CN113940973A - Traditional Chinese medicine composition for enriching blood and regulating menstruation and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for enriching blood and regulating menstruation and preparation method and application thereof Download PDFInfo
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- CN113940973A CN113940973A CN202111489519.7A CN202111489519A CN113940973A CN 113940973 A CN113940973 A CN 113940973A CN 202111489519 A CN202111489519 A CN 202111489519A CN 113940973 A CN113940973 A CN 113940973A
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Abstract
The invention discloses a traditional Chinese medicine composition for enriching blood and regulating menstruation and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1-6 parts of ginseng, 3-15 parts of rhizoma polygonati, 3-15 parts of arillus longan, 3-15 parts of Chinese date, 1-8 parts of peony, 1-8 parts of rose, 3-15 parts of poria cocos, 1-6 parts of dried orange peel and 1-6 parts of liquorice. The invention uses solvent (such as water) to extract effective components in the traditional Chinese medicine composition, and the obtained effective components can be used for preparing health-care food after being dried. The advantages of the invention include: the traditional Chinese medicine composition has the advantages that the compatibility is reasonable, the method for extracting the effective components is simple and appropriate, various effective components in different original materials can be effectively extracted, the prepared traditional Chinese medicine composition can meet the blood enriching and menstruation regulating requirements of people with blood deficiency, the traditional Chinese medicine composition is convenient to eat, and the decoction and heating operation is not needed during eating.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to a traditional Chinese medicine composition for enriching blood and regulating menstruation and a preparation method and application thereof.
Background
China is a high incidence area of anemia diseases in the world, wherein the incidence rate of male diseases is 20%, the incidence rate of female diseases is 47%, and the incidence rate of female diseases is far higher than that of male diseases. Physiologically, most women consume qi and blood, and pregnancy, childbirth, lactation and menstruation all consume a large amount of qi and blood. Consumption of qi and blood tends to cause blood deficiency, which causes many problems.
In young women, excessive blood loss, hemoglobin and erythrocyte number decrease, and symptoms such as dizziness, vexation, short breath, hypodynamia, inappetence, insomnia, dreaminess, pale face and lips are often caused by menstrual disorder, functional uterine bleeding and the like. When a woman carries a fetus in October, the woman needs sufficient blood to nourish the fetus, and the fetus needs to be nourished by the blood of the mother, so that the pregnant woman generally has symptoms of anemia, anorexia, dizziness, pale complexion and the like. And the excessive blood loss or induced labor and abortion of women during the production can cause excessive bleeding, and various diseases are more easily caused by anemia. Severe anemia can also lead to premature appearance of wrinkles, white hair, and tooth loss. During the post-partum lactation period, the mother needs to enrich the blood and generate milk. When women reach the climacteric period, a series of problems of menorrhagia or disorder, hectic fever, sweating, chest distress, vertigo, waist soreness and bone pain and the like occur due to deficiency of liver and kidney and disharmony between heart and kidney.
The human body is the "body of blood, and only when blood is sufficient, the face looks ruddy, and the skin is tender and glossy. For women, the pursuit of beautiful appearance, slimming and emphasis on nourishing blood is pursued. The traditional Chinese medicine indicates that: "women have the basic of nourishing blood". If women are not good at enriching blood and nourishing blood, the symptoms of blood deficiency such as sallow complexion, pale lips and nails, dry limbs, withered hair, dizziness, dim eyesight, hypodynamia, shortness of breath and the like, namely anemia, can easily occur. Severe anemia patients are also very easy to have premature senility symptoms such as wrinkles, white hair, tooth loss, teeter and the like. Therefore, women are compelling to enrich and nourish blood. Anemia in women affects health and beauty, the complexion is ruddy when qi and blood are full, the spirit is good, the complexion is not smooth when qi is insufficient, and the complexion is not ruddy when blood is insufficient.
Deficiency of both qi and blood can also lead to irregular menstruation. For example: the amount is large and advanced, the traditional Chinese medicine understands that qi has the function of consolidating qi, and qi deficiency does not consolidate blood; the traditional Chinese medicine is understood as blood deficiency after the dosage is small and the patient is dragged; dysmenorrhea is understood as the pain caused by qi and blood deficiency of thoroughfare and conception vessels failing to nourish the uterus, or the pain caused by malnutrition of liver qi stagnation, qi stagnation and blood stasis, or the pain caused by stagnation of qi. Therefore, women usually pay attention to blood tonifying and menstruation regulating. The traditional Chinese medicine for enriching the blood and regulating menstruation generally needs time for decoction, or even if a decoction mode is adopted, the traditional Chinese medicine is inconvenient to heat and carry, and a large number of people in need often cannot meet the requirements for enriching the blood and regulating menstruation. If a health food which has good effects of enriching the blood and regulating menstruation and is convenient to carry and eat can be developed, the method has a huge application prospect.
Disclosure of Invention
The invention aims to provide a composition for enriching blood and regulating menstruation and a preparation method and application thereof, and aims to solve the problems that the composition is inconvenient to carry and eat and cannot meet the requirements for enriching blood and regulating menstruation.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the traditional Chinese medicine composition for enriching blood and regulating menstruation provided by the invention comprises the following raw materials in parts by weight: 1-6 parts of ginseng, 3-15 parts of rhizoma polygonati, 3-15 parts of arillus longan, 3-15 parts of Chinese date, 1-8 parts of peony, 1-8 parts of rose, 3-15 parts of poria cocos, 1-6 parts of dried orange peel and 1-6 parts of liquorice.
Preferably, the traditional Chinese medicine composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 2-4 parts of ginseng, 6-12 parts of rhizoma polygonati, 6-12 parts of arillus longan, 6-12 parts of Chinese date, 2-6 parts of peony, 2-6 parts of rose, 6-12 parts of poria cocos, 2-4 parts of dried orange peel and 2-4 parts of liquorice.
Preferably, the traditional Chinese medicine composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of tuckahoe, 3 parts of dried orange peel and 3 parts of liquorice.
In a second aspect, the present invention provides a method for preparing a blood-enriching menstruation-regulating Chinese medicinal composition according to the first aspect, which comprises the following steps:
(1) mixing Ginseng radix, rhizoma Polygonati, arillus longan, fructus Jujubae, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix to obtain mixture;
(2) extracting the mixture with solvent, filtering to obtain filtrate, and concentrating the filtrate under reduced pressure to obtain soft extract;
(3) vacuum drying the thick paste, and pulverizing to obtain the final product.
Preferably, the extraction method of step (2) is selected from any one or more of decoction extraction method, ultrasonic extraction method and microwave extraction method.
Preferably, the extraction method in step (2) is a decoction extraction method, the number of times of decoction extraction is 2, the solvent is water, the weight of the solvent used in each extraction is 4-10 times of the weight of the mixture, and the time of each decoction extraction is 45-90 min.
Preferably, the extraction method in step (2) is an ultrasonic extraction method, and step (1) specifically includes: vacuum drying rhizoma Polygonati, arillus longan, and fructus Jujubae to dry and crisp state, mixing Ginseng radix, rhizoma Polygonati, arillus longan, fructus Jujubae, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix, and pulverizing into coarse powder to obtain mixture.
Further preferably, the number of times of ultrasonic extraction is 1-3, the solvent is water, the weight of the solvent used in each extraction is 4-8 times of the weight of the mixture, the temperature of ultrasonic extraction is 25-45 ℃, and the time of each extraction is 20-60 min.
In a third aspect, the invention provides an application of the blood-enriching menstruation-regulating traditional Chinese medicine composition in preparation of blood-enriching menstruation-regulating health food.
Preferably, the blood-enriching menstruation-regulating health food is in the form of any one of powder, granules, tablets, hard capsules, soft capsules, pills and oral liquid.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the traditional Chinese medicine composition with the effects of enriching the blood and regulating menstruation is obtained through elaborate compatibility, achieves the effect of enriching the blood by tonifying qi, nourishing the blood and invigorating the spleen, achieves the effect of regulating menstruation by enriching the blood and promoting blood circulation to regulate menstruation, and relieves and improves the problems of pale or sallow complexion, rough skin, lusterless hair, pale lips and tongue, dizziness, amnesia, vexation, insomnia and dreaminess, difficulty in concentration of attention, numbness and cold hands and feet, weakness in movement, whispering and no speaking, short breath, long spots, irregular menstruation and even dysmenorrhea and the like caused by blood deficiency.
The method for extracting the effective components is simple and appropriate, various effective components in different original materials can be effectively extracted, the prepared traditional Chinese medicine composition can meet the blood enriching and menstruation regulating requirements of people with blood deficiency, the traditional Chinese medicine composition is convenient to eat, and the decoction and heating operation is not needed when the traditional Chinese medicine composition is eaten.
Detailed Description
The present invention will be described in detail with reference to specific embodiments, which are illustrative of the present invention and are not to be construed as limiting the present invention.
In a first aspect, the traditional Chinese medicine composition for enriching blood and regulating menstruation provided by the invention comprises the following raw materials in parts by weight: 1-6 parts of ginseng, 3-15 parts of rhizoma polygonati, 3-15 parts of arillus longan, 3-15 parts of Chinese date, 1-8 parts of peony, 1-8 parts of rose, 3-15 parts of poria cocos, 1-6 parts of dried orange peel and 1-6 parts of liquorice.
The pharmacological actions of the raw materials adopted by the invention are respectively as follows:
ginseng: sweet and slightly bitter in flavor and slightly warm in nature. Invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, nourishing blood, tranquilizing mind, and improving intelligence, and can be used for treating asthenia, weak limbs, slight cold pulse, spleen deficiency, anorexia, lung deficiency, cough, thirst due to body fluid consumption, internal heat, diabetes, deficiency of qi and blood, asthenia due to chronic diseases, palpitation, insomnia, sexual impotence, and cold womb;
rhizoma polygonati: sweet taste, mild nature, qi and blood tonifying, spleen strengthening, lung moistening and kidney tonifying, and is used for spleen and stomach qi deficiency, tiredness and hypodynamia, stomach yin deficiency, dry mouth and poor appetite, lung deficiency and dry cough, over-strained cough and hemoptysis, essence and blood deficiency, soreness and weakness of waist and knees, early white beard and hair, internal heat and thirst quenching;
longan pulp: sweet in flavor and warm in nature. Tonifying heart and spleen, nourishing blood and tranquillizing, and can be used for treating deficiency of qi and blood, palpitation, blood deficiency and sallow complexion;
chinese date: sweet taste, warm nature, middle-jiao and qi invigorating, blood nourishing and tranquilization, and can be used for treating spleen deficiency, anorexia, asthenia, and loose stool;
peony: neutral in nature, bitter and light in taste, and effective in promoting blood circulation and regulating menstruation, and can be used for treating menoxenia and dysmenorrhea;
and (3) rose: sweet and slightly bitter taste, warm nature, qi regulating and depression relieving, blood regulating and menstruation regulating, and can be used for treating stagnation of liver-qi, distending pain of stomach and hypochondrium, breast distention, menoxenia, etc.;
tuckahoe, poria cocos: sweet and light taste, mild nature, diuresis and dampness eliminating, spleen strengthening and heart calming, and is used for treating edema oliguria, phlegm and fluid retention and dizziness and palpitation, spleen deficiency and poor appetite, uneasiness, palpitation and insomnia;
dried orange peel: bitter and pungent taste, warm nature, qi regulating, spleen invigorating, dampness eliminating, phlegm eliminating, abdominal distention, anorexia, vomiting, diarrhea, cough and excessive phlegm;
licorice root: sweet taste, mild nature, invigorating spleen and replenishing qi, clearing away heat and toxic material, and harmonizing the effects of the other drugs, and can be used for relieving drug toxicity, pungency, etc.
It can be understood that the traditional Chinese medicine composition for enriching blood and regulating menstruation provided by the invention takes 1-6 parts of ginseng and 3-15 parts of rhizoma polygonati as a monarch according to the theory of monarch, minister, assistant and guide of traditional Chinese medicine, has the effect of tonifying qi, and can generate blood by qi; 3-15 parts of longan aril, 3-15 parts of Chinese date, 1-8 parts of peony and 1-8 parts of rose are taken as ministers, and the Chinese medicinal composition has the effects of nourishing blood, promoting blood circulation and regulating menstruation; 3-15 parts of poria cocos and 1-6 parts of dried orange peel are taken as adjuvants, so that the effects of tonifying spleen and regulating qi are achieved, the spleen is the acquired root, the source of qi and blood generation is the spleen, and the spleen can regulate the circulation of blood in the body, so that the qi and blood are more sufficient; 1-6 parts of liquorice is used as a guide to coordinate the properties of the medicaments. The components are added into the composition according to a specific proportion to be combined, and the effects of benefiting qi and nourishing blood, and promoting blood circulation to regulate menstruation are achieved.
In one embodiment, the blood-enriching menstruation-regulating traditional Chinese medicine composition comprises the following raw materials in parts by weight: 2-4 parts of ginseng, 6-12 parts of rhizoma polygonati, 6-12 parts of arillus longan, 6-12 parts of Chinese date, 2-6 parts of peony, 2-6 parts of rose, 6-12 parts of poria cocos, 2-4 parts of dried orange peel and 2-4 parts of liquorice.
In one embodiment, the blood-enriching menstruation-regulating traditional Chinese medicine composition comprises the following raw materials in parts by weight: the composite material comprises the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of tuckahoe, 3 parts of dried orange peel and 3 parts of liquorice.
In a second aspect, the present invention provides a method for preparing a blood-enriching menstruation-regulating Chinese medicinal composition according to the first aspect, which comprises the following steps:
(1) mixing Ginseng radix, rhizoma Polygonati, arillus longan, fructus Jujubae, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix to obtain mixture;
(2) extracting the mixture with solvent, filtering to obtain filtrate, and concentrating the filtrate under reduced pressure to obtain soft extract;
(3) vacuum drying the thick paste, and pulverizing to obtain the final product.
In one embodiment, the extraction method of step (2) is selected from any one or more of decoction extraction, ultrasonic extraction and microwave extraction.
In one embodiment, the extraction method in step (2) is decoction extraction, the number of times of decoction extraction is 2, the solvent is water, the weight of the solvent used in each extraction is 4-10 times of the weight of the mixture, and the time for each decoction extraction is 45-90 min.
In one embodiment, the extraction method in step (2) is an ultrasonic extraction method, and step (1) specifically includes: vacuum drying rhizoma Polygonati, arillus longan, and fructus Jujubae to dry and crisp state, mixing Ginseng radix, rhizoma Polygonati, arillus longan, fructus Jujubae, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix, and pulverizing into coarse powder to obtain mixture.
Further, the temperature of vacuum drying to a crisp state is 60-70 ℃.
Further, the number of times of ultrasonic extraction is 1-3, the solvent is water, the weight of the solvent used in each extraction is 4-8 times of the weight of the mixture, the temperature of ultrasonic extraction is 25-45 ℃, and the time of each extraction is 20-60 min.
In one embodiment, the thick paste has a relative density of 1.20 to 1.30. The term "relative density" as used herein refers to the ratio of the mass of the thick paste at 50 ℃ to the mass of the same volume of water.
In a third aspect, the invention provides an application of the blood-enriching menstruation-regulating traditional Chinese medicine composition in preparation of blood-enriching menstruation-regulating health food.
In one embodiment, the blood-enriching menstruation-regulating health food is in the form of any one of powder, granules, tablets, hard capsules, soft capsules, pills and oral liquid.
In one embodiment, the blood-enriching menstruation-regulating health food is prepared from the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
Further, the pharmaceutically acceptable auxiliary materials comprise any one or more of isomaltulose, erythritol, maltitol, isomalt, maltodextrin, soluble starch, beta-cyclodextrin, sucralose, mogroside and magnesium stearate.
The invention adopts the components to carry out elaborate compatibility to obtain the traditional Chinese medicine composition with the effects of enriching the blood and regulating menstruation, and applies the traditional Chinese medicine composition to health-care food, and the invention is further explained in detail by combining specific embodiments.
Example 1
The composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 1 part of ginseng, 3 parts of rhizoma polygonati, 3 parts of arillus longan, 3 parts of Chinese date, 1 part of peony, 1 part of rose, 3 parts of tuckahoe, 1 part of dried orange peel and 1 part of liquorice.
The preparation method comprises the following steps:
(1) decocting ginseng, rhizoma polygonati, arillus longan, Chinese date, peony, rose, tuckahoe, dried orange peel and liquorice with water as a solvent for 2 times, wherein the amount of water is 6 times of the weight of the mixture each time, the decoction is carried out for 60min each time, filtering is carried out to obtain filtrate, and the filtrate is decompressed and concentrated (at 55-70 ℃ and-0.080-0.095 Mpa) to form thick paste with the relative density of 1.20-1.30 (at 50 ℃);
(2) vacuum drying the soft extract (75 + -5 deg.C, -0.080 to-0.095 Mpa), pulverizing to obtain dry extract powder, and making into Chinese medicinal composition with effects of replenishing blood and regulating menstruation.
Example 2
The composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 6 parts of ginseng, 15 parts of rhizoma polygonati, 15 parts of arillus longan, 15 parts of Chinese date, 8 parts of peony, 8 parts of rose, 15 parts of poria cocos, 6 parts of dried orange peel and 6 parts of liquorice.
The preparation method comprises the following steps:
(1) decocting ginseng, rhizoma polygonati, arillus longan, Chinese date, peony, rose, tuckahoe, dried orange peel and liquorice with water as a solvent for 2 times, wherein the amount of water is 6 times of the weight of the mixture each time, the decoction is carried out for 60min each time, filtering is carried out to obtain filtrate, and the filtrate is decompressed and concentrated (at 55-70 ℃ and-0.080-0.095 Mpa) to form thick paste with the relative density of 1.20-1.30 (at 50 ℃);
(2) vacuum drying the soft extract (75 + -5 deg.C, -0.080 to-0.095 Mpa), pulverizing to obtain dry extract powder, and making into Chinese medicinal composition with effects of replenishing blood and regulating menstruation.
Example 3
The composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 4 parts of ginseng, 10 parts of rhizoma polygonati, 10 parts of arillus longan, 10 parts of Chinese date, 5 parts of peony, 5 parts of rose, 12 parts of poria cocos, 2 parts of dried orange peel and 2 parts of liquorice.
The preparation method comprises the following steps:
(1) decocting ginseng, rhizoma polygonati, arillus longan, Chinese date, peony, rose, tuckahoe, dried orange peel and liquorice with water as a solvent for 2 times, wherein the amount of water is 6 times of the weight of the mixture each time, the decoction is carried out for 60min each time, filtering is carried out to obtain filtrate, and the filtrate is decompressed and concentrated (at 55-70 ℃ and-0.080-0.095 Mpa) to form thick paste with the relative density of 1.20-1.30 (at 50 ℃);
(2) vacuum drying the soft extract (75 + -5 deg.C, -0.080 to-0.095 Mpa), pulverizing to obtain dry extract powder, and making into Chinese medicinal composition with effects of replenishing blood and regulating menstruation.
Example 4
1. The composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of tuckahoe, 3 parts of dried orange peel and 3 parts of liquorice.
The preparation method comprises the following steps:
(1) decocting ginseng, rhizoma polygonati, arillus longan, Chinese date, peony, rose, tuckahoe, dried orange peel and liquorice with water as a solvent for 2 times, wherein the amount of water is 6 times of the weight of the mixture each time, the decoction is carried out for 60min each time, filtering is carried out to obtain filtrate, and the filtrate is decompressed and concentrated (at 55-70 ℃ and-0.080-0.095 Mpa) to form thick paste with the relative density of 1.20-1.30 (at 50 ℃);
(2) vacuum drying the soft extract (75 + -5 deg.C, -0.080 to-0.095 Mpa), pulverizing to obtain dry extract powder, and making into Chinese medicinal composition with effects of replenishing blood and regulating menstruation.
2. The preparation method of the health care product comprises the following steps:
and (3) adding 5 parts of the traditional Chinese medicine composition obtained in the step (2) into 3 parts of maltitol and 2 parts of isomaltitol, granulating by using a rapid wet granulator, drying (70 +/-5 ℃), and granulating to obtain granules.
Comparative example 1
Weighing the following raw materials in parts by weight: 9 parts of longan aril, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of poria cocos, 3 parts of dried orange peel and 3 parts of liquorice, and then the traditional Chinese medicine composition is prepared according to the preparation method of the embodiment 4. Taking 5 parts of the traditional Chinese medicine composition of the comparative example according to the parts by weight, adding 3 parts of maltitol and 2 parts of isomaltitol, granulating by a rapid wet granulator, drying (70 +/-5 ℃) and granulating to obtain granules.
Example 5
1. The composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of tuckahoe, 3 parts of dried orange peel and 3 parts of liquorice.
The preparation method comprises the following steps:
(1) vacuum drying rhizoma Polygonati, arillus longan, and fructus Jujubae (60-70 deg.C) to dry and crisp state, mixing with Ginseng radix, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix, pulverizing into coarse powder, and performing ultrasonic extraction for 2 times, wherein the amount of water is 6 times of the weight of the mixture, and the extraction parameters are as follows: filtering at 40 deg.C for 30min to obtain filtrate, and concentrating under reduced pressure (55-70 deg.C, -0.080-0.095 Mpa) to obtain soft extract with relative density of 1.20-1.30(50 deg.C);
(2) vacuum drying the thick paste (1) at 75 + -5 deg.C and-0.080-0.095 Mpa, and pulverizing to obtain dry extract powder.
2. The preparation method of the health care product comprises the following steps:
and (3) taking 10 parts of the traditional Chinese medicine composition obtained in the step (2), adding 9 parts of isomaltulose and 1 part of maltodextrin, and uniformly mixing to prepare the solid beverage.
Comparative example 2
Weighing the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 9 parts of poria cocos, 3 parts of dried orange peel and 3 parts of liquorice, and then preparing the traditional Chinese medicine composition according to the preparation method of the embodiment 5. According to the weight portion, 10 portions of the traditional Chinese medicine composition of the comparative example are taken, 9 portions of isomaltulose and 1 portion of maltodextrin are added, and the mixture is uniformly mixed to prepare the solid beverage.
Example 6
1. The composition for enriching blood and regulating menstruation comprises the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of tuckahoe, 3 parts of dried orange peel and 3 parts of liquorice.
The preparation method comprises the following steps:
(1) vacuum drying rhizoma Polygonati, arillus longan, and fructus Jujubae (60-70 deg.C) to dry and crisp state, mixing with Ginseng radix, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix, pulverizing into coarse powder, and performing ultrasonic extraction for 2 times, wherein the amount of water is 6 times of the weight of the mixture, and the extraction parameters are as follows: filtering at 30 deg.C for 60min to obtain filtrate, and concentrating under reduced pressure (55-70 deg.C, -0.080-0.095 Mpa) to obtain soft extract with relative density of 1.20-1.30(50 deg.C);
(2) vacuum drying the thick paste (1) at 75 + -5 deg.C and-0.080-0.095 Mpa, and pulverizing to obtain dry extract powder.
2. The preparation method of the health care product comprises the following steps:
taking 50 parts of the traditional Chinese medicine composition obtained in the step (2), adding 30 parts of maltitol, 20 parts of isomaltitol and 1 part of magnesium stearate, uniformly mixing, and pressing into tablets with the specification of 1.2 g/tablet by using a tablet press.
Efficacy experiment of blood-enriching menstruation-regulating traditional Chinese medicine composition
1. Experimental sample
Control group: oral liquid for benefiting qi and nourishing blood; experimental groups: granules prepared from Chinese medicinal composition for enriching blood and regulating menstruation (from example 4 and comparative example 1)
2. Experimental sample
Control group: randomly dividing 70 female Balb/c mice (weight of 20-25g) into 7 groups, 10 mice in each group, blank group, model group, oral liquid group for tonifying qi and nourishing blood, low, medium and high dose experimental group and comparative experimental group; example 5 solid beverages prepared from the Chinese medicinal composition for enriching blood and regulating menstruation were dissolved and diluted with purified water 3, 2, and 1 times by weight respectively, and used in the low, medium, and high dose test groups, respectively, and granules prepared from the Chinese medicinal composition of comparative example 1 were dissolved and diluted with purified water 2 times by weight respectively, and used in the medium dose test group.
3. Experimental methods
The blank group and the model group are 0.1ml/10g, and distilled water is infused for 1 time every day; the oral liquid for replenishing qi and nourishing blood is administered by 0.1ml/10g for 1 time per day; 0.1ml/10g of low, medium and high dose experimental groups and 0.1ml/10g of comparative experimental group are prepared by distilled water and administrated by drenching for 1 time every day; the experiment was continued for 2 weeks.
The model group, the oral liquid group for benefiting qi and nourishing blood, the low-dose experiment group, the medium-dose experiment group, the high-dose experiment group and the comparative experiment group are respectively injected with 80mg/kg of cyclophosphamide per day in the abdominal cavity from the 5 th day of administration for 10 days continuously. The blank group was injected with an equal volume of physiological saline. After 2 hours from the last dose, each mouse was bled at the inner canthus 0.1ml, anticoagulated with disodium EDTA, and the white blood cell count (WBC), red blood cell count (RBC), and Hemoglobin (HGB) were counted.
4. Results of the experiment
TABLE 1 influence of the Chinese medicinal composition for tonifying blood and regulating menstruation on hemogram
| Group of | WBC(×109/L) | RBC(×1012/L) | HGB(g/L) |
| Blank space | 7.58±0.26** | 8.61±0.39** | 152.7±2.8** |
| Model (model) | 4.83±0.42 | 5.77±0.37 | 101.5±2.3 |
| Oral liquid for benefiting qi and nourishing blood | 6.32±0.58* | 7.30±0.45** | 129.9±5.2** |
| Low dose test group | 7.16±0.45** | 7.13±0.31** | 129.1±7.0** |
| Middle dose test group | 7.66±0.93** | 7.87±0.55** | 136.8±6.7** |
| High dose test group | 7.54±0.54** | 7.63±0.49** | 131.7±6.5** |
| Comparative example test group | 6.11±0.53* | 7.01±0.42** | 120.7±6.1* |
Compared to the model group, p < 0.05, p < 0.01.
As can be seen from Table 1, after administration, the peripheral blood leukocytes, erythrocytes and hemoglobin were significantly reduced in the model group compared with those in the blank group (p < 0.01); compared with a model group, the low, medium and high dose experiment groups of the solid beverage prepared from the blood-enriching menstruation-regulating traditional Chinese medicine composition can obviously improve the content of peripheral blood white cells, red cells and hemoglobin (p is less than 0.01), and the blood-enriching menstruation-regulating traditional Chinese medicine composition and the health food provided by the invention have ideal blood-enriching effect. Compared with the comparative experiment group with the same dosage, the solid beverage adopted by the comparative experiment group is lack of ginseng and polygonatum, and the intermediate dosage experiment group has more obvious effect of improving the content of peripheral blood leucocyte, erythrocyte and hemoglobin, which shows that the raw materials of the formula of the invention are lack of one material and different in effective components, and have the synergistic effect.
Clinical test of curative effect of blood-enriching menstruation-regulating traditional Chinese medicine composition and health food
First, test purpose
Through tests, the curative effects of the traditional Chinese medicine composition for enriching blood and regulating menstruation and the health food are researched.
II, experimental samples: (1) control group: WUJIBAIFENG pill; (2) experiment group one: example 4A health food for tonifying blood and regulating menstruation, prepared from a Chinese medicinal composition; (3) experiment group two: example 5A health food for tonifying blood and regulating menstruation, prepared from the Chinese medicinal composition; comparison group: comparative example 2A health food for tonifying blood and regulating menstruation is prepared from the Chinese medicinal composition.
Thirdly, selecting the subjects: 60 cases of irregular menstruation were selected, and all cases met the standard of irregular menstruation diagnosis and Chinese medicine syndrome diagnosis: firstly, the menstruation is advanced; ② the later period of menstruation; ③ irregular menstruation; fourthly, hypomenorrhea; fifthly, menorrhagia; sixthly, the Western medicine diagnoses the ovulatory dysfunction uterine bleeding.
Fourthly, an experimental method: the control group takes WUJIBAIFENG pill 2 times daily, 1 pill each time. The composition is administered for 3 months. The first experimental group and the second experimental group respectively take the blood-enriching menstruation-regulating health-care food prepared by the traditional Chinese medicine composition in the embodiment 4 and the embodiment 5, and the contrast group takes the finished product prepared by the traditional Chinese medicine composition in the comparative example 2; 1 bag (10 g each) for 1 day. The treatment course is the same as that of the control group.
Fifthly, the evaluation standard of curative effect: and (3) healing: the menstrual cycle, menstrual flow and menstrual period are recovered to be normal, and other symptoms disappear; the effect is shown: the menstrual cycle is recovered for (28 +/-7) days, the menstrual cycle is recovered within 7 days, and the menstrual amount and other symptoms are improved compared with those before the administration; and (4) invalidation: the menstrual cycle, menstrual flow and menstrual period are not obviously improved after treatment.
Sixth, experimental results
TABLE 2 blood-enriching menstruation-regulating curative effect test
As can be seen from table 2, after administration, compared with the Wuji Baifeng pill, the blood-enriching menstruation-regulating health food (prepared by selecting the traditional Chinese medicine composition in example 4) and the blood-enriching menstruation-regulating health food (prepared by selecting the traditional Chinese medicine composition in example 5) can both significantly increase the effective rate of menstruation, which indicates that the blood-enriching menstruation-regulating health food and the blood-enriching menstruation-regulating health food provided by the invention have ideal functions of enriching blood and regulating menstruation. The experimental products of the comparison group lack peony flowers and roses, and compared with the comparison group I, the blood enriching and menstruation regulating effects of the experiment group I and the experiment group II are more remarkable. The raw materials of the formula of the invention are all absent, and the effective components of the raw materials are different, so that the invention has the synergistic effect.
The preparation method provided by the embodiment of the invention has the advantages that the compatibility is reasonable, the method for extracting the effective components is simple and appropriate, various effective components in different original materials can be effectively extracted, the prepared traditional Chinese medicine composition can meet the blood enriching and menstruation regulating requirements of people with blood deficiency, the eating is convenient, and the decoction and heating operation is not needed during the eating.
The technical solutions provided by the embodiments of the present invention are described in detail above, and the principles and embodiments of the present invention are explained herein by using specific examples, and the descriptions of the embodiments are only used to help understanding the principles of the embodiments of the present invention; meanwhile, for a person skilled in the art, according to the embodiments of the present invention, there may be variations in the specific implementation manners and application ranges, and in summary, the content of the present description should not be construed as a limitation to the present invention.
Claims (10)
1. A traditional Chinese medicine composition for enriching blood and regulating menstruation is characterized in that:
the composite material comprises the following raw materials in parts by weight: 1-6 parts of ginseng, 3-15 parts of rhizoma polygonati, 3-15 parts of arillus longan, 3-15 parts of Chinese date, 1-8 parts of peony, 1-8 parts of rose, 3-15 parts of poria cocos, 1-6 parts of dried orange peel and 1-6 parts of liquorice.
2. The traditional Chinese medicine composition for enriching blood and regulating menstruation according to claim 1, which is characterized in that:
the composite material comprises the following raw materials in parts by weight: 2-4 parts of ginseng, 6-12 parts of rhizoma polygonati, 6-12 parts of arillus longan, 6-12 parts of Chinese date, 2-6 parts of peony, 2-6 parts of rose, 6-12 parts of poria cocos, 2-4 parts of dried orange peel and 2-4 parts of liquorice.
3. The traditional Chinese medicine composition for enriching blood and regulating menstruation according to claim 2, which is characterized in that:
the composite material comprises the following raw materials in parts by weight: 3 parts of ginseng, 9 parts of rhizoma polygonati, 9 parts of arillus longan, 9 parts of Chinese date, 4 parts of peony, 4 parts of rose, 9 parts of tuckahoe, 3 parts of dried orange peel and 3 parts of liquorice.
4. A method for preparing the traditional Chinese medicine composition for enriching the blood and regulating menstruation according to any one of claims 1 to 3, which comprises the following steps:
(1) mixing Ginseng radix, rhizoma Polygonati, arillus longan, fructus Jujubae, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix to obtain mixture;
(2) extracting the mixture with solvent, filtering to obtain filtrate, and concentrating the filtrate under reduced pressure to obtain soft extract;
(3) vacuum drying the thick paste, and pulverizing to obtain the final product.
5. The preparation method of the traditional Chinese medicine composition for enriching blood and regulating menstruation according to claim 4, which is characterized by comprising the following steps:
the extraction method of the step (2) is any one or combination of a decoction extraction method, an ultrasonic extraction method and a microwave extraction method.
6. The preparation method of the traditional Chinese medicine composition for enriching blood and regulating menstruation according to claim 4, which is characterized by comprising the following steps: the extraction method in the step (2) is a decoction extraction method, the times of decoction extraction are 2 times, the solvent is water, the weight of the solvent used in each extraction is 4-10 times of the weight of the mixture, and the time of each decoction extraction is 45-90 min.
7. The preparation method of the traditional Chinese medicine composition for enriching blood and regulating menstruation according to claim 4, which is characterized by comprising the following steps:
the extraction method in the step (2) is an ultrasonic extraction method, and the step (1) specifically comprises the following steps: vacuum drying rhizoma Polygonati, arillus longan, and fructus Jujubae to dry and crisp state, mixing Ginseng radix, rhizoma Polygonati, arillus longan, fructus Jujubae, flos moutan, flos Rosae Rugosae, Poria, pericarpium Citri Tangerinae, and Glycyrrhrizae radix, and pulverizing into coarse powder to obtain mixture.
8. The preparation method of the traditional Chinese medicine composition for enriching blood and regulating menstruation according to claim 7, which is characterized by comprising the following steps:
the ultrasonic extraction is performed for 1-3 times, the solvent is water, the dosage of the solvent used in each extraction is 4-8 times of that of the mixture, the temperature of the ultrasonic extraction is 25-45 ℃, and the time of each extraction is 20-60 min.
9. Use of the blood-enriching menstruation-regulating Chinese medicinal composition as claimed in any one of claims 1 to 3 in preparation of blood-enriching menstruation-regulating health food.
10. Use according to claim 9, characterized in that:
the dosage form of the blood-enriching menstruation-regulating health food is any one of powder, granules, tablets, hard capsules, soft capsules, pills and oral liquid.
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| CN110075202A (en) * | 2019-05-22 | 2019-08-02 | 湖南众一医药咨询有限公司 | A kind of qi-blood tonifying Chinese medicine composition and preparation method thereof |
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| CN110075202A (en) * | 2019-05-22 | 2019-08-02 | 湖南众一医药咨询有限公司 | A kind of qi-blood tonifying Chinese medicine composition and preparation method thereof |
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