CN114015290B - Modified hyaluronic acid anti-fog coating material and preparation method and application thereof - Google Patents
Modified hyaluronic acid anti-fog coating material and preparation method and application thereof Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
- C09D105/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Coating Of Shaped Articles Made Of Macromolecular Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
- Surface Treatment Of Optical Elements (AREA)
Abstract
The invention discloses a preparation method of a modified hyaluronic acid anti-fog coating material, which comprises the following steps: (1) Adding EDC and NHS with equal molar ratio into the hyaluronic acid aqueous solution, wherein the molar ratio of EDC to NHS is 1:1, then adjusting the pH value of the solution to be 4.0-6.0, and stirring for 0.5-2h; (2) Adding dopamine hydrochloride to ensure that the molar ratio of the dopamine hydrochloride to glucuronic acid in the hyaluronic acid is 0.1-5, and carrying out dark reaction for 8-24 hours under the protection of inert gas; dialyzing to remove small molecular substances, and obtaining the modified hyaluronic acid anti-fog coating material. The product prepared by the invention can be polymerized in situ on the surface of a resin lens or a plastic packaging material to obtain an anti-fog film which is firmly combined with a substrate material, effectively overcomes the defects of poor bonding force and rapid attenuation of anti-fog performance of the traditional anti-fog coating, does not influence the light transmittance of the original material, and has wide application prospect in the fields of resin lenses, food packaging materials, medicine packaging materials, photovoltaic materials and the like.
Description
Technical Field
The invention belongs to the field of new coating materials, and particularly relates to a modified hyaluronic acid anti-fog coating material, a preparation method thereof, and application of the modified hyaluronic acid anti-fog coating material in coating films on surfaces of resin optical lenses, optical plastic materials, food packaging materials, medicine packaging materials and photovoltaic materials so as to improve the anti-fog performance of the materials.
Technical Field
The polymer optical resin material has wide application in daily life, industrial and agricultural production and medical treatment fields. For example, polycarbonate is widely applied to aerospace plane observation windows, automobile bulletproof windows, high-speed rail train window materials, astronauts helmets, outdoor sport protective glasses lenses and the like. The CR-39 resin material widely used for resin lens production is polymerized and cured under the action of heat and a catalyst, becomes the most widely used resin lens type, and as an optical lens, the parameters of the properties of the CR-39 material are quite suitable: the glass has the advantages of 1.5 (close to common glass lenses), 1.32 specific gravity (almost half of glass), 58-59 Abbe number (only little dispersion), impact resistance and high light transmittance, and can be dyed and coated. The agricultural film and mulching film material widely used in the field of modern facility agriculture widely uses Polyethylene (PE) and polyvinyl chloride (PVC) materials, ensures the growth environment of crops in the aspects of heat preservation and light transmission, improves the crop yield and adjusts the harvest period.
Fogging is a widely occurring natural phenomenon that occurs on the basis of the fact that, as a large amount of water vapor is present in the air, when a partial pressure of the water vapor cools to a dew point temperature (i.e., the temperature to which the water in the air is saturated in the gaseous state and condensed into liquid water at a fixed pressure) the condensed water floats in the air to form a fog. The fogging on the surface of the transparent material can affect the light transmission of the material and seriously affect the service performance. Agricultural plastic greenhouse films such as PE and PVC can also cause slow growth and development of crops and burn the crops by too strong light due to light refraction generated by water drops on the surface of the film layer; in addition, the condensed water is too much and may cause withering when it drops on the crops. When PE material is used for food packaging, food preservation can also be affected by fogging. Therefore, the research on the anti-fogging of the transparent plastic material is an extremely important subject.
According to the theory of liquid surface infiltration, when the surface of the material is highly hydrophilic, fog drops tend to spread highly on the surface of the material to form a transparent water film, and the contact angle theta of the water drops on the surface of the material is close to 0 degree, so that the scattering phenomenon caused by light rays passing through the water drops is eliminated; when the surface of the material is highly hydrophobic, the contact angle theta of water drops on the surface of the material is close to 180 degrees, the fog exists on the surface of the material in the form of small water drops under the combined action of the surface chemical components and the microstructure of the material, and the small water drops can gather and then slide off the surface when the material is subjected to external force or at a certain inclination angle, so that the anti-fog effect is achieved. Antifogging materials can therefore be divided into two broad categories, hydrophilic antifogging and hydrophobic antifogging.
The hydrophilic antifogging agent has the advantages of simple process, low cost and the like, and related researches are more at present. The hydrophilic coating is coated on the surface of the transparent material, so that the wetting state of the fog drops on the surface of the material is improved, and the aim of preventing fog is fulfilled. The hydrophilic antifogging coating material is divided into three types according to specific hydrophilic antifogging coating material systems: (1) a functionalized polymer antifogging material; (2) an inorganic anti-fog material; (3) organic-inorganic hybrid antifogging material. The research on hydrophilic antifogging coatings has received much attention, but the problems of antifogging effect, timeliness, mechanical strength, applicability to various transparent substrates and the like still remain the main direction of the research.
In the aspect of improving the antifogging property of the material by modifying the surface of the optical material, the general physical adsorption coating is easy to run off in the processes of cleaning, friction and use, so that the antifogging property is quickly attenuated, and frequent coating is required. Chemically bonded coatings generally require physical or chemical activation of the substrate, which is a cumbersome and costly process. Therefore, there is a strong need to develop a robust coating material and coating method that does not require pre-treatment activation of the substrate.
Disclosure of Invention
Aiming at the problems, the invention provides a modified hyaluronic acid anti-fog coating material, a preparation method and application thereof, which can meet the surface anti-fog requirements of different transparent optical materials, particularly the surface anti-fog requirements of materials such as resin optical lenses, food packaging films, drug packaging films, photovoltaic solar cells and the like, and can endow the anti-fog performance with durability and obvious anti-fog performance so as to solve the technical defects of weak anti-fog performance or short anti-fog effective time and the like in the prior art.
In order to achieve the technical purpose of the invention, the technical scheme of the invention is as follows:
a preparation method of a modified hyaluronic acid anti-fog coating material comprises the following steps:
(1) Adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) to 0.1-2 wt% of the aqueous solution of hyaluronic acid, wherein the molar ratio of EDC to NHS is 1:1, then adjusting the pH value of the solution to 4.0-6.0, and stirring for 0.5-2 h;
(2) Adding dopamine hydrochloride into the solution obtained in the step (1) to ensure that the molar ratio of the dopamine hydrochloride to glucuronic acid in the hyaluronic acid is 0.1-5:1, and carrying out dark reaction for 8-24 hours under the protection of inert gas;
(3) And (3) dialyzing the solution obtained in the step (2), wherein the cut-off molecular weight is 3500Da, and removing small molecular substances to obtain the modified hyaluronic acid anti-fog coating material.
Preferably, the hyaluronic acid is a linear acidic polysaccharide produced by fermentation of streptococcus zooepidemicus.
Preferably, the molecular weight of the hyaluronic acid is in the range of 400,000-2,000,000Da.
Preferably, the inert gas is nitrogen.
The invention also provides the modified hyaluronic acid anti-fog coating material prepared by the method.
The invention also provides application of the modified hyaluronic acid anti-fog coating in improving the anti-fog performance of a base material by coating the surface of the base material.
Preferably, the base material includes an optical resin lens or a transparent plastic article.
Preferably, the substrate material is CR39 optical resin, acrylic optical resin, polyurethane optical resin, polyethylene, polypropylene, or polyvinyl chloride.
Preferably, the application comprises the following steps:
(2-1) preparing an aqueous solution of the modified hyaluronic acid anti-fog coating material as a coating solution, and then adjusting the pH value of the coating solution to 8.0-9.0; the preferred pH is 8.5;
(2-2) cleaning to remove impurities on the surface of the base material;
(2-3) adhering the coating liquid to the surface of the base material by coating;
(2-4) curing in an air atmosphere at 40-60 ℃, preferably 50 ℃, for 5-30 min.
The method for adjusting the pH value of the coating liquid in the step (2-1) comprises the following steps: adjusted with NaOH solution at a concentration of 1-4% by weight.
The cleaning in the step (2-2) comprises: ultrasonic cleaning or deionized water rinsing.
The coating film in the step (2-3) is a pulling coating film, a rotating coating film or a blade coating film.
The preferred curing time in step (2-4) is 10min.
The concentration of the coating liquid is determined according to the requirements, and the invention is not limited.
Compared with the prior art, the invention has the beneficial technical effects as follows:
(1) By selecting hyaluronic acid as a super-hydrophilic material, compared with the conventional polyvinyl alcohol, sodium carboxymethyl cellulose, chitosan, polyacrylic acid and the like, the hyaluronic acid has larger molecular weight and better film forming property, so that the surface of the optical material is endowed with better super-hydrophilicity, water drops obtain lower contact angles on the surface of the material, and the material macroscopically shows better anti-fog performance.
(2) Chemically bonded dopamine is introduced into a hyaluronic acid structure, and dopamine groups in the air atmosphere are subjected to polymerization reaction on the surface of an optical material under the condition of weak alkalinity adjustment, so that a firm chemical bonding effect is formed on the surface of the material, hyaluronic acid and the optical substrate material can form a firm anti-fog coating on the surface of the optical substrate material through a polydopamine medium, and the duration time of the anti-fog coating is prolonged.
The invention solves the problems of fast performance attenuation, low coating firmness and the like existing in the prior anti-fog treatment agent which uses water-soluble polymers such as polyvinyl alcohol, sodium carboxymethyl cellulose, chitosan and the like as the surface of the optical material, takes super-hydrophilic modified hyaluronic acid as the anti-fog coating material, introduces active groups through chemical modification, and leads the hyaluronic acid and the surface of the optical plastic material to form multi-site chemical bonding action through in-situ polymerization on the surface of the optical material, thereby improving the firmness and the anti-fog performance of the anti-fog coating, and being expected to be widely applied to various fields such as resin lenses, packaging materials, swimming goggles, observation windows, food packaging and the like.
Drawings
FIG. 1 is a graph comparing the antifogging effects of the lenses of example 1 and commercial treatments (comparative samples) after 50 ultrasonic cleaning passes.
FIG. 2 is a graph comparing the antifogging effect of the lens after 50 ultrasonic washes of example 2 and commercial treatment (comparative sample).
FIG. 3 is a graph comparing the anti-fogging effect of example 3 and commercial treatments (comparative samples) after 50 ultrasonic cleaning cycles.
FIG. 4 is a graph comparing the antifogging effect of the lens after 50 ultrasonic washes of example 4 and commercial treatment (comparative sample).
Detailed Description
The preparation method of the modified hyaluronic acid anti-fogging coating material of the present invention and the anti-fogging treatment for the surface of resin lenses or other plastic materials are further described in detail with reference to the following specific examples, which are not intended to limit the scope of the present invention.
The light transmittance performance of the material is tested by adopting optical transmission spectrum analysis, and the light transmittance is tested by using an SGW-820 light transmittance and haze tester according to the national standard GB/T2410-2008 'transparent plastic light transmittance and haze test method'.
The antifogging property of the material is measured by the contact angle between a water drop and a hydrophilic antifogging coating, and the contact angle of the water drop on the surface of the material is generally considered to be lower than 7 degrees, so that the antifogging property of the film surface is realized. The contact angle was measured by a model JC2000D video contact angle measuring instrument manufactured by morning digital technology equipment ltd, shanghai. The specific operation method comprises the following steps: under the condition of room temperature, the microinjector is fixed above the objective table, the transparent optical resin substrate is fixed on the objective table, the focal length of the camera is adjusted to 2 times (the focal length is usually adjusted to 2-2.5 times when a droplet contact angle is measured), and then the knob at the back of the camera base is rotated to adjust the distance from the camera to the objective table, so that the image is clearest. Deionized water (0.8. Mu.L sample size for contact angle) was pressed out with a micro-syringe. From the live image, a clear water droplet appears at the lower end of the injector. The knob of the stage base is rotated to make the stage rise slowly, and the stage descends after touching the water drop hung at the lower end of the sample injector, so that the water drop is left on the optical resin substrate. The computer is operated to fix the picture, and the image is frozen within 10s after sampling. The contact angle of the water drop was measured by the goniometry method.
In order to evaluate the stability of the anti-fog film, two modes of rinsing with clear water and ultrasonic cleaning are adopted for evaluation, rinsing with clear water and ultrasonic cleaning are respectively carried out for 1 minute at room temperature, then the film is placed in a drying oven at 40 ℃ for drying, a sample rinsed with clear water tests the contact angle of a sample rinsed for 100 times, and a sample cleaned with ultrasonic cleaning tests the contact angle of a sample cleaned for 50 times, so that the anti-fog film layer scrubbing resistance is evaluated.
In order to evaluate the stability of the antifogging film in the actual use process, the optical resin material plated with the antifogging film is placed in an environment of 25 ℃, the surface of the material is subjected to a haar test, the hazing condition of the surface is observed by naked eyes once in the morning and at night, the number of days for which the antifogging effect is increased is recorded as 1 day if no obvious hazing is observed every one day of continuous test, and the observation lasts for 300 days.
In order to visually evaluate the antifogging performance of the antifogging film, the resin lens sample after being cleaned by ultrasonic waves for 50 times is placed in a refrigerator for refrigeration for 6 hours at 4 ℃, and is taken out to observe the formation condition of the antifogging film on the surface.
Example 1
Dissolving 200mg hyaluronic acid (0.53 mmol glucuronic acid unit) with molecular weight of 800,000Da in 50ml deionized water, stirring and dissolving for 1h at room temperature, slowly adding EDC and NHS with equal molar ratio into the solution, uniformly stirring for 30min, adjusting the pH of the mixed solution to 5.0, and adding 10mg dopamine hydrochloride (0.053 mmol) into the mixed solution. In N 2 Stirring at room temperature under the protection of atmosphere, maintaining the pH value of the reaction solution at 5.0 by using 1mol/L NaOH solution and 1mol/L HCl solution, and continuing the reaction at room temperature for 8 hours. After the reaction, the obtained solution is dialyzed (molecular weight cutoff =3500 Da) in an acidic environment of deionized water with pH =5 for purification for 3 days, and the solution of the dopamine graft modified hyaluronic acid coating layer is obtained.
Diluting the solution of the modified hyaluronic acid coating to 0.5% aqueous solution, adjusting the pH of the coating solution to 8.0 by using 1% NaOH aqueous solution, and coating the resin lens by adopting an SYDC-100 type dipping and pulling coating machine. And (3) putting the optical resin lens subjected to precise cleaning into a coating liquid, wherein the pulling speed is 4000um/s, the dipping time is 5s, the coating times are 8 times, the coating interval time is 15s each time, and vertically pulling the dipped optical resin substrate up to obtain the required coating.
And (3) putting the coated optical resin lens into a temperature-controlled drying oven, keeping the temperature of the optical resin lens constant for 30 minutes at 40 ℃ in the air atmosphere, curing, and slowly cooling to room temperature to finish the coating and curing of the anti-fog film layer. In the same manner, a commercial product was coated with carboxymethyl cellulose on the surface of a resin lens, and the light transmittance, contact angle, and water washing and ultrasonic water washing manners were compared to compare the stability of the antifogging film, and the results are shown in table 1. The actual antifogging effect of the sample after the antifogging film is destroyed by ultrasonic cleaning is shown in the attached figure 1.
TABLE 1 comparison of the effectiveness of the treatment of the anti-fog coating and commercial treatment made in example 1
Example 2
Dissolving 50mg of hyaluronic acid (0.13 mmol of glucuronic acid unit) with molecular weight of 1,000,000Da in 50ml of deionized water, stirring and dissolving for 1h at room temperature, slowly adding EDC and NHS in an equal molar ratio into the solution, uniformly stirring for 30min, adjusting the pH of the mixed solution to 5.0, and adding 25mg of dopamine hydrochloride (0.13 mmol) into the mixed solution. In N 2 Stirring at room temperature under the protection of atmosphere, maintaining the pH value of the reaction solution at 5.0 by using 1mol/L NaOH solution and 1mol/L HCl solution, and continuing the reaction for 24 hours at room temperature. After the reaction, the obtained solution is dialyzed (molecular weight cutoff =3500 Da) in an acidic environment of deionized water with pH =5 for purification for 3 days, and the solution of the dopamine graft modified hyaluronic acid coating layer is obtained.
Diluting the solution of the modified hyaluronic acid coating to 0.5% aqueous solution, adjusting the pH of the coating solution to 8.5 by using 1% NaOH aqueous solution, and coating the resin lens by adopting an SYDC-100 type dipping and pulling coating machine. And (3) putting the optical resin lens subjected to precise cleaning into a coating liquid, wherein the pulling speed is 4000um/s, the dipping time is 5s, the coating times are 8, the coating interval time is 15s each time, and vertically pulling the dipped optical resin substrate up to obtain the required coating.
And (3) putting the coated optical resin lens into a temperature-controlled drying oven, keeping the temperature of the optical resin lens at 60 ℃ in an air atmosphere for 10 minutes for curing, and slowly cooling the optical resin lens to room temperature to finish the coating and curing of the anti-fog film layer. In the same manner, a commercial product was coated with carboxymethyl cellulose on the surface of a resin lens, and the light transmittance, contact angle, and water washing and ultrasonic water washing manners were compared to compare the stability of the antifogging film, and the results are shown in table 2. The actual antifogging effect of the sample after the antifogging film is destroyed by ultrasonic cleaning is shown in figure 2.
Table 2 comparison of the treatment effects of the anti-fog coating and commercial treatment made in example 2
Example 3
200mg of hyaluronic acid (0.53 mmol of glucuronic acid unit) with molecular weight of 2,000,000Da is dissolved in 50ml of deionized water, stirred and dissolved for 1h at room temperature, EDC and NHS with equal molar ratio are slowly added into the solution, stirred uniformly for 1h, the pH of the mixed solution is adjusted to 6.0, and 500mg of dopamine hydrochloride (2.65 mmol) is added into the mixed solution. In N 2 Stirring at room temperature under the protection of atmosphere, maintaining the pH value of the reaction solution at 6.0 by using 1mol/L NaOH solution and 1mol/L HCl solution, and continuing the reaction at room temperature for 12 hours. After the reaction, the obtained solution was dialyzed (molecular weight cutoff =3500 Da) in an acidic environment of deionized water with pH =5 for 3 days to obtain a solution of the dopamine graft modified hyaluronic acid coating layer.
Diluting the solution of the modified hyaluronic acid coating to 0.5% aqueous solution, adjusting the pH of the coating solution to 9.0 by using 1% NaOH aqueous solution, and coating the resin lens by adopting an SYDC-100 type dipping and pulling coating machine. And (3) putting the optical resin lens subjected to precise cleaning into a coating liquid, wherein the pulling speed is 4000um/s, the dipping time is 5s, the coating times are 8, the coating interval time is 15s each time, and vertically pulling the dipped optical resin substrate up to obtain the required coating.
And (3) putting the coated optical resin lens into a temperature-controlled drying oven, keeping the temperature of the optical resin lens at 60 ℃ in an air atmosphere for 5 minutes for curing, and slowly cooling the optical resin lens to room temperature to finish the coating and curing of the anti-fog film layer. In the same manner, a commercial product was coated with carboxymethyl cellulose on the surface of a resin lens, and the light transmittance, contact angle, and water washing and ultrasonic water washing manners were compared to compare the stability of the antifogging film, and the results are shown in table 3. The actual antifogging effect of the sample after the antifogging film is destroyed by ultrasonic cleaning is shown in figure 3.
Table 3 comparison of the treatment effects of the anti-fog coating and commercial treatment made in example 3
Example 4
Dissolving 1g hyaluronic acid (2.65 mmol glucuronic acid unit) with molecular weight of 400,000Da in 50ml deionized water, stirring and dissolving for 1h at room temperature, slowly adding EDC and NHS with equal molar ratio into the solution, uniformly stirring for 2h, adjusting the pH of the mixed solution to 4.0, and adding 500mg dopamine hydrochloride (2.65 mmol) into the mixed solution. In N 2 Stirring at room temperature under the atmosphere protection, maintaining the pH value of the reaction solution at 4.0 by using 1mol/L NaOH solution and 1mol/L LHCl solution, and continuing the reaction for 24 hours at room temperature. After the reaction, the obtained solution was dialyzed (molecular weight cutoff =3500 Da) in an acidic environment of deionized water with pH =5 for 3 days to obtain a solution of the dopamine graft modified hyaluronic acid coating layer.
Diluting the solution of the modified hyaluronic acid coating to 0.5% aqueous solution, adjusting the pH of the coating solution to 8.0 by using 4% NaOH aqueous solution, and coating the resin lens by adopting an SYDC-100 type dipping and pulling coating machine. And (3) putting the optical resin lens subjected to precise cleaning into a coating liquid, wherein the pulling speed is 4000um/s, the dipping time is 5s, the coating times are 8 times, the coating interval time is 15s each time, and vertically pulling the dipped optical resin substrate up to obtain the required coating.
And (3) putting the coated optical resin lens into a temperature-controlled drying oven, keeping the temperature constant at 50 ℃ in an air atmosphere for 30 minutes for curing, and slowly cooling to room temperature to finish the coating and curing treatment of the anti-fog film layer on the resin optical lens. In the same treatment manner, a commercial product was coated with carboxymethyl cellulose on the surface of the resin lens, and the light transmittance, contact angle, and water washing and ultrasonic water washing manners were compared to compare the stability of the antifogging film, and the results are shown in table 4. The actual antifogging effect of the sample after the antifogging film is destroyed by ultrasonic cleaning is shown in figure 4.
Table 4 comparative results of treatment of the anti-fog coating and commercial treatment made in example 4
Example 5
The stability of the anti-fog coatings obtained using the method described above under simulated actual use conditions is shown in table 5:
TABLE 5 Stable Properties of the anti-fog coatings prepared in examples 1-4 under simulated actual use conditions
Within 300 days of continuous observation, each sample had no significant fogging.
Claims (9)
1. The application of the modified hyaluronic acid anti-fog coating material in improving the anti-fog performance of the base material by coating the surface of the base material is characterized in that the modified hyaluronic acid anti-fog coating material is applied to the surface of an optical plastic material;
the preparation method of the modified hyaluronic acid anti-fog coating material comprises the following steps:
(1) Adding 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide into a 0.1-2 wt% aqueous solution of hyaluronic acid, wherein the molar ratio of 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride to N-hydroxysuccinimide is 1:1, then adjusting the pH value of the solution to 4.0-6.0, and stirring for 0.5-2h; the molecular weight range of the hyaluronic acid is between 400,000 and 2,000,000 Da;
(2) Adding dopamine hydrochloride into the solution obtained in the step (1) to ensure that the molar ratio of the dopamine hydrochloride to glucuronic acid in hyaluronic acid is 0.1-5, and carrying out dark reaction for 8-24 hours under the protection of inert gas;
(3) And (3) dialyzing the solution obtained in the step (2), wherein the cut-off molecular weight is 3500Da, and removing small molecular substances to obtain the modified hyaluronic acid anti-fog coating material.
2. The use of claim 1, wherein the hyaluronic acid is a linear acidic polysaccharide produced by fermentation of Streptococcus zooepidemicus.
3. Use according to claim 1, wherein the substrate material comprises an optical resin lens or a transparent plastic article.
4. The application according to claim 1, characterized in that it comprises the following steps:
(2-1) preparing an aqueous solution of the modified hyaluronic acid anti-fog coating material as a coating liquid, and then adjusting the pH value of the coating liquid to 8.0-9.0;
(2-2) cleaning to remove impurities on the surface of the base material;
(2-3) adhering the coating liquid to the surface of the base material by coating;
(2-4) curing at 40-60 ℃ for 5-30min in an air atmosphere.
5. The use according to claim 4, wherein the pH of the coating liquid is adjusted to 8.5 in step (2-1).
6. The use according to claim 4, wherein the method for adjusting the pH value of the coating liquid in step (2-1) is: adjusting with NaOH solution with concentration of 1% -4% by weight.
7. The use according to claim 4, wherein the coating film of step (2-3) is a drawdown coating film, a spin coating film or a blade coating film.
8. Use according to claim 4, wherein the curing time in step (2-4) is 10min.
9. Use according to claim 4, wherein in step (2-4) the curing is at 50 ℃.
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