CN114014871A - Method for extracting artemisinin from sweet wormwood herb - Google Patents
Method for extracting artemisinin from sweet wormwood herb Download PDFInfo
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- CN114014871A CN114014871A CN202111243207.8A CN202111243207A CN114014871A CN 114014871 A CN114014871 A CN 114014871A CN 202111243207 A CN202111243207 A CN 202111243207A CN 114014871 A CN114014871 A CN 114014871A
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- sweet wormwood
- storage pool
- petroleum ether
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- 235000001405 Artemisia annua Nutrition 0.000 title claims abstract description 61
- 240000000011 Artemisia annua Species 0.000 title claims abstract description 61
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 title claims abstract description 27
- 229960004191 artemisinin Drugs 0.000 title claims abstract description 27
- 229930101531 artemisinin Natural products 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract description 70
- 238000003756 stirring Methods 0.000 claims abstract description 63
- 238000000605 extraction Methods 0.000 claims abstract description 50
- 239000003208 petroleum Substances 0.000 claims abstract description 36
- 239000000843 powder Substances 0.000 claims abstract description 32
- 241000049464 Artemisia apiacea Species 0.000 claims abstract description 23
- 235000011570 Artemisia caruifolia var apiacea Nutrition 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 12
- 238000001914 filtration Methods 0.000 claims abstract description 8
- 239000000706 filtrate Substances 0.000 claims abstract description 4
- 230000000670 limiting effect Effects 0.000 claims description 14
- 235000003826 Artemisia Nutrition 0.000 claims description 4
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims description 4
- 244000030166 artemisia Species 0.000 claims description 4
- 235000009052 artemisia Nutrition 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 239000002699 waste material Substances 0.000 abstract description 4
- 238000002386 leaching Methods 0.000 description 28
- 230000033001 locomotion Effects 0.000 description 7
- 238000007790 scraping Methods 0.000 description 7
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 6
- 235000017491 Bambusa tulda Nutrition 0.000 description 6
- 241001330002 Bambuseae Species 0.000 description 6
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 6
- 239000011425 bamboo Substances 0.000 description 6
- 230000002441 reversible effect Effects 0.000 description 5
- 239000012535 impurity Substances 0.000 description 4
- 230000000737 periodic effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 201000004409 schistosomiasis Diseases 0.000 description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 2
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 239000001522 artemisia absinthium l. herb extract Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940119569 wormwood extract Drugs 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/20—Spiro-condensed systems
Abstract
The invention discloses a preparation method for extracting artemisinin by utilizing artemisia apiacea, which comprises the following steps of crushing artemisia apiacea leaves to obtain artemisia apiacea leaf powder; step two, adding the sweet wormwood leaf powder into petroleum ether for continuous extraction for three times; step three, combining the sweet wormwood extracting solutions extracted for three times, filtering, recovering petroleum ether from the filtrate, and concentrating under reduced pressure to obtain the paste. The sweet wormwood herb extraction is carried out in the extraction device, the sliding block is driven to move in the storage pool through the first motor, petroleum ether in the storage pool is pressed into the extraction cavity, the inner stirring paddle in the extraction cavity stirs sweet wormwood herb powder when the petroleum ether and sweet wormwood herb powder react, the outer stirring paddle stirs petroleum ether solution, and the stirring directions of the inner stirring paddle and the outer stirring paddle are opposite, so that the contact area of the petroleum ether and the sweet wormwood herb powder can be effectively increased, the extraction rate of the sweet wormwood herb is further ensured, and the waste of resources is avoided.
Description
Technical Field
The invention relates to the technical field of sweet wormwood extraction, in particular to a preparation method for extracting artemisinin by utilizing sweet wormwood.
Background
The sweet wormwood is a traditional Chinese medicine, is a ground dry part of a chrysanthemum plant sweet wormwood, and is also a raw material medicine of a new veterinary medicine sweet wormwood powder registered in the application. The artemisinin and the derivatives thereof are found to have not only the function of resisting the crude protozoa but also various pharmacological effects, mainly show in the aspects of schistosomiasis resistance, arrhythmia resistance, systemic lupus erythematosus resistance, endotoxin resistance, immune system regulation and the like, and carry out human clinical research in the aspects of schistosomiasis resistance and systemic lupus erythematosus resistance. Therefore, the medicinal value of the sweet wormwood is very high, but in the prior art, when the artemisinin in the sweet wormwood is extracted, the extraction rate of the artemisinin is limited, and a large amount of artemisinin can be remained in sweet wormwood leaves, so that a large amount of waste of resources is caused.
Disclosure of Invention
The invention aims to provide a preparation method for extracting artemisinin by utilizing artemisia apiacea, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: the preparation method for extracting artemisinin by utilizing artemisia apiacea comprises the following steps:
step one, pulverizing the artemisia leaves to obtain artemisia leaf powder;
step two, adding the sweet wormwood leaf powder into petroleum ether for continuous extraction for three times;
step three, combining the sweet wormwood extracting solutions extracted for three times, filtering, recovering petroleum ether from the filtrate, and concentrating under reduced pressure to obtain the paste.
Preferably, the extraction of artemisinin in step two is accomplished in a leaching unit.
Preferably, the leaching device is including the storage pool and fix the jar that draws at storage pool top, the inside of drawing the jar is formed with extraction cavity and filter chamber, and be linked together through straight-through valve between extraction cavity and the filter chamber, be linked together through the check valve between storage pool and the extraction cavity, the inside of storage pool is provided with the slider that is used for promoting petroleum ether to the inside removal of extraction cavity, the inside of extraction cavity is fixed with the section of thick bamboo of placing sweet wormwood that is used for holding sweet wormwood leaf powder, the inside of extraction cavity still is provided with the interior stirring rake that is used for stirring sweet wormwood leaf powder respectively and is used for stirring the outer stirring rake of petroleum ether solution, interior stirring rake is located the inside that the section of thick bamboo was placed to outer stirring rake is located the outside that the section of thick bamboo was placed to outer stirring rake and the rotation direction of interior stirring rake are opposite.
Preferably, the position of the top of the extraction tank, which corresponds to the extraction cavity, is in an opening shape, the opening part of the extraction tank is detachably covered with an upper cover, the center of the bottom of the upper cover is fixedly connected with a connecting column along the vertical direction, a first loop bar is rotatably sleeved on the connecting column, the top of the first loop bar is fixedly connected with a straight gear, the bottom of the first loop bar is fixedly connected with a first bevel gear, and the outer stirring paddles are annularly distributed on the circumferential surface of the first loop bar; a limiting frame is fixedly connected to the circumferential surface of the top of the connecting column, a rack meshed with the straight gear is connected to the inside of the limiting frame in a sliding mode, a rotating rod is hinged to one end of the rack, and the tail end of the rotating rod is connected with the output end of a third motor fixed to the bottom of the upper cover; the second loop bar is sleeved on the circumferential surface of the bottom of the connecting column in a rotating mode, the top of the second loop bar is fixedly connected with a third bevel gear, the inner stirring paddles are annularly distributed on the circumferential surface of the second loop bar, two second bevel gears are connected between the first bevel gear and the second loop bar in a meshed mode, and the two second bevel gears are distributed on the two sides of the connecting column and are connected through a center shaft.
Preferably, there is first motor through fixed plate fixed mounting on the one end outer wall of storage pool along its length direction, the output drive of first motor is connected with the threaded rod, the threaded rod is connected with the inner wall rotation of its other end after extending to the inside in storage pool, the screw thread has cup jointed the slider on the threaded rod, the top is formed with the fixed block with slider matched with in the cavity in storage pool, the bilateral symmetry's of threaded rod distributes and has two guide bars, the both ends of guide bar respectively with the inside both ends fixed connection in storage pool, and slider and two guide bar sliding connection.
Preferably, an extract outlet is formed on the outer wall of the filter cavity, and a filter assembly is installed in the filter cavity at a position corresponding to the extract outlet.
Preferably, the filter assembly comprises a housing, the filter chamber is communicated with the extract outlet through the housing, a second motor is fixedly mounted at any end of the housing along the length direction of the housing, a protective cover is covered outside the second motor, a filter cartridge is rotatably mounted inside the housing, and a motor shaft of the second motor penetrates through the housing and then is fixedly connected with the center of the filter cartridge.
Preferably, the bottom of the shell is provided with a scraper plate tangential to the rotation direction of the scraper plate.
Compared with the prior art, the invention provides the preparation method for extracting the artemisinin by utilizing the sweet wormwood herb, which has the following beneficial effects:
(1) the sweet wormwood herb extraction is carried out in the extraction device, the sliding block is driven to move in the storage pool through the first motor, petroleum ether in the storage pool is pressed into the extraction cavity, the inner stirring paddle in the extraction cavity stirs sweet wormwood herb powder when the petroleum ether and sweet wormwood herb powder react, the outer stirring paddle stirs petroleum ether solution, and the stirring directions of the inner stirring paddle and the outer stirring paddle are opposite, so that the contact area of the petroleum ether and the sweet wormwood herb powder can be effectively increased, the extraction rate of the sweet wormwood herb is further ensured, and the waste of resources is avoided.
(2) The artemisinine liquid after the leaching is discharged to the outside after being filtered by the filter assembly and is collected and processed, the filter cartridge in the filter assembly is always in a rotating state during working, and is in contact with the scraping plate, and the scraping plate scrapes off attached impurities on the filter cartridge, so that the filter cartridge is further prevented from being blocked.
(3) The invention can continuously realize three times of extraction operation of the artemisinin, more thoroughly extract the artemisinin in the sweet wormwood herb powder and realize the maximum utilization of resources.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention without limiting the invention in which:
FIG. 1 is a schematic view of the external structure of a leaching apparatus according to the present invention;
FIG. 2 is a schematic view showing the internal structure of a leaching apparatus according to the present invention;
FIG. 3 is a schematic front view of the interior of a leaching apparatus according to the present invention;
FIG. 4 is a schematic view of the assembly of the outer and inner paddles on the connecting column of the present invention;
FIG. 5 is a schematic view of the structure of FIG. 4 from another angle;
FIG. 6 is a schematic view of the construction of the filter assembly of the present invention;
fig. 7 is a schematic view of the construction of the housing in the filter assembly of the present invention.
In the figure: 1. a storage pool; 2. an extraction tank; 3. an extract outlet; 4. a fixing plate; 5. a first motor; 6. a threaded rod; 7. a guide bar; 8. a slider; 9. a fixed block; 10. leaching a cavity; 11. a filter chamber; 12. a sweet wormwood placing cylinder; 13. a filter assembly; 131. a housing; 132. a filter cartridge; 133. a protective cover; 134. a second motor; 135. a scraping plate; 14. a straight-through valve; 15. a check valve; 16. an upper cover; 17. connecting columns; 18. a first loop bar; 19. a first bevel gear; 20. an outer stirring paddle; 21. a spur gear; 22. a second bevel gear; 23. a second loop bar; 24. a third bevel gear; 25. an inner stirring paddle; 26. a limiting frame; 27. a rack; 28. a rotating rod; 29. a third motor.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the embodiments of the present invention, it should be understood that the terms "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing embodiments of the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the embodiments of the present invention.
The embodiment discloses a preparation method for extracting artemisinin by utilizing artemisia apiacea, which comprises the following steps:
firstly screening the artemisia apiacea leaves to be extracted, removing impurities in the artemisia apiacea leaves, then heating and drying the screened clean artemisia apiacea leaves, and crushing after drying to obtain artemisia apiacea leaf powder;
then putting the crushed and processed artemisia apiacea leaf powder into a leaching device, adding a proper amount of petroleum ether into the leaching device to fully contact with the artemisia apiacea leaf powder for extraction, and continuously extracting for three times;
and finally, combining the sweet wormwood extracting solutions extracted for three times, filtering, recovering petroleum ether from the filtrate, and concentrating under reduced pressure to obtain the sweet wormwood paste.
The leaching device in the application is shown in figures 1-7, and comprises a storage pool 1 and an extraction tank 2 fixed at the top of the storage pool 1, wherein a leaching cavity 10 and a filtering cavity 11 are formed inside the extraction tank 2, the leaching cavity 10 is communicated with the filtering cavity 11 through a straight-through valve 14, the storage pool 1 is communicated with the leaching cavity 10 through a check valve 15, a slide block 8 for pushing petroleum ether to move towards the inside of the leaching cavity 10 is arranged inside the storage pool 1, the slide block 8 moves inside the storage pool 1 to press the petroleum ether, so that the petroleum ether opens the check valve 15 to enter the leaching cavity 10, a sweet wormwood placing cylinder 12 for containing sweet wormwood leaf powder is fixed inside the leaching cavity 10, sweet wormwood powder to be extracted is placed in the sweet wormwood placing cylinder 12, the liquid level of the petroleum ether is not higher than the sweet wormwood placing cylinder 12, the sweet wormwood powder is prevented from migrating out of the sweet wormwood placing cylinder 12 along with the petroleum ether solution, the inside of leaching cavity 10 still is provided with the interior stirring rake 25 that is used for stirring sweet wormwood leaf powder respectively and is used for stirring the outer stirring rake 20 of petroleum ether solution, interior stirring rake 25 is located the inside that a section of thick bamboo 12 was placed to the sweet wormwood, outer stirring rake 20 is located the outside that a section of thick bamboo 12 was placed to the sweet wormwood, and outer stirring rake 20 is opposite with the direction of rotation of interior stirring rake 25, in the leaching, interior stirring rake 25 stirs the sweet wormwood powder, and outer stirring rake 20 then stirs petroleum ether solution, and because both all stir opposite direction, consequently can effectual increase petroleum ether and sweet wormwood powder's area of contact, and then ensured the extraction rate of artemisinin, avoid causing the waste of resource.
Specifically, the position of the top of the extraction tank 2 corresponding to the extraction cavity 10 is in an open shape, the opening of the extraction tank 2 is detachably covered with an upper cover 16, the center of the bottom of the upper cover 16 is fixedly connected with a connecting column 17 along the vertical direction, a first sleeve rod 18 is rotatably sleeved on the connecting column 17, the top of the first sleeve rod 18 is fixedly connected with a straight gear 21, the bottom of the first sleeve rod 18 is fixedly connected with a first bevel gear 19, and outer stirring paddles 20 are annularly distributed on the circumferential surface of the first sleeve rod 18; a limiting frame 26 is fixedly connected to the circumferential surface of the top of the connecting column 17, a rack 27 meshed with the straight gear 21 is connected to the inside of the limiting frame 26 in a sliding mode, one end of the rack 27 is hinged to a rotating rod 28, the tail end of the rotating rod 28 is connected with the output end of a third motor 29 fixed to the bottom of the upper cover 16, the third motor 29 drives the rotating rod 28 to do circumferential rotation movement, the rack 27 is hinged to the rotating rod 28 and does reciprocating linear movement along the limiting frame 26 under the action of the limiting frame 26, and the rack 27 is meshed with the straight gear 21 in the linear movement process, so that the first loop bar 18 is driven to do reciprocating forward and reverse rotation, the outer stirring paddles 20 on the first loop bar 18 do periodic forward and reverse rotation, the outer stirring paddles 20 do periodic forward and reverse rotation to stir petroleum ether, and the petroleum ether forms disturbance and reverse rotation.
Second loop bar 23 has been cup jointed in the rotation on the periphery of spliced pole 17 bottom, the top fixedly connected with third bevel gear 24 of second loop bar 23, interior stirring rake 25 ring-type distributes on the periphery of second loop bar 23, the meshing is connected with two second bevel gears 22 between first bevel gear 19 and the second loop bar 23, two second bevel gears 22 distribute in the both sides of spliced pole 17 and link to each other through the center pin, it is rotatory in step with it that first bevel gear 19 is driven during first loop bar 18 periodic positive and negative rotation, two second bevel gears 22 are owing to mesh with first bevel gear 19, consequently, the rotation of first bevel gear 19 drives third bevel gear 24 through two second bevel gears 22 and rotates, and then drive second loop bar 23 periodic the rotation, interior stirring rake 25 stirs the sweet wormwood powder in the section of thick bamboo 12 is placed to sweet wormwood with second loop bar 23 synchronization action.
The outer wall of one end of the storage pool 1 along the length direction is fixedly provided with a first motor 5 through a fixing plate 4, the output end of the first motor 5 is connected with a threaded rod 6 in a driving way, the threaded rod 6 is connected with the inner wall of the other end of the storage pool 1 after extending into the storage pool 1 in a rotating way, a sliding block 8 is sleeved on the threaded rod 6 in a threaded way, a fixed block 9 matched with the sliding block 8 is formed at the top in the cavity of the storage pool 1, two guide rods 7 are symmetrically distributed at two sides of the threaded rod 6, two ends of the guide rods 7 are respectively fixedly connected with two ends in the storage pool 1, the sliding block 8 is connected with the two guide rods 7 in a sliding way, the sliding block 8 slides along the interior of the storage pool 1 and is realized by the threaded rod 6 driven by the first motor 5 to rotate, the threaded rod 6 rotates, and the sliding block 8 is in threaded connection with the threaded rod 6, so that the linear movement is carried out along the axial direction of the threaded rod 6 under the limiting action of the two guide rods 7, the slide 8 presses the petroleum ether to open the check valve 15 into the leaching chamber 10.
Be formed with extract outlet 3 on the outer wall of filter chamber 11, the sweet wormwood liquid after the extraction flows out from extract outlet 3, because sweet wormwood powder still can have certain impurity at the in-process of leaching, in order to obtain comparatively pure sweet wormwood extract, need be after the leaching further filtration to the leaching liquor, install filter assembly 13 in the inside of filter chamber 11 and correspond the position department of extract outlet 3 in this embodiment.
Specifically, the filter assembly 13 in this embodiment includes a housing 131, the filter chamber 11 is communicated with the extract outlet 3 through the housing 131, a second motor 134 is fixedly mounted at any end of the housing 131 along a length direction thereof, a protective cover 133 is covered outside the second motor 134, a filter cartridge 132 is rotatably mounted inside the housing 131, a motor shaft of the second motor 134 penetrates through the housing 131 and then is fixedly connected with a center of the filter cartridge 132, when the extract is filtered, the filter cartridge 132 is continuously driven by the second motor 134 to rotate, so as to prevent the filter cartridge 132 from being blocked to prevent the extract from being taken out smoothly. In addition, in this embodiment, a scraping plate 135 tangential to the rotation direction of the scraping plate 135 is installed at the bottom of the housing 131, the filter cartridge 132 in the selected state is continuously in contact with the scraping plate 135, and the scraping plate 135 scrapes off impurities attached to the filter cartridge 132, thereby further preventing the filter cartridge 132 from being blocked.
When the leaching device is used, firstly, the upper cover 16 is opened, the sweet wormwood powder to be extracted is placed in the sweet wormwood placing cylinder 12, then, the upper cover 16 is tightly covered, the inner stirring paddle 25 is placed in the sweet wormwood placing cylinder 12, the outer stirring paddle 20 is placed outside the sweet wormwood placing cylinder 12, the first motor 5 is started, the first motor 5 drives the threaded rod 6 to rotate, the sliding block 8 slides along the inside of the storage pool 1 to extrude petroleum ether, the pressure of the petroleum ether in the storage pool 1 is increased, the check valve 15 is opened to enter the leaching cavity 10, at the moment, the third motor 29 is started, the third motor 29 drives the rotating rod 28 to do circumferential rotation motion, the rack 27 is hinged with the rotating rod 28 and does reciprocating linear motion along the limiting frame 26 under the action of the limiting frame 26, the rack 27 is meshed with the straight gear 21 in the linear motion process, so as to drive the first sleeve rod 18 to do reciprocating forward and reverse rotation, and then the outer stirring paddle 20 on the first loop bar 18 periodically rotates forward and backward, the outer stirring paddle 20 periodically rotates forward and backward to stir petroleum ether, the petroleum ether is disturbed and overturned, the inner stirring paddle 25 synchronously acts with the second loop bar 23 to stir the sweet wormwood powder in the sweet wormwood placing barrel 12, after leaching is completed, leaching liquor enters the filter cavity 11 through the straight-through valve 14, the leaching liquor is filtered by the filter component 13 before flowing out of the extracting liquor outlet 3, and pure sweet wormwood extracting liquor is obtained after filtering treatment. And then starting the first motor 5, so that the petroleum ether in the storage pool 1 enters the leaching cavity 10 for secondary extraction, and repeating the steps for three times to completely extract the artemisinin in the sweet wormwood herb powder.
In the description of the present invention, the terms "first", "second", "another", and "yet" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more features. In the description of the embodiments of the present invention, "a plurality" means two or more unless specifically limited otherwise.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (8)
1. The preparation method for extracting artemisinin by utilizing artemisia apiacea is characterized by comprising the following steps of:
step one, pulverizing the artemisia leaves to obtain artemisia leaf powder;
step two, adding the sweet wormwood leaf powder into petroleum ether for continuous extraction for three times;
step three, combining the sweet wormwood extracting solutions extracted for three times, filtering, recovering petroleum ether from the filtrate, and concentrating under reduced pressure to obtain the paste.
2. The method for extracting artemisinin using artemisia apiacea as claimed in claim 1, wherein the extraction of artemisinin in step two is done in the extraction device.
3. The preparation method of artemisinin by using artemisia apiacea as claimed in claim 2, wherein the extraction device comprises a storage pool (1) and an extraction tank (2) fixed on top of the storage pool (1), an extraction cavity (10) and a filter cavity (11) are formed inside the extraction tank (2), the extraction cavity (10) and the filter cavity (11) are communicated through a through valve (14), the storage pool (1) and the extraction cavity (10) are communicated through a check valve (15), a slide block (8) for pushing petroleum ether to move towards the inside of the extraction cavity (10) is arranged inside the storage pool (1), an artemisia apiacea placing cylinder (12) for containing artemisia apiacea leaf powder is fixed inside the extraction cavity (10), an inner stirring paddle (25) for stirring artemisia apiacea leaf powder and an outer stirring paddle (20) for stirring petroleum ether solution are arranged inside the extraction cavity (10) respectively, the inner stirring paddle (25) is positioned inside the sweet wormwood placing barrel (12), the outer stirring paddle (20) is positioned outside the sweet wormwood placing barrel (12), and the rotating directions of the outer stirring paddle (20) and the inner stirring paddle (25) are opposite.
4. The preparation method for extracting artemisinin by using artemisia apiacea as claimed in claim 3, wherein the position of the top of the extraction tank (2) corresponding to the extraction cavity (10) is open, the opening of the extraction tank (2) is detachably covered with an upper cover (16), the center of the bottom of the upper cover (16) is fixedly connected with a connecting column (17) along the vertical direction, a first loop bar (18) is rotatably sleeved on the connecting column (17), the top of the first loop bar (18) is fixedly connected with a straight gear (21), the bottom of the first loop bar (18) is fixedly connected with a first bevel gear (19), and the outer stirring paddles (20) are annularly distributed on the circumferential surface of the first loop bar (18); a limiting frame (26) is fixedly connected to the circumferential surface of the top of the connecting column (17), a rack (27) meshed with the straight gear (21) is connected to the inside of the limiting frame (26) in a sliding mode, a rotating rod (28) is hinged to one end of the rack (27), and the tail end of the rotating rod (28) is connected with the output end of a third motor (29) fixed to the bottom of the upper cover (16); second loop bar (23) has been cup jointed in the rotation on the periphery of spliced pole (17) bottom, the top fixedly connected with third bevel gear (24) of second loop bar (23), interior stirring rake (25) ring-type distribution is on the periphery of second loop bar (23), the meshing is connected with two second bevel gears (22) between first bevel gear (19) and second loop bar (23), two second bevel gears (22) distribute in the both sides of spliced pole (17) and link to each other through the center pin.
5. The preparation method of extracting artemisinin by using artemisia apiacea as claimed in claim 3, wherein a first motor (5) is fixedly installed on the outer wall of one end of the storage pool (1) along the length direction of the storage pool through a fixing plate (4), the output end of the first motor (5) is connected with a threaded rod (6) in a driving mode, the threaded rod (6) is connected with the inner wall of the other end of the storage pool (1) in a rotating mode after extending to the inside of the storage pool (1), a sliding block (8) is sleeved on the threaded rod (6) in a threaded mode, a fixing block (9) matched with the sliding block (8) is formed at the top of the inner cavity of the storage pool (1), two guide rods (7) are symmetrically distributed on two sides of the threaded rod (6), two ends of each guide rod (7) are fixedly connected with two ends of the inside of the storage pool (1), and the sliding block (8) is connected with the two guide rods (7) in a sliding mode.
6. The preparation method for extracting artemisinin by using artemisia apiacea as claimed in claim 3, wherein the extract outlet (3) is formed on the outer wall of the filter cavity (11), and the filter assembly (13) is installed inside the filter cavity (11) at the position corresponding to the extract outlet (3).
7. The preparation method of artemisinin by using artemisia apiacea as claimed in claim 6, wherein the filter assembly (13) comprises a housing (131), the filter chamber (11) is communicated with the extract outlet (3) through the housing (131), a second motor (134) is fixedly mounted on the housing (131) along any one end of the length direction, a protective cover (133) covers the second motor (134), a filter cartridge (132) is rotatably mounted inside the housing (131), and a motor shaft of the second motor (134) penetrates through the housing (131) and then is fixedly connected with the center of the filter cartridge (132).
8. The method for preparing artemisinin by using artemisia apiacea as claimed in claim 7, wherein a scraper plate (135) tangential to the rotation direction of the scraper plate (135) is installed at the bottom of the shell (131).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111243207.8A CN114014871A (en) | 2021-10-25 | 2021-10-25 | Method for extracting artemisinin from sweet wormwood herb |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111243207.8A CN114014871A (en) | 2021-10-25 | 2021-10-25 | Method for extracting artemisinin from sweet wormwood herb |
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| CN117899700A (en) * | 2024-03-12 | 2024-04-19 | 成都理工大学 | Acid insoluble matter extraction element based on carbonate rock |
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