CN114008218B - 前列腺癌和淋巴癌的染色体构象标志物 - Google Patents

前列腺癌和淋巴癌的染色体构象标志物 Download PDF

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CN114008218B
CN114008218B CN202080044081.9A CN202080044081A CN114008218B CN 114008218 B CN114008218 B CN 114008218B CN 202080044081 A CN202080044081 A CN 202080044081A CN 114008218 B CN114008218 B CN 114008218B
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chromosomal
dlbcl
interactions
markers
probe
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CN114008218A (zh
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E·亨特
A·拉马达斯
A·阿库利切夫
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Oxford Biodynamics PLC
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Oxford Biodynamics PLC
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Priority claimed from GBGB1906487.2A external-priority patent/GB201906487D0/en
Priority claimed from GB201914729A external-priority patent/GB201914729D0/en
Priority claimed from GBGB2006286.5A external-priority patent/GB202006286D0/en
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Priority to CN202510697824.7A priority Critical patent/CN120591403A/zh
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CN202080044081.9A 2019-05-08 2020-05-06 前列腺癌和淋巴癌的染色体构象标志物 Active CN114008218B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202510697824.7A CN120591403A (zh) 2019-05-08 2020-05-06 前列腺癌和淋巴癌的染色体构象标志物

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1906487.2A GB201906487D0 (en) 2019-05-08 2019-05-08 DNA Marker
GB1906487.2 2019-05-08
GB201914729A GB201914729D0 (en) 2019-10-11 2019-10-11 DNA marker
GB1914729.7 2019-10-11
GB2006286.5 2020-04-29
GBGB2006286.5A GB202006286D0 (en) 2020-04-29 2020-04-29 DNA marker
PCT/GB2020/051105 WO2020225551A1 (en) 2019-05-08 2020-05-06 Chromosome conformation markers of prostate cancer and lymphoma

Related Child Applications (1)

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CN202510697824.7A Division CN120591403A (zh) 2019-05-08 2020-05-06 前列腺癌和淋巴癌的染色体构象标志物

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CN114008218A CN114008218A (zh) 2022-02-01
CN114008218B true CN114008218B (zh) 2025-06-06

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CN202510697824.7A Pending CN120591403A (zh) 2019-05-08 2020-05-06 前列腺癌和淋巴癌的染色体构象标志物

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US (1) US20230049379A1 (https=)
EP (1) EP3966350A1 (https=)
JP (2) JP7617029B2 (https=)
KR (1) KR20220007132A (https=)
CN (2) CN114008218B (https=)
AU (3) AU2020268861B2 (https=)
CA (1) CA3138719A1 (https=)
GB (3) GB2626699B (https=)
IL (1) IL287597A (https=)
MY (1) MY203765A (https=)
SG (1) SG11202112221TA (https=)
TW (1) TWI873135B (https=)
WO (1) WO2020225551A1 (https=)
ZA (1) ZA202109658B (https=)

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Publication number Priority date Publication date Assignee Title
TW202302862A (zh) * 2021-03-04 2023-01-16 英商牛津生物力學公眾有限公司 染色體交互作用標記物
WO2025215190A1 (en) * 2024-04-12 2025-10-16 Oxford BioDynamics PLC Method of typing chromosome markers

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018100381A1 (en) * 2016-12-01 2018-06-07 Oxford Biodynamics Limited Application of epigenetic chromsomal interactions in cancer diagnostics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008323649A1 (en) * 2007-11-08 2009-05-14 University Of Washington DNA microarray based identification and mapping of balanced translocation breakpoints
US10364469B2 (en) * 2014-01-16 2019-07-30 Illumina, Inc Gene expression panel for prognosis of prostate cancer recurrence
JP6745820B2 (ja) * 2015-05-29 2020-08-26 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 前立腺がん予後判定の方法
JP2018527016A (ja) * 2015-06-24 2018-09-20 オックスフォード バイオダイナミックス リミテッド 染色体相互作用の検出

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018100381A1 (en) * 2016-12-01 2018-06-07 Oxford Biodynamics Limited Application of epigenetic chromsomal interactions in cancer diagnostics

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WHITE BLOOD CELLS FROM PROSTATE CANCER PATIENTS CARRY DISTINCT CHROMOSOME CONFORMATIONS;Dmitri Pchejetski等;THE JOURNAL OF UROLOGY;20180519;第199卷(第4S期);e542页 *

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SG11202112221TA (en) 2021-12-30
JP2022532108A (ja) 2022-07-13
GB202117415D0 (en) 2022-01-19
MY203765A (en) 2024-07-17
AU2021286282B2 (en) 2022-04-07
ZA202109658B (en) 2022-08-31
AU2020268861B2 (en) 2022-02-03
TW202108773A (zh) 2021-03-01
US20230049379A1 (en) 2023-02-16
EP3966350A1 (en) 2022-03-16
CA3138719A1 (en) 2020-11-12
AU2020268861A1 (en) 2021-11-25
KR20220007132A (ko) 2022-01-18
GB2597895A (en) 2022-02-09
IL287597A (en) 2021-12-01
CN120591403A (zh) 2025-09-05
GB2597895B (en) 2024-09-11
TWI873135B (zh) 2025-02-21
AU2021286283A1 (en) 2022-01-06
GB2626699B (en) 2024-11-20
GB2626699A (en) 2024-07-31
AU2021286283B2 (en) 2022-04-07
GB202406403D0 (en) 2024-06-19
JP7617029B2 (ja) 2025-01-17
WO2020225551A1 (en) 2020-11-12
AU2021286282A1 (en) 2022-01-06
JP2025032205A (ja) 2025-03-11
CN114008218A (zh) 2022-02-01

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