Preferably, in order to further increase the approximation of the first and second stimulation signals, the graphical features of the first stimulation signal and the graphical features of the second stimulation signal are the same in the same overall area displayed in the same stimulation display device. Still preferably, the contour shape is the same.
To increase the approximation, the area of the intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is more than 50%, preferably more than 60%, still more preferably more than 80%, most preferably 85% -95% of the total area of the graphical features of the first stimulation signal or the total area of the graphical features of the second stimulation signal. It is apparent that the larger the area of the intersection portion, the greater the approximation of the first stimulus signal and the second stimulus signal, as shown in fig. 2.
For example, as shown in the first stimulus signal of fig. 3A and the second stimulus signal of fig. 3B, the difference between the two stimulus signals is only the difference between the apple positions, so that other portions except for the difference between the apple positions can be regarded as intersection portions of the first stimulus signal and the second stimulus signal. Here, fig. 3A and 3B illustrate only one exemplary stimulation signal graphical feature, and the present application is not limited thereto, but other types of suitable graphics may be selected, such as faces, environmental objects, mathematical geometries, geological geographies, emotional expressions, and the like.
The consideration of the graphical features or visual manifestations of the first and second stimulation signals is described in detail above, but the application is not limited thereto, and the adjustment of the time parameters of the first and second stimulation signals may also be considered.
Preferably, the total presentation time of the visual stimulus regimen is from 5 minutes to 30 minutes, preferably from 8 minutes to 15 minutes, and more preferably from 9 minutes to 12 minutes, so as to not only satisfy the need to obtain sufficient operational data, but also avoid putting a great deal of care on the user or subject.
In order to provide sufficient visual stimulation of the brain of the user, the duration of each of the first and second stimulation signals in the visual stimulation regimen is at least 50 milliseconds, preferably at least 100 milliseconds, more preferably 80-200 milliseconds, and most preferably 100-150 milliseconds. And the time interval between adjacent ones of the first and/or second stimulation signals in the visual stimulation protocol is 1000 to 3000 milliseconds, preferably 1500-2500 milliseconds, more preferably 1800-2200 milliseconds, and most preferably 2000 milliseconds.
As described above, in the technical solution of the present application, the cognitive function of the user is evaluated and screened according to the operation data of the user performing the interactive operation in response to the visual stimulus solution. The operational data may include at least one of:
a) Reaction time (milliseconds);
b) The amount of change in reaction time (milliseconds);
c) Missing error conditions, including the number of times the first or second stimulus signal is missed (primarily for assessing the degree of concentration);
d) Misjudging error conditions including the number of interactions that made an error to either the first stimulus signal or the second stimulus signal (primarily for evaluating the ability to control suppression of impulses);
e) Guessing an error condition: making a false guess for the next stimulus signal results in a missing error or misjudgment error.
The technical scheme of the application can comprise a macroscopic evaluation module, wherein the macroscopic evaluation module is used for evaluating the cognitive function of the user according to the overall operation data of the user for carrying out interactive operation on the visual stimulus scheme. By analyzing and researching the macroscopic data, the situation of the overall cognitive function of the user can be known.
The evaluation system and the evaluation method of the present application are described in detail above. In addition, the application also provides an application of the cognitive function assessment system or the cognitive function assessment method in the cognitive function defect (or even disorder such as attention deficit/hyperactivity disorder), wherein the cognitive function assessment system is the cognitive function assessment system of the application, and the cognitive function assessment method is the cognitive function assessment method of the application. In addition, while the description herein will be described primarily in terms of screening and assessment of ADHD, it should be understood that this is by way of example only, and the present application is not limited to use in screening and assessment of other types of cognitive dysfunction (even disorders), and modulation of other types of cognitive dysfunction or disorder (screening, assessment, training) is within the scope of the present application.
From the above description, the technical solution of the present application has the following advantages: the method provides a relatively objective and databased screening and evaluating mode; the operation is simple and easy to understand, and the requirement on a user or a tested person is low; for the evaluator, no complicated operation instruction is required for the user; the application range is wide, and the Chinese medicinal composition can be used for people over 4 years old to 80 years old; moreover, the time required for the screening evaluation is relatively friendly, and can be generally about 20 minutes, and can be shortened to about 10 minutes for children; in addition, the technical scheme is not influenced by interference factors such as culture, language, left-right hand operation and the like, can focus on evaluating or screening a target cognitive function object, such as measuring attention and inhibiting power in isolation, and shielding interference factors such as language level, hand agility, knowledge level and the like which influence the accuracy of an evaluation result; moreover, the practice effect of the scheme is low, and the method can be used for clinical repeated screening and evaluation tests, for example, the method can be used for evaluating the effect of ADHD children before and after treatment.
From the above description, it is known that in the field of cognitive functions, detection of the response time of a user is very important. Many screening, assessment, training, etc. of cognitive functions rely on accurate detection of the user's response time. When the cognitive function of the user is regulated (evaluated, screened, trained and the like), the stimulation scheme is generated from the processor (such as a computer host) and sent to the stimulation display device (such as a display screen and/or a sound emitting device), after the stimulation display device displays the stimulation signals of the stimulation scheme to the user, the user performs interactive operation on the interactive device, and operation data (such as the response time of the core parameters) of the interactive operation are collected by the data collection device and sent to the processor (or the computer host). In the embodiment of integrating the interaction device and the data acquisition device into the interaction terminal, the interaction terminal sends the operation data to the host computer after receiving the operation instruction of the user.
In the whole information transmission process, besides that the response time of the user receiving the stimulation signal and making operation is the target parameter to be detected, the detection of the response time caused by the time delay of the system itself constitutes noise. This time delay is mainly due to: the computer host has a processing time delay between receiving an instruction and sending a stimulation protocol to the stimulation display device, the stimulation display device has a presentation time delay between receiving the stimulation protocol from the computer host and completing the display to the user, and the interaction device or the data acquisition device has an acquisition time delay between receiving an operation signal of the user and sending the operation signal to the computer host.
For example, for a computer host, the information processing speeds of different configurations may be inconsistent, even though the same hardware configuration may be inconsistent when performing different tasks. For a stimulus presentation device, such as a display, a typical display has a display mode with a frame rate of 60 frames per second, that is, 16.67ms between the two frames presented. For another example, as for the keyboard of the interactive terminal, when the user clicks a key on the keyboard, the keyboard senses that the key is pressed and transmits the information to the host computer, and there is a time delay in this process.
Currently, the overall delay of conventional systems can be as high as 150ms, or even longer, which can have a very serious noise impact on detecting the user's reaction time, accounting for almost 30% to 100% of the reaction time. If this time delay is fixed, the noise can be directly subtracted upon detection of the reaction time, however, the overall delay in conventional regulatory systems and the time delays of the individual hardware devices are variable, even though the time delays are different when the same system or the same hardware device is performing different tasks, which can vary by up to 100ms. This results in accurate detection of the user's reaction time being very difficult enough to lead to erroneous assessment and diagnostic results. The inventor of the present application has found the existence of the above technical problem in the process of intensively studying cumin in the field, and proposed the following hardware solution according to the found technical problem.
The application provides an evaluation system of cognitive function for performing reaction time detection in the field of cognitive function, which comprises: a computer host provided with an operating system and evaluation software for selecting a stimulation protocol; a stimulus presentation device in communication with the computer for presenting a stimulus regimen to a user; interaction means for the user to interactively operate in response to the stimulation protocol; and the data acquisition device is used for acquiring operation data of the user for performing interactive operation in response to the stimulation scheme and transmitting the operation data to the computer for evaluating the cognitive function of the user, wherein the computer host has a processing time delay from the moment of receiving instructions of the evaluation software to the moment of transmitting stimulation signals to the stimulation display device, the stimulation display device has a presentation time delay from the moment of receiving the stimulation signals from the computer host to the moment of completing presentation to the user, and the interaction device or the data acquisition device has a acquisition time delay from the moment of receiving the operation signals of the user to the moment of transmitting the operation signals to the computer host. Wherein the total delay of the sum of the processing time delay, the presentation time delay and the acquisition time delay is 0 to 60ms, preferably 0 to 30ms, more preferably 0 to 10ms, still more preferably 0 to 5ms; and/or the total delay varies by no more than 10ms, preferably no more than 5ms, and even more preferably no more than 1ms; and/or any one of the processing time delay, the presentation time delay and the acquisition time delay is 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, still more preferably 0 to 1ms; and/or any one of the processing time delay, the presentation time delay and the acquisition time delay is a preset fixed value, and the minimum value of the fixed value is zero; and/or any of the processing time delay, the presentation time delay, and the acquisition time delay are notified to a user.
By controlling the parameters, the overall time delay of the system can be limited and optimized, the error (or variation) of the total delay can be limited and optimized, and the time delay of each hardware device of the system can be limited and optimized, or the time delay can be designed to be a preset fixed value, so that the noise can be filtered conveniently.
According to the scheme, the noise can be controlled in a smaller numerical range (even to zero) and/or set to a fixed value, so that the accurate detection of the response time of a user is relatively easy to realize, and the aim of the application is fulfilled; as an alternative, any one of the processing time delay, the presentation time delay and the acquisition time delay may be designed to be notified to the user, so that after the user or the operator knows the relevant time delay information, the noise may be directly removed during data analysis, and the purpose of the present application may also be achieved, so as to achieve accurate detection of the response time of the user (or the tested person).
The technical scheme is simple, but needs to be established on the basis of analysis and research on technical problems, the noise source is required to be found in millisecond-level information processing and data processing, the scientific research field of cognitive functions is not immersed for a long time, and no creative or creative labor is not realized at all.
The hardware devices in the above system may also be different according to different embodiments, for example, the stimulus display device may be a display screen or a sound emitting device; or the stimulation display device, the interaction device and the data acquisition device can be integrated into a touch screen; or the interaction device and the data acquisition device are integrated into a keyboard or a mouse; or the stimulation display device is virtual reality or augmented reality equipment, and the interaction device and the data acquisition device are integrated into a handle operation device. The evaluation system may be fixedly arranged or may be portable, depending on the application scenario.
The individual hardware devices of the above system may be arranged independently, preferably also integrated at least to some extent. The hardware devices may be hardware devices (such as a keyboard, a mouse, a display, etc.) commonly used in ordinary life, but the core parameter of the delay time is required to be modified or designed according to the technical scheme. Preferably, a dedicated hardware device dedicated to the detection of the reaction time of the user in the field of cognitive functions can be designed. For example, the keyboard may have only a few (e.g., 1-4) keys. The information connection between the hardware devices can also be designed without a time delay or with a time delay within an acceptably small range or with a fixed value. For example, the time delay between the host computer and the display may be zero. Or the time delay is signalled to the user.
In this application, various hardware devices are also provided. For example, a computer host, which is a computer host for performing reaction time detection in the cognitive function field, is provided with an operating system and evaluation software for selecting a stimulation scheme, and has a processing time delay from the moment of receiving an instruction of the evaluation software to the moment of sending a stimulation signal to the stimulation presentation device. Wherein, like the above-mentioned evaluation system, the processing time delay is 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, still more preferably 0 to 1ms; and/or the processing time delay varies by no more than 10ms, preferably no more than 5ms, and even more preferably no more than 1ms; and/or the processing time delay is a preset fixed value, and the minimum value of the fixed value is zero; and/or the processing time delay is signalled to the user.
For example, the stimulus display device is used for detecting response time in the cognitive function field, and the stimulus display device has a presentation time delay from the moment of receiving the stimulus signal from the host computer to the moment of completing presentation to the user, wherein the presentation time delay is 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, and still more preferably 0 to 1ms; and/or the presentation time delay is a preset fixed value, and the minimum value of the fixed value is zero; and/or the presentation time delay is signalled to the user. Preferably, the stimulus presentation means is a display screen or a touch screen or a virtual reality or augmented reality device.
For another example, the interactive terminal is used for detecting the response time in the cognitive function field, the interactive terminal is used for the user to perform interactive operation in response to a stimulation scheme, collecting operation data of the user to perform interactive operation in response to the stimulation scheme and sending the operation data to the computer host, and the interactive terminal has a collection time delay between the moment of receiving the operation signal of the user and the moment of sending the operation signal to the computer host, wherein the collection time delay is 0 to 30ms, preferably 0 to 10ms, more preferably 0 to 5ms, and still more preferably 0 to 1ms; and/or the change in the acquisition time delay is not more than 10ms, preferably not more than 5ms, and even more preferably not more than 1ms; and/or the acquisition time delay is a preset fixed value, and the minimum value of the fixed value is zero; and/or the acquisition time delay is informed to the user. The interactive terminal may comprise an interactive device and/or a data acquisition device. The interactive terminal may be a keyboard and/or a mouse.
It will be appreciated that while only some hardware devices have been listed in this specification as requiring time delay, this is by way of example only and not by way of limitation, and the design concept may be applied to all hardware and software devices currently and in the future that are suitable for use in the reaction time detection field, with the purpose of reducing noise or designing noise to a fixed or determinable value, or informing a user or operator of the noise. In addition, as described above, the stimulation signals of the stimulation protocol are visual stimulation signals, auditory stimulation signals, tactile stimulation signals, gustatory stimulation signals, or motor sensory stimulation signals. In some embodiments, a combination of the different types of stimulation signals described above is also possible. Based on the different types of stimulation signals, an appropriate stimulation presentation device and/or data acquisition device may be selected. Hereinafter, a visual stimulus signal will be mainly described as an example, but it is understood that this is only exemplary and not limiting to the scope of the present application, and that these applicable embodiments fall within the scope of the present application for other types of stimulus signals (e.g., auditory stimulus signals, tactile stimulus signals, gustatory stimulus signals, or motor sensory stimulus signals, etc.).
In addition, it should be particularly pointed out that, in each time range (e.g., 0 to 60ms,0-30ms,0-10ms,0-5ms, not more than 10ms (0-10 ms), not more than 5ms (0-5 ms), not more than 1ms (0-1 ms); 0-1ms, etc.) in the above technical content involving time delay, the technical solution of the present application covers the end point values of each time range, and the value of each point between the end point values of both ends that is increased or decreased by 0.1 ms. For example, for 0-1ms, the present application covers 0.0ms,0.1ms,0.2ms,0.3ms,0.4ms,0.5ms,0.6ms,0.7ms,0.8ms,0.9ms,1.0ms.
The preferred embodiments of the present application have been described in detail above, but the present application is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solutions of the present application within the scope of the technical concept of the present application, and all the simple modifications belong to the protection scope of the present application.
In addition, the specific features described in the foregoing embodiments may be combined in any suitable manner, and in order to avoid unnecessary repetition, various possible combinations are not described in detail.
Moreover, any combination of the various embodiments of the present application may be made without departing from the spirit of the present application, which should also be considered as disclosed herein.
Claims (61)
1. An evaluation system of cognitive function, the evaluation system of cognitive function comprising:
a processor for selecting a stimulation protocol from a stimulation database;
a stimulus presentation device in communication with the processor for presenting a stimulus regimen to a user;
interaction means for the user to interactively operate in response to the stimulation protocol;
a data acquisition device for acquiring operation data of the user for interactive operation in response to the stimulation protocol for evaluating cognitive functions of the user,
wherein the stimulation regimen comprises: at least one first stimulation signal and at least one second stimulation signal displayed in sequence according to a predetermined or random order, wherein the first stimulation signal when displayed requires the user to perform interaction operation by using the interaction device, and the second stimulation signal when displayed requires the user to do no interaction operation or perform different interaction operation,
In the stimulation protocol, n first stimulation signals are displayed consecutively and m second stimulation signals are displayed subsequently; and/or n second stimulus signals are displayed continuously, and m first stimulus signals are displayed subsequently, wherein n is a natural number greater than or equal to 3, and m is 1, 2 or 3.
2. The cognitive function assessment system of claim 1, wherein the assessment system includes an assessment device in communication with the data acquisition device for receiving the operational data provided by the data acquisition device and assessing the cognitive function of the user based on the operational data.
3. The cognitive function assessment system of claim 2, wherein the assessment device is provided integrally with the processor or is provided independently of the processor; and/or
The evaluation device is in communication with the processor for transmitting an evaluation of the cognitive function of the user to the processor, which selects an updated stimulation regimen based on the evaluation.
4. The cognitive function assessment system of claim 1, wherein at least two of the stimulus presentation device, the interaction device, and the data acquisition device are integrally provided or are provided independently of one another.
5. The cognitive function assessment system of claim 1, wherein the stimulation signal of the stimulation protocol is a visual stimulation signal, an auditory stimulation signal, a tactile stimulation signal, a gustatory stimulation signal, or a motor perception stimulation signal.
6. The cognitive function assessment system of claim 1, wherein the first and second stimulation signals are visual stimulation signals, and the graphical features of the first stimulation signal and the graphical features of the second stimulation signal are an intersection relationship for inducing the user to do the same.
7. The cognitive function assessment system of claim 6, wherein the graphical features of the first stimulation signal and the graphical features of the second stimulation signal are the same overall area displayed in the same stimulation display device.
8. The cognitive function assessment system of claim 7, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is greater than 50% of a total area of the graphical features of the first stimulation signal or a total area of the graphical features of the second stimulation signal.
9. The cognitive function assessment system of claim 8, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is greater than 60% of a total area of the graphical features of the first stimulation signal or the graphical features of the second stimulation signal.
10. The cognitive function assessment system of claim 9, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is greater than 80% of a total area of the graphical features of the first stimulation signal or the graphical features of the second stimulation signal.
11. The cognitive function assessment system of claim 10, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is 85% -95% of a total area of the graphical features of the first stimulation signal or the graphical features of the second stimulation signal.
12. The cognitive function assessment system of claim 1, wherein the overall presentation time of the stimulation regimen is from 5 minutes to 30 minutes.
13. The cognitive function assessment system of claim 12, wherein the overall presentation time of the stimulation regimen is from 8 minutes to 15 minutes.
14. The cognitive function assessment system of claim 13, wherein the overall presentation time of the stimulation regimen is 9 minutes to 12 minutes.
15. The cognitive function assessment system of claim 1, wherein the total number of the first and second stimulation signals of the stimulation protocol is at least 100.
16. The cognitive function assessment system of claim 15, wherein the total number of the first and second stimulation signals of the stimulation protocol is 150 to 1000.
17. The cognitive function assessment system of claim 16, wherein the total number of the first and second stimulation signals of the stimulation protocol is 300 to 800.
18. The cognitive function assessment system of claim 17, wherein the total number of the first and second stimulation signals of the stimulation protocol is 500 to 700.
19. The cognitive function assessment system of claim 1, wherein each of the first and second stimulation signals in the stimulation protocol has a duration of at least 50 milliseconds.
20. The cognitive function assessment system of claim 19, wherein each of the first and second stimulation signals in the stimulation protocol has a duration of at least 100 milliseconds.
21. The cognitive function assessment system of claim 19, wherein each of the first and second stimulation signals in the stimulation protocol has a duration of 80-200 milliseconds.
22. The cognitive function assessment system of claim 20, wherein each of the first and second stimulation signals in the stimulation protocol has a duration of 100-150 milliseconds.
23. The cognitive function assessment system of claim 1, wherein a time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1000 to 3000 milliseconds.
24. The cognitive function assessment system of claim 1, wherein a time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1500-2500 milliseconds.
25. The cognitive function assessment system of claim 24, wherein a time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1800-2200 milliseconds.
26. The cognitive function assessment system of claim 25, wherein a time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 2000 milliseconds.
27. The cognitive function assessment system of claim 1, wherein the presentation of the stimulation protocol includes at least two time periods with different proportions of stimulation signals, the number of occurrences of the first stimulation signal being less than the number of occurrences of the second stimulation signal during one presentation time period; and/or in another presentation period, the number of occurrences of the first stimulus signal is greater than the number of occurrences of the second stimulus signal.
28. The cognitive function assessment system of claim 27, wherein,
in the one presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 1/5 to 1/2; and/or
In the other presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 2 to 5.
29. The cognitive function assessment system of claim 28, wherein,
in the one presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 1/3 to 1/4; and/or
In the other presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 3 to 4.
30. The cognitive function assessment system of claim 27, wherein the one presentation period precedes the other presentation period; or alternatively, the one presentation time period and the other presentation time period are presented alternately.
31. The cognitive function assessment system of claim 1, wherein the operational data of the user interoperating in response to the stimulation protocol comprises at least one of:
a) Reaction time;
b) The amount of change in reaction time;
c) Missing error conditions including the number of times the first or second stimulus signal is missed;
d) Misjudging error conditions including the number of interactions that made an error to the first stimulus signal or the second stimulus signal;
e) Guessing an error condition: making a false guess for the next stimulus signal results in a missing error or misjudgment error.
32. The cognitive function assessment system according to claim 2, wherein the assessment device comprises: and the macro evaluation module is used for evaluating the cognitive function of the user according to the overall operation data of the user for the interactive operation of the stimulation scheme.
33. A method for evaluating cognitive function, comprising:
selecting a stimulation protocol from a stimulation database;
presenting the stimulation regimen to a user;
causing the user to interoperate in response to the stimulation protocol;
collecting operational data of the user for interactive operation in response to the stimulation protocol for assessing cognitive function of the user,
wherein the stimulation regimen comprises: at least one first stimulation signal and at least one second stimulation signal displayed in sequence according to a predetermined or random order, wherein the first stimulation signal requires the user to perform interaction operation by using an interaction device when displayed, and the second stimulation signal requires the user to do no interaction operation or perform different interaction operation when displayed,
in the stimulation protocol, n first stimulation signals are displayed consecutively and m second stimulation signals are displayed subsequently; and/or n second stimulus signals are displayed continuously, and m first stimulus signals are displayed subsequently, wherein n is a natural number greater than or equal to 3, and m is 1, 2 or 3.
34. The method for assessing cognitive function of claim 33, wherein the stimulation signal of the stimulation protocol is a visual stimulation signal, an auditory stimulation signal, a tactile stimulation signal, a gustatory stimulation signal, or a motor perception stimulation signal.
35. The method for assessing cognitive function of claim 33, wherein the first and second stimulation signals are visual stimulation signals and the graphical features of the first stimulation signal and the graphical features of the second stimulation signal are an intersection relationship for inducing the user to do the same.
36. The method for assessing cognitive function of claim 35, wherein the graphical features of the first stimulation signal and the graphical features of the second stimulation signal are the same overall area displayed in the same stimulation display device.
37. The method for evaluating cognitive function of claim 36, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is greater than 50% of a total area of the graphical features of the first stimulation signal or a total area of the graphical features of the second stimulation signal.
38. The method for evaluating cognitive function of claim 37, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is greater than 60% of a total area of the graphical features of the first stimulation signal or the graphical features of the second stimulation signal.
39. The method for evaluating cognitive function of claim 38, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is greater than 80% of a total area of the graphical features of the first stimulation signal or the graphical features of the second stimulation signal.
40. The method for assessing cognitive function of claim 39, wherein an area of an intersection between the graphical features of the first stimulation signal and the graphical features of the second stimulation signal is 85% -95% of a total area of the graphical features of the first stimulation signal or the graphical features of the second stimulation signal.
41. The method for assessing cognitive function of claim 33, wherein the overall presentation time of the stimulation regimen is from 5 minutes to 30 minutes.
42. The method for assessing cognitive function of claim 41, wherein the overall presentation time of the stimulation regimen is from 8 minutes to 15 minutes.
43. The method of assessing cognitive function of claim 42, wherein the overall presentation time of the stimulation regimen is from 9 minutes to 12 minutes.
44. The method for assessing cognitive function of claim 33, wherein the total number of the first and second stimulation signals of the stimulation protocol is at least 100.
45. The method for assessing cognitive function of claim 44, wherein the total number of first and second stimulation signals of the stimulation protocol is 150 to 1000.
46. The method for assessing cognitive function of claim 45, wherein the total number of the first and second stimulation signals of the stimulation protocol is 300 to 800.
47. The method for assessing cognitive function of claim 46, wherein the total number of the first and second stimulation signals of the stimulation protocol is 500 to 700.
48. The method for assessing cognitive function of claim 33, wherein the duration of each of the first and second stimulation signals in the stimulation protocol is at least 50 milliseconds.
49. The method for assessing cognitive function of claim 48 wherein each of said first and second stimulation signals in said stimulation protocol is at least 100 milliseconds in duration.
50. The method for assessing cognitive function of claim 48 wherein each of said first and second stimulation signals in said stimulation protocol is 80-200 milliseconds in duration.
51. The method for assessing cognitive function of claim 50, wherein the duration of each of the first and second stimulation signals in the stimulation protocol is 100-150 milliseconds.
52. The method for assessing cognitive function of claim 33, wherein the time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1000 to 3000 milliseconds.
53. The method for assessing cognitive function of claim 52, wherein the time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1500-2500 milliseconds.
54. The method for assessing cognitive function of claim 53, wherein a time interval between adjacent ones of the first and/or second stimulation signals in the stimulation protocol is 1800-2200 milliseconds.
55. A method of assessing cognitive function in accordance with claim 54, wherein the time interval between adjacent ones of said first and/or second stimulation signals in said stimulation protocol is 2000 milliseconds.
56. The method for assessing cognitive function of claim 33 wherein the presentation of the stimulation protocol includes at least two time periods in which the proportion of the number of stimulation signals is different, the number of occurrences of the first stimulation signal being less than the number of occurrences of the second stimulation signal during one presentation time period; and/or in another presentation period, the number of occurrences of the first stimulus signal is greater than the number of occurrences of the second stimulus signal.
57. The method for evaluating cognitive function of claim 56, wherein,
in the one presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 1/5 to 1/2; and/or
In the other presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 2 to 5.
58. The method for evaluating cognitive function of claim 57, wherein,
in the one presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 1/3 to 1/4; and/or
In the other presentation period, a ratio of the number of occurrences of the first stimulus signal to the number of occurrences of the second stimulus signal is 3 to 4.
59. The method for assessing cognitive function of claim 56, wherein said one presentation period precedes said another presentation period; or alternatively, the one presentation time period and the other presentation time period are presented alternately.
60. The method of assessing cognitive function of claim 33, wherein the operational data of the user interoperating in response to the stimulation protocol includes at least one of:
a) Reaction time;
b) The amount of change in reaction time;
c) Missing error conditions including the number of times the first or second stimulus signal is missed;
d) Misjudging error conditions including the number of interactions that made an error to the first stimulus signal or the second stimulus signal;
e) Guessing an error condition: making a false guess for the next stimulus signal results in a missing error or misjudgment error.
61. The method for evaluating cognitive function of claim 33, wherein the method comprises: and evaluating the cognitive function of the user according to the overall operation data of the interactive operation of the user aiming at the stimulation scheme.
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