CN113975593A - 一种可达龙药物球囊及其制备方法 - Google Patents
一种可达龙药物球囊及其制备方法 Download PDFInfo
- Publication number
- CN113975593A CN113975593A CN202111084578.6A CN202111084578A CN113975593A CN 113975593 A CN113975593 A CN 113975593A CN 202111084578 A CN202111084578 A CN 202111084578A CN 113975593 A CN113975593 A CN 113975593A
- Authority
- CN
- China
- Prior art keywords
- balloon
- codantone
- drug
- medicine
- compared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000011248 coating agent Substances 0.000 claims abstract description 9
- 238000000576 coating method Methods 0.000 claims abstract description 9
- 239000011259 mixed solution Substances 0.000 claims abstract description 9
- 229920000954 Polyglycolide Polymers 0.000 claims abstract description 8
- 229920001610 polycaprolactone Polymers 0.000 claims abstract description 8
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000004632 polycaprolactone Substances 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 8
- 238000011282 treatment Methods 0.000 abstract description 15
- 230000000694 effects Effects 0.000 abstract description 5
- 230000006378 damage Effects 0.000 abstract description 3
- 210000003516 pericardium Anatomy 0.000 abstract description 3
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract description 2
- 238000005516 engineering process Methods 0.000 abstract description 2
- 210000004165 myocardium Anatomy 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 description 11
- 206010003658 Atrial Fibrillation Diseases 0.000 description 6
- 230000033764 rhythmic process Effects 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 3
- 229920004934 Dacron® Polymers 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 description 2
- 229960005260 amiodarone Drugs 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 210000003492 pulmonary vein Anatomy 0.000 description 2
- 230000002861 ventricular Effects 0.000 description 2
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 241000208011 Digitalis Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 241000009328 Perro Species 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- 229940097320 beta blocking agent Drugs 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000007831 electrophysiology Effects 0.000 description 1
- 238000002001 electrophysiology Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000007674 radiofrequency ablation Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M25/1027—Making of balloon catheters
- A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
- A61M2025/1031—Surface processing of balloon members, e.g. coating or deposition; Mounting additional parts onto the balloon member's surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Manufacturing & Machinery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明涉及一种可达龙药物球囊及其制备方法,通过将可达龙、聚乙交酯、聚己内酯的混合溶液涂覆于球囊表面而得。相比于药物治疗,本发明具有减少药物使用量,不存在停药率,副作用大量减少的优点;相比于非药物治疗,本发明运用技术成熟,无需损伤正常心肌,临床并发症较少;相比于心包内用药,本发明不需要特殊导管,技术操作难度低,可操作性强;相比于其他治疗方法,本发明所需的治疗费用最低。
Description
技术领域
本发明属于房颤治疗领域,特别涉及一种可达龙药物球囊及其制备方法。
背景技术
房颤是临床最常见的持续性心律失常,常见心悸、眩晕等症状,其最主要的危害是形成血栓从而导致脑卒中。现阶段针对房颤的治疗包括维持窦性心律及预防血栓形成。恢复窦性心律是治疗房颤的根本,对于不能恢复窦性心律的患者,应维持其心室率在较慢水平。恢复窦性心律包括药物治疗及非药物治疗两种方式。常用药物包括β受体阻滞剂、洋地黄类、钙通道拮抗剂、胺碘酮等。非药物治疗主要是指通过射频消融术控制房颤,降低其发生率。近年来文献报道了一种新的治疗方式,采用介入与药物治疗相结合的方法,利用一种特殊导管,将胺碘酮等药物注入心包。(Garcia,Jose R et al.“Minimally InvasiveDelivery of Hydrogel-Encapsulated Amiodarone to the Epicardium Reduces AtrialFibrillation.”Circulation.Arrhythmia and electrophysiology vol.11,5(2018):)从而实现心包内给药,以维持心室率。但是,心包内用药这一方法目前仅进行了动物实验,尚未有临床研究,需要特殊导管,操作难度较大。
发明内容
本发明所要解决的技术问题是提供一种可达龙药物球囊及其制备方法,解决了可达龙药物与球囊的结合及定位释放上的困难。
本发明提供了一种可达龙药物球囊,通过将可达龙、聚乙交酯、聚己内酯的混合溶液涂覆于球囊表面而得。
本发明提供了一种可达龙药物球囊的制备方法,包括:
将质量比为1-2:1-2:1-2的可达龙、聚乙交酯、聚己内酯的混合溶液涂覆于球囊表面,多次烘干、浸泡,得到可达龙药物球囊。
所述烘干温度为30℃。
所述浸泡时间为30s-60s。
有益效果
由于可达龙属于水溶性药物,因此本发明通过PGA和PCL的结合,解决了可达龙药物与球囊的结合及定位释放上的困难;相比于药物治疗,本发明具有减少药物使用量,不存在停药率,副作用大量减少的优点;相比于非药物治疗,本发明运用技术成熟,无需损伤正常心肌,临床并发症较少;相比于心包内用药,本发明不需要特殊导管,技术操作难度低,可操作性强;相比于其他治疗方法,本发明所需的治疗费用最低。
附图说明
图1为可达龙药物球囊组织残余率。
具体实施方式
下面结合具体实施例,进一步阐述本发明。应理解,这些实施例仅用于说明本发明而不用于限制本发明的范围。此外应理解,在阅读了本发明讲授的内容之后,本领域技术人员可以对本发明作各种改动或修改,这些等价形式同样落于本申请所附权利要求书所限定的范围。
实施例1
将质量比为2:1:1的可达龙、聚乙交酯、聚己内酯的混合溶液涂覆于球囊表面,多次烘干、浸泡,得到可达龙药物球囊。通过称重法精确药物含量,低温烘干保存。
①可达龙药物球囊组织释放率
以喷涂法将可达龙覆盖在球囊表面,测出并计算每个球囊实际载药量,通过介入方法,采用狗动物模型,将可达龙药物球囊置入肺静脉进行球囊扩张60秒。即刻取相应肺静脉段,通过高效液相测药物浓度(表1)。
表1:可达龙药物球囊药物组织释放率(n=5)
球囊实际药物含量 | 组织实际药物含量 | 释放百分比 |
1.024±0.042 | 0.28±0.039 | 27.34% |
由表1可知,可达龙药物球囊释放效果好。
②可达龙药物球囊组织残余量率(n=5)
可达龙药物球囊释放药物后,按照时间点0天,1天,3天,7天,14天,28天,180天,360天测组织药物残余量(图1)。
由图1可知,可达龙药物球囊有良好的缓释效果。
比较例1
将质量比为3:1的可达龙、聚乙交酯的混合溶液涂覆于球囊表面,多次烘干、浸泡,得到可达龙药物球囊。通过称重法精确药物含量,低温烘干保存。
表2可达龙药物球囊药物组织释放率(n=5)
球囊实际药物含量 | 组织实际药物含量 | 释放百分比 |
1.018±0.027 | 0.13±0.026 | 12.77% |
比较例2
将质量比为3:1的可达龙、聚己内酯的混合溶液涂覆于球囊表面,多次烘干、浸泡,得到可达龙药物球囊。通过称重法精确药物含量,低温烘干保存。
表3可达龙药物球囊药物组织释放率(n=5)
球囊实际药物含量 | 组织实际药物含量 | 释放百分比 |
1.009±0.016 | 0.17±0.027 | 16.85% |
比较例3
将质量比为3:1的可达龙、聚乳酸的混合溶液涂覆于球囊表面,多次烘干、浸泡,得到可达龙药物球囊。通过称重法精确药物含量,低温烘干保存。
表4可达龙药物球囊药物组织释放率(n=5)
球囊实际药物含量 | 组织实际药物含量 | 释放百分比 |
1.065±0.078 | 0.11±0.028 | 10.33% |
Claims (4)
1.一种可达龙药物球囊,其特征在于:通过将可达龙、聚乙交酯、聚己内酯的混合溶液涂覆于球囊表面而得。
2.一种可达龙药物球囊的制备方法,包括:
将质量比为1-2:1-2:1-2的可达龙、聚乙交酯、聚己内酯的混合溶液涂覆于球囊表面,多次烘干、浸泡,得到可达龙药物球囊。
3.根据权利要求1所述的制备方法,其特征在于:所述烘干温度为30℃。
4.根据权利要求1所述的制备方法,其特征在于:所述浸泡时间为30s-60s。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111084578.6A CN113975593A (zh) | 2021-09-16 | 2021-09-16 | 一种可达龙药物球囊及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202111084578.6A CN113975593A (zh) | 2021-09-16 | 2021-09-16 | 一种可达龙药物球囊及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113975593A true CN113975593A (zh) | 2022-01-28 |
Family
ID=79735877
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202111084578.6A Pending CN113975593A (zh) | 2021-09-16 | 2021-09-16 | 一种可达龙药物球囊及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN113975593A (zh) |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040175429A1 (en) * | 2002-12-31 | 2004-09-09 | Sreedhara Alavattam | Biodegradable microparticles that stabilize and control the release of proteins |
CN1799650A (zh) * | 2005-12-30 | 2006-07-12 | 李文涛 | 生物可降解载药物高分子材料支架的制备方法 |
CN102458497A (zh) * | 2009-04-24 | 2012-05-16 | 优洛可股份有限公司 | 涂有虫胶和太平洋紫杉醇的导管球囊 |
KR20120138180A (ko) * | 2011-06-14 | 2012-12-24 | 가천대학교 산학협력단 | 약물 전달을 위한 리포좀-마이크로 구조체 및 이의 제조방법 |
CN104857573A (zh) * | 2010-03-25 | 2015-08-26 | 路通医疗股份有限公司 | 用于医疗设备的释药涂层 |
US20170281914A1 (en) * | 2016-03-31 | 2017-10-05 | Surmodics, Inc. | Localized treatment of tissues through transcatheter delivery of active agents |
CN110141760A (zh) * | 2019-06-05 | 2019-08-20 | 山东百多安医疗器械有限公司 | 一种表面载药的椎体成形扩张球囊及其制备方法 |
CN110691567A (zh) * | 2017-04-20 | 2020-01-14 | 480生物医药股份有限公司 | 用于治疗窦炎的可植入支架 |
-
2021
- 2021-09-16 CN CN202111084578.6A patent/CN113975593A/zh active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040175429A1 (en) * | 2002-12-31 | 2004-09-09 | Sreedhara Alavattam | Biodegradable microparticles that stabilize and control the release of proteins |
CN1799650A (zh) * | 2005-12-30 | 2006-07-12 | 李文涛 | 生物可降解载药物高分子材料支架的制备方法 |
CN102458497A (zh) * | 2009-04-24 | 2012-05-16 | 优洛可股份有限公司 | 涂有虫胶和太平洋紫杉醇的导管球囊 |
CN104857573A (zh) * | 2010-03-25 | 2015-08-26 | 路通医疗股份有限公司 | 用于医疗设备的释药涂层 |
KR20120138180A (ko) * | 2011-06-14 | 2012-12-24 | 가천대학교 산학협력단 | 약물 전달을 위한 리포좀-마이크로 구조체 및 이의 제조방법 |
US20170281914A1 (en) * | 2016-03-31 | 2017-10-05 | Surmodics, Inc. | Localized treatment of tissues through transcatheter delivery of active agents |
CN110691567A (zh) * | 2017-04-20 | 2020-01-14 | 480生物医药股份有限公司 | 用于治疗窦炎的可植入支架 |
CN110141760A (zh) * | 2019-06-05 | 2019-08-20 | 山东百多安医疗器械有限公司 | 一种表面载药的椎体成形扩张球囊及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Child et al. | The pharmacological properties in animals of CT1341—a new steroid anaesthetic agent | |
HARRISON et al. | The antiarrhythmic properties of lidocaine and procaine amide: clinical and physiologic studies of their cardiovascular effects in man | |
Rentrop et al. | Acute coronary occlusion with impending infarction as an angiographic complication relieved by a guide‐wire recanalization | |
DE69833665T2 (de) | Zusammensetzungen zur vereinfachung von chirurgischen verfahren | |
Coleman et al. | The immediate cardiovascular effects of pancuronium, alcuronium and tubocurarine in man | |
US9795774B2 (en) | Microneedle assembly formulation for skin treatment | |
Hashimoto et al. | Adrenergic mechanism participating in induction of atrial fibrillation by ACh | |
CN111166760A (zh) | β-烟酰胺单核苷酸或其前体的组合物及制备方法、应用 | |
Brunette et al. | Comparison of standard versus high-dose epinephrine in the resuscitation of cardiac arrest in dogs | |
JP2008501033A (ja) | 心停止前、心停止中および心停止後の哺乳動物の治療法 | |
Natale et al. | Safety of nurse‐administered deep sedation for defibrillator implantation in the electrophysiology laboratory | |
CN113975593A (zh) | 一种可达龙药物球囊及其制备方法 | |
CN117100992A (zh) | 一种水溶性米诺地尔微针及其制备方法和应用 | |
Møller et al. | Effect of alfentanil anaesthesia on the adrenocortical and hyperglycaemic response to abdominal surgery | |
WO2017019709A1 (en) | Composition and method for reducing scarring | |
CN108635362A (zh) | 一种治疗糖尿病足的药物组合物 | |
CN110420209B (zh) | 一种治疗糖尿病周围神经痛的药物组合物及其应用 | |
CN110183505B (zh) | 用于改善心肌梗塞导致的心电st段变化的药物 | |
KR20070035517A (ko) | 심장 정지 전, 중 및 후의 포유동물 치료방법 | |
US11963976B2 (en) | Heparin composition for treating ischemia | |
RU2320328C2 (ru) | Способ лечения персистирующей формы фибрилляции предсердий | |
CN110215453A (zh) | 一种用于促进皮肤伤口愈合的药物配方 | |
US20210069297A1 (en) | Viscous composition for treating ischemia | |
CN118045182A (zh) | 5型磷酸二酯酶抑制剂在制备治疗心脏三尖瓣闭合不全的药物中的应用 | |
Gutiérrez et al. | Pharmacokinetics of a new parenteral formulation of tilmicosin-LA in cows. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |