CN113975225A - External traditional Chinese medicine preparation for treating hyperplasia of mammary glands as well as preparation method and application thereof - Google Patents
External traditional Chinese medicine preparation for treating hyperplasia of mammary glands as well as preparation method and application thereof Download PDFInfo
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- CN113975225A CN113975225A CN202111334840.8A CN202111334840A CN113975225A CN 113975225 A CN113975225 A CN 113975225A CN 202111334840 A CN202111334840 A CN 202111334840A CN 113975225 A CN113975225 A CN 113975225A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0041—Mammary glands, e.g. breasts, udder; Intramammary administration
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, a preparation method and application thereof. The external traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 5-15 parts of peach kernel, 10-20 parts of safflower, 5-15 parts of rhizoma sparganii, 5-15 parts of curcuma zedoary, 2-8 parts of borneol, 1-6 parts of leech and 15-25 parts of rhubarb. The traditional Chinese medicine composition is developed by combining clinical practice on the basis of the traditional Chinese medicine dialectics, has the effects of breaking blood and removing stasis, and counteracting toxic substances and dissipating binds by combining the medicines, and has the characteristics of exact curative effect, quick response, high cure rate, no toxic or side effect and easy acceptance by patients when used for treating the hyperplasia of mammary glands.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, a preparation method and application thereof.
Background
The hyperplasia of mammary glands is a common disease of women, is one of clinical difficult and complicated diseases and belongs to the category of breast impediment in traditional Chinese medicine. One side or breast of a patient can touch a plurality of nodules with different sizes, and the nodules are mostly scattered or fused into irregular masses, tough and tough, slightly hard and painful, have no adhesion with skin and deep tissues and can be pushed; the mammary gland of a patient often feels discomfort and pain due to falling and swelling, and is mostly related to the menstrual cycle: some patients have symptoms aggravated before menstruation and some patients have discharge or bleeding on the nipple. The pathogenesis of hyperplasia of mammary glands can be related to ovarian dysfunction, the proportion of lutein and female hormone is out of balance, the secretion of lutein is reduced, and the quantity of female hormone is relatively increased. According to the traditional Chinese medicine, the pathogenesis of the breast nodules is stagnation of liver qi, disharmony of Chong and conception channels, and qi stagnation and blood stasis, and the clinical treatment method of breaking blood and removing stasis, attacking toxin and dissipating stagnation is adopted, so that a good treatment effect is achieved, and the safe and effective traditional Chinese medicine preparation has great significance.
Disclosure of Invention
On the basis of the traditional Chinese medicine dialectical theory research on the hyperplasia of mammary glands, the inventor screens and compounds a plurality of traditional Chinese medicines through years of clinical tests to obtain the formula of the invention.
The invention aims to provide an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which has scientific and reasonable formula compatibility, definite curative effect, convenient use, good patient compliance, no toxic or side effect and difficult relapse, and a preparation method and application thereof.
Specifically, in order to achieve the above object, the first aspect of the present invention provides an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which comprises the following raw materials by weight: 5-15 parts of peach kernel, 10-20 parts of safflower, 5-15 parts of rhizoma sparganii, 5-15 parts of curcuma zedoary, 2-8 parts of borneol, 1-6 parts of leech and 15-25 parts of rhubarb.
Further, the external traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 8-12 parts of peach kernel, 13-17 parts of safflower, 8-12 parts of rhizoma sparganii, 8-12 parts of curcuma zedoary, 4-6 parts of borneol, 2-4 parts of leech and 18-22 parts of rhubarb.
Furthermore, the external traditional Chinese medicine preparation comprises the following raw materials in parts by weight: 10 parts of peach kernel, 15 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 5 parts of borneol, 3 parts of leech and 20 parts of rhubarb.
The second aspect of the present invention provides a preparation method of the external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, comprising: weighing the raw materials according to the proportion in parts by weight, soaking peach kernel, safflower, rhizoma sparganii, curcuma zedoary, leech and rhubarb into alcohol, sealing, taking the filtrate, adding distilled water and borneol into the filtrate, and uniformly stirring to obtain the finished product.
Wherein the concentration of the alcohol is 85-95%, and the weight portion of the alcohol is 4900-5100 portions.
The sealing time is 25-35 days.
After adding distilled water, the concentration of alcohol in the filtrate is 55-65%.
In some specific embodiments, the method comprises the steps of:
soaking 5-15 parts of peach kernel, 10-20 parts of safflower, 5-15 parts of rhizoma sparganii, 5-15 parts of rhizoma zedoariae, 1-6 parts of leech and 15-25 parts of rheum officinale in 4900 and 5100 parts of alcohol with the concentration of 85-95%, sealing for 25-35 days, taking the filtrate, adding distilled water into the filtrate to ensure that the concentration of the alcohol in the filtrate is 55-65%, adding 2-8 parts of borneol, and uniformly stirring to obtain the finished product.
Further, the method comprises the steps of:
soaking 10 parts of peach kernel, 15 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 3 parts of leech and 20 parts of rhubarb into 5000 parts of 90% alcohol, sealing for 30 days, taking filtrate, adding distilled water into the filtrate to enable the concentration of the alcohol in the filtrate to be 60%, adding 5 parts of borneol, and uniformly stirring to obtain a finished product.
The invention relates to an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which comprises the following usage and dosage: the medicine is applied topically, 2-3 times a day, and 20 days is a treatment course.
The third aspect of the invention provides an application of the external traditional Chinese medicine preparation in preparing a medicine for treating hyperplasia of mammary glands.
The medicine mechanism of the invention is as follows: peach kernel, semen Persicae has the actions of activating blood and resolving phlegm, moistening intestines to relieve constipation, and is clinically indicated for various blood stasis syndromes, it enters heart and liver blood system due to its bitter taste, so it is good at clearing blood stagnation and removing blood stasis strongly. Safflower promotes blood circulation and removes obstruction in the channels. Rhubarb, radix et rhizoma Rhei purges away accumulation, clears heat and fire, stops bleeding, detoxifies, activates blood and removes stasis. Borneol has the functions of inducing resuscitation, refreshing mind, clearing heat and relieving pain, is bitter and cold in property, clears heat and relieves pain, and has better effects of clearing heat and removing toxicity. Leeches, radix astragali. Rhizoma Sparganii has effects of removing blood stasis, activating qi-flowing, resolving food stagnation and relieving pain. E Zhu has the actions of breaking blood and moving qi, and resolving food stagnation and alleviating pain, it is pungent and bitter in flavor dispersing and purgative, warm in property, and can break blood and move qi.
The invention has the following advantages:
1. the traditional Chinese medicine composition is developed by combining clinical practice on the basis of the traditional Chinese medicine dialectics, has the effects of breaking blood and removing stasis, and counteracting toxic substances and dissipating binds by combining the medicines, and has the characteristics of exact curative effect, quick response, high cure rate, no toxic or side effect and easy acceptance by patients when used for treating the hyperplasia of mammary glands.
2. The invention has the advantages of easily obtained raw materials, low cost and simple and easy preparation method.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention.
Example 1
The embodiment provides an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which is prepared by the following steps:
soaking 5 parts of peach kernel, 18 parts of safflower, 8 parts of rhizoma sparganii, 5 parts of curcuma zedoary, 5 parts of leech and 25 parts of rhubarb into 4900 parts of 90% alcohol, sealing for 28 days, taking filtrate, adding distilled water into the filtrate to enable the alcohol concentration in the filtrate to be 60%, adding 6 parts of borneol, and uniformly stirring to obtain the finished product.
Example 2
The embodiment provides an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which is prepared by the following steps:
soaking 12 parts of peach kernel, 10 parts of safflower, 15 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 1 part of leech and 18 parts of rhubarb into 5000 parts of 90% alcohol, sealing for 25 days, taking filtrate, adding 8 parts of borneol into the filtrate after adding distilled water to enable the concentration of the alcohol in the filtrate to be 60%, and uniformly stirring to obtain a finished product.
Example 3
The embodiment provides an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which is prepared by the following steps:
soaking 10 parts of peach kernel, 15 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 3 parts of leech and 20 parts of rhubarb into 5000 parts of 90% alcohol, sealing for 30 days, taking filtrate, adding distilled water into the filtrate to enable the concentration of the alcohol in the filtrate to be 60%, adding 5 parts of borneol, and uniformly stirring to obtain a finished product.
Example 4
The embodiment provides an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which is prepared by the following steps:
soaking 8 parts of peach kernel, 20 parts of safflower, 5 parts of rhizoma sparganii, 12 parts of curcuma zedoary, 6 parts of leech and 16 parts of rhubarb into 5100 parts of 90% alcohol, sealing for 35 days, taking filtrate, adding distilled water into the filtrate to enable the concentration of the alcohol in the filtrate to be 60%, adding 2 parts of borneol, and uniformly stirring to obtain the finished product.
Example 5
The embodiment provides an external traditional Chinese medicine preparation for treating hyperplasia of mammary glands, which is prepared by the following steps:
soaking 15 parts of peach kernel, 15 parts of safflower, 10 parts of rhizoma sparganii, 15 parts of curcuma zedoary, 3 parts of leech and 22 parts of rhubarb into 5000 parts of 90% alcohol, sealing for 30 days, taking filtrate, adding distilled water into the filtrate to enable the concentration of the alcohol in the filtrate to be 60%, adding 4 parts of borneol, and uniformly stirring to obtain a finished product.
Test examples
In order to show that the external traditional Chinese medicine preparation has the effect of treating hyperplasia of mammary glands, the invention carries out the following curative effect tests.
180 patients with hyperplasia of mammary glands are externally applied with the external traditional Chinese medicine preparation of the embodiment 3 of the invention for local application, 2 to 3 times a day, and 20 days is a treatment course.
Judgment of therapeutic effect
And (3) healing: the symptom signs disappear completely, no positive signs can be detected in the whole body, and no abnormal findings are found in the galactophore examination.
Improvement: the symptoms basically disappear, and discomfort symptoms such as local tightening and the like exist in rainy seasons or after being suffered from cold, and the symptoms can be improved after the liquid medicine is smeared.
And (4) invalidation: the symptoms did not improve.
After three treatment courses, 115 patients are cured, 64 percent of the patients are cured, 49 patients are improved, 27 percent of the patients are cured, 16 patients are ineffective, 9 percent of the patients are cured, and the total effective rate is 91 percent.
The treatment shows that the external traditional Chinese medicine preparation has no side effect on patients, and no abnormality is found in three routine tests and liver and kidney function detection. Several typical cases are listed below:
case 1: when a patient feels a diagnosis for a certain woman in the age of 40 years and suffers from hyperplasia of mammary glands for more than 2 years, the breasts at two sides are plump and uncomfortable and painful, so the patient is diagnosed with the disease, the medicine provided by the embodiment 1 of the invention is applied topically and is smeared locally twice a day, the disease is cured after three treatment courses, the galactophore examination is normal, and the disease does not relapse after follow-up for one year.
Case 2: a patient has certain Liu, a woman is 46 years old, suffers from hyperplasia of mammary glands for more than 3 years, has nodules in breasts, is painful like acupuncture, and has breast heaving discomfort and pain before menstruation comes. The drug treatment of example 3 of the present invention was administered for three treatment courses with normal breast penetration test. The disease does not relapse after one year of follow-up visit.
Case 3: after the patient is treated by the medicament of the embodiment 5 of the invention for three courses, the patient is cured, and the breast hyperplasia is checked to be normal. The disease does not relapse after one year of follow-up visit.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. An external traditional Chinese medicine preparation for treating hyperplasia of mammary glands is characterized by comprising the following raw materials in parts by weight: 5-15 parts of peach kernel, 10-20 parts of safflower, 5-15 parts of rhizoma sparganii, 5-15 parts of curcuma zedoary, 2-8 parts of borneol, 1-6 parts of leech and 15-25 parts of rhubarb.
2. The external traditional Chinese medicine preparation for treating hyperplasia of mammary glands according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 8-12 parts of peach kernel, 13-17 parts of safflower, 8-12 parts of rhizoma sparganii, 8-12 parts of curcuma zedoary, 4-6 parts of borneol, 2-4 parts of leech and 18-22 parts of rhubarb.
3. The external traditional Chinese medicine preparation for treating hyperplasia of mammary glands according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 10 parts of peach kernel, 15 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 5 parts of borneol, 3 parts of leech and 20 parts of rhubarb.
4. A method for preparing the external traditional Chinese medicine preparation for treating hyperplasia of mammary glands according to any one of claims 1 to 3, which comprises the following steps:
weighing the raw materials according to the proportion in parts by weight, soaking peach kernel, safflower, rhizoma sparganii, curcuma zedoary, leech and rhubarb into alcohol, sealing, taking the filtrate, adding distilled water and borneol into the filtrate, and uniformly stirring to obtain the finished product.
5. The method for preparing an external traditional Chinese medicine preparation for treating mammary gland hyperplasia according to claim 4, wherein the concentration of the alcohol is 85-95%, and the weight portion of the alcohol is 4900-5100 portions.
6. The method for preparing an external traditional Chinese medicine preparation for treating mammary gland hyperplasia according to claim 4, wherein the sealing time is 25-35 days.
7. The method for preparing an external Chinese medicinal preparation for treating mammary gland hyperplasia according to claim 4, wherein the concentration of alcohol in the filtrate is 55-65% after adding distilled water.
8. The method for preparing the external traditional Chinese medicine preparation for treating the hyperplasia of mammary glands according to any one of claims 4 to 7, wherein the method comprises the following steps:
soaking 5-15 parts of peach kernel, 10-20 parts of safflower, 5-15 parts of rhizoma sparganii, 5-15 parts of rhizoma zedoariae, 1-6 parts of leech and 15-25 parts of rheum officinale in 4900 and 5100 parts of alcohol with the concentration of 85-95%, sealing for 25-35 days, taking the filtrate, adding distilled water into the filtrate to ensure that the concentration of the alcohol in the filtrate is 55-65%, adding 2-8 parts of borneol, and uniformly stirring to obtain the finished product.
9. The method for preparing the external traditional Chinese medicine preparation for treating the hyperplasia of mammary glands according to claim 8, wherein the method comprises the following steps:
soaking 10 parts of peach kernel, 15 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 3 parts of leech and 20 parts of rhubarb into 5000 parts of 90% alcohol, sealing for 30 days, taking filtrate, adding distilled water into the filtrate to enable the concentration of the alcohol in the filtrate to be 60%, adding 5 parts of borneol, and uniformly stirring to obtain a finished product.
10. The use of the topical Chinese medicinal preparation of claim 1 in the preparation of a medicament for the treatment of mammary gland hyperplasia.
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CN202111334840.8A CN113975225A (en) | 2021-11-11 | 2021-11-11 | External traditional Chinese medicine preparation for treating hyperplasia of mammary glands as well as preparation method and application thereof |
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CN202111334840.8A CN113975225A (en) | 2021-11-11 | 2021-11-11 | External traditional Chinese medicine preparation for treating hyperplasia of mammary glands as well as preparation method and application thereof |
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Application publication date: 20220128 |