CN113975261B

CN113975261B - Combined medicinal cream for anesthesia and preparation method thereof

Info

Publication number: CN113975261B
Application number: CN202111472201.8A
Authority: CN
Inventors: 郭晓光; 张亚娟
Original assignee: First Affiliated Hospital of Zhengzhou University
Current assignee: First Affiliated Hospital of Zhengzhou University
Priority date: 2021-12-06
Filing date: 2021-12-06
Publication date: 2023-02-17
Anticipated expiration: 2041-12-06
Also published as: CN113975261A

Abstract

The invention discloses a combined pharmaceutical cream for anesthesia and a preparation method thereof, and the combined pharmaceutical cream comprises, by mass, 30-100 parts of lidocaine, 30-100 parts of prilocaine, 5-10 parts of a soothing agent, 20-35 parts of an emulsifier, 15-30 parts of a thickening agent, and 9000-9500 parts of purified water. The pharmaceutical composition has the advantages of small and narrow distribution of microemulsion particle size, good transdermal effect, quick anesthesia effect, long anesthesia maintenance time and capability of preventing cold tremor after anesthesia, and the synergistic effect of the components of the pharmaceutical composition enables the drug effect of lidocaine to be more fully exerted, so that the anesthetic effect of the prepared anesthetic is better, the harm to patients due to insufficient anesthesia is avoided, and the sensitization risk caused by lidocaine and prilocaine is reduced.

Description

Combined medicinal cream for anesthesia and preparation method thereof

Technical Field

The invention relates to the technical field of anesthetic drugs, in particular to a combined drug cream for anesthesia and a preparation method thereof.

Background

Narcotic drugs are drugs that have an anesthetic effect on the central nervous system, are continuously, abused or unjustified in use, are prone to physical and mental dependence, and can become addictive. However, during medical work, it is necessary to inject anesthetic drugs into patients so as to facilitate the work of medical staff. When the anesthetic drug acts, the drug effect of the drug is poor, or the tolerance of a patient is poor, so that the patient is injured due to insufficient anesthesia or other adverse reactions, the lidocaine-containing cream can be used for local cortical anesthesia, in recent years, a plurality of manufacturers make lidocaine into ointment, and the ointment has the permeation effect on local mucous membranes and skin and acts on superficial nerve endings to generate the analgesic effect. The lidocaine ointment can also be smeared on an article to be led in, and after the lidocaine ointment acts with the mucous membrane and the skin which are locally contacted, a person can tolerate invasive operation more and can receive medical supplies more comfortably. The single component anesthetic drugs in the current market and lidocaine also cause allergic reactions in the skin, especially in patients with sensitive muscles, and more severe redness when patients are intolerant to lidocaine. Therefore, how to avoid lidocaine allergy is a technical problem to be solved urgently.

Disclosure of Invention

The invention aims to solve the problems and provides a combined medicine cream for anesthesia and a preparation method thereof. In order to solve the technical problems, the invention adopts the following technical scheme:

a combined medicine cream for anesthesia comprises, by mass, 30-100 parts of lidocaine, 30-100 parts of prilocaine, 5-10 parts of a soothing agent, 20-35 parts of an emulsifier, 15-30 parts of a thickening agent and 9000-9500 parts of purified water.

Further, 10-15 parts of a pH regulator is also included.

Further, 1-25 parts of menthol is also included.

A process for preparing a combined medicinal cream for anesthesia comprises the following steps of weighing 30-100 parts of lidocaine, 30-100 parts of prilocaine, 10-15 parts of pH regulator, 5-10 parts of soothing agent, 20-35 parts of emulsifier, 15-30 parts of thickener, 1-25 parts of menthol and 9000-9500 parts of purified water in parts by mass; firstly, 9000-9500 parts of purified water is put into a mixing device, then 30-100 parts of lidocaine and 30-100 parts of prilocaine are added into the mixing device, the mixture is heated to 80 ℃ and then stirred by a stirring device to be dissolved, 5-10 parts of a soothing agent, 20-35 parts of an emulsifier, 15-30 parts of a thickening agent and 1-25 parts of menthol are added after the dissolution, and the stirring device is continuously started to stir for 10-30 minutes; adding 10-15 parts of pH regulator to regulate the pH value of the solution in the mixing equipment to 6.0-8.0, and then continuously stirring uniformly to obtain the combined medicinal cream for anesthesia.

Due to the adoption of the technical scheme, the invention has the remarkable technical effects that: (1) The pharmaceutical composition has the advantages of small and narrow distribution of microemulsion particle size, good transdermal effect, quick response to anesthesia, long anesthesia maintenance time and capability of preventing cold tremor after anesthesia, and the synergistic effect of the components of the pharmaceutical composition enables the drug effect of lidocaine to be more fully exerted, so that the anesthetic effect of the prepared anesthetic is better, the harm to patients due to insufficient anesthesia is avoided, and the sensitization risk caused by lidocaine and prilocaine is reduced. (2) Realize having the rotation process and the static process of transmission shaft at the in-process that first drive lever rotated the round through agitating unit, when the transmission shaft was in the rotation process, the transmission shaft drove stirring paddle leaf and rotates, drove the liquid medicine motion in the agitator, when the transmission shaft was in the static process, arc-shaped groove lockplate is locked to the arc-shaped groove lockplate, and then realizes transmission shaft and stirring paddle leaf's static to the realization stops pivoted liquid medicine in the agitator, stir inefficiency, stirring time length in order to solve current agitated vessel, easily leads to the uneven problem of each medicine component distribution in the cream, and reach and improve stirring efficiency, shorten stirring time, improve the purpose of each medicine component distribution homogeneity. .

Drawings

FIG. 1 is a schematic view showing the construction of a stirring apparatus for preparing a combined pharmaceutical cream for anesthesia in the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "vertical", "upper", "lower", "horizontal", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, which are only for convenience of description of the present invention and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, "first," "second," "third," and "fourth" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it should be further noted that, unless otherwise specifically stated or limited, the terms "disposed," "mounted," "connected," and "connected" are to be construed broadly and may be, for example, fixedly connected, detachably connected, integrally connected, mechanically connected, electrically connected, directly connected, connected through an intermediate medium, or connected through the insides of two elements. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.

Example 1

A combined medicine cream for anesthesia comprises, by mass, 30-100 parts of lidocaine, 30-100 parts of prilocaine, 10-15 parts of a pH regulator, 5-10 parts of a soothing agent, 20-35 parts of an emulsifier, 15-30 parts of a thickening agent, 1-25 parts of menthol and 9000-9500 parts of purified water.

A preparation method of a combined medicinal cream for anesthesia comprises weighing the above components and dosages; firstly, 9000-9500 parts of purified water is put into a mixing device, then 30-100 parts of lidocaine and 30-100 parts of prilocaine are added into the mixing device, the mixture is heated to 80 ℃ and then stirred by a stirring device to be dissolved, 5-10 parts of a soothing agent, 20-35 parts of an emulsifier, 15-30 parts of a thickening agent and 1-25 parts of menthol are added after the dissolution, and the stirring device is continuously started to stir for 10-30 minutes; adding 10-15 parts of pH regulator to regulate the pH value of the solution in the mixing equipment to 6.0-8.0, and then continuously stirring uniformly to obtain the combined medicinal cream for anesthesia.

Agitating unit includes driving motor, drive shaft 1, first transfer line 2, first link 3, drive post 4, axis of rotation 5, second connecting rod 6, arc lockplate 7, arc wall lockplate 9, transmission groove 8, second transfer line 10 and transmission shaft 11, driving motor is connected with the transmission of drive shaft 1, the one end of first transfer line 2 with 1 fixed connection of drive shaft, the other end of first transfer line 2 with the one end of first link 3 rotates to be connected, the other end of first link 3 rotates with the one end of second link 6 to be connected, the middle part of second link 6 rotates to set up in axis of rotation 5, arc lockplate 7 rotates to set up in axis of rotation 5 and with 6 middle part fixed connection of second link, be provided with drive post 4 on the other end of second link 6, arc lockplate 7 sets up with the cooperation of arc wall lockplate 9, the fixed transmission shaft that sets up of arc wall lockplate 9 is 11, the one end of second transfer line 10 is fixed to be set up on transmission shaft 11 and with the fixed setting of arc wall plate 9, transmission shaft 11 rotates to set up on the support on the agitator and is connected with the transmission rod 8, the other end of transmission rod sets up with the cooperation of second transfer line 8 and the transmission groove 8.

Four stirring blades are uniformly distributed on the stirring rod.

The stirring device has the following working principle: starting a driving motor, driving drive shaft 1 rotates, drive shaft 1 drives first drive rod 2 anticlockwise rotation, first drive rod 2 drives second connecting rod 6 anticlockwise swing through first connecting rod 3, first drive rod 2 rotates to D point from A point when, second connecting rod 6 drives arc lockplate 7 anticlockwise rotation and begins to break away from with arc wall lockplate 9, just drive post 4 on second connecting rod 6 just anticlockwise swing gets into transmission groove 8 and drives transmission shaft 11 anticlockwise rotation, first drive rod 2 rotates to B point in-process from D point with first connecting rod 3's rotation connecting axle, drive post 4 anticlockwise swing drives the stirring rod anticlockwise rotation through second drive rod 10 and transmission shaft 11 and stirs, first drive rod 2 rotates to B point from D point with first connecting rod 3's rotation connecting axle, drive post 4 swings to right side extreme position department, first drive rod 2 continues to rotate, drive post 4 begins clockwise swing and drives the stirring rod through second drive rod 10 and transmission shaft 11 and rotates and stirs the stirring rod, realizes that stirring rod rotates clockwise from D point to B point when this stirring rod drives the paddle 4 swing to right side extreme position department, first drive rod 6 drives stirring rod 6 and stirring rod 6 rotates the stirring point and stirring rod 6, stirring rod 6 drives the stirring rod 6 and stirring rod rotates clockwise, stirring rod 6 and stirring rod 6 stirring point rotation, shorten stirring time, first transmission pole 2 rotates to A point from C point with the rotation connecting axle of first link 3 when, just drive post 4 swings and keeps away from transmission groove 8 and swings to left side extreme position department, and this in-process arc wall lockplate 9 clockwise swing and all the time with arc wall lockplate 9 block in order to keep second transmission pole 10 and transmission shaft 11 locking motionless, first transmission pole 2 rotates to D point in-process from A point with the rotation connecting axle of first link 3, just drive post 4 swings and is close to transmission groove 8, and this in-process arc wall lockplate 9 anticlockwise swing and all the time with arc wall 9 block in order to keep second transmission pole 10 and transmission shaft 11 locking motionless, thereby realize transmission shaft 11's rotation process and the static process at first transmission pole 2 rotation round in-process, when transmission shaft 11 is in the rotation process, transmission shaft 11 drives stirring paddle and rotates, drives the liquid medicine motion in the agitator, when transmission shaft 11 is in the static process, arc 7 locks arc wall groove 9, and then realize the stillness of transmission shaft 11 and the paddle blade rotation to the stirring cream in order to improve the medicine stirring efficiency, the distribution of stirring equipment that stirring ground is difficult.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features of the embodiments described above are not described, but should be considered as within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.

The above-mentioned embodiments only express the embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A method of preparing a combination pharmaceutical cream for anesthesia, characterized in that: weighing 30-100 parts of lidocaine, 30-100 parts of prilocaine, 10-15 parts of pH regulator, 5-10 parts of soothing agent, 20-35 parts of emulsifier, 15-30 parts of thickener, 1-25 parts of menthol and 9000-9500 parts of purified water according to the mass parts; 9000-9500 parts of purified water is firstly put into a mixing device, 30-100 parts of lidocaine and 30-100 parts of prilocaine are added into the mixing device, the mixture is heated to 80 degrees and then stirred by stirring equipment until the mixture is dissolved, wherein the stirring device comprises a driving motor, a driving shaft, a first transmission rod, a first connecting rod, a driving column, a rotating shaft, a second connecting rod, an arc-shaped locking plate, an arc-shaped groove locking plate, a transmission groove, a second transmission rod and a transmission shaft, the driving motor is in transmission connection with the driving shaft, one end of the first transmission rod is fixedly connected with the driving shaft, the other end of the first transmission rod is rotatably connected with one end of the first connecting rod, the other end of the first connecting rod is rotatably connected with one end of the second connecting rod, the middle of the second connecting rod is rotatably arranged on the rotating shaft, the arc-shaped locking plate is rotatably arranged on the rotating shaft and fixedly connected with the middle of the second connecting rod, the driving column is arranged on the other end of the second connecting rod, the arc-shaped groove locking plate is fixedly arranged on the transmission shaft, the second transmission rod is fixedly arranged on the transmission shaft, the stirring rod transmission plate, and the stirring rod is connected with the stirring rod, and the stirring rod transmission support, and the stirring rod is arranged on the stirring support, and the stirring support: starting a driving motor, driving a driving shaft to rotate, driving the first transmission rod to rotate anticlockwise, driving the first transmission rod to swing anticlockwise through a first connecting rod, driving a drive column on the second connecting rod to enter a transmission groove and drive the transmission shaft to rotate anticlockwise just when a rotating connecting shaft of the first transmission rod and the first connecting rod rotates to a point D from the point A, driving the arc-shaped locking plate to rotate anticlockwise and start to separate from the arc-shaped groove locking plate through the second connecting rod, driving the drive column on the second connecting rod to swing anticlockwise and drive the stirring rod to stir anticlockwise through the second transmission rod and the transmission shaft in the process of rotating the first transmission rod and the rotating connecting shaft of the first connecting rod from the point D to the point B, and driving the drive column to swing to a right limit position when the first transmission rod and the rotating connecting shaft of the first connecting rod rotate to the point B from the point D, first drive lever continues to rotate, the drive post begins clockwise turning and drives the stirring rod clockwise turning through secondary drive pole and transmission shaft and stirs, realizes the stirring process of stirring rod from this, when the rotation connecting axle of first drive pole and first connecting rod rotates to the C point from the B point, drive post on the second connecting rod just clockwise turning breaks away from the driving groove, just the second connecting rod drives arc lockplate clockwise turning and begins the block with the arc wall lockplate in order to realize that arc wall lockplate, secondary drive pole and transmission shaft locking are motionless, the stirring rod is motionless, stirring paddle leaf on the stirring rod stops the rotation of the liquid medicine in the agitator, when the rotation connecting axle of first drive pole and first connecting rod rotates to the A point from the C point, just the driving post swing is kept away from the driving groove and is swung to left side extreme position department, in the process, the arc-shaped groove locking plate swings clockwise and is always clamped with the arc-shaped groove locking plate to keep the second transmission rod and the transmission shaft locked, the first transmission rod and a rotating connecting shaft of the first connecting rod rotate from the point A to the point D, the driving column swings close to the transmission groove, in the process, the arc-shaped groove locking plate swings anticlockwise and is always clamped with the arc-shaped groove locking plate to keep the second transmission rod and the transmission shaft locked, therefore, the rotating process and the static process of the transmission shaft are realized in the process of one circle of rotation of the first transmission rod, when the transmission shaft is in the rotating process, the transmission shaft drives the stirring paddle to rotate to drive the liquid medicine in the stirring barrel to move, when the transmission shaft is in the static process, the arc-shaped groove locking plate locks the arc-shaped groove, further, the static state of the transmission shaft and the stirring paddle is realized, so that the liquid medicine rotating in the stirring barrel is blocked, 5-10 parts of the moderator, 20-35 parts of the emulsifier, 15-30 parts of the thickener and 1-25 parts of the menthol, and the stirring device is continuously started to stir for 10-30 minutes; adding 10-15 parts of pH regulator to regulate the pH value of the solution in the mixing equipment to 6.0-8.0, and continuously stirring uniformly to obtain the combined medicinal cream for anesthesia.