CN114010954A - In-vivo optical medical device - Google Patents
In-vivo optical medical device Download PDFInfo
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- CN114010954A CN114010954A CN202111327517.8A CN202111327517A CN114010954A CN 114010954 A CN114010954 A CN 114010954A CN 202111327517 A CN202111327517 A CN 202111327517A CN 114010954 A CN114010954 A CN 114010954A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0626—Monitoring, verifying, controlling systems and methods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
- A61N2005/0633—Arrangements for lifting or hinging the frame which supports the light sources
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0653—Organic light emitting diodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
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- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
An in vivo light medical device is disclosed. The method comprises the following steps: a chassis; a bracket mounted on the chassis; a plurality of light sources arranged on the support along a first direction for providing therapeutic radiation; and the driving structure is used for controlling the support to move relative to the base frame so as to adjust the shape and size of the radiation area. The method specifically comprises the steps that a plurality of light sources are designed on a support and are arranged along a first direction, and irradiation areas in a zebra shape or different sizes and shapes are formed by controlling different light sources, so that the whole affected part can obtain equal radiation light energy; the driving structure is used for controlling the movement of the support, and the shape and the size of the radiation area of the light source are adjusted by adjusting the movement speed of the support, so that the shapes and the sizes of different affected areas are met, and the radiation of non-affected areas can be avoided.
Description
Technical Field
The present disclosure relates generally to the field of photomedical equipment, and more particularly to an in vivo photomedical device.
Background
Phototherapy includes photodynamic therapy (PDT) in which light of a specific wavelength or wavelength band is directed at a target cell that is sensitized by the administration of a photoreactive, photostimulating or photosensitizing agent. Photoreactive agents have a specific light absorption band and are typically administered to a patient by intravenous injection, orally, or by local delivery to a treatment site. Typically, abnormal cells in the body can selectively absorb specific photoreactive agents in amounts far in excess of the normal amounts for healthy cells. When the abnormal cells have absorbed and/or are molecularly bound to the photoreactive agent, the abnormal cells may be treated by exposing the cells to light of an appropriate wavelength or wavelength band that generally corresponds to the absorption wavelength or wavelength band of the photoreactive agent.
PDT is targeted for diagnosis or treatment. In diagnostic applications, the wavelength of light is selected to cause the photoreactive agent to fluoresce as a means of obtaining information about the target cell without damaging the target cell. In therapeutic applications, the wavelength of light delivered to target cells treated with the photoreactive agent causes the photoreactive agent to photoreactive with oxygen in the local target cells, thereby generating free radical species (e.g., singlet oxygen) that lyse or necrose the local cells.
When the diseases are in human bodies, such as bladder cancer, throat cancer, bronchial cancer and the like, the conventional medication means has slow effect, so the light medical treatment mode is mostly adopted. At present, the light source for in vivo treatment is mainly laser optical fiber, however, in practical use, the affected part has the characteristics of uneven appearance and non-uniform overall shape, so that the optical fiber is difficult to emit light with uniform energy and suitable for the light treatment shape of the affected part, the light energy loss of the optical fiber is large, the light emitting area is small, and the control is difficult. Therefore, we propose an intracorporeal optical medical device to solve the above-mentioned problems of large light energy loss, poor light emitting consistency, small light emitting area and uneasy control.
Disclosure of Invention
In view of the above-mentioned drawbacks and deficiencies of the prior art, it is desirable to provide an in vivo optical medical device which has improved uniformity of light emission, an enlarged area of a light source irradiation region, a simple structure, and easy implementation.
In a first aspect, the present application provides an in vivo photomedical device, comprising:
a chassis;
a bracket mounted on the chassis;
a plurality of light sources arranged on the support along a first direction for providing therapeutic radiation;
and the driving structure is used for controlling the support to move relative to the base frame so as to adjust the shape and size of the radiation area.
According to the technical scheme provided by the embodiment of the application, the light source is divided into at least 2 light source regions along the arrangement direction; a distance sensor is arranged on the bracket corresponding to each light source area and used for detecting the distance s between the light source and the treated area; the working current I of the light source in each light source region meets the following conditions: i is Q/s;
wherein Q is a set constant.
According to the technical scheme provided by the embodiment of the application, the set constant Q is I/sLower part；
Wherein s isLower partThe shortest distance between the light source region and the region to be treated, and V is the rated operating current.
According to the technical scheme provided by the embodiment of the application, the distance sensor is a laser sensor.
According to the technical scheme provided by the embodiment of the application, the driving structure comprises a first driving structure used for driving the support to rotate on the bottom frame.
According to the technical scheme provided by the embodiment of the application, the rotating shaft of the first driving structure is perpendicular to the first direction or parallel to the first direction.
According to the technical scheme provided by the embodiment of the application, the driving structure comprises a second driving structure used for driving the support to move on the bottom frame along a second direction.
According to the technical scheme provided by the embodiment of the application, the medical treatment device further comprises an identification module fixed on the support and used for acquiring the shape and the size of the treatment area.
According to the technical scheme provided by the embodiment of the application, the identification module is a miniature camera fixed on the bracket.
According to the technical scheme provided by the embodiment of the application, the light source is an OLED light source, an LED light source, a miniLED light source, a micro light source, a quantum point light source or an optical fiber.
In summary, the present technical solution discloses a specific structure of an in vivo optical medical device. The method specifically comprises the steps that a plurality of light sources are designed on a support and are arranged along a first direction, and irradiation areas in a zebra shape or different sizes and shapes are formed by controlling different light sources, so that the whole affected part can obtain equal radiation light energy; the driving structure is used for controlling the movement of the support, and the shape and the size of the radiation area of the light source are adjusted by adjusting the movement speed of the support, so that the shapes and the sizes of different affected areas are met, and the radiation of non-affected areas can be avoided.
Drawings
Other features, objects and advantages of the present application will become more apparent upon reading of the following detailed description of non-limiting embodiments thereof, made with reference to the accompanying drawings in which:
FIG. 1 is a schematic diagram of an in vivo photomedical device constructed using multiple light sources.
FIG. 2 is a schematic diagram of an in vivo photomedical device using a single elongated light source.
FIG. 3 is a schematic diagram of a first embodiment of an in-vivo photomedical device.
FIG. 4 is a schematic diagram of a fourth embodiment of an in vivo photomedical device.
FIG. 5 is a schematic view of a small circular treatment area.
Fig. 6 is a schematic view of a large circular treatment area.
Fig. 7 is a schematic view of a square shaped treatment area.
Fig. 8 is a schematic view of a rectangular shaped treatment area.
Fig. 9 is a schematic view of an annular treatment region.
Reference numbers in the figures: 1. a support; 2. a light source.
Detailed Description
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and not restrictive of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
Example 1
Please refer to fig. 1, which illustrates a schematic structural diagram of an in-vivo optical medical device according to the present embodiment, including:
a bottom frame, a plurality of supporting frames and a plurality of supporting frames,
the bracket 1 is arranged on the underframe;
a plurality of light sources 2 arranged on the support 1 along a first direction for providing therapeutic radiation; here, the first direction is a length direction of the stent 1;
and the driving structure is used for controlling the support 1 to move relative to the underframe so as to adjust the shape and size of the radiation area.
As shown in fig. 1, the light source 2 may be a plurality of OLED light sources spliced together, and is distributed over the entire holder along the length direction of the holder, as shown in fig. 2, in other embodiments, the light source may also be a single long-strip OLED light source. Whether 1 or a plurality of light sources, as long as the length of the distribution area is smaller than the length of the support 1.
In other embodiments, the light source 2 may also be an LED light source, miniLED light source, micro-LED light source, quantum dot light source, or optical fiber;
the light source can be selected according to the treatment requirement, the phototherapy effect of the light of different colours:
the irradiation depth of the yellow green light with the wave band of 510 nm-590 nm is between the blue light and the red light, so that the dredging and the expansion of the capillary vessel in the skin depth can be promoted, the resistance of cells is enhanced, and the treatment effect of the affected part is accelerated.
Red light with a waveband of 590-810 nm can enable mitochondria to release cytochrome c oxidase, increase adenosine triphosphate, and enable cells to provide energy by utilizing the adenosine triphosphate, so that the metabolism of the cells is promoted; meanwhile, the red light irradiation heats molecules in the blood vessel, so as to adjust the blood vessel expansion and improve the blood circulation; the blue light irradiation of the 440-510 nm wave band can be used for relieving pain and swelling caused by inflammation.
In the present embodiment, the movement of the carriage 1 is achieved by: the bracket 1 is connected with a bottom frame in a sliding way, and the bottom frame is in a long strip shape and is vertical to the middle part of the bracket. One end of the underframe is also provided with a miniature servo motor, and the miniature servo motor is connected with the support 1 through a screw rod sliding block structure to realize the movement of the support 1.
One end of the chassis is fixed with a flexible supporting rod which is used for sending the chassis, the bracket, the micro servo motor, the lead screw, the sliding block and the phototherapy device integrated with the light source into the body or taking the phototherapy device out of the body. Meanwhile, a control module for controlling the micro servo motor and the light source is connected with the control module through a control circuit, and the control circuit is arranged along with the flexible branches, so that power supply and control of the micro servo motor and the light source are realized.
The micro servo motor can form a square or rectangular treatment area in the process of driving the strip light source to reciprocate by the driving bracket 1, as shown in fig. 7 or fig. 8. For example, a large phototherapy area or a small phototherapy area can be realized by controlling the length of the reciprocating path of the support on the chassis, so that the phototherapy device is suitable for disease areas with different shapes and sizes, such as long strips, squares and the like, and radiation of non-diseased areas can be avoided.
Further, the light source 2 is divided into at least two light source areas along the arrangement direction, and a distance sensor is arranged on the bracket 1 and is arranged corresponding to each light source area and used for detecting the distance s between the light source and the treated area;
the operating current I of the light source 2 in each light source region satisfies the following condition: QS;
wherein Q is a set constant, and Q is I/sLower part；
Wherein s isLower partThe distance between the shortest light source area and the treated area, and I is rated working current;
here, the type of the distance sensor is, for example, a laser sensor;
when the distance between the light source 2 and the affected part detected by the corresponding distance sensor is larger, the working current of the corresponding light source is increased, so that the same radiant light energy can be obtained in the whole affected area.
Example 2
In this embodiment, based on embodiment 1, the control module classifies the severity of the focal zone, for example, an elongated focal zone, wherein the severity of the central portion is a and the severity of the two ends is B, and the severity of a is greater than B; when the control module judges that the position of the bracket is aligned with the middle part of the focus, the rotating speed of the micro servo motor is adjusted and controlled to be a, and when the control module judges that the position of the sliding block is aligned with the two ends of the focus, the rotating speed of the micro servo motor is adjusted and controlled to be b, wherein a is smaller than b.
The moving speed of the treatment light source is adjusted according to the severity of the focus area, so that the area with the heavier severity can be treated for a longer time in one treatment period, a treatment scheme is customized according to local conditions, and the treatment effect is improved.
Example 3
In this embodiment, based on embodiment 2, if the light source is an elongated light source, the control module adjusts the irradiation intensity by adjusting the duty ratio of the input current of the light source for different severity focal zones. For example, when the control module determines that the position of the bracket is aligned with the middle of the focus, the input current of the control light source is adjusted to be c, and when the control module determines that the position of the sliding block is aligned with the two ends of the focus, the input current of the control light source is adjusted to be d, wherein c is larger than d.
On the basis of embodiment 2, if the plurality of light sources are spliced together, for focal areas with different severity, the corresponding treatment is realized by controlling different illumination intensities of different light-emitting units.
The phototherapy of different intensity also can be realized to this embodiment, can be in a treatment cycle, and the heavier region of severity can obtain stronger phototherapy, realizes customizing the treatment scheme according to local conditions, promotes treatment. Is suitable for different severity of disease region.
Example 4
In this embodiment, on the basis of embodiment 1, the driving structure is replaced with a second driving structure for driving the support 1 to rotate.
Wherein, the pivot of support 1 can select following arbitrary mode setting:
1. the rotating shaft is arranged in the middle of the support 1 and is perpendicular to the support, at the moment, the second driving mechanism can be a micro servo motor, for example, and the rotating shaft of the support 1 is coaxially fixed on the rotating shaft of the micro servo motor. When the micro servo motor works, the support is driven to rotate around the center of the support, a circular phototherapy area can be formed in the support rotating process, and the support can be suitable for a circular treatment area as shown in fig. 5.
2. The rotating shaft is arranged at one end of the bracket 1 and is vertical to the bracket. In this case, the second driving mechanism may be, for example, a micro servo motor, and the rotating shaft of the bracket 1 is coaxially fixed to the rotating shaft of the micro servo motor. When the miniature servo motor works, the support is driven to rotate around the rotating shaft at the end part of the support, a large circular phototherapy area can be formed in the support rotating process, and the miniature servo motor is suitable for a circular treatment area as shown in fig. 6.
3. The rotating shaft is arranged at one end of the bracket 1 and is parallel to the length direction of the bracket, at the moment, the second driving mechanism can be a micro servo motor, for example, and the rotating shaft of the bracket 1 is coaxially fixed on the rotating shaft of the micro servo motor. When the micro servo motor works, the bracket is driven to rotate around the rotating shaft at the end part of the bracket.
A large annular phototherapy area can be formed in the rotation process of the support, as shown in fig. 9, and the radial direction of the annular phototherapy area is perpendicular to the length direction of the support, which can be suitable for an annular treatment area.
The size of the annular area is determined by the area covered by the light source on the support.
No matter what kind of above-mentioned embodiment, miniature servo motor all fixes on a mounting panel, and the one end of mounting panel is fixed with flexible branch for send into the phototherapy device of mounting panel, support, miniature servo motor, lead screw, slider and light source an organic whole in vivo or take out from the body.
The technical scheme of the implementation can realize the treatment of annular and circular focus areas with different sizes.
Example 5
In this embodiment, on the basis of embodiment 1, the treatment apparatus further includes an identification module fixed on the support 1, and configured to obtain the shape and size of the treatment region.
In the embodiment, the identification module is fixed on the bracket 1 and used for acquiring the shape and the size of the treatment area; here, the type of the module is identified, for example, a miniature camera.
The miniature camera is favorable for acquiring internal images in real time in the process of stretching the device, accurately controls the insertion position and realizes accurate treatment.
The above description is only a preferred embodiment of the application and is illustrative of the principles of the technology employed. It will be appreciated by a person skilled in the art that the scope of the invention as referred to in the present application is not limited to the embodiments with a specific combination of the above-mentioned features, but also covers other embodiments with any combination of the above-mentioned features or their equivalents without departing from the inventive concept. For example, the above features may be replaced with (but not limited to) features having similar functions disclosed in the present application.
Claims (10)
1. An in vivo photomedical device, comprising:
a chassis;
a bracket (1) mounted on the chassis;
a plurality of light sources (2) arranged on said support (1) along a first direction for providing therapeutic radiation;
and the driving structure is used for controlling the support (1) to move relative to the base frame so as to adjust the shape and size of the radiation area.
2. An in-vivo photomedical device according to claim 1, wherein the light source (2) is divided along its direction of arrangement into at least 2 light source zones; a distance sensor is arranged on the bracket (1) corresponding to each light source area and used for detecting the distance s between the light source and the treated area; the operating current I of the light source (2) in each light source region meets the following condition: i is Q/s;
wherein Q is a set constant.
3. An in vivo photomedical device according to claim 2, where the set constant Q ═ I/sLower part；
Wherein s isLower partI is the distance between the shortest light source zone and the treated area, and I is the rated operating current.
4. An in vivo photomedical device according to claim 2, wherein the distance sensor is a laser sensor.
5. An in-vivo photomedical device according to any of claims 1-4, wherein the drive mechanism comprises a first drive mechanism for driving the rotation of the stent (1) on the base frame.
6. The in vivo photomedical device of claim 5, wherein the axis of rotation of the first drive structure is perpendicular to the first direction or parallel to the first direction.
7. An in-vivo photomedical device according to any of claims 1-4, wherein the drive structure comprises a second drive structure for driving the movement of the stent (1) on the chassis in a second direction.
8. An in-vivo photomedical device according to any of claims 1-4, further comprising an identification module fixed to the stent (1) for obtaining the shape and size of the treatment area.
9. An in-vivo photomedical device according to any of claims 1-4, wherein the identification module is a miniature camera fixed to the stent (1).
10. An in vivo photomedical device according to any of claims 1-4, where the light source (2) is an OLED light source, an LED light source, a miniLED light source, a micro-rolled light source, a quantum dot light source or an optical fiber.
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| CN113101536A (en) * | 2021-05-21 | 2021-07-13 | 中国科学院半导体研究所 | Phototherapy device and assembling method thereof |
| CN113440734A (en) * | 2021-06-30 | 2021-09-28 | 固安翌光科技有限公司 | Optical device for photodynamic therapy and method of making same |
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