CN114027889A - Cell sampling device - Google Patents
Cell sampling device Download PDFInfo
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- CN114027889A CN114027889A CN202111566546.XA CN202111566546A CN114027889A CN 114027889 A CN114027889 A CN 114027889A CN 202111566546 A CN202111566546 A CN 202111566546A CN 114027889 A CN114027889 A CN 114027889A
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- fixedly connected
- cell sampling
- sampling device
- cell
- wall
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- 238000005070 sampling Methods 0.000 title claims abstract description 60
- 238000003860 storage Methods 0.000 claims abstract description 44
- 238000007789 sealing Methods 0.000 claims description 17
- 238000004804 winding Methods 0.000 claims description 6
- 239000000758 substrate Substances 0.000 claims description 4
- 238000005406 washing Methods 0.000 claims 1
- 238000004321 preservation Methods 0.000 abstract description 10
- 238000001514 detection method Methods 0.000 abstract description 9
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000000151 deposition Methods 0.000 abstract description 2
- 238000004088 simulation Methods 0.000 abstract description 2
- 210000000214 mouth Anatomy 0.000 description 16
- 238000004140 cleaning Methods 0.000 description 9
- 230000001954 sterilising effect Effects 0.000 description 6
- 230000006907 apoptotic process Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0096—Casings for storing test samples
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention provides a cell sampling device, and relates to the technical field of cell sampling. This cell sampling device, including the base plate, base plate roof both sides intermediate position fixedly connected with connecting rod, two connecting rod roof fixedly connected with mounting panel, mounting panel roof one side fixed mounting has constant temperature to preserve the case, a plurality of storage tanks have been seted up at constant temperature preservation roof portion, slidable mounting has the storage tube in the storage tank, constant temperature preserves case one side and is provided with the temperature control regulator, temperature control regulator front side top-down is provided with a plurality of temperature control adjust knob. Through being provided with good cell sampling oral swab structure, the cell sampling oral swab of actual collection can carry out good saving, can carry out the good saving of cell sampling oral swab with the human environment of depositing of simulation, does benefit to subsequent cell detection work.
Description
Technical Field
The invention relates to the technical field of cell sampling and inspection, in particular to a cell sampling and inspection device.
Background
The flow cytometer is a signal analysis technology for detecting suspended single cells or particles, is known as "CT" in laboratories, and can be used for apoptosis detection, cell sorting, cytokine expression analysis in single cells, and the like. Two methods for down-flow cytometry detection of apoptosis are briefly described herein. The flow cytometer is a signal analysis technology for detecting suspended single cells or particles, is known as "CT" in laboratories, and can be used for apoptosis detection, cell sorting, cytokine expression analysis in single cells, and the like. Two methods for down-flow cytometry detection of apoptosis are briefly described herein.
At present, current cell sampling device carries out the cell sampling during operation, it lacks good cell sampling oral cavity swab structure, the cell sampling oral cavity swab of actual collection can't carry out good saving, can't simulate human deposit environment promptly and carry out the good saving of cell sampling oral cavity swab, in addition lack good cell sampling oral cavity swab pretreatment mechanism, cell sampling oral cavity swab can't carry out quick sterilization to the collection container before taking, after actual cell sampling oral cavity swab takes, its miscellaneous fungus is more, easily cause the pollution of gathering cell sampling oral cavity swab.
To this end, we developed a new cell sampling device.
Disclosure of Invention
Technical problem to be solved
In view of the shortcomings of the prior art, the invention provides a cell sampling device, which solves the problems.
(II) technical scheme
In order to achieve the purpose, the invention is realized by the following technical scheme: a cell sampling device comprises a substrate, connecting rods are fixedly connected to the middle positions of two sides of the top wall of the substrate, two top walls of the connecting rods are fixedly connected with a mounting plate, a constant-temperature storage box is fixedly mounted on one side of the top wall of the mounting plate, a plurality of storage grooves are formed in the top of the constant-temperature storage box, storage tubes are slidably mounted in the storage grooves, a temperature controller is arranged on one side of the constant-temperature storage box, a plurality of temperature control adjusting knobs are arranged on the front side of the temperature controller from top to bottom, the constant-temperature storage temperature of the constant-temperature storage box can be adjusted through the temperature controller, a sealing plug is slidably connected to the opening at the top of the storage tube, a plurality of sealing rings are fixedly sleeved on the outer side wall below the sealing plug from top to bottom, the outer side walls of the plurality of sealing rings are slidably connected with the inner walls of the storage tubes, the sealing plug can be held to be taken down from the storage tube on the corresponding side of the sealing plug, and the collected cell sampling oral swabs are stored in the storage tube, and the constant-temperature storage box can simulate the storage environment of a human body, so that the storage tube in which the cell sampling oral swabs are arranged in the storage groove is stored at constant temperature, and the subsequent cell detection work is facilitated.
Preferably, sliding connection has the auto-lock card that slides on the connecting rod, two the auto-lock card that slides lateral wall fixedly connected with limiting plate in one side in opposite directions, the altitude mixture control of the high realization limiting plate of auto-lock card on the connecting rod of accessible both sides, the work of placing of whole device can be carried out be rectangular array form between the wall of limiting plate about the both sides and seted up a plurality of spacing grooves, can place the cell in a plurality of spacing grooves and adopt and examine and use the test tube, spacing inslot wall fixedly connected with rubber circle, base plate roof central point puts the fixedly connected with rubber pad, and rubber circle and rubber pad have played the test tube guard action for the cell is adopted and examined.
Preferably, the other side of the top wall of the mounting plate is fixedly connected with a fixing frame and a group of stand columns in sequence from one side to the other side, the top of the fixing frame is slidably provided with a cleaning box, disinfection alcohol can be poured into the cleaning box to clean the cell sampling tool, one group of the stand columns are arranged symmetrically front and back, a winding drum is rotatably connected between the two stand columns, the two stand column top walls are fixedly connected with a mounting frame, a sterilizing lamp is fixedly arranged on the side wall of one side of the mounting frame to sterilize the cell sampling tool, a limiting ring is fixedly connected at the opening at the top of the cleaning box, handles are fixedly connected at two sides of the top wall of the limiting ring and can be held to take out the cleaning box, a connecting rope is wound on the winding drum, the extending end of the connecting rope is fixedly connected with a spring clamp, and two elastic clamping ends of the spring clamp are provided with clamping arms, two the arm lock is from a side lateral wall fixedly connected with handle, and the accessible grips two handles and stimulates two arm locks and carries out cell sampling examination oral cavity swab centre gripping use, prevents that the hand from holding cell sampling examination oral cavity swab and producing the pollution to it.
The working principle is as follows: the cell sampling oral swab can be clamped by holding two handles 16 to pull two clamping arms 15 to clamp the cell sampling oral swab, the cell sampling oral swab extends into the left side of the oral wall (contacts the inside of a left cheek), then the oral wall is wiped up and down in a rolling mode (about 15-30 times wiping) by using the tooth brushing force, a second oral swab is taken by the same method and extends into the right side of the oral wall to sample, a cell DNA sample is continuously scraped, the sampled oral swab is placed in cell preservation liquid to break the head, the head is placed in a preservation tube, a bar code is pasted, the oral swab is placed in a sending back bag, name and date are written, the sampling is completed, the collected cell sampling oral swab can be stored in the preservation tube 8, at the moment, the constant-temperature preservation box 6 can simulate the storage environment of a human body, the preservation tube 8 of the cell sampling oral swab in the storage groove 7 is preserved at constant temperature, and subsequent cell detection work is facilitated.
(III) advantageous effects
The invention provides a cell sampling device. The method has the following beneficial effects:
1. this cell sampling device through being provided with good cell sampling oral cavity swab structure, the cell sampling oral cavity swab of actual collection can carry out good saving, can carry out the good saving of cell sampling oral cavity swab with the human environment of depositing of simulation, does benefit to subsequent cell detection work.
2. This cell sampling device through being provided with good cell sampling oral cavity swab pretreatment mechanism, can carry out quick sterilization to the collection container before cell sampling oral cavity swab takes, and after actual cell sampling oral cavity swab takes, its miscellaneous fungus is less, is difficult for causing the pollution of gathering cell sampling oral cavity swab.
Drawings
FIG. 1 is a front view of a cell sampling apparatus according to the present invention;
FIG. 2 is a perspective view of a constant temperature storage case of the present invention;
FIG. 3 is a perspective view of a limiting plate of the present invention;
FIG. 4 is a schematic view of a holding tube structure according to the present invention;
FIG. 5 is an enlarged view taken at A of FIG. 1 in accordance with the present invention;
FIG. 6 is an enlarged view of the invention at B in FIG. 1.
Wherein, 1, a substrate; 2. a connecting rod; 3. mounting a plate; 4. self-locking sliding cards; 5. a limiting plate; 6. a constant temperature storage box; 7. a storage tank; 8. preserving the tube; 9. a column; 10. a reel; 11. a mounting frame; 12. a sterilizing lamp; 13. connecting ropes; 14. a spring clip; 15. clamping arms; 16. a handle; 17. a fixed mount; 18. a cleaning tank; 19. a limiting ring; 20. a handle; 21. a sealing plug; 22. a temperature control regulator; 23. a support; 24. a rubber pad; 25. a limiting groove; 26. a rubber ring; 27. and (5) sealing rings.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
as shown in FIGS. 1 to 6, the embodiment of the invention provides a cell sampling device, which comprises a base plate 1, connecting rods 2 are fixedly connected to the middle positions of the two sides of the top wall of the base plate 1, mounting plates 3 are fixedly connected to the top walls of the two connecting rods 2, a constant temperature storage box 6 is fixedly mounted on one side of the top wall of the mounting plates 3, a plurality of storage grooves 7 are formed in the top of the constant temperature storage box 6, storage tubes 8 are slidably mounted in the storage grooves 7, a temperature control regulator 22 is arranged on one side of the constant temperature storage box 6, a plurality of temperature control regulating knobs are arranged on the front side of the temperature control regulator 22 from top to bottom, the constant temperature storage temperature of the constant temperature storage box 6 can be regulated through the temperature control regulator 22, a sealing plug 21 is slidably connected to an opening at the top of the storage tubes 8, a plurality of sealing rings 27 are fixedly sleeved on the outer side wall below the sealing plug 21 from top to bottom, the outer side walls of the sealing rings 27 are slidably connected to the inner walls of the storage tubes 8, the sealing plug 21 can be held and taken down from the preservation pipe 8 on the corresponding side, the collected cell sampling oral swabs are stored in the preservation pipe 8, at the moment, the constant-temperature preservation box 6 can simulate the storage environment of a human body, and the preservation pipe 8 in which the cell sampling oral swabs are arranged in the storage tank 7 is preserved at constant temperature, so that the subsequent cell detection work is facilitated.
Example two:
the difference between the present embodiment and the first embodiment is: sliding connection has self-locking sliding card 4 on connecting rod 2, two self-locking sliding card 4 lateral wall fixedly connected with limiting plate 5 in opposite directions, the altitude mixture control of limiting plate 5 is realized to the height of self-locking sliding card 4 on the connecting rod 2 of accessible both sides, four corners fixedly connected with supports 23 of 1 diapire of base plate, can carry out the integrated device place between the wall of work limiting plate 5 about and be the rectangle array form and seted up a plurality of spacing grooves 25, can place the test tube for cell sampling in a plurality of spacing grooves 25, spacing groove 25 inside wall fixedly connected with rubber collar 26, 1 roof central point of base plate puts fixedly connected with rubber pad 24, rubber collar 26 and rubber pad 24 have played the test tube guard action for cell sampling.
Example three:
the present embodiment is different from the first and second embodiments in that: the other side of the top wall of the mounting plate 3 is fixedly connected with a fixing frame 17 and a group of upright posts 9 from one side to the other side in sequence, the top of the fixing frame 17 is slidably provided with a cleaning box 18, the sterilizing alcohol can be poured into the cleaning box 18 to clean the cell sampling tool, the group of upright posts 9 are arranged symmetrically front and back, a winding drum 10 is rotatably connected between the two upright posts 9, the top walls of the two upright posts 9 are fixedly connected with a mounting frame 11, a sterilizing lamp 12 is fixedly arranged on the side wall of one side of the mounting frame 11 to sterilize the cell sampling tool, a limiting ring 19 is fixedly connected at the opening at the top of the cleaning box 18, handles 20 are fixedly connected at the two sides of the top wall of the limiting ring 19 and can be held by the two handles 20 to take out the cleaning box 18, a connecting rope 13 is wound on the winding drum 10, a spring clamp 14 is fixedly connected at the extending end of the connecting rope 13, and clamp arms 15 are arranged at the two elastic clamping ends of the spring clamp 14, the two clamping arms 15 are fixedly connected with a handle 16 on the side wall away from one another, and the two clamping arms 15 can be pulled to clamp the cell collection oral swab by holding the two handles 16, so that the cell collection oral swab is prevented from being polluted by hands.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (8)
1. A cell-sampling device comprising a substrate (1), characterized in that: the middle positions of two sides of the top wall of the base plate (1) are fixedly connected with connecting rods (2), and the top walls of the two connecting rods (2) are fixedly connected with mounting plates (3);
the connecting rod (2) is connected with self-locking sliding clamps (4) in a sliding mode, and the side walls of the two self-locking sliding clamps (4) on the opposite sides are fixedly connected with limiting plates (5);
a constant-temperature storage box (6) is fixedly mounted on one side of the top wall of the mounting plate (3), a plurality of storage grooves (7) are formed in the top of the constant-temperature storage box (6), and storage tubes (8) are slidably mounted in the storage grooves (7);
a fixed frame (17) and a group of upright posts (9) are fixedly connected to the other side of the top wall of the mounting plate (3) from one side to the other side in sequence;
mount (17) top slidable mounting has washing case (18), and is a set of symmetry form setting around for two and being, two stand (9) rotate between stand (9) and be connected with reel (10), two stand (9) roof fixedly connected with mounting bracket (11), mounting bracket (11) one side lateral wall fixed mounting has sterilamp (12).
2. A cell sampling device according to claim 1 wherein: the base plate (1) roof central point puts fixedly connected with rubber pad (24), four corners fixedly connected with supports (23) of base plate (1) diapire.
3. A cell sampling device according to claim 1 wherein: a plurality of limiting grooves (25) are formed between the upper side wall and the lower side wall of the limiting plate (5) in a rectangular array mode, and rubber rings (26) are fixedly connected to the inner side walls of the limiting grooves (25).
4. A cell sampling device according to claim 1 wherein: wash case (18) top opening part fixedly connected with spacing collar (19), spacing collar (19) roof both sides fixedly connected with handle (20).
5. A cell sampling device according to claim 1 wherein: the winding drum is characterized in that a connecting rope (13) is wound on the winding drum (10), and a spring clamp (14) is fixedly connected to the extending end of the connecting rope (13).
6. A cell sampling device according to claim 5 wherein: two elasticity clamping ends of spring clamp (14) are provided with arm lock (15), two arm lock (15) leave one side lateral wall fixedly connected with handle (16) mutually.
7. A cell sampling device according to claim 1 wherein: a temperature control regulator (22) is arranged on one side of the constant-temperature storage box (6), and a plurality of temperature control adjusting knobs are arranged on the front side of the temperature control regulator (22) from top to bottom.
8. A cell sampling device according to claim 1 wherein: the opening part at the top of the storage tube (8) is connected with a sealing plug (21) in a sliding mode, a plurality of sealing rings (27) are fixedly sleeved on the outer side wall below the sealing plug (21) from top to bottom, and the outer side wall of each sealing ring (27) is connected with the inner wall of the storage tube (8) in a sliding mode.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111566546.XA CN114027889A (en) | 2021-12-20 | 2021-12-20 | Cell sampling device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111566546.XA CN114027889A (en) | 2021-12-20 | 2021-12-20 | Cell sampling device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114027889A true CN114027889A (en) | 2022-02-11 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111566546.XA Pending CN114027889A (en) | 2021-12-20 | 2021-12-20 | Cell sampling device |
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| Country | Link |
|---|---|
| CN (1) | CN114027889A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI804291B (en) * | 2022-04-27 | 2023-06-01 | 臺北醫學大學 | Sampling device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104665878A (en) * | 2014-12-25 | 2015-06-03 | 王菊 | Automatic flushing type body fluid sampling device for department of neurology |
| US20160066565A1 (en) * | 2007-12-13 | 2016-03-10 | Biocell Center Corporation | Isolator devices for collection, parametrical characterization and long-term preservation of organic fluids and/or materials containing stem cells |
| CN209019497U (en) * | 2017-10-18 | 2019-06-25 | 杨公利 | Surgery disinfection apparatus |
| CN209423676U (en) * | 2018-09-25 | 2019-09-24 | 刘宓 | A kind of device for the storage of clinical laboratory's sample |
| CN214847251U (en) * | 2021-07-23 | 2021-11-23 | 王星阳 | Art education teaching terminal |
-
2021
- 2021-12-20 CN CN202111566546.XA patent/CN114027889A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160066565A1 (en) * | 2007-12-13 | 2016-03-10 | Biocell Center Corporation | Isolator devices for collection, parametrical characterization and long-term preservation of organic fluids and/or materials containing stem cells |
| CN104665878A (en) * | 2014-12-25 | 2015-06-03 | 王菊 | Automatic flushing type body fluid sampling device for department of neurology |
| CN209019497U (en) * | 2017-10-18 | 2019-06-25 | 杨公利 | Surgery disinfection apparatus |
| CN209423676U (en) * | 2018-09-25 | 2019-09-24 | 刘宓 | A kind of device for the storage of clinical laboratory's sample |
| CN214847251U (en) * | 2021-07-23 | 2021-11-23 | 王星阳 | Art education teaching terminal |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI804291B (en) * | 2022-04-27 | 2023-06-01 | 臺北醫學大學 | Sampling device |
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