CN114040926B - 结合cd123的多肽及其用途 - Google Patents

结合cd123的多肽及其用途

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Publication number
CN114040926B
CN114040926B CN202080048186.1A CN202080048186A CN114040926B CN 114040926 B CN114040926 B CN 114040926B CN 202080048186 A CN202080048186 A CN 202080048186A CN 114040926 B CN114040926 B CN 114040926B
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China
Prior art keywords
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ser
pro
lys
leu
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Active
Application number
CN202080048186.1A
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English (en)
Chinese (zh)
Other versions
CN114040926A (zh
Inventor
C·马塞多
K·琼斯
W·克拉戈
A·霍兰兹
M·马
J·C·蒂穆尔
B·P·埃克尔曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yinxibi Bioscience Co ltd
Original Assignee
Yinxibi Bioscience Co ltd
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Yinxibi Bioscience Co ltd, Inhibrx Inc filed Critical Yinxibi Bioscience Co ltd
Priority to CN202510986247.3A priority Critical patent/CN121021694A/zh
Publication of CN114040926A publication Critical patent/CN114040926A/zh
Application granted granted Critical
Publication of CN114040926B publication Critical patent/CN114040926B/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN202080048186.1A 2019-05-04 2020-05-01 结合cd123的多肽及其用途 Active CN114040926B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510986247.3A CN121021694A (zh) 2019-05-04 2020-05-01 结合cd123的多肽及其用途

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962843407P 2019-05-04 2019-05-04
US62/843,407 2019-05-04
PCT/US2020/030968 WO2020227071A1 (en) 2019-05-04 2020-05-01 Cd123-binding polypeptides and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202510986247.3A Division CN121021694A (zh) 2019-05-04 2020-05-01 结合cd123的多肽及其用途

Publications (2)

Publication Number Publication Date
CN114040926A CN114040926A (zh) 2022-02-11
CN114040926B true CN114040926B (zh) 2025-07-29

Family

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CN202080048186.1A Active CN114040926B (zh) 2019-05-04 2020-05-01 结合cd123的多肽及其用途
CN202510986247.3A Pending CN121021694A (zh) 2019-05-04 2020-05-01 结合cd123的多肽及其用途

Family Applications After (1)

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Country Status (7)

Country Link
US (2) US11434297B2 (enExample)
EP (1) EP3966242A1 (enExample)
JP (2) JP2022532868A (enExample)
CN (2) CN114040926B (enExample)
AU (1) AU2020269268A1 (enExample)
CA (1) CA3139061A1 (enExample)
WO (1) WO2020227071A1 (enExample)

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JP7013753B2 (ja) * 2017-09-15 2022-02-01 株式会社三洋物産 遊技機
JP7013754B2 (ja) * 2017-09-15 2022-02-01 株式会社三洋物産 遊技機
JP2020151570A (ja) * 2020-06-24 2020-09-24 株式会社三洋物産 遊技機
JP6879413B2 (ja) * 2020-06-24 2021-06-02 株式会社三洋物産 遊技機
WO2022099175A1 (en) * 2020-11-09 2022-05-12 2Seventy Bio, Inc. Cd33 targeted immunotherapies
EP4294829A4 (en) * 2021-02-17 2025-03-19 IGM Biosciences Inc. ANTI-CD123 BINDING MOLECULES AND THEIR USES
US20240141071A1 (en) * 2021-02-26 2024-05-02 LAVA Therapeutics N.V. Antibodies that bind cd123 and gamma-delta t cell receptors
JP2021079226A (ja) * 2021-03-01 2021-05-27 株式会社三洋物産 遊技機
JP2021079225A (ja) * 2021-03-01 2021-05-27 株式会社三洋物産 遊技機
JP2021087833A (ja) * 2021-03-01 2021-06-10 株式会社三洋物産 遊技機
JP2021087836A (ja) * 2021-03-01 2021-06-10 株式会社三洋物産 遊技機
IL309957A (en) 2021-07-14 2024-03-01 2Seventy Bio Inc Engineered t cell receptors fused to binding domains from antibodies
KR20250008809A (ko) 2022-04-08 2025-01-15 리제너론 파마슈티칼스 인코포레이티드 다분할 수용체 및 신호전달 복합체
JP7556434B2 (ja) * 2022-08-22 2024-09-26 株式会社三洋物産 遊技機
JP7556433B2 (ja) * 2022-08-22 2024-09-26 株式会社三洋物産 遊技機
JP7556432B2 (ja) * 2022-08-22 2024-09-26 株式会社三洋物産 遊技機
CN115724972B (zh) * 2022-09-06 2024-08-20 河北森朗生物科技有限公司 抗cd123的纳米抗体、嵌合抗原受体及其应用

Citations (2)

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WO2015044386A1 (en) * 2013-09-26 2015-04-02 Ablynx Nv Bispecific nanobodies
WO2018102795A2 (en) * 2016-12-02 2018-06-07 University Of Southern California Synthetic immune receptors and methods of use thereof

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US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
ES2375931T3 (es) 1997-12-05 2012-03-07 The Scripps Research Institute Humanización de anticuerpo murino.
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
EP2330201B1 (en) 2003-10-22 2017-04-05 Keck Graduate Institute Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
KR101245983B1 (ko) 2004-03-31 2013-06-28 제넨테크, 인크. 인간화 항-ｔｇｆ-베타 항체
NZ604510A (en) 2010-08-17 2013-10-25 Csl Ltd Dilutable biocidal compositions and methods of use
WO2015017214A1 (en) 2013-07-29 2015-02-05 Bluebird Bio, Inc. Multipartite signaling proteins and uses thereof
WO2016028896A1 (en) 2014-08-19 2016-02-25 Novartis Ag Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
JP7001474B2 (ja) 2015-01-21 2022-01-19 インヒブルクス，インコーポレイティド 非免疫原性単一ドメイン抗体
TW201709932A (zh) * 2015-06-12 2017-03-16 西雅圖遺傳學公司 Ｃｄ１２３抗體及其共軛物
KR20180042361A (ko) 2015-08-24 2018-04-25 셀렉티스 통합된 통제가능한 기능들을 가진 키메라 항원 수용체들
UA122079C2 (uk) 2015-12-04 2020-09-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Поліпептид, що специфічно зв'язується з lrp5 і lrp6
EP3387014B1 (en) * 2015-12-11 2022-01-19 Leadartis, S.L. Single chain fusionconstructs comprising multimeric antibody fragments fused to collagen trimerization domains
IL265484B1 (en) * 2016-09-21 2025-09-01 Aptevo Res & Development Llc Cd123 binding proteins and related compositions and methods
EP3541846A1 (en) * 2016-11-16 2019-09-25 Ablynx NV T cell recruiting polypeptides capable of binding cd123 and tcr alpha/beta

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Publication number Priority date Publication date Assignee Title
WO2015044386A1 (en) * 2013-09-26 2015-04-02 Ablynx Nv Bispecific nanobodies
WO2018102795A2 (en) * 2016-12-02 2018-06-07 University Of Southern California Synthetic immune receptors and methods of use thereof

Also Published As

Publication number Publication date
JP2022532868A (ja) 2022-07-20
WO2020227071A1 (en) 2020-11-12
US20200347142A1 (en) 2020-11-05
AU2020269268A1 (en) 2021-11-11
US20230065306A1 (en) 2023-03-02
CN114040926A (zh) 2022-02-11
US11919963B2 (en) 2024-03-05
CA3139061A1 (en) 2020-11-12
JP2025060941A (ja) 2025-04-10
EP3966242A1 (en) 2022-03-16
CN121021694A (zh) 2025-11-28
US11434297B2 (en) 2022-09-06

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