CN112494470A - Preparation process of anesthetic pharmaceutical composition - Google Patents
Preparation process of anesthetic pharmaceutical composition Download PDFInfo
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- CN112494470A CN112494470A CN202011564447.3A CN202011564447A CN112494470A CN 112494470 A CN112494470 A CN 112494470A CN 202011564447 A CN202011564447 A CN 202011564447A CN 112494470 A CN112494470 A CN 112494470A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/80—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis
- B01F27/90—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms
- B01F27/906—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a substantially vertical axis with paddles or arms with fixed axis
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/121—Maintenance of mixers using mechanical means using a brush for cleaning out rests of products
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/12—Maintenance of mixers using mechanical means
- B01F35/123—Maintenance of mixers using mechanical means using scrapers for cleaning mixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/40—Mounting or supporting mixing devices or receptacles; Clamping or holding arrangements therefor
- B01F35/41—Mounting or supporting stirrer shafts or stirrer units on receptacles
- B01F35/411—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft
- B01F35/4111—Mounting or supporting stirrer shafts or stirrer units on receptacles by supporting only one extremity of the shaft at the top of the receptacle
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
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- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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- Anesthesiology (AREA)
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Abstract
The invention relates to the technical field of anesthetic drugs, in particular to a preparation process of an anesthetic drug composition, which comprises the following steps: s1, weighing lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate according to the prescription amount, wherein the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: the polysorbate proportion is 30-100 parts to 1-25 parts to 200 parts to 1000 parts to 4500 parts to 15-200 parts; s2, firstly, putting ethanol and clean water into a mixing device to prepare an ethanol solution with the concentration of 5% -90%, then adding lidocaine hydrochloride and menthol into the mixing device, stirring until the lidocaine hydrochloride and the menthol are dissolved, adding glycerin and polysorbate after the lidocaine and the menthol are dissolved, and stirring for 10-60 minutes; s3, adjusting the pH value of the solution in the mixing equipment to 2.0-8.0, filtering the liquid medicine, supplementing water and sterilizing, and then filling and sealing the liquid medicine; the prepared anesthetic has better drug effect, solves the problem that the traditional anesthetic has weaker anesthetic effect, and avoids the injury of patients due to insufficient anesthesia.
Description
Technical Field
The invention relates to the technical field of medicines, in particular to a preparation process of an anesthetic pharmaceutical composition.
Background
Narcotic drugs are drugs that have an anesthetic effect on the central nervous system, are continuously, abused or unjustified in use, are prone to physical and mental dependence, and can become addictive. However, during medical work, it is necessary to inject anesthetic drugs into patients so as to facilitate the work of medical staff.
In the prior art, the components of the anesthetic in the current market are single, and when the anesthetic plays a role, the drug effect of the drug is poor, or the tolerance of a patient is poor, so that the patient is injured due to insufficient anesthesia or other adverse reactions, and therefore, a preparation process of the anesthetic composition is provided for solving the problems.
Disclosure of Invention
In order to make up for the defects of the prior art, the components of the anesthetic in the current market are single, and when the anesthetic plays a role, the drug effect of the drug is poor, or the tolerance of a patient is poor, so that the patient is injured due to insufficient anesthesia or other adverse reactions.
A process for preparing an anesthetic pharmaceutical composition, the process comprising the steps of;
s1, weighing lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate according to the prescription amount, wherein the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: the polysorbate proportion is 30-100 parts to 1-25 parts to 200 parts to 1000 parts to 4500 parts to 15-200 parts;
s2, firstly, putting ethanol and clean water into a mixing device to prepare an ethanol solution with the concentration of 5% -90%, then adding lidocaine hydrochloride and menthol into the mixing device, stirring until the lidocaine hydrochloride and the menthol are dissolved, adding glycerin and polysorbate after the lidocaine and the menthol are dissolved, and stirring for 10-60 minutes;
and S3, adjusting the pH value of the solution in the mixing equipment to 2.0-8.0, filtering the liquid medicine, supplementing water and sterilizing, filtering, and filling and sealing the liquid medicine.
Preferably, the mixing equipment comprises a frame body, a stirring barrel, a lifting assembly and a stirring assembly; the stirring barrel is fixedly connected to the inner side wall of the bottom end of the frame body; the lifting assembly is arranged in the frame body; the stirring component is arranged in the stirring barrel, is fixedly connected with the lifting component and comprises a motor, a rotating rod and a stirring rod; the motor is fixedly connected with the lifting assembly, the rotating rod is fixedly connected to the output end of the motor, and the end part of the rotating rod, far away from the motor, is fixedly connected with a first bevel gear; the stirring rod is fixedly connected to the outer side wall of the rotating rod; during operation, add the raw materials to the agitator, start cylinder and motor, the motor drives the dwang and rotates, the dwang drives the puddler and rotates, make the puddler carry out intensive mixing to the raw materials, the cylinder promotes the push rod, thereby drive the backing plate and move, in the backing plate motion process, it slides along the guide pin bushing inside wall to drive the guide arm, and in the backing plate motion process, the drive motor descends, thereby make the puddler be close to the agitator bottom gradually, the stirring scope of puddler has been enlarged, thereby make the raw materials stirring in the agitator more abundant, thereby make the mixing rate of accelerating the raw materials, promote the work efficiency of compounding work.
Preferably, the lifting assembly comprises a cylinder, a base plate, a guide pillar and a guide sleeve; the air cylinder is fixedly connected to the top of the frame body, arranged in a mirror image mode relative to the center line of the top surface of the frame body, and provided with a push rod at the output end; the base plate is fixedly connected to the end part of the push rod far away from the cylinder; the guide posts are fixedly connected to the bottom of the base plate and arranged in a mirror image mode relative to the center line of the bottom surface of the base plate; the guide sleeve is sleeved on the outer side wall of the guide pillar, and one end of the guide sleeve is fixedly connected to the inner side wall of the bottom end of the frame body; the motor is fixedly connected to the top of the base plate; the during operation, the cylinder starts, promote the push rod and move, thereby drive the backing plate and move, it slides along the guide pin bushing inside wall to drive the guide arm in the backing plate motion process, the guide arm plays the supporting role of direction to the motion of backing plate, guarantee the stationary motion of backing plate, thereby make the puddler stir the work smoothly to the raw materials in the agitator, in the backing plate motion process, make the puddler stir near the agitator bottom inside wall gradually, the stirring scope of puddler has been enlarged, thereby improve the mixing rate of raw materials.
Preferably, a pair of sliding chutes is arranged on the inner side wall of the stirring barrel; a wall cleaning component is arranged inside the stirring barrel; the wall cleaning assembly comprises a screw rod, a connecting rod and a scraper; the screw rod is rotatably connected to the inner side wall of the stirring barrel, a pair of sliding blocks is sleeved on the outer side wall of the screw rod, and a second bevel gear is fixedly connected to the middle of the screw rod; the second bevel gear is meshed with the first bevel gear; the sliding block is connected with the screw rod through a ball screw nut pair; the scraper is connected in the chute in a sliding manner through a spring and is in sliding fit with the inner side wall of the stirring barrel, and one side of the scraper, which is close to the inner side wall of the stirring barrel, is fixedly connected with a brush; one end of the connecting rod is hinged to the top of the sliding block, and the other end of the connecting rod is hinged to the side wall of the scraper; when the automatic cleaning device works, when the stirring rod is gradually close to the inner side wall of the bottom end of the stirring barrel, the first bevel gear fixedly connected with the end part of the rotating rod is gradually close to the second bevel gear, the first bevel gear is driven by the rotating rod to rotate, when the air cylinder pushes the push rod to move to the end point of the stroke of the push rod, the first bevel gear is meshed with the second bevel gear so as to drive the second bevel gear to rotate with the screw rod, the screw rod is sleeved with a sliding block which is connected with the sliding block through a ball screw nut pair, threads on the screw rod are symmetrically arranged, so that the two sliding blocks slide on the screw rod, the movement is reversely deviated, the connecting rod is driven to swing in the sliding process of the sliding block so as to push the scraping plate to slide in the sliding groove, and in the sliding process of the scraping plate, the cleaning, avoid the raw materials adhesion to cause the stirring inadequately on the agitator inside wall.
Preferably, the inner side wall of the guide sleeve is provided with a first groove, and the outer side wall of the guide sleeve is fixedly connected with a rectangular block; an oil nozzle is fixedly connected in the first groove; a second groove is formed in the top of the rectangular block; an oil bag is fixedly connected inside the second groove; the interior of the oil bag is communicated with an oil nozzle; the bottom of the backing plate is fixedly connected with a pressure lever; the compression bar is in contact with the oil bag; the during operation, when the push rod drives the backing plate and moves, the depression bar extrusion oil pocket of drive backing plate bottom rigid coupling for oil pocket pressurized carries out the oil spout, thereby makes the inside lubricating oil of oil pocket spout from the fuel sprayer, thereby lubricates the guide arm lateral wall, reduces the wearing and tearing between guide arm and the guide pin bushing, makes more steady of backing plate motion, thereby guarantees the smooth completion of stirring compounding work.
Preferably, a cavity is arranged on the inner side wall of the bottom end of the stirring barrel; a plurality of resistance wires are fixedly connected to the inner side wall of the cavity; a pair of fan blades is fixedly connected to the outer side wall of the screw rod; the during operation, when stirring the inside raw materials of agitator, switch on the resistance wire to make the resistance wire generate heat, thereby heat the inside raw materials of agitator, thereby accelerate the mixing rate of raw materials, thereby promote stirring efficiency, at second bevel gear and first bevel gear meshing in-process, drive the lead screw and rotate, the lead screw drives the flabellum and rotates, thereby plays the effect of supplementary stirring to the mixture of raw materials.
The invention has the advantages that:
1. the invention is prepared by the lidocaine hydrochloride, the menthol, the glycerol, the ethanol and the polysorbate according to a certain proportion, so that the drug effect of the lidocaine hydrochloride is more fully exerted, the anesthetic effect of the prepared anesthetic is better, and the patient is prevented from being injured due to insufficient anesthesia;
2. according to the invention, through the matching work of the stirring barrel, the air cylinder, the push rod, the base plate, the pressure rod, the guide pillar, the guide sleeve, the motor, the rotating rod and the stirring rod, the raw materials in the stirring barrel are fully stirred, so that the raw materials are more fully mixed, and the prepared medicine has better efficacy.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
FIG. 1 is a schematic flow chart of the preparation process of the present invention;
FIG. 2 is a schematic three-dimensional structure of the mixing apparatus of the present invention;
FIG. 3 is a partial cross-sectional view of a mixing apparatus of the present invention;
FIG. 4 is an enlarged view of a portion of FIG. 3 at A;
FIG. 5 is an enlarged view of a portion of FIG. 3 at B;
fig. 6 is a partially enlarged view at C in fig. 3.
In the figure: 1. a frame body; 2. a stirring barrel; 21. a chute; 22. a cavity; 221. a resistance wire; 3. a lifting assembly; 31. a cylinder; 311. a push rod; 32. a base plate; 321. a pressure lever; 33. a guide post; 34. a guide sleeve; 341. a first groove; 342. an oil jet; 35. a rectangular block; 351. a second groove; 352. an oil pocket; 4. a stirring assembly; 41. a motor; 42. rotating the rod; 43. a stirring rod; 44. a first bevel gear; 5. a wall cleaning component; 51. a screw rod; 511. a fan blade; 52. a connecting rod; 53. a squeegee; 531. a brush; 54. a slider; 55. a second bevel gear.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
A process for preparing an anesthetic pharmaceutical composition, the process comprising the steps of;
s1, weighing lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate according to the prescription amount, wherein the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: the polysorbate is 30 parts to 5 parts to 200 parts to 1000 parts to 15 parts;
s2, firstly, putting ethanol and clean water into a mixing device to prepare an ethanol solution with the concentration of 5%, then adding lidocaine hydrochloride and menthol into the mixing device, stirring until the lidocaine hydrochloride and the menthol are dissolved, adding glycerin and polysorbate after the lidocaine and the menthol are dissolved, and stirring for 45 minutes;
and S3, adjusting the pH value of the solution in the mixing equipment to 3, filtering the liquid medicine, supplementing water and sterilizing the liquid medicine, and filling and sealing the liquid medicine.
2 adult mice with consistent health conditions are selected, one of the adult mice is injected with the existing single-dose anesthetic, the other adult mouse is injected with the same dose of the anesthetic prepared by the embodiment, after the injection is finished, the two adult mice are observed, and the anesthetic degrees of the two adult mice are detected.
Example 2
A process for preparing an anesthetic pharmaceutical composition, the process comprising the steps of;
s1, weighing lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate according to the prescription amount, wherein the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: the polysorbate accounts for 100 parts to 25 parts to 1200 parts to 4500 parts to 200 parts;
s2, firstly, putting ethanol and clean water into a mixing device to prepare an ethanol solution with the concentration of 90%, then adding lidocaine hydrochloride and menthol into the mixing device, stirring until the lidocaine hydrochloride and the menthol are dissolved, adding glycerin and polysorbate after the lidocaine and the menthol are dissolved, and stirring for 45 minutes;
and S3, adjusting the pH value of the solution in the mixing equipment to 8.0, filtering the liquid medicine, supplementing water and sterilizing and filtering the liquid medicine, and filling and sealing the liquid medicine.
2 adult mice with consistent health conditions are selected, one of the adult mice is injected with the existing single-dose anesthetic, the other adult mouse is injected with the same dose of the anesthetic prepared by the embodiment, after the injection is finished, the two adult mice are observed, and the anesthetic degrees of the two adult mice are detected.
Example 3
A process for preparing an anesthetic pharmaceutical composition, the process comprising the steps of;
s1, weighing lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate according to the prescription amount, wherein the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: the polysorbate accounts for 60 parts to 15 parts to 700 parts to 2200 parts to 115 parts;
s2, firstly, putting ethanol and clean water into a mixing device to prepare 50% ethanol solution, then adding lidocaine hydrochloride and menthol into the mixing device, stirring until the lidocaine hydrochloride and the menthol are dissolved, adding glycerin and polysorbate after the lidocaine and the menthol are dissolved, and stirring for 45 minutes;
and S3, adjusting the pH value of the solution in the mixing equipment to 5, filtering the liquid medicine, supplementing water and sterilizing the liquid medicine, and filling and sealing the liquid medicine.
2 adult mice with consistent health conditions are selected, one of the adult mice is injected with the existing single-dose anesthetic, the other adult mouse is injected with the same dose of the anesthetic prepared by the embodiment, after the injection is finished, the two adult mice are observed, and the anesthetic degrees of the two adult mice are detected.
It can be seen from examples 1 to 3 that the level of anesthesia in the mice injected with the anesthetic prepared in this example in example 3 was higher than that in the mice injected with the anesthetic alone, the level of anesthesia in the mice injected with the anesthetic prepared in this example in example 2 was higher than that in the mice injected with the anesthetic alone, the level of anesthesia in the mice injected with the anesthetic prepared in this example in example 1 was higher than that in the mice injected with the anesthetic alone, and the anesthetic effect of example 3 was the best and the best example, from which it can be seen that the anesthetic effect of the anesthetic prepared in this example was better than that of the anesthetic alone.
Referring to fig. 1-6, as an embodiment of the present invention, the mixing apparatus includes a frame 1, a mixing tank 2, a lifting component 3, and a mixing component 4; the stirring barrel 2 is fixedly connected to the inner side wall of the bottom end of the frame body 1; the lifting assembly 3 is arranged in the frame body 1; the stirring component 4 is arranged in the stirring barrel 2, is fixedly connected with the lifting component 3 and comprises a motor 41, a rotating rod 42 and a stirring rod 43; the motor 41 is fixedly connected with the lifting component 3, the rotating rod 42 is fixedly connected with the output end of the motor 41, and the end part of the rotating rod, which is far away from the motor 41, is fixedly connected with a first bevel gear 44; the stirring rod 43 is fixedly connected to the outer side wall of the rotating rod 42; the during operation, add the raw materials to agitator 2 in, start cylinder 31 and motor 41, motor 41 drives dwang 42 and rotates, dwang 42 drives puddler 43 and rotates, make puddler 43 carry out intensive mixing to the raw materials, cylinder 31 promotes push rod 311, thereby drive backing plate 32 and move, in the backing plate 32 motion process, it slides along guide pin bushing 34 inside wall to drive the guide arm, and in backing plate 32 motion process, drive motor 41 descends, thereby make puddler 43 be close to 2 bottoms of agitator gradually, the stirring scope of puddler 43 has been enlarged, thereby make the more abundant of raw materials stirring in the agitator 2, thereby make the mixing rate of accelerating the raw materials, promote the work efficiency of compounding work.
As an embodiment of the present invention, the lifting assembly 3 includes a cylinder 31, a backing plate 32, a guide pillar 33 and a guide sleeve 34; the cylinder 31 is fixedly connected to the top of the frame 1, arranged in a mirror image manner with respect to the center line of the top surface of the frame 1, and provided with a push rod 311 at the output end; the backing plate 32 is fixedly connected to the end part of the push rod 311 far away from the cylinder 31; the guide post 33 is fixedly connected to the bottom of the backing plate 32 and arranged in a mirror image mode relative to the center line of the bottom surface of the backing plate 32; the guide sleeve 34 is sleeved on the outer side wall of the guide post 33, and one end of the guide sleeve is fixedly connected to the inner side wall of the bottom end of the frame body 1; the motor 41 is fixedly connected to the top of the backing plate 32; the during operation, cylinder 31 starts, promote push rod 311 and move, thereby drive backing plate 32 and move, it slides along guide pin bushing 34 inside wall to drive the guide arm in backing plate 32 motion process, the guide arm plays the supporting role of direction to the motion of backing plate 32, guarantee backing plate 32's steady motion, thereby make puddler 43 carry out stirring work smoothly to the raw materials in agitator 2, in backing plate 32 motion process, make puddler 43 stir near 2 bottom inside walls of agitator gradually, the stirring scope of puddler 43 has been enlarged, thereby improve the mixing rate of raw materials.
As an embodiment of the present invention, a pair of chutes 21 is provided on the inner side wall of the stirring barrel 2; a wall cleaning component 5 is arranged in the stirring barrel 2; the wall cleaning assembly 5 comprises a screw rod 51, a connecting rod 52 and a scraper 53; the screw rod 51 is rotatably connected to the inner side wall of the stirring barrel 2, a pair of slide blocks 54 is sleeved on the outer side wall of the screw rod, and a second bevel gear 55 is fixedly connected to the middle of the screw rod; the second bevel gear 55 is meshed with the first bevel gear 44; the slide block 54 is connected with the screw 51 through a ball screw nut pair; the scraper 53 is connected in the chute 21 in a sliding manner through a spring and is in sliding fit with the inner side wall of the stirring barrel 2, and a brush 531 is fixedly connected to one side of the scraper close to the inner side wall of the stirring barrel 2; one end of the connecting rod 52 is hinged to the top of the sliding block 54, and the other end of the connecting rod is hinged to the side wall of the scraper 53; when the stirring device works, when the stirring rod 43 is gradually close to the inner side wall of the bottom end of the stirring barrel 2, the first bevel gear 44 fixedly connected with the end part of the rotating rod 42 is gradually close to the second bevel gear 55, and the first bevel gear 44 is driven by the rotating rod 42 to rotate, when the cylinder 31 pushes the push rod 311 to move to the end point of the stroke of the push rod 311, the first bevel gear 44 is meshed with the second bevel gear 55, so as to drive the second bevel gear 55 to rotate with the screw rod 51, the screw rod 51 is sleeved with the slide block 54, the slide block 54 is a ball screw nut pair, and the threads on the screw rod 51 are symmetrically arranged, so that the two slide blocks 54 slide on the screw rod 51, and the movement directions are opposite to each other, the connecting rod 52 is driven to swing in the sliding process of the slide block 54, so as to push the scraper 53 to slide in the chute 21, and, thereby clean the raw materials of adhesion on 2 inside walls of agitator, avoid the raw materials adhesion to cause the stirring insufficient on 2 inside walls of agitator.
As an embodiment of the present invention, a first groove 341 is disposed on an inner sidewall of the guide sleeve 34, and a rectangular block 35 is fixedly connected to an outer sidewall thereof; an oil nozzle 342 is fixedly connected in the first groove 341; the top of the rectangular block 35 is provided with a second groove 351; an oil bag 352 is fixedly connected inside the second groove 351; the inside of the oil bag 352 is communicated with the oil nozzle 342; a pressure lever 321 is fixedly connected to the bottom of the backing plate 32; the pressure rod 321 is in contact with the oil bag 352; during operation, when the push rod 311 drives the backing plate 32 to move, the pressing rod 321 which drives the bottom of the backing plate 32 to fixedly connect extrudes the oil bag 352, so that the oil bag 352 is pressed to spray oil, the lubricating oil inside the oil bag 352 is sprayed out from the oil nozzle 342, the outer side wall of the guide rod is lubricated, the abrasion between the guide rod and the guide sleeve 34 is reduced, the backing plate 32 is made to move more stably, and the smooth completion of stirring and mixing work is ensured.
As an embodiment of the present invention, a cavity 22 is provided on the inner side wall of the bottom end of the stirring barrel 2; a plurality of resistance wires 221 are fixedly connected to the inner side wall of the cavity 22; a pair of fan blades 511 is fixedly connected to the outer side wall of the screw rod 51; the during operation, when stirring the raw materials inside agitator 2, switch on resistance wire 221 to make resistance wire 221 generate heat, thereby heat the raw materials inside agitator 2, thereby accelerate the mixing rate of raw materials, thereby promote stirring efficiency, at second bevel gear 55 and first bevel gear 44 meshing in-process, drive lead screw 51 and rotate, lead screw 51 drives flabellum 511 and rotates, thereby play the effect of supplementary stirring to the mixture of raw materials.
The working principle is as follows: adding raw materials into the stirring barrel 2, starting the cylinder 31 and the motor 41, the motor 41 driving the rotating rod 42 to rotate, thereby driving the stirring rod 43 to rotate, so that the stirring rod 43 stirs the raw materials, the cylinder 31 pushing the push rod 311 to drive the backing plate 32 to move, during the movement of the backing plate 32, the driving guide rod slides along the inner side wall of the guide sleeve 34, and during the movement of the backing plate 32, the driving motor 41 descends, thereby gradually approaching the stirring rod 43 to the bottom end of the stirring barrel 2, expanding the stirring range of the stirring rod 43, so that the raw materials in the stirring barrel 2 are stirred more sufficiently, accelerating the mixing speed of the raw materials, improving the working efficiency of the mixing work, when the stirring rod 43 gradually approaches the inner side wall of the bottom end of the stirring barrel 2, the first bevel gear 44 fixedly connected to the end of the rotating rod 42 gradually approaches the second bevel gear 55, and the first bevel gear 44 rotates under the driving of, when the cylinder 31 pushes the push rod 311 to move to the end point of the stroke of the push rod 311, the first bevel gear 44 is engaged with the second bevel gear 55, thereby driving the second bevel gear 55 to rotate with the screw rod 51, and the screw rod 51 is sleeved with the slide block 54, the screw rod 51 and the slide block 54 are connected by a ball screw nut pair, and the threads on the screw rod 51 are symmetrically arranged, thereby enabling the two slide blocks 54 to slide on the screw rod 51, and the movement is reversed, the connecting rod 52 is driven to swing in the sliding process of the slide block 54, thereby pushing the scraper 53 to slide in the chute 21, in the sliding process of the scraper 53, the cleaning brush is driven to clean the inner side wall 531 of the stirring barrel 2, thereby cleaning the raw material adhered on the inner side wall of the stirring barrel 2, avoiding the raw material from adhering on the inner side wall of the stirring barrel 2 to cause insufficient stirring, when stirring, make resistance wire 221 generate heat, thereby heat the inside raw materials of agitator 2, accelerate the mixing rate of raw materials, thereby promote stirring efficiency, at second bevel gear 55 and first bevel gear 44 meshing in-process, it rotates to drive lead screw 51, lead screw 51 drives flabellum 511 and rotates, thereby play the effect of supplementary stirring to the mixture of raw materials, when backing plate 32 glides, it extrudes oil pocket 352 to drive depression bar 321, make oil pocket 352 pressurized carry out the oil spout, thereby make the inside lubricating oil of oil pocket 352 spout from oil sprayer 342, thereby lubricate the guide arm lateral wall, reduce the wearing and tearing between guide arm and the guide pin bushing 34, make the more steady of backing plate 32 motion, thereby guarantee the smooth completion of stirring compounding work.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
Claims (6)
1. A preparation process of an anesthetic pharmaceutical composition is characterized by comprising the following steps: the preparation process comprises the following steps;
s1, weighing lidocaine hydrochloride, menthol, glycerin, ethanol and polysorbate according to the prescription amount, wherein the ratio of lidocaine hydrochloride: menthol: glycerol: ethanol: the polysorbate proportion is 30-100 parts to 1-25 parts to 200 parts to 1000 parts to 4500 parts to 15-200 parts;
s2, firstly, putting ethanol and clean water into a mixing device to prepare an ethanol solution with the concentration of 5% -90%, then adding lidocaine hydrochloride and menthol into the mixing device, stirring until the lidocaine hydrochloride and the menthol are dissolved, adding glycerin and polysorbate after the lidocaine and the menthol are dissolved, and stirring for 10-60 minutes;
and S3, adjusting the pH value of the solution in the mixing equipment to 2.0-8.0, filtering the liquid medicine, supplementing water and sterilizing, filtering, and filling and sealing the liquid medicine.
2. The process for preparing an anesthetic pharmaceutical composition as claimed in claim 1, wherein: the mixing equipment comprises a frame body (1), a stirring barrel (2), a lifting assembly (3) and a stirring assembly (4); the stirring barrel (2) is fixedly connected to the inner side wall of the bottom end of the frame body (1); the lifting assembly (3) is arranged in the frame body (1); the stirring component (4) is arranged in the stirring barrel (2), is fixedly connected with the lifting component (3), and comprises a motor (41), a rotating rod (42) and a stirring rod (43); the motor (41) is fixedly connected with the lifting component (3), the rotating rod (42) is fixedly connected with the output end of the motor (41), and the end part of the rotating rod, which is far away from the motor (41), is fixedly connected with a first bevel gear (44); the stirring rod (43) is fixedly connected to the outer side wall of the rotating rod (42).
3. The process for preparing an anesthetic pharmaceutical composition as claimed in claim 2, wherein: the lifting assembly (3) comprises a cylinder (31), a backing plate (32), a guide post (33) and a guide sleeve (34); the air cylinder (31) is fixedly connected to the top of the frame body (1), is arranged in a mirror image mode relative to the center line of the top surface of the frame body (1), and is provided with a push rod (311) at the output end; the backing plate (32) is fixedly connected to the end part of the push rod (311) far away from the cylinder (31); the guide posts (33) are fixedly connected to the bottom of the base plate (32) and are arranged in a mirror image mode relative to the center line of the bottom surface of the base plate (32); the guide sleeve (34) is sleeved on the outer side wall of the guide post (33), and one end of the guide sleeve is fixedly connected to the inner side wall of the bottom end of the frame body (1); the motor (41) is fixedly connected to the top of the backing plate (32).
4. The process for preparing an anesthetic pharmaceutical composition as claimed in claim 3, wherein: a pair of chutes (21) is arranged on the inner side wall of the stirring barrel (2); a wall cleaning component (5) is arranged in the stirring barrel (2); the wall cleaning component (5) comprises a screw rod (51), a connecting rod (52) and a scraper (53); the screw rod (51) is rotatably connected to the inner side wall of the stirring barrel (2), a pair of sliding blocks (54) is sleeved on the outer side wall of the screw rod, and a second bevel gear (55) is fixedly connected to the middle of the screw rod; the second bevel gear (55) is meshed with the first bevel gear (44); the sliding block (54) is connected with the screw rod (51) through a ball screw nut pair; the scraper (53) is connected in the chute (21) in a sliding way through a spring and is in sliding fit with the inner side wall of the stirring barrel (2), and one side of the scraper close to the inner side wall of the stirring barrel (2) is fixedly connected with a brush (531); one end of the connecting rod (52) is hinged to the top of the sliding block (54), and the other end of the connecting rod is hinged to the side wall of the scraper (53).
5. The process for preparing an anesthetic pharmaceutical composition as claimed in claim 4, wherein: a first groove (341) is formed in the inner side wall of the guide sleeve (34), and a rectangular block (35) is fixedly connected to the outer side wall of the guide sleeve; an oil nozzle (342) is fixedly connected in the first groove (341); the top of the rectangular block (35) is provided with a second groove (351); an oil bag (352) is fixedly connected inside the second groove (351); the inside of the oil bag (352) is communicated with an oil nozzle (342); a pressure lever (321) is fixedly connected to the bottom of the backing plate (32); the pressure rod (321) is in contact with the oil bag (352) firstly.
6. The process for preparing an anesthetic pharmaceutical composition as claimed in claim 5, wherein: a cavity (22) is arranged on the inner side wall of the bottom end of the stirring barrel (2); a plurality of resistance wires (221) are fixedly connected to the inner side wall of the cavity (22); and a pair of fan blades (511) is fixedly connected to the outer side wall of the screw rod (51).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011564447.3A CN112494470A (en) | 2020-12-25 | 2020-12-25 | Preparation process of anesthetic pharmaceutical composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011564447.3A CN112494470A (en) | 2020-12-25 | 2020-12-25 | Preparation process of anesthetic pharmaceutical composition |
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| Publication Number | Publication Date |
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| CN112494470A true CN112494470A (en) | 2021-03-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011564447.3A Withdrawn CN112494470A (en) | 2020-12-25 | 2020-12-25 | Preparation process of anesthetic pharmaceutical composition |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113975261A (en) * | 2021-12-06 | 2022-01-28 | 郑州大学第一附属医院 | Combined medicinal cream for anesthesia and preparation method thereof |
-
2020
- 2020-12-25 CN CN202011564447.3A patent/CN112494470A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113975261A (en) * | 2021-12-06 | 2022-01-28 | 郑州大学第一附属医院 | Combined medicinal cream for anesthesia and preparation method thereof |
| CN113975261B (en) * | 2021-12-06 | 2023-02-17 | 郑州大学第一附属医院 | Combined medicinal cream for anesthesia and preparation method thereof |
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