CN113968024B - Accurate temperature control type biological 3D printing system - Google Patents
Accurate temperature control type biological 3D printing system Download PDFInfo
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- CN113968024B CN113968024B CN202111174121.4A CN202111174121A CN113968024B CN 113968024 B CN113968024 B CN 113968024B CN 202111174121 A CN202111174121 A CN 202111174121A CN 113968024 B CN113968024 B CN 113968024B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/16—Cooling
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/10—Processes of additive manufacturing
- B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
- B29C64/112—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using individual droplets, e.g. from jetting heads
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/20—Apparatus for additive manufacturing; Details thereof or accessories therefor
- B29C64/295—Heating elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/307—Handling of material to be used in additive manufacturing
- B29C64/321—Feeding
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
- B29C64/30—Auxiliary operations or equipment
- B29C64/386—Data acquisition or data processing for additive manufacturing
- B29C64/393—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y30/00—Apparatus for additive manufacturing; Details thereof or accessories therefor
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y40/00—Auxiliary operations or equipment, e.g. for material handling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y50/00—Data acquisition or data processing for additive manufacturing
- B33Y50/02—Data acquisition or data processing for additive manufacturing for controlling or regulating additive manufacturing processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
- B29C35/16—Cooling
- B29C2035/1658—Cooling using gas
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- Optics & Photonics (AREA)
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Thermal Sciences (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention relates to an accurate temperature control type biological 3D printing system which comprises a temperature control device, a temperature control printing head, a storage bin and a temperature control feeding pipe, wherein the temperature control printing head is movably arranged on the upper side of the temperature control device, the storage bin is arranged in a water bath temperature control box and is connected with the temperature control printing head through the temperature control feeding pipe, the temperature control device comprises a cover body, a box body and a base which are sequentially arranged from top to bottom, a first refrigeration assembly is arranged in the cover body, a second refrigeration assembly is arranged in the base, an infrared observation window is arranged on the side wall of the box body, a temperature measurement assembly corresponding to the infrared observation window is arranged in the box body, the box body comprises a plurality of connecting shells which are embedded and overlapped, the temperature measurement assembly comprises a temperature measurement base and a plurality of temperature measurement modules, and the temperature measurement modules are sequentially embedded and overlapped. The temperature control device has uniform internal temperature, ensures accurate temperature control, can adjust the height according to requirements, and is provided with heat insulation structures on the outer sides of the printing nozzle and the conveying pipe.
Description
Technical Field
The invention relates to the technical field of biological 3D printing, in particular to an accurate temperature control type biological 3D printing system.
Background
With the rapid development of human society, biomedical engineering gradually draws attention of people, and especially, biological 3D printing technology is rapidly developed. At present, the biological 3D printing technology mainly adopts extrusion type and inkjet type printing, wherein the extrusion type printing is limited by the structure of the printing equipment and the used materials, the materials are easy to have the problems of filament breakage, cell damage and the like in the extrusion process, and most of the biological ink used by the inkjet type biological 3D printer is Gelatin, GelMa and other temperature-sensitive materials, because the biological ink is in a liquid state above the gel temperature and in a gel state below the gel temperature, and the temperature inside the nozzle is above the gel temperature, the biological ink inside the nozzle is in a liquid state, so that the nozzle of the inkjet type biological 3D printer utilizes the driving modes of piezoelectricity or thermal bubble and the like to generate tiny liquid drops at the nozzle opening, the liquid drops are quickly sprayed out and pass through the gas temperature field set in the temperature control device, and after the convective heat exchange between the liquid drops and the gas temperature is completed, the state of the liquid drops is changed into a gel state and is adhered to the bottom plate of the temperature control device, however, in the inkjet biological 3D printing process, because some of the biological inks used have the characteristics of temperature sensitivity and the temperature-sensitive property, and the activity of cells is greatly influenced by the temperature, the temperature control in the printing process is very important.
In addition, the biological 3D printer temperature control device in the prior art is limited by the layout of the local refrigerating device, so that the temperature gradient of the air inside the biological 3D printer temperature control device is easy to occur, and the internal temperature distribution of the device is uneven, the internal gas temperature field is generally calculated by combining the heat source temperature of the temperature control device in the conventional analysis of the internal gas temperature field of the biological 3D printer temperature control device, the actual temperature of the internal gas cannot be analyzed, and the control on the internal gas temperature field of the biological 3D printer temperature control device is not accurate enough, so that the printing effect is influenced.
Disclosure of Invention
The invention aims to provide an accurate temperature control type biological 3D printing system, wherein the temperature inside a temperature control device is uniform, and the temperature distribution condition inside a box body is accurately reflected by utilizing a temperature measurement component and an infrared observation device, so that the accurate temperature control is ensured, the printing effect is ensured, the heights of the box body and the temperature measurement component of the temperature control device can be adjusted according to needs, the application range is wide, and meanwhile, heat insulation structures are arranged on the outer sides of a printing spray head and a conveying pipe, so that the temperature of a biological material is ensured to meet the requirements.
The purpose of the invention is realized by the following technical scheme:
the utility model provides a biological 3D printing system of accurate control by temperature change formula, beats printer head, feed bin and control by temperature change conveying pipe including temperature control device, control by temperature change, and wherein the printer head is beaten movably to control by temperature change locates the temperature control device upside, in a water bath temperature control box and through control by temperature change conveying pipe and the printer head is beaten in the control by temperature change is connected, temperature control device is including lid, box and the base that from top to bottom sets gradually, just be equipped with first refrigeration subassembly in the lid, be equipped with second refrigeration subassembly in the base, be equipped with infrared observation window on the box lateral wall, just the inside temperature measurement subassembly that is equipped with of box corresponds infrared observation window.
The box includes a plurality of connection casings that follow the direction of height gomphosis stack in proper order, temperature measurement subassembly) includes temperature measurement base and a plurality of temperature measurement module, and each temperature measurement module along the direction of height gomphosis stack in proper order.
The upper end of the connecting shell is provided with a connecting and positioning groove, the lower end of the connecting shell is provided with a connecting and positioning bulge, the outer side of the connecting shell is sleeved with a heat-insulating sleeve, cavities are formed in two side walls of the heat-insulating sleeve, the heat-insulating sleeves are sequentially stacked along with the connecting shells of all layers, and the cavities in the heat-insulating sleeves are sequentially communicated after stacking; the temperature measurement module comprises a first support and a first heat conducting piece, a first connecting protrusion is arranged on the upper side of the first support, a limiting groove is arranged on the lower side of the first support, the temperature measurement base comprises a second support and a second heat conducting piece, and a second connecting protrusion is arranged on the upper side of the second support.
The first heat conducting part is arranged on the first support through first heat insulation blocks, heat insulation grooves are formed in the upper side and the lower side of the first support, the two ends of the second heat conducting part are arranged on the second support through second heat insulation blocks, and heat insulation pads are arranged at the lower ends of the support legs of the second support.
A lower cover plate is arranged on the lower side of the cover body, the first refrigeration assembly is fixedly arranged on the lower cover plate through a first fixed pressing plate, the first refrigeration assembly comprises a first semiconductor refrigeration piece and a first cooling piece, and the first semiconductor refrigeration piece is embedded between the first cooling piece and the lower cover plate; be equipped with the mounting panel in the base, just second refrigeration subassembly passes through second fixed pressing plate and adorns admittedly on the mounting panel, second refrigeration subassembly includes second semiconductor refrigeration spare and second cooling part, and second semiconductor refrigeration spare inlays locates second cooling part) and between the mounting panel.
The lid includes heat preservation cover and lower apron, wherein goes up the heat preservation cover and detains and arrange down on the apron, first refrigeration subassembly is located in the heat preservation cover and is installed under on the apron, go up heat preservation cover middle part and apron middle part all is equipped with prints the through-hole down, it is equipped with the connect through-hole that supplies first refrigeration subassembly to connect to pass to go up heat preservation cover one side, the apron downside is equipped with the apron bellying down.
The base includes heat preservation casing and mounting panel, and wherein the heat preservation casing includes that the middle part is equipped with installation open-ended heat preservation roof, and the mounting panel is installed in heat preservation roof downside, and second refrigeration subassembly locate in the heat preservation casing and install in on the mounting panel, heat preservation casing one end is equipped with the opening that supplies second refrigeration subassembly to connect to pass, the mounting panel upside is equipped with installation positioning groove and passes the installation opening at heat preservation roof middle part.
The temperature control printing head comprises a printing nozzle, a temperature control jacket and a printing head mounting plate, wherein the tail end of the printing nozzle is fixedly arranged on the printing head mounting plate, the temperature control jacket is sleeved on the printing nozzle, a temperature control cavity is arranged inside the temperature control jacket, a water inlet and a water outlet are formed in the temperature control jacket and communicated with the temperature control cavity, and a touch sensor insertion hole and a heating rod insertion hole are formed in one side of the temperature control jacket.
The temperature control feeding pipe comprises an external temperature control pipe and a material conveying pipe arranged in the external temperature control pipe, a water bath flow channel is formed between the outer wall of the material conveying pipe and the inner wall of the external temperature control pipe, the material conveying pipe is communicated with the storage bin, and the water bath flow channel is communicated with the water bath temperature control box.
The water bath temperature control box is characterized in that connecting joints are arranged at two ends of the temperature control feeding pipe, a first connecting part is arranged on one side of each connecting joint and connected with the external temperature control pipe, a second connecting part and a gland are arranged on the other side of each connecting joint and in sealing connection with the corresponding gland, the conveying pipe penetrates through the connecting joints, the connecting joint at the input end of the temperature control feeding pipe is connected with a water inlet pipe, the connecting joint at the output end of the temperature control feeding pipe is connected with a water outlet pipe, and the water inlet pipe and the water outlet pipe are communicated with the water bath temperature control box.
The invention has the advantages and positive effects that:
1. the temperature measuring assembly is matched with the infrared observation device to reflect the temperature distribution in the box body more accurately, so that the actual temperature in the box body can be accurately controlled.
2. The box body of the temperature control device and the temperature measuring component in the box body comprise a plurality of modules which are sequentially embedded and stacked along the height direction, and the temperature measuring device can be adjusted according to printing requirements and has a wider application range.
3. According to the invention, the temperature control outer sleeve is arranged outside the printing nozzle to realize monitoring and adjustment of the temperature inside the printing nozzle, the external temperature control pipe is arranged outside the material conveying pipe, and a water bath runner between the material conveying pipe and the external temperature control pipe is communicated with the water bath temperature control box, so that the heat preservation effect in the process of biological material transmission is realized.
Drawings
Figure 1 is a schematic structural view of the present invention,
figure 2 is a perspective view of the temperature control device of figure 1,
figure 3 is a cross-sectional view of the temperature control device of figure 2,
figure 4 is a perspective view of the upper heat retaining cover of figure 3,
figure 5 is a schematic view of the first cooling element installation of figure 3,
FIG. 6 is a schematic view of the bottom side structure of the lower cover plate in FIG. 5,
figure 7 is a perspective view of the housing of figure 2,
figure 8 is a perspective view of the insulating sleeve of figure 7,
FIG. 9 is a schematic diagram of the temperature measuring assembly and the printing structure inside the case of FIG. 3,
FIG. 10 is a perspective view of the thermometric assembly of FIG. 9,
figure 11 is a perspective view of the thermometry module of figure 10,
FIG. 12 is a perspective view of the thermometric base of FIG. 10,
FIG. 13 is a schematic view showing the connection between the thermometric base and the adjacent thermometric module in FIG. 10,
figure 14 is a perspective view of the base of figure 2,
FIG. 15 is a schematic view of the base of FIG. 14 with the side insulating panels removed,
figure 16 is a schematic view of another angular configuration of the base of figure 15,
figure 17 is a cross-sectional view of the temperature-controlled print head of figure 1,
figure 18 is a left side view of the temperature controlled print head of figure 17,
FIG. 19 is a schematic view of the internal structure of the temperature controlled feed pipe of FIG. 1,
figure 20 is a cross-sectional view of the temperature controlled feed tube of figure 19,
FIG. 21 is a schematic view of the temperature controlled feed tube feed end configuration of FIG. 19,
FIG. 22 is a schematic view of the discharge end configuration of the temperature controlled feed tube of FIG. 19.
Wherein, 1 is a cover body, 11 is an upper heat-insulating cover, 111 is a printing through hole, 12 is a first cooling piece, 13 is a first bolt, 14 is a first fixed pressing plate, 15 is a first heat-insulating bottom plate, 16 is a second heat-insulating bottom plate, 17 is a first semiconductor cooling piece, 18 is a lower cover plate, 19 is a cover plate bulge, 2 is a box body, 21 is a heat-insulating sleeve, 211 is a cavity, 212 is a notch, 22 is a connecting shell, 23 is an observation window, 24 is a connecting positioning groove, 25 is an infrared observation window, 3 is a base, 31 is a heat-insulating side plate, 32 is a heat-insulating top plate, 33 is a third bolt, 34 is an installing positioning groove, 35 is a mounting plate, 36 is a second cooling piece, 37 is a second bolt, 38 is a second fixed pressing plate, 39 is a second semiconductor cooling piece, 4 is a temperature-controlled printing head, 401 is a printing nozzle, 402 is a temperature-controlled outer sleeve, 404 is a water inlet, 404 is a water outlet 403, 405 is a printing head mounting plate, 406 is the touch sensor inserted hole, 407 is the heating rod inserted hole, 5 is water bath temperature control box, 6 is the feed bin, 7 is the control by temperature change conveying pipe, 701 is outside temperature control pipe, 702 is the conveying pipeline, 703 is the water bath runner, 704 is the attach fitting, 7041 is first connecting portion, 7042 is the second connecting portion, 705 is the inlet tube, 706 is the gland, 707 is the outlet pipe, 8 is the workstation, 9 is the temperature measurement subassembly, 91 is the temperature measurement module, 911 is first support, 9111 is first connecting bulge, 9112 is spacing recess, 9113 is adiabatic recess, 912 is first heat insulating block, 913 is first heat-conducting piece, 92 is the temperature measurement base, 921 is the second support, 9211 is the second connecting bulge, 922 is the second heat insulating block, 923 is the second heat-conducting piece, 924 is the heat insulating mattress.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
As shown in fig. 1 to 22, the present invention comprises a temperature control device, a temperature control print head 4, a stock bin 6 and a temperature control feed pipe 7, wherein the temperature control print head 4 is movably arranged on the upper side of the temperature control device, the stock bin 6 is arranged in a water bath temperature control box 5 and is connected with the temperature control print head 4 through the temperature control feed pipe 7, as shown in fig. 2 to 3, the temperature control device comprises a cover body 1, a box body 2 and a base 3 which are sequentially arranged from top to bottom, wherein as shown in fig. 3 to 5, a first refrigeration component is arranged in the cover body 1, as shown in fig. 14 to 16, a second refrigeration component is arranged in the base 3, the first refrigeration component and the second refrigeration component simultaneously refrigerate to the air near the cover body 1 and the base 3 in the temperature control device, so as to greatly reduce the temperature gradient in the whole device, make the temperature in the whole device tend to be uniform, and be more beneficial to ink jet type biological 3D printing, the printing effect is improved, as shown in fig. 9-13, the infrared observation window 25 is arranged on the side wall of the box body 2, the temperature measurement component 9 arranged in the box body 2 corresponds to the infrared observation window 25, the temperature measurement component 9 comprises a plurality of temperature measurement modules 91, the temperature measurement modules 91 have good heat conduction effect and can rapidly conduct heat transfer with air nearby, so that the temperature of the modules is consistent with that of air nearby, and the infrared observation device can accurately reflect the temperature distribution condition in the box body 2 by observing the temperature of each module, so that the printing forming temperature of the biological material is monitored. When the temperature inside the box body 2 reaches the required temperature, the temperature control printing head 4 filled with the biological material enters the box body 2, the biological material is converted into a gel state from liquid under the influence of the lower temperature inside the box body 2 and drops on a printing structure arranged in the temperature control device, and the temperature control printing head 4 moves according to a set path of the system to finish printing and forming. The infrared observation device and the printing structure in the temperature control device are all known in the art.
As shown in fig. 3 and 7, the box body 2 comprises a plurality of connecting shells 22, the upper ends of the connecting shells 22 are provided with connecting and positioning grooves 24, the lower ends of the connecting and positioning grooves are provided with connecting and positioning protrusions, the connecting and positioning grooves 24 at the upper ends of the connecting shells 22 are matched and positioned with the connecting and positioning protrusions at the lower ends of the upper adjacent connecting shells 22, and then the connecting shells 22 are sequentially stacked in the height direction, so that the height of the box body 2 can be adjusted as required, the printing height of the box body is matched with that of a biological material, and the application range is wider. In this embodiment, the connecting housing 22 is made of aluminum.
As shown in fig. 7-8, the outer side of the connecting shell 22 can be sleeved with a thermal insulation sleeve 21 as required, and the thermal insulation sleeve 21 is matched with the connecting shell 22 in shape so as to prevent the influence of external air on the temperature inside the connecting module and the influence on the printing effect. As shown in fig. 8, in this embodiment, cavities 211 are formed in both side walls of the thermal insulation sleeve 21, and a notch 212 is formed in the cavity wall inside the cavity 211, as shown in fig. 2, each layer of thermal insulation sleeve 21 can be sequentially stacked along with each layer of connection housing 22, and the cavities 211 inside each thermal insulation sleeve 21 are sequentially communicated after stacking, and can achieve a thermal insulation effect after injecting water with a proper temperature, wherein a thermal insulation water inlet is formed in any one of the connection housings 22 and is communicated with the cavity 211 inside the connection housing, and a thermal insulation water outlet is formed in the other connection housing 22 and is communicated with the cavity 211 inside the connection housing. In addition, as shown in fig. 8, an opening is formed at one side of the thermal insulation sleeve 21, so that the thermal insulation sleeve 21 can have a slight opening width to be conveniently sleeved on the corresponding connecting shell 22.
As shown in fig. 9, an infrared observation window 25 is arranged on one side of the box body 2, an observation window 23 is arranged on the other side of the box body, and the temperature measurement component 9 is arranged on one side close to the first window 25. In this embodiment, infrared observation window 25 lens adopts the germanium lens, can make the infrared ray pass to be convenient for utilize outside infrared observation device to observe the temperature distribution condition of temperature measurement module 31, observation window 23 adopts transparent glass, makes operating personnel can observe the state of printing structural biomaterial in real time at the printing in-process, also can utilize high-speed camera to catch the gel process that biological ink drips in addition for improve the printing parameter of printer.
As shown in fig. 10-13, temperature measurement assembly 9 includes temperature measurement base 92 and a plurality of temperature measurement module 91, wherein temperature measurement module 91 includes first support 911 and first heat-conducting piece 913, just first support 911 upside is equipped with first connection arch 9111, and the downside is equipped with spacing recess 9112, temperature measurement base 92 includes second support 921 and second heat-conducting piece 923, just second support 921 upside is equipped with second connection arch 9211. According to the invention, the height of the temperature measuring assembly 9 can be adjusted according to actual needs, so that the height of the box body 2 can be adjusted, wherein as shown in fig. 13, the second connecting bulge 9211 on the upper side of the second support 921 is matched with the limiting groove 9112 on the lower side of the first support 911 of the temperature measuring module 91 adjacent to the upper side, and any two adjacent temperature measuring modules 91 are matched, positioned and connected through the first connecting bulge 9111 and the limiting groove 9112 on the adjacent side. In this embodiment, the first positioning protrusion 9111, the second positioning protrusion 9211 and the limiting groove 9112 are dovetail structures.
As shown in fig. 11, two ends of the first heat conducting member 913 are respectively mounted on the first bracket 911 through a first heat insulation block 912, and as shown in fig. 13, heat insulation grooves 9113 are respectively disposed on the upper side and the lower side of the first bracket 911, and the heat insulation grooves 9113 are respectively disposed on two sides of the positioning groove 9112, so that connection with other parts can be reduced, and heat transfer can be reduced. As shown in fig. 12, two ends of the second heat conducting member 923 are respectively installed on the second support 921 through a second thermal insulation block 922, and a thermal insulation pad 924 is disposed at a lower end of each support leg of the second support 921.
In this embodiment, the first heat conducting member 913 and the second heat conducting member 923 are made of red copper, which has a good heat conducting effect and can rapidly conduct heat transfer with air near the red copper, so that the temperature of the red copper is consistent with that of the air near the red copper, and the temperature of the air in the attachment can be accurately reflected under an external infrared observation device. The first thermal insulation block 912, the second thermal insulation block 922 and the thermal insulation pad 924 can adopt aerogel felts.
As shown in fig. 3 to 6, the cover body 1 includes an upper heat-insulating cover 11 and a lower cover plate 18, wherein the upper heat-insulating cover 11 is fastened on the lower cover plate 18, and the first refrigeration assembly is disposed in the upper heat-insulating cover 11 and mounted on the lower cover plate 18. In this embodiment, first refrigeration subassembly includes first semiconductor refrigeration spare 17 and first cooling piece 12, wherein first cooling piece 12 with apron 18 can be dismantled down and connect, first semiconductor refrigeration spare 17 inlay locate first cooling piece 12 with between apron 18 down, first semiconductor refrigeration spare 17 one side can refrigerate, and the another side can produce a large amount of heats, consequently is connected first semiconductor refrigeration spare 17 with first cooling piece 12, utilizes the cooling piece to distribute away the heat that first semiconductor refrigeration spare 17 produced, prevents that first semiconductor refrigeration spare 17 from being burnt out, first semiconductor refrigeration spare 17 is field-known technique and purchases the product for the market, first cooling piece 12 can adopt the flood peak with external circulating water intercommunication, and simple structure is workable.
As shown in fig. 3 to 6, in this embodiment, the first refrigeration assembly is fixedly mounted on the lower cover plate 18 through a first fixed pressing plate 14, wherein the upper side of the first cooling element 12 abuts against the first fixed pressing plate 14, and two ends of the first fixed pressing plate 14 are fixedly connected to the lower cover plate 18 through first bolts 13, respectively.
As shown in fig. 3-6, be equipped with two sets of first refrigeration subassemblies in this embodiment, and go up the cover that keeps warm 11 middle parts and 18 middle parts of lower apron all are equipped with and print through-hole 111 and supply the biomaterial to instil into, and two sets of first refrigeration subassemblies are located respectively print through-hole 111 both sides, 18 both sides of lower apron all are equipped with first heat preservation bottom plate 15, the middle part is equipped with second heat preservation bottom plate 16 in order to realize the heat preservation effect with the cooperation of last cover that keeps warm 11, as shown in fig. 2 in addition, it is equipped with the joint that connecting hole supplied first refrigeration subassembly to go up 11 one sides of cover that keeps warm and passes.
As shown in fig. 6, the lower cover 18 is provided with a cover protrusion 19 at the lower side for engaging with the adjacent connecting housing 22 on the box 2, and the two sides of the lower cover 18 cover the cavities 211 at the two sides of the connecting housing 22 to ensure the sealing.
As shown in fig. 14 to 16, the base 3 includes a heat preservation casing and a mounting plate 35, wherein the heat preservation casing includes a heat preservation side plate 31 and a heat preservation top plate 32, the upper end of the heat preservation side plate 31 is installed on the edge of the heat preservation top plate 32 through a third bolt 33, the mounting plate 35 is installed on the lower side of the heat preservation top plate 32, the second refrigeration component is installed in the heat preservation casing and detachably installed on the mounting plate 35, one end of the heat preservation casing is provided with an opening for the joint of the second refrigeration component to pass through, in this embodiment, the second refrigeration component is the same as the first refrigeration component in composition and includes a second semiconductor refrigeration component 39 and a second refrigeration component 36, and only the parameters such as size, power and the like are different.
As shown in fig. 15, the upper side of the mounting plate 35 is provided with a mounting and positioning groove 34 for being connected with the adjacent connecting shell 22 on the box body 2 in a matching manner, the heat preservation top plate 32 is provided with a mounting opening for the mounting and positioning groove 34 to pass through, the lower sides of the adjacent connecting shell 22 on the heat preservation top plate 32 and the box body 2 are abutted to ensure that the inner cavity of the heat preservation top plate is sealed, and in addition, the mounting opening can enable cold air generated by the second refrigeration component to enter the box body 2. In addition, in this embodiment, the second refrigeration assembly is fixedly mounted on the lower side of the mounting plate 35 through a second fixed pressing plate 38, two ends of the second fixed pressing plate 38 are fixedly connected with the mounting plate 35 through second bolts 37, and a second semiconductor refrigeration part 39 in the second refrigeration assembly is embedded between the second cooling part 36 and the mounting plate 35.
As shown in fig. 17 to 18, the temperature-controlled print head 4 comprises a print head 401, a temperature-controlled jacket 402 and a print head mounting plate 405, wherein the tail end of the printing nozzle 401 is fixedly mounted on the printing head mounting plate 405, in this embodiment, the printing mounting plate 405 is mounted on an XYZ three-way moving mechanism to drive the temperature control printing head 4 to adjust the position, the temperature control jacket 402 is sleeved on the printing nozzle 401, a temperature control cavity is arranged inside the temperature control jacket 402, a water inlet 403 and a water outlet 404 which are arranged on the temperature control jacket 402 are communicated with the temperature control cavity, in addition, a sensor insertion port 406 and a heating rod insertion port 407 are provided on one side of the temperature control jacket 402, wherein the detecting end of the head end enters the temperature control cavity after the touch sensor is inserted into the touch sensor insertion opening 406, and the heating rod is inserted into the heating rod insertion hole 407, and then the heating end at the head end enters the temperature control cavity. Temperature control water enters and exits through the water inlet 403 and the water outlet 404, the touch sensor detects the temperature of the temperature control water in real time, and the temperature is adjusted by heating the heating rod, so that the temperature inside the printing nozzle 401 is ensured to be above the gel temperature, and the biological ink inside the printing nozzle is in a liquid state. The printing nozzle 401, the feeler, the heating rod and the XYZ three-way moving mechanism are all known in the art and are commercially available products.
As shown in fig. 19 to 22, the temperature-controlled feeding pipe 7 includes an external temperature-controlled pipe 701 and a feeding pipe 702 disposed in the external temperature-controlled pipe 701, a water bath channel 703 is formed between an outer wall of the feeding pipe 702 and an inner wall of the external temperature-controlled pipe 701, the feeding pipe 702 is communicated with the storage bin 6 to transport the biomaterial to the temperature-controlled printing head 4, and in order to ensure that the biomaterial temperature is above the gel temperature during the transportation process, the water bath channel 703 is communicated with the water bath temperature-controlled tank 5, and the water temperature in the water bath channel 703 is controlled and adjusted by the water bath temperature-controlled tank 5, so as to ensure that the temperature inside the feeding pipe 702 meets the requirement. The water bath temperature control box 5 is well known in the art and is a commercially available product.
As shown in fig. 21 to 22, in this embodiment, two ends of the temperature control feeding pipe 7 are each provided with a connection joint 704, one side of the connection joint 704 is provided with a first connection portion 7041 connected to the external temperature control pipe 701, the other side is provided with a second connection portion 7042 connected to a gland 706 for sealing, the feeding pipe 702 passes through the connection joint 704, the connection joint 704 at the input end of the temperature control feeding pipe 7 is connected to a water inlet pipe 705, the connection joint 704 at the output end of the temperature control feeding pipe 7 is connected to a water outlet pipe 707, water flows into the water bath flow passage 703 through the water inlet pipe 705 and the first connection portion 7041 of the input end connection joint 704 in sequence and flows out through the first connection portion 7041 of the output end connection joint 704 and the water outlet pipe 707, the second connection portion 7042 is sealed with the gland 706 to prevent water leakage, a sealing ring is provided between the outer end surface of the second connection portion 7042 and the bottom 706, the water inlet pipe 705 and the water outlet pipe 707 are both communicated with the water bath temperature control box 5.
As shown in fig. 1, the various parts of the invention are mounted on a table 8.
The working principle of the invention is as follows:
when the temperature-measuring device works, the cover body 1 of the temperature-measuring device and the refrigerating assembly in the base 3 refrigerate into the box body 2 at the same time, so that the temperature gradient in the whole temperature-measuring device can be greatly reduced, the low temperature in the whole temperature-measuring device tends to be uniform, at the moment, when high-temperature liquid biological materials are dripped into the temperature-measuring device from the printing through hole 111 of the cover body 1 and then exchange heat with air, so that the solid biological materials are solidified to fall on a printing structure in the temperature-measuring device, the temperature-measuring printing head 4 moves according to the system setting, so that the biological materials are dripped into the temperature-measuring device and accumulated layer by layer to form a biological product with a special shape, in addition, the temperature-measuring assembly 9 is matched with an infrared observation device, so that the temperature distribution in the box body 2 can be accurately reflected, the actual temperature in the box body 2 can be accurately controlled, and the printing effect is enhanced.
The box body 2 of the temperature control device and the temperature measurement component 9 in the box body comprise a plurality of modules which are sequentially embedded and stacked along the height direction, the temperature control device can be adjusted according to printing requirements, the application range is wider, in addition, in order to ensure the temperature of the biological materials in the printing nozzle 401 and in the transmission process, the temperature control printing head 4 and the temperature control feed pipe 7 are designed, wherein the temperature control printing head 4 is provided with a temperature control jacket 402 outside the printing nozzle 401 to realize the monitoring and the adjustment of the temperature in the printing nozzle 401, the temperature control feed pipe 7 is provided with an external temperature control pipe 701 outside the feed pipe 702, and a water bath flow channel 703 between the feed pipe 702 and the external temperature control pipe 701 is communicated with a water bath temperature control box 5, so that the heat preservation and the temperature adjustment in the biological material transmission process are realized.
Claims (8)
1. The utility model provides a biological 3D printing system of accurate control by temperature change formula which characterized in that: the temperature control device comprises a temperature control device, a temperature control printing head (4), a stock bin (6) and a temperature control feeding pipe (7), wherein the temperature control printing head (4) is movably arranged on the upper side of the temperature control device, the stock bin (6) is arranged in a water bath temperature control box (5) and is connected with the temperature control printing head (4) through the temperature control feeding pipe (7), the temperature control device comprises a cover body (1), a box body (2) and a base (3) which are sequentially arranged from top to bottom, a first refrigerating assembly is arranged in the cover body (1), a second refrigerating assembly is arranged in the base (3), an infrared observation window (25) is arranged on the side wall of the box body (2), and a temperature measuring assembly (9) is arranged in the box body (2) and corresponds to the infrared observation window (25);
the box body (2) comprises a plurality of connecting shells (22) which are sequentially embedded and overlapped along the height direction, the temperature measuring assembly (9) comprises a temperature measuring base (92) and a plurality of temperature measuring modules (91), and the temperature measuring modules (91) are sequentially embedded and overlapped along the height direction;
the upper end of the connecting shell (22) is provided with a connecting and positioning groove (24), the lower end of the connecting shell is provided with a connecting and positioning bulge, the outer side of the connecting shell (22) is sleeved with a heat-insulating sleeve (21), cavities (211) are respectively arranged in two side walls of the heat-insulating sleeve (21), each layer of heat-insulating sleeve (21) is sequentially stacked along with each layer of connecting shell (22), and the cavities (211) in each heat-insulating sleeve (21) are sequentially communicated after stacking; temperature measurement module (91) includes first support (911) and first heat-conducting piece (913), just first support (911) upside is equipped with first connection arch (9111), downside and is equipped with spacing recess (9112), temperature measurement base (92) include second support (921) and second heat-conducting piece (923), just second support (921) upside is equipped with the second and connects arch (9211).
2. The accurate temperature controlled biological 3D printing system according to claim 1, wherein: first heat-conducting piece (913) both ends respectively through first heat insulating block (912) install in on first support (911), just first support (911) upside and downside all are equipped with adiabatic recess (9113), second heat-conducting piece (923) both ends respectively through second heat insulating block (922) install in on second support (921), just each stabilizer blade lower extreme of second support (921) all is equipped with heat insulating mattress (924).
3. The accurate temperature controlled bio-3D printing system according to claim 1, wherein: a lower cover plate (18) is arranged on the lower side of the cover body (1), the first refrigeration assembly is fixedly arranged on the lower cover plate (18) through a first fixed pressing plate (14), the first refrigeration assembly comprises a first semiconductor refrigeration piece (17) and a first cooling piece (12), and the first semiconductor refrigeration piece (17) is embedded between the first cooling piece (12) and the lower cover plate (18); be equipped with mounting panel (35) in base (3), just second refrigeration subassembly is adorned admittedly through second fixed pressing plate (38) on mounting panel (35), second refrigeration subassembly includes second semiconductor refrigeration piece (39) and second cooling piece (36), and second semiconductor refrigeration piece (39) inlay locate second cooling piece (36) with between mounting panel (35).
4. The accurate temperature controlled bio-3D printing system according to claim 1 or 3, wherein: the cover body (1) comprises an upper heat-insulation cover (11) and a lower cover plate (18), wherein the upper heat-insulation cover (11) is buckled on the lower cover plate (18), a first refrigeration assembly is arranged in the upper heat-insulation cover (11) and is arranged on the lower cover plate (18), the middle of the upper heat-insulation cover (11) and the middle of the lower cover plate (18) are respectively provided with a printing through hole (111), one side of the upper heat-insulation cover (11) is provided with a connecting through hole for the first refrigeration assembly to pass through, and the lower side of the lower cover plate (18) is provided with a cover plate protruding part (19).
5. The accurate temperature controlled bio-3D printing system according to claim 1 or 3, wherein: base (3) are including heat preservation casing and mounting panel (35), and wherein the heat preservation casing includes that the middle part is equipped with installation open-ended heat preservation roof (32), and mounting panel (35) are installed in heat preservation roof (32) downside, and the second refrigeration subassembly locate in the heat preservation casing and install in on mounting panel (35), heat preservation casing one end is equipped with the opening that supplies the second refrigeration subassembly to connect to pass, mounting panel (35) upside is equipped with installation positioning groove (34) and passes the installation opening at heat preservation roof (32) middle part.
6. The accurate temperature controlled bio-3D printing system according to claim 1, wherein: the temperature control printing head (4) comprises a printing nozzle (401), a temperature control outer sleeve (402) and a printing head mounting plate (405), wherein the tail end of the printing nozzle (401) is fixedly mounted on the printing head mounting plate (405), the temperature control outer sleeve (402) is sleeved on the printing nozzle (401), a temperature control cavity is arranged inside the temperature control outer sleeve (402), a water inlet (403) and a water outlet (404) are formed in the temperature control outer sleeve (402) and communicated with the temperature control cavity, and a touch sensor insertion hole (406) and a heating rod insertion hole (407) are formed in one side of the temperature control outer sleeve (402).
7. The accurate temperature controlled bio-3D printing system according to claim 1, wherein: the temperature control feeding pipe (7) comprises an external temperature control pipe (701) and a material conveying pipe (702) arranged in the external temperature control pipe (701), a water bath runner (703) is formed between the outer wall of the material conveying pipe (702) and the inner wall of the external temperature control pipe (701), the material conveying pipe (702) is communicated with the storage bin (6), and the water bath runner (703) is communicated with the water bath temperature control box (5).
8. The accurate temperature controlled bio-3D printing system according to claim 7, wherein: both ends of the temperature control feeding pipe (7) are provided with connecting joints (704), one side of each connecting joint (704) is provided with a first connecting part (7041) to be connected with the external temperature control pipe (701), the other side of each connecting joint is provided with a second connecting part (7042) to be hermetically connected with a gland (706), the feeding pipe (702) penetrates through the connecting joints (704), the connecting joint (704) at the input end of the temperature control feeding pipe (7) is connected with a water inlet pipe (705), the connecting joint (704) at the output end of the temperature control feeding pipe (7) is connected with a water outlet pipe (707), and the water inlet pipe (705) and the water outlet pipe (707) are communicated with the water bath temperature control box (5).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111174121.4A CN113968024B (en) | 2021-10-09 | 2021-10-09 | Accurate temperature control type biological 3D printing system |
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| CN202111174121.4A CN113968024B (en) | 2021-10-09 | 2021-10-09 | Accurate temperature control type biological 3D printing system |
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| CN113968024A (en) | 2022-01-25 |
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