CN113995783A - Method for preparing veterinary Shuanghuanglian oral liquid - Google Patents

Method for preparing veterinary Shuanghuanglian oral liquid Download PDF

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Publication number
CN113995783A
CN113995783A CN202111575818.2A CN202111575818A CN113995783A CN 113995783 A CN113995783 A CN 113995783A CN 202111575818 A CN202111575818 A CN 202111575818A CN 113995783 A CN113995783 A CN 113995783A
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wall
mixing
liquid
fixedly connected
preparing
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石松明
朱纯朴
何友
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Jiangxi Leadafy Bio Pharmaceutical Co ltd
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Jiangxi Leadafy Bio Pharmaceutical Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A61K36/634—Forsythia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to a method for preparing a Shuanghuanglian oral liquid for livestock, which comprises the steps of mixing a honeysuckle extract, a forsythia extract and a scutellaria extract according to a weight ratio of 1:1.5:1, and then feeding the mixture into a preparation device for processing and production, wherein the preparation device comprises a mixing cylinder, an inner cylinder is arranged inside the mixing cylinder, a base is arranged below the mixing cylinder, an outer wall of the mixing cylinder is fixedly connected with an outer attachment sleeve, the outer wall of the outer attachment sleeve is fixedly connected with three equidistant wheel rings, the inner wall of the base is provided with three equidistant sliding grooves, and the three wheel rings on the outer attachment sleeve are respectively and movably connected with the three sliding grooves on the base. The invention utilizes the rotary mixing barrel to rotatably mix the added raw material liquid, improves the overall mixing effect of the raw material liquid, and solves the problems of insufficient mixing and pungent odor caused by stirring and mixing the raw material liquid in the existing medicine preparation process.

Description

Method for preparing veterinary Shuanghuanglian oral liquid
Technical Field
The invention relates to the technical field of medicine preparation, in particular to a method for preparing veterinary Shuanghuanglian oral liquid.
Background
The Shuanghuanglian is prepared from honeysuckle, scutellaria and forsythia, has the effects of dispelling wind, relieving exterior syndrome and clearing heat and removing toxicity, is used for treating cold caused by wind-heat common cold with symptoms of fever, cough and pharyngalgia, and is available in common formulations such as granules, oral liquid, injection and the like.
The Shuanghuanglian oral liquid for veterinary use is an effective medicine for mainly treating the cold of beasts, can also play a good role in the aspects of treatment and prevention of respiratory diseases and the like, is usually used for assisting in treating escherichia coli and mycoplasma infection, is a pure traditional Chinese medicine compound preparation which is wider in clinical use for veterinary use, mainly comprises 3 traditional Chinese medicines of scutellaria baicalensis, honeysuckle and fructus forsythiae, has the effects of relieving exterior syndrome with pungent and cool natured drugs and clearing heat and toxic materials, and can be used for treating the cold and fever diseases of dogs, cats and chickens.
Modern medical research shows that the Shuanghuanglian oral liquid as a pure Chinese medicinal preparation can resist various pathogenic microorganisms and has broad-spectrum bactericidal action, so the Shuanghuanglian oral liquid is widely applied and popularized in intensive and large-scale livestock and poultry breeding industries.
Veterinary two coptis chinensis oral liquid need mix the liquid medicine of three kinds of traditional chinese medicines in the preparation process, adopt vertical formula mixing vessel of placing to hold the dress at present mostly to adopt the stirring rod to mix, this kind of mode can be because of stirring the inhomogeneous condition of insufficient cause liquid medicine mixing, and this kind of mixed mode can produce pungent smell because of mixing the stirring moreover, influences operational environment.
Disclosure of Invention
The invention provides a method for preparing Shuanghuanglian oral liquid for livestock, which comprises the following steps:
mixing the honeysuckle extract, the forsythia extract and the scutellaria extract according to the weight ratio of 1:1.5:1, and then feeding the mixture into a preparation device for processing production;
the extraction method of the honeysuckle extract, the forsythia extract and the scutellaria extract comprises the following steps: soaking flos Lonicerae, fructus forsythiae and Scutellariae radix in water respectively, decocting for 1-3 times at 75-85 deg.C for 10-30min, heating water to 90-110 deg.C, and decocting for 25-35 min; then filtering and concentrating to respectively obtain honeysuckle extract, forsythia extract and scutellaria extract;
the preparation facilities includes the mixing drum, the inside of mixing drum is provided with the inner tube, and the below of mixing drum is provided with the base, the outer wall fixedly connected with of mixing drum attaches the sleeve outward, and attaches the rim of the three equidistance of telescopic outer wall fixedly connected with outward, the spout of three equidistance is seted up to the inner wall of base, and attaches three rim on the sleeve outward respectively with the three spout swing joint on the base, it is provided with a roll-over roller to attach telescopic outside to be the circumference equidistance outward, and the outer wall of roll-over roller all is provided with the rubber pad, and roll-over roller and attach swing joint between the sleeve outward.
The device utilizes the rotating mixing barrel to rotate and mix the added raw material liquid, thereby improving the overall mixing effect of the raw material liquid and solving the problems of insufficient mixing and pungent odor caused by stirring and mixing the raw material liquid in the existing medicine preparation process; the spout of rim and base has guaranteed the smooth nature when mixing drum rotates, and the upset roller then provides the pivoted drive power to attaching the sleeve from the outside, and the cooperation of a plurality of upset rollers is used, has guaranteed mixing drum pivoted stability and continuation, and the rubber pad has then avoided attaching the sleeve to the outer damage that causes during the rotation of upset roller, has increased the upset roller simultaneously and has attached the frictional force between the sleeve outward.
Preferably, the below of base is provided with the plywood, the support frame of two rows of symmetries of upside outer wall fixedly connected with of plywood, fixed connection between the other end of support frame and the outer wall of base, and the below of plywood is provided with the bottom plate, and four symmetrical rectangular channels have all been seted up to the downside outer wall of plywood and the upside outer wall of bottom plate, fixedly connected with attenuator between two upper and lower rectangular channels.
Preferably, one side of base is provided with the side seat, fixed connection between side seat and the plywood, and all seted up the round hole on the upset roller, the inner wall fixedly connected with bull stick of round hole, the both ends of bull stick respectively with one side outer wall of side seat and one side outer wall fixed connection of base.
Preferably, it is a plurality of equal fixedly connected with on the bull stick drives the rim plate, has seted up the annular groove on the side seat, the inner wall fixedly connected with motor of recess, and there is the minor axis at the output of motor through the coupling joint, and the other end fixedly connected with initiative rim plate of minor axis, and is provided with the belt between action rim plate and the drive rim plate.
Preferably, the spout has been seted up to the one end inner wall of mixing drum, and the inner wall swing joint of spout has the protecgulum, has seted up the round hole on the protecgulum, and the inner wall of round hole is provided with the feed liquor seat, and the inner wall of feed liquor seat has seted up the thread groove, and feed liquor seat fixedly connected with mixes the liquid and connects, mixes and is provided with three outer interface that attaches on the liquid connects.
The device comprises a front cover, a liquid inlet seat, a liquid mixing joint, a rear cover, a liquid outlet seat, a liquid discharge joint, a valve, a filter cavity and a discharge door, wherein before mixing operation, three external medicine liquid pipes are connected with the liquid mixing joint, and the valve of the liquid discharge joint is closed; then the device is started, the three liquid medicine pipes convey the three liquid medicines to the interior of the mixing barrel through the liquid mixing joint, and the front cover keeps a relatively static state during the rotation of the mixing barrel; after the mixing operation, stopping the rotation of the mixing cylinder, connecting an externally attached infusion tube with a liquid discharge joint, and opening a valve to extract the mixed liquid medicine; after the device is used, the discharge door is opened to carry out uniform treatment on the waste residues in the filter cavity; the liquid mixing joint can simultaneously convey three different types of liquid medicines into the mixing barrel, and the front cover is rotationally connected with the mixing barrel, so that the liquid medicines can be continuously conveyed in a rotating and mixing state of the mixing barrel, and the continuity of liquid medicine conveying is ensured; the filter chamber can filter remaining fixed residue in the liquid medicine and concentrate, and the device of being convenient for of bin gate is moved the back and is carried out centralized processing to the residue.
Preferably, the outer wall of the other end of the mixing barrel is provided with a rear cover, the rear cover is provided with a round hole, the inner wall of the round hole is fixedly connected with a liquid outlet seat, the inner wall of the liquid outlet seat is fixedly connected with a liquid drainage connector, and the liquid drainage connector is provided with a valve.
Preferably, the inside of mixing drum is provided with the filter chamber, and the filter chamber is located between protecgulum and the inner tube, and has seted up the bin outlet on the mixing drum, and the bin outlet is located filter chamber department, the outer wall fixedly connected with bin gate of bin outlet.
Preferably, the one end fixedly connected with section of thick bamboo head of inner tube, the section of thick bamboo head is located the inside of filter chamber, and is provided with a plurality of flabellum boards on the section of thick bamboo head for the circumference equidistance.
Preferably, the outer wall fixedly connected with filter of section of thick bamboo head, the filter is round platform form, and has seted up a plurality of filtration pores on the filter.
Preferably, the top outer wall fixedly connected with footstock of a section of thick bamboo head, the footstock is located the front side of going out the liquid seat, and is the circumference equidistance on the footstock and has seted up a plurality of rectangular channels, swing joint has the buffer board between the both sides inner wall of rectangular channel, the buffer spring of two symmetries of one side outer wall fixedly connected with of buffer board, fixed connection between the other end of buffer spring and the outer wall of a section of thick bamboo head.
The beneficial effects of the invention are as follows:
1. according to the invention, through the arrangement of the mixing cylinder, the inner cylinder, the base, the external sleeve, the wheel ring, the turnover roller and the rubber pad, after raw material liquid enters the mixing cylinder, the turnover roller rotates under stress to drive the external sleeve to rotate, so that the raw material liquid in the inner cylinder is fully mixed; the device utilizes the rotating mixing barrel to rotate and mix the added raw material liquid, thereby improving the overall mixing effect of the raw material liquid and solving the problems of insufficient mixing and pungent odor caused by stirring and mixing the raw material liquid in the existing medicine preparation process; the spout of rim and base has guaranteed the smooth nature when mixing drum rotates, and the upset roller then provides the pivoted drive power to attaching the sleeve from the outside, and the cooperation of a plurality of upset rollers is used, has guaranteed mixing drum pivoted stability and continuation, and the rubber pad has then avoided attaching the sleeve to the outer damage that causes during the rotation of upset roller, has increased the upset roller simultaneously and has attached the frictional force between the sleeve outward.
2. The invention realizes the rotation of a plurality of rotating rods by arranging the laminate, the support frame, the bottom plate, the damper, the side seat, the rotating rods, the traction wheel disc, the motor, the driving wheel disc and the belt, wherein the motor drives the driving wheel disc to rotate; the damper can play a role in buffering and damping, so that excessive shaking caused by rotation of the mixing cylinder during use is avoided, and the stability of the device during use is improved; the belt and the wheel disc are utilized to drive the plurality of overturning rollers to rotate, so that the uniform motion state of the overturning rollers is realized, and the rotation mixing of the mixing drum is realized.
3. According to the invention, through the arrangement of the front cover, the liquid inlet seat, the liquid mixing joint, the rear cover, the liquid outlet seat, the liquid discharging joint, the valve, the filter cavity and the discharging door, before mixing operation, three external medicine liquid pipes are connected with the liquid mixing joint, and the valve of the liquid discharging joint is closed; then the device is started, the three liquid medicine pipes convey the three liquid medicines to the interior of the mixing barrel through the liquid mixing joint, and the front cover keeps a relatively static state during the rotation of the mixing barrel; after the mixing operation, stopping the rotation of the mixing cylinder, connecting an externally attached infusion tube with a liquid discharge joint, and opening a valve to extract the mixed liquid medicine; after the device is used, the discharge door is opened to carry out uniform treatment on the waste residues in the filter cavity; the liquid mixing joint can simultaneously convey three different types of liquid medicines into the mixing barrel, and the front cover is rotationally connected with the mixing barrel, so that the liquid medicines can be continuously conveyed in a rotating and mixing state of the mixing barrel, and the continuity of liquid medicine conveying is ensured; the filter chamber can filter remaining fixed residue in the liquid medicine and concentrate, and the device of being convenient for of bin gate is moved the back and is carried out centralized processing to the residue.
4. According to the invention, three kinds of liquid medicines are simultaneously conveyed into the mixing barrel through the barrel head, the fan blade plate, the filter holes, the top seat, the buffer plate and the buffer spring, the liquid medicines enter the filter cavity from the liquid outlet seat, the liquid medicines are firstly contacted with the buffer plate, the buffer plate is stressed to turn over and extrude the buffer spring, the buffer spring is stressed to generate elastic deformation to offset the impact force of the liquid medicines, and then residues in the liquid medicines in the inner barrel, entering the filter cavity through the filter plate, of the liquid medicines in the filter cavity are retained in the filter cavity to wait for uniform treatment; the fan blade plate provides a supporting force for the filter plate and simultaneously ensures the fluency of the liquid medicine entering the inner barrel; the filter plate and the filter holes can carry out deep filtration on the liquid medicine, residues in the liquid medicine are retained in the filter cavity, and the integral quality of the mixed liquid medicine is ensured; utilize buffer board and buffer spring to carry out the impulsive force to the liquid medicine that gets into in the mixing drum and cut down, avoid the liquid medicine direct impact on inner tube or filter, cause the inner tube to warp or the condition that the filtration pore emergence of filter blockked up, improve the life and the result of use of device.
Drawings
Fig. 1 is a schematic overall structure diagram of a method for preparing Shuanghuanglian oral liquid for livestock according to the present invention;
fig. 2 is a schematic side view of a method for preparing Shuanghuanglian oral liquid for livestock according to the present invention;
fig. 3 is a partial structural schematic view of a method for preparing Shuanghuanglian oral liquid for livestock according to the present invention;
FIG. 4 is a schematic sectional view of a method for preparing Shuanghuanglian oral liquid for livestock according to the present invention;
fig. 5 is a schematic partial split structure diagram of a method for preparing Shuanghuanglian oral liquid for livestock according to the present invention;
fig. 6 is a schematic structural view of a barrel head of a method for preparing Shuanghuanglian oral liquid for livestock provided by the invention.
In the figure: 1. a mixing drum; 2. an inner barrel; 3. a base; 4. an externally attached sleeve; 5. a wheel ring; 6. turning over the roller; 7. a rubber pad; 8. laminating the board; 9. a support frame; 10. a base plate; 11. a damper; 12. a side seat; 13. a rotating rod; 14. a traction wheel disc; 15. an electric motor; 16. a driving wheel disc; 17. a belt; 18. a front cover; 19. a liquid inlet seat; 20. a liquid mixing joint; 21. a rear cover; 22. a liquid outlet seat; 23. a liquid discharge joint; 24. a valve; 25. a filter chamber; 26. a discharge gate; 27. a cartridge head; 28. a leaf plate; 29. a filter plate; 30. filtering holes; 31. a top seat; 32. a buffer plate; 33. a buffer spring.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
A method for preparing SHUANGHUANGLIAN oral liquid for animal use, as shown in figure 1, figure 2 and figure 3, comprises the following steps: mixing the honeysuckle extract, the forsythia extract and the scutellaria extract according to the weight ratio of 1:1.5:1, and then feeding the mixture into a preparation device for processing production;
the extraction method of the honeysuckle extract, the forsythia extract and the scutellaria extract comprises the following steps: soaking flos Lonicerae, fructus forsythiae and Scutellariae radix in water respectively, decocting for 1-3 times at 75-85 deg.C for 10-30min, heating water to 90-110 deg.C, and decocting for 25-25 min; then filtering and concentrating to respectively obtain honeysuckle extract, forsythia extract and scutellaria extract;
example 1:
the extraction method of the honeysuckle extract, the forsythia extract and the scutellaria extract comprises the following steps: soaking flos Lonicerae, fructus forsythiae and Scutellariae radix in water respectively, decocting at 75 deg.C for 10min for 1 time, and heating water to 90 deg.C for 25 min; then filtering and concentrating to respectively obtain honeysuckle extract, forsythia extract and scutellaria extract.
Example 2:
the extraction method of the honeysuckle extract, the forsythia extract and the scutellaria extract comprises the following steps: soaking flos Lonicerae, fructus forsythiae and Scutellariae radix in water respectively, decocting for 3 times at 85 deg.C for 30min, heating water to 110 deg.C, and decocting for 35 min; then filtering and concentrating to respectively obtain honeysuckle extract, forsythia extract and scutellaria extract.
Example 3:
the extraction method of the honeysuckle extract, the forsythia extract and the scutellaria extract comprises the following steps: soaking flos Lonicerae, fructus forsythiae and Scutellariae radix in water respectively, decocting for 2 times at 80 deg.C for 20min, heating water to 100 deg.C, and decocting for 30 min; then filtering and concentrating to respectively obtain honeysuckle extract, forsythia extract and scutellaria extract;
the preparation device comprises a mixing cylinder 1, an inner cylinder 2 is arranged in the mixing cylinder 1, a base 3 is arranged below the mixing cylinder 1, the outer wall of the mixing cylinder 1 is connected with an external sleeve 4 through a bolt, the outer wall of the external sleeve 4 is connected with three equidistant wheel rings 5 through bolts, the inner wall of the base 3 is provided with three equidistant sliding grooves, three wheel rings 5 on the external sleeve 4 are respectively connected with three sliding grooves on the base 3 in a sliding way, a pair of turnover rollers 6 are arranged on the outer part of the external sleeve 4 in a circumferential equidistance way, rubber pads 7 are arranged on the outer walls of the turnover rollers 6, the overturning roller 6 is rotationally connected with the external sleeve 4, and the added raw material liquid is rotationally mixed by the rotating mixing cylinder 1, so that the overall mixing effect of the raw material liquid is improved, and the problems of insufficient mixing and pungent odor generation caused by stirring and mixing of the raw material liquid in the existing medicine preparation process are solved; the smooth nature when mixing drum 1 has been guaranteed to the spout of rim 5 and base 3, and upset roller 6 then attaches sleeve 4 to the external portion and provides the pivoted drive power, and the cooperation of a plurality of upset rollers 6 is used, has guaranteed mixing drum 1 pivoted stability and continuation, and rubber pad 7 has then avoided attaching sleeve 4 to the external during the rotation of upset roller 6 and has caused the damage, has increased simultaneously upset roller 6 and has attached the frictional force between the sleeve 4 outward.
Further, as shown in fig. 1, 2 and 3, a layer plate 8 is arranged below the base 3, two rows of symmetrical support frames 9 are connected to the outer wall of the upper side of the layer plate 8 through bolts, the other end of each support frame 9 is connected to the outer wall of the base 3 through bolts, a bottom plate 10 is arranged below the layer plate 8, four symmetrical rectangular grooves are formed in the outer wall of the lower side of the layer plate 8 and the outer wall of the upper side of the bottom plate 10, a damper 11 is connected between the upper rectangular groove and the lower rectangular groove through bolts, the damper 11 can play a role in buffering and damping, excessive shaking caused by rotation of the mixing drum 1 during use is avoided, and the stability of the device during use is improved; a side seat 12 is arranged on one side of the base 3, the side seat 12 is connected with the layer plate 8 through bolts, round holes are formed in the turnover rollers 6, the inner walls of the round holes are connected with a rotating rod 13 through bolts, and two ends of the rotating rod 13 are respectively connected with the outer wall of one side of the side seat 12 and the outer wall of one side of the base 3 through bolts; all there is driving wheel dish 14 through bolted connection on a plurality of bull sticks 13, the annular groove has been seted up on the side seat 12, there is motor 15 the inner wall of recess through bolted connection, there is the minor axis motor 15's output through the coupling joint, there is driving wheel dish 16 the other end of minor axis through bolted connection, and be provided with belt 17 between driving wheel dish 16 and the driving wheel dish 14, it rotates to utilize belt 17 and rim plate to drive a plurality of upset rollers 6, realize the unified motion state of upset roller 6, thereby realize that the rotation of mixing drum 1 mixes.
Furthermore, as shown in fig. 4 and 5, a sliding groove is formed in an inner wall of one end of the mixing cylinder 1, the inner wall of the sliding groove is rotatably connected with a front cover 18, a circular hole is formed in the front cover 18, a liquid inlet seat 19 is arranged on the inner wall of the circular hole, a threaded groove is formed in the inner wall of the liquid inlet seat 19, the liquid inlet seat 19 is connected with a liquid mixing joint 20 through threads on the inner wall, three external connectors are arranged on the liquid mixing joint 20, the liquid mixing joint 20 can simultaneously convey three different types of liquid medicines into the mixing cylinder 1, the front cover 18 is rotatably connected with the mixing cylinder 1, the liquid medicines can be continuously conveyed in a rotating and mixing state of the mixing cylinder 1, and the continuity of liquid medicine conveying is ensured; a rear cover 21 is arranged on the outer wall of the other end of the mixing barrel 1, a round hole is formed in the rear cover 21, the inner wall of the round hole is connected with a liquid outlet seat 22 through a bolt, the inner wall of the liquid outlet seat 22 is connected with a liquid drainage connector 23 through a bolt, and a valve 24 is arranged on the liquid drainage connector 23; the inside of mixing drum 1 is provided with filter chamber 25, and filter chamber 25 is located between protecgulum 18 and the inner tube 2, and has seted up the bin outlet on the mixing drum 1, and the bin outlet is located filter chamber 25 department, and there is bin gate 26 in the outer wall of bin outlet through bolted connection, and filter chamber 25 can filter remaining fixed residue in the liquid medicine and concentrate, and bin gate 26 is convenient for carry out centralized processing to the residue after the device operation.
Furthermore, as shown in fig. 4 and 6, one end of the inner cylinder 2 is connected with a cylinder head 27 through a bolt, the cylinder head 27 is located inside the filter chamber 25, and a plurality of vane plates 28 are circumferentially and equidistantly arranged on the cylinder head 27, and the vane plates 28 provide a supporting force for the filter plate 29 and ensure the fluency of the liquid medicine entering the inner cylinder 2; the outer wall of the barrel head 27 is connected with a filter plate 29 through a bolt, the filter plate 29 is in a circular truncated cone shape, a plurality of filter holes 30 are formed in the filter plate 29, the filter plate 29 and the filter holes 30 can carry out deep filtration on the liquid medicine, residues in the liquid medicine are retained in the filter cavity 25, and the integral quality of the mixed liquid medicine is guaranteed; barrel head 27's top outer wall has footstock 31 through bolted connection, footstock 31 is located the front side of going out liquid seat 22, and be the circumference equidistance on the footstock 31 and seted up a plurality of rectangular channels, it is connected with buffer board 32 to rotate between the both sides inner wall of rectangular channel, one side outer wall of buffer board 32 has two symmetrical buffer spring 33 through bolted connection, pass through bolted connection between buffer spring 33's the other end and barrel head 27's the outer wall, utilize buffer board 32 and buffer spring 33 to carry out the impulsive force to the liquid medicine that gets into in mixing drum 1 and reduce, avoid the liquid medicine direct impact on inner tube 2 or filter 29, cause the condition that filter hole 30 of inner tube 2 deformation or filter 29 takes place to block up, improve device's life and result of use.
The working principle is as follows: before mixing operation, three external medicine liquid pipes are connected with the liquid mixing joint 20, the valve 24 of the liquid discharging joint 23 is closed, the device is started, the three medicine liquid pipes convey three kinds of medicine liquid to the interior of the mixing barrel 1 through the liquid mixing joint 20, the medicine liquid enters the filter cavity 25 from the liquid outlet seat 22, the medicine liquid can be firstly contacted with the buffer plate 32, the buffer plate 32 is forced to overturn and extrudes the buffer spring 33, the buffer spring 33 is forced to generate elastic deformation to offset the impact force of the medicine liquid, then the medicine liquid enters the inner barrel 2 through the filter plate 29 in the filter cavity 25, residues in the medicine liquid are retained in the filter cavity 25 to be treated uniformly, then the motor 15 drives the driving wheel disc 16 to rotate, the driving wheel disc 16 drives the traction wheel disc 14 to rotate through the belt 17, so that the rotation of the plurality of rotating rods 13 is realized, the overturning roller 6 is forced to rotate to drive the outer sleeve 4 to rotate, the ring 5 rotates in the chute of the base 3 to realize the integral rotation of the mixing cylinder 1, the liquid medicine in the inner cylinder 2 is turned and mixed, and the front cover 18 keeps a relatively static state during the rotation of the mixing cylinder 1, so that the liquid medicine is continuously conveyed in the rotation and mixing state of the mixing cylinder 1, and the continuity of the liquid medicine conveying is ensured; after the mixing operation, the rotation of the mixing cylinder 1 is stopped, the attached infusion tube is connected to the liquid discharge joint 23, the valve 24 is opened to extract the mixed liquid medicine, and the discharge door 26 is opened to treat the waste residue in the filter chamber 25 after the device is used.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.

Claims (10)

1. A method for preparing Shuanghuanglian oral liquid for livestock is characterized by comprising the following steps:
mixing the honeysuckle extract, the forsythia extract and the scutellaria extract according to the weight ratio of 1:1.5:1, and then feeding the mixture into a preparation device for processing production;
the extraction method of the honeysuckle extract, the forsythia extract and the scutellaria extract comprises the following steps: soaking flos Lonicerae, fructus forsythiae and Scutellariae radix in water respectively, decocting for 1-3 times at 75-85 deg.C for 10-30min, heating water to 90-110 deg.C, and decocting for 25-35 min; then filtering and concentrating to respectively obtain honeysuckle extract, forsythia extract and scutellaria extract;
the preparation device comprises a mixing drum (1), wherein an inner barrel (2) is arranged inside the mixing drum (1), a base (3) is arranged below the mixing drum (1), a sleeve (4) is attached to the outer wall of the mixing drum (1) in an outer attaching mode, a wheel ring (5) with three equal distances is fixedly connected to the outer wall of the sleeve (4) in an outer attaching mode, three equal-distance sliding grooves are formed in the inner wall of the base (3), the three wheel ring (5) on the sleeve (4) in an outer attaching mode is movably connected with the three sliding grooves in the base (3) respectively, a pair of turning rollers (6) are arranged in a circumferential equal distance mode outside the sleeve (4) in an outer attaching mode, a rubber pad (7) is arranged on the outer wall of each turning roller (6), and the turning rollers (6) are movably connected with the outer attaching mode between the sleeves (4).
2. The method for preparing Shuanghuanglian oral liquid for livestock according to claim 1, characterized in that a laminate (8) is arranged below the base (3), two rows of symmetrical support frames (9) are fixedly connected to the outer wall of the upper side of the laminate (8), the other end of each support frame (9) is fixedly connected to the outer wall of the base (3), a bottom plate (10) is arranged below the laminate (8), four symmetrical rectangular grooves are respectively formed in the outer wall of the lower side of the laminate (8) and the outer wall of the upper side of the bottom plate (10), and a damper (11) is fixedly connected between the upper rectangular groove and the lower rectangular groove.
3. The method for preparing Shuanghuanglian oral liquid for veterinary use according to claim 2, wherein one side of the base (3) is provided with a side seat (12), the side seat (12) is fixedly connected with the laminate (8), round holes are formed in the turning rollers (6), the inner walls of the round holes are fixedly connected with a rotating rod (13), and two ends of the rotating rod (13) are respectively fixedly connected with the outer wall of one side of the side seat (12) and the outer wall of one side of the base (3).
4. The method for preparing Shuanghuanglian oral liquid for veterinary use according to claim 3, wherein a plurality of the rotation rods (13) are all fixedly connected with a traction wheel disc (14), the side seats (12) are provided with annular grooves, the inner walls of the grooves are fixedly connected with an electric motor (15), the output end of the electric motor (15) is connected with a short shaft through a coupler, the other end of the short shaft is fixedly connected with an active wheel disc (16), and a belt (17) is arranged between the active wheel disc (16) and the traction wheel disc (14).
5. The method for preparing Shuanghuanglian oral liquid for livestock according to claim 1, characterized in that a chute is formed on an inner wall of one end of the mixing barrel (1), a front cover (18) is movably connected to an inner wall of the chute, a circular hole is formed on the front cover (18), a liquid inlet seat (19) is arranged on an inner wall of the circular hole, a thread groove is formed on an inner wall of the liquid inlet seat (19), a liquid mixing joint (20) is fixedly connected to the liquid inlet seat (19), and three external connectors are arranged on the liquid mixing joint (20).
6. The method for preparing Shuanghuanglian oral liquid for livestock according to claim 5, characterized in that a rear cover (21) is arranged on the outer wall of the other end of the mixing barrel (1), a round hole is formed on the rear cover (21), a liquid outlet seat (22) is fixedly connected to the inner wall of the round hole, a liquid discharge joint (23) is fixedly connected to the inner wall of the liquid outlet seat (22), and a valve (24) is arranged on the liquid discharge joint (23).
7. The method for preparing Shuanghuanglian oral liquid for livestock according to claim 5, characterized in that a filter chamber (25) is arranged inside the mixing barrel (1), the filter chamber (25) is located between the front cover (18) and the inner barrel (2), a discharge outlet is arranged on the mixing barrel (1), the discharge outlet is located at the filter chamber (25), and a discharge gate (26) is fixedly connected to the outer wall of the discharge outlet.
8. The method for preparing Shuanghuanglian oral liquid for veterinary use according to claim 7, wherein a barrel head (27) is fixedly connected to one end of the inner barrel (2), the barrel head (27) is located inside the filter chamber (25), and a plurality of fan-blade plates (28) are circumferentially and equidistantly arranged on the barrel head (27).
9. The method for preparing Shuanghuanglian oral liquid for veterinary use according to claim 8, wherein the outer wall of the barrel head (27) is fixedly connected with a filter plate (29), the filter plate (29) is in a circular truncated cone shape, and a plurality of filter holes (30) are formed in the filter plate (29).
10. The method for preparing Shuanghuanglian oral liquid for veterinary use according to claim 9, wherein the outer wall of the top end of the barrel head (27) is fixedly connected with a top seat (31), the top seat (31) is located at the front side of the liquid outlet seat (22), the top seat (31) is provided with a plurality of rectangular grooves with equal intervals on the circumference, the inner walls at two sides of the rectangular grooves are movably connected with a buffer plate (32), the outer wall at one side of the buffer plate (32) is fixedly connected with two symmetrical buffer springs (33), and the other ends of the buffer springs (33) are fixedly connected with the outer wall of the barrel head (27).
CN202111575818.2A 2021-12-21 2021-12-21 Method for preparing veterinary Shuanghuanglian oral liquid Pending CN113995783A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117162562A (en) * 2023-09-01 2023-12-05 西藏月王药诊生态藏药科技有限公司 Treatment method for extracting total tanshinone extract from Tibetan radix salviae miltiorrhizae

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Publication number Priority date Publication date Assignee Title
CN105193948A (en) * 2015-10-29 2015-12-30 林州中农生物肽科技有限公司 Preparation method of Shuanghuanglian oral liquid for animals
CN210250587U (en) * 2018-11-29 2020-04-07 潍坊富言中药研发有限公司 Veterinary shuanghuanglian oral liquid production device
CN213219217U (en) * 2020-05-19 2021-05-18 东莞市亚洲制药有限公司 Preparation facilities of two coptis oral liquids

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105193948A (en) * 2015-10-29 2015-12-30 林州中农生物肽科技有限公司 Preparation method of Shuanghuanglian oral liquid for animals
CN210250587U (en) * 2018-11-29 2020-04-07 潍坊富言中药研发有限公司 Veterinary shuanghuanglian oral liquid production device
CN213219217U (en) * 2020-05-19 2021-05-18 东莞市亚洲制药有限公司 Preparation facilities of two coptis oral liquids

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117162562A (en) * 2023-09-01 2023-12-05 西藏月王药诊生态藏药科技有限公司 Treatment method for extracting total tanshinone extract from Tibetan radix salviae miltiorrhizae
CN117162562B (en) * 2023-09-01 2024-02-09 西藏月王药诊生态藏药科技有限公司 Treatment method for extracting total tanshinone extract from Tibetan radix salviae miltiorrhizae

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