CN101190249B - Composition for preventing and controlling high-altitude disease and preparation method thereof - Google Patents
Composition for preventing and controlling high-altitude disease and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition used for preventing and treating mountain sickness; particularly, the invention uses mountain plants as raw materials to prepare drugs, foods or health care products; more particularly, the composition consists of the following raw medicines by weight: 18-100 parts of codonopsis, 6-25 parts of common stonecrop herb and 80-280 parts of fructus hippophae. The invention also discloses the preparation method. The composition prepared has the functions of anti-hypoxia, antiradiation, alleviating fatigue and improving immunity. If contains glucose and cane sugar, the invention is especially suitable for being taken during touring in mountain areas; if contains isomaltitol, the invention is suitable for being taken in plain areas. The invention has the advantages of small volume, convenient carrying, easy being taken (no need to be taken with boiled water), good taste and compliance, which provides novel choice for the public.
Description
Technical field
The present invention relates to a kind of compositions of preventing and treating altitude sickness, particularly, is to be the product that feedstock production forms with the plateau plant.
Background technology
Radix Codonopsis, Radix Rhodiolae, Fructus Hippophae are the plateau frequently seen plants, and China is medicinal, edible with a long history.
Radix Codonopsis has invigorating the spleen and replenishing QI, the effect that spleen invigorating is promoted the production of body fluid; Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the extremity asthenia.Contained rhodioside of Radix Rhodiolae and tyrosol have resisting fatigue, anti-hypoxia, anti-microwave radiation, antitoxin and to nervous system and metabolic dual regulation, also are a kind of environmental adaptation medicines.Fructus Hippophae is rich in vitamin C and several amino acids, have regain one's strength, allaying tiredness, strong intensive culture god's effect; Fructus Hippophae also have eliminate the phlegm, sharp lung, nourishing the stomach, spleen invigorating, invigorate blood circulation, the pharmacological effect of blood stasis dispelling, be that the folk prescription made of primary raw material or compound preparation are to cardiovascular system diseases with the Fructus Hippophae, digestive system disease, ophthalmic diseases, and the erosion of official's neck, burn, scald, knife injury and frosted treatment have significant curative effect, and tumor patient is had certain treatment and auxiliary treatment effect preferably.
China CN1232649A, application number is 98113929.9, name is called health rhodiola root beverage, disclosing with the Radix Rhodiolae rhizome is primary raw material, through 60～80% ethanol extractions, again behind the processing step such as extraction, add the beverage of the fruit juice gained that is rich in Vc, this fruit juice that is rich in Vc is juice of Fructus Hippophae.The per 2 liters of solution of Radix Rhodiolae reserve liquid are equivalent to 1 kilogram of crude drug in whole (being 1kg) in the embodiment, it is 10000ml to cumulative volume that every 1000ml reserve liquid adds the juice of Fructus Hippophae diluent, and every as can be known 1kg Radix Rhodiolae that converts need add 19000ml juice of Fructus Hippophae diluent (but not disclosing the consumption that every ml juice of Fructus Hippophae diluent is equivalent to Hippophae (rhamnoides) original juice or Fructus Hippophae).This beverage has the Fructus Hippophae fruital, and is tasty and refreshing, refresh oneself, and can eliminate the fatigue that a variety of causes causes, improves attention and work efficiency.
China CN1130531A, application number is 95119857.2, name is called a kind of medicine that prevents altitude sickness, disclosing raw material weight percentage ratio is the medicine of Radix Rhodiolae 2～99%, Fructus Hippophae 0～90%, Fructus Lycii 0～90%, the further preferable range of its raw material is Radix Rhodiolae 30～70%, Fructus Hippophae 15～55%, Fructus Lycii 15～55%, can also add an amount of Radix Ginseng or vitamin drug on the basis of this raw material.This medicine has for the intravital radical metabolism disorder of high aborigines to be regulated and the improvement effect, and high altitude erythrocytosis is had better therapeutic effect.
Shang Weijian is the relevant report that material combination uses with Radix Codonopsis, Radix Rhodiolae, Fructus Hippophae.
Summary of the invention
Technical problem to be solved by this invention provides a kind of compositions of preventing and treating altitude sickness, has anti-hypoxia, radioprotective, and relieving fatigue improves effects such as immunity.
The present composition contains the following weight proportion raw material and is prepared from: 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, 80～280 parts of Fructus Hippophae.Can also on the basis of above-mentioned raw materials, add in 15～35 parts of 15～55 parts of the Cortex Acanthopanacis Giraldii or the Radixs Astragali one or both.
Wherein, Radix Codonopsis Radix Codonopsis Pilosulae is the dry root of campanulaceae plant Radix Codonopsis Codonopsis pilosula (Franch.) Nannf., plain flower Radix Codonopsis Codonopsis pilosulavar Nannf.var.modesta (Nannf.) L.T.Shen or radix codonpsis tangshen Codonopsis tangshen Oliv..The plain flower of preferred Sichuan genuine medicinal materials Radix Codonopsis (main product is in area, edge of a knife dam, Jiuzhaigou country, Sichuan) has another name called nine stockaded village cutter parties.Radix Rhodiolae is selected the plant of the pharmaceutically acceptable or edible rhodiola Rhodiola of present report for use.Fructus Hippophae is the mature fruit of the Hippophae Hippophae rhamnoides L. of Fructus Elaeagni section, can select bright Fructus Hippophae or dry Fructus Hippophae for use.
The present composition is prepared from by the following weight proportion raw material: 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, 80～280 parts of Fructus Hippophae.
Further, it is prepared from by the following weight proportion raw material: 40～50 parts of Radix Codonopsis, 12～15 parts of Radix Rhodiolaes, 170～190 parts of Fructus Hippophae.
Further, it is prepared from by the following weight proportion raw material: 45 parts of Radix Codonopsis, 14 parts of Radix Rhodiolaes, 180 parts of Fructus Hippophae.
The preferred bright Fructus Hippophae of the present composition is a raw material, to extract the kind of effective ingredient of dry Fructus Hippophae gained many because of squeezing bright Fructus Hippophae gained effective ingredient, the effect that the composition that the composition of bright Fructus Hippophae squeezing gained can extract with other two flavors raw material of the present composition produces Synergistic, and aspect preparation technology, directly squeeze bright Fructus Hippophae easier, be easy to get.
The present composition is to be active component with Radix Codonopsis, Radix Rhodiolae, Fructus Hippophae, the preparation that add pharmaceutically, acceptable auxiliary or complementary composition is prepared from the health product, on the food.
Wherein, the dosage form of preferred composition is common dosage forms such as buccal tablet, tablet, capsule, granule or oral liquid.
The present composition prepares the adjuvant that the gained buccal tablet also contains the following weight proportioning: 25～200 parts of one or more in hydroxyl isomaltulose, glucose or the sucrose, 0.05～1 part of Mentholum; Wherein hydroxyl isomaltulose, glucose or sucrose is according to concrete operating position adjustment, be suitable for taking in the highlands contain glucose or sucrose buccal tablet to increase energy supply, be suitable for taking generation sugar in the plains region, preferred hydroxyl isomaltulose is an adjuvant.
Further, one or more 50 parts in the preferred hydroxyl isomaltulose of adjuvant weight proportion, glucose or the sucrose, 0.3 part of Mentholum.
Another technical problem to be solved by this invention provides the method for preparing the present composition, and it comprises the steps:
A, take by weighing the following weight proportion raw material: 80～280 parts of 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, bright Fructus Hippophae or dry Fructus Hippophae;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
Or get dry Fructus Hippophae and boil with ethanol or decocting, filtering, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae boils with ethanol or decocting, filters, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add pharmaceutically, on the health product, acceptable auxiliary or the preparation of complementary composition on the food, promptly.
The preparation method of buccal tablet of the present invention comprises the steps:
A, take by weighing the following weight proportion raw material: 80～280 parts of 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, bright Fructus Hippophae or dry Fructus Hippophae;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
Or get dry Fructus Hippophae and boil with ethanol or decocting, filtering, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae boils with ethanol or decocting, filters, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add in the adjuvant and stir, filter, filtrate concentrates, and when the cooling concentration liquid temp is reduced to below 90 ℃, adds the Mentholum with dissolve with ethanol while stirring, stir, and cooling, molding, packing is promptly.
According to the Chinese medicine rationale, the patient has the symptom of fatigue, hypoimmunity, belongs to taste imbalances more, promoting the circulation of blood not smooth because of; So when patient's fatigue, hypoimmunity is appropriate to the occasion strengthens the spleen and stomach, and invigorates blood circulation promoting the circulation of blood.The spleen has the function to transport and transform nutrients, dependent territory; Lung department is respectful falls, and belongs to gold; Heart happiness is warm, and controlling blood and vessel, gods belong to fire; The suitable GUIXIN of row medicine, spleen, lung three warps, function of spleen and stomach regulating is earlier.The present composition is selected Radix Codonopsis, Radix Rhodiolae, Fructus Hippophae three compatibility for use, Radix Codonopsis wherein, and nature and flavor are sweet, flat, return lung, spleen, and invigorating the spleen and replenishing QI, spleen invigorating are promoted the production of body fluid, and are monarch drug; Radix Rhodiolae, nature and flavor are sweet, bitter, flat, return lung, heart channel, benefiting QI for activating blood circulation, promote blood circulation and relieving asthma, and are ministerial drug; Fructus Hippophae, nature and flavor acid, puckery, warm, relieving cough and resolving phlegm, promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis are adjuvant.Three medicine compatibilities use, the Radix Codonopsis function of spleen and stomach regulating supplementing QI for promoting the production of body fluid of holding concurrently, and Radix Rhodiolae helps heart promoting the circulation of blood, and the effect of auxiliary Radix Codonopsis performance spleen invigorating QI invigorating is aided with Fructus Hippophae and prevents the taste food stagnation, invigorates blood circulation to help Radix Codonopsis, Radix Rhodiolae respectively to take charge of its effect.The three supplements and complements each other, and the merit of performance Synergistic has additional special dietary, anti-hypoxia, and radioprotective, relieving fatigue improves effects such as immunity.
According to another contrast test, the present composition and two Chinese patent application number are that 98113929.9 (name is called health rhodiola root beverage, CN1232649A) and application number be 95119857.2 (name be called a kind of medicine that prevents altitude sickness, CN1130531A) prepared and product compare, present composition effect is remarkable aspect raising immunity, mouthfeel is good, comprehensively takes effective.Its oral formulations that is prepared from is convenient to take, and can effectively improve user's body constitution.Buccal tablet of the present invention is taken when dextrose plus saccharose is particularly suitable for the highlands tourism because of containing; It is edible with the hydroxyl isomaltulose to be that adjuvant is suitable for the plains region; And it is little, easy to carry that this buccal tablet has a volume, taking convenience (not needing boiled water to take), characteristics such as mouthfeel is good, and compliance is good.
Obviously, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill knowledge and the customary means of this area.
The specific embodiment of form is described in further detail foregoing of the present invention again by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following example.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
The specific embodiment
The preparation of embodiment 1 present composition
A, take by weighing the following weight proportion raw material: Radix Codonopsis 450g, Radix Rhodiolae 140g, bright Fructus Hippophae 1800g, Mentholum 3g, glucose 250g, sucrose 250g;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae water and decoct, filter, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add in heating and the dissolved isomaltulose alcohol-water solution and stir, filter, filtrate decompression concentrates, and cooling when treating that temperature drops to below 90 ℃, adds the Mentholum with dissolve with ethanol while stirring, stir, cooling, molding, packing is promptly.
The preparation of embodiment 2 present compositions
A, take by weighing the following weight proportion raw material: Radix Codonopsis 200g, Radix Rhodiolae 70g, bright Fructus Hippophae 900g, Mentholum 1g, glucose 150g;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae water and decoct, filter, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add in heating and the dissolved isomaltulose alcohol-water solution and stir, filter, filtrate decompression concentrates, cooling treats that temperature drops to below 90 ℃, adds the Mentholum of using dissolve with ethanol in advance while stirring, stir, cooling, molding, packing is promptly.
The preparation of embodiment 3 present compositions
A, take by weighing the following weight proportion raw material: Radix Codonopsis 950g, Radix Rhodiolae 240g, bright Fructus Hippophae 2600g, Mentholum 3g, sucrose 200g, hydroxyl isomaltulose 260g;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae and decoct with 95%v/v ethanol, filter, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add in heating and the dissolved isomaltulose alcohol-water solution and stir, filter, filtrate decompression concentrates, cooling treats that temperature drops to below 90 ℃, adds the Mentholum of using dissolve with ethanol in advance while stirring, stir, cooling, molding, packing is promptly.
The preparation of embodiment 4 present compositions
A, take by weighing the following weight proportion raw material: Radix Codonopsis 450g, Radix Rhodiolae 140g, bright Fructus Hippophae 1800g, Cortex Acanthopanacis Giraldii 200g, Mentholum 3.5g, hydroxyl isomaltulose 500g;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae and decoct with 50%v/v ethanol, filter, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add in heating and the dissolved isomaltulose alcohol-water solution and stir, filter, filtrate decompression concentrates, cooling treats that temperature drops to below 90 ℃, adds the Mentholum of using dissolve with ethanol in advance while stirring, stir, cooling, molding, packing is promptly.
The preparation of embodiment 5 present compositions
A, take by weighing the following weight proportion raw material: Radix Codonopsis 500g, Radix Rhodiolae 140g, bright Fructus Hippophae 1800g, Cortex Acanthopanacis Giraldii 300g, Radix Astragali 200g, Mentholum 4g, glucose 100g, sucrose 200g, hydroxyl isomaltulose 200g;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae and decoct with 60%v/v ethanol, filter, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add in heating and the dissolved isomaltulose alcohol-water solution and stir, filter, filtrate decompression concentrates, cooling treats that temperature drops to below 90 ℃, adds the Mentholum of using dissolve with ethanol in advance while stirring, stir, cooling, molding, packing is promptly.
Below pass through the beneficial effect of the screening contrast test of present composition proportioning raw materials with the proof present composition.
Sample preparation: get each 10g of buccal tablet that various embodiments of the present invention make, add water 10ml grinding and be made into suspension.(name is called health rhodiola root beverage to be 98113929.9 by application number, call patent 1 in the following text) the method for patent of invention description embodiment 1 record prepare oral liquid, application number is 95119857.2, and (name is called a kind of medicine that prevents altitude sickness, call patent 2 in the following text) the method for patent of invention description embodiment 1 record prepare beverage, make in the suspension unit volume that Radix Rhodiolae content and the embodiment of the invention 1 make in the unit volume of oral liquid and beverage Radix Rhodiolae content identical.
Test method: be regardless of with the mice male and female, body weight 23～26g, 16 every group, gavage above-mentioned patent 1 oral liquid, patent 2 beverages respectively, embodiment 1～5 preparation and product.Gavage 0.5ml every day one time, serve on 7 days, put to death in the 8th day.Behind the sacrifice of animal, put into 75% ethanol and soak 20min, the abdominal cavity injects phosphate buffered saline (PBS) 2.5ml, behind the stomach wall that gently shakes, get peritoneal fluid 1.5ml, put in vitro, add 3 mixing of freshly-slaughtered poultry blood, after shaking up, sucking-off liquid places on the micro slide, and area is 2cm * 1.5cm, hatch 30min for 37 ℃, after taking out in the incubator, macrophage adheres on the micro slide, 20～22 ℃ of airings, methanol is fixed, Ji's Albert'stain Albert, 10 * 400 times of oily mirrors are observed down, calculate phagocytic rate, the results are shown in Table 1.
Each inventive embodiments of table 1 is taken the effect contrast test to the influence and the mouthfeel of Turnover of Mouse Peritoneal Macrophages vigor
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Patent 1 | Patent 2 | |
| Improve immunity (average phagocytic rate %) | 78 | 71 | 68 | 74 | 74 | 56 | 63 |
| Mouthfeel | Fine | Good | Good | Good | Good | Difference | Difference |
| The resultant effect of taking in the highlands | Fine | Good | Good | Good | Good | Difference | Good |
Illustrate that according to above-mentioned test data the embodiment of the invention 1～5 preparation gets product and compares with patent 2 than patent 1, obviously be better than patent 1 and patent 2 in present composition effect aspect raising immunity and the mouthfeel; The resultant effect present composition that take the highlands is all good than patent 1, and embodiment 1 products obtained therefrom effect is good than patent 2, and embodiment 2～5 is suitable with patent 2 effects.
The present composition, the aspects such as significant degree of taking in the highlands when the inherent anti-hypoxia of the ratio range of 18～100 parts of raw material Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, 80～280 parts of bright Fructus Hippophae, resisting fatigue, additional special dietary, raising immunity, mouthfeel all produce effect; Effect is remarkable in the ratio range of 40～50 parts of raw material Radix Codonopsis, 12～15 parts of Radix Rhodiolaes, 170～190 parts of bright Fructus Hippophae; When the raw material weight proportioning is 45 parts of Radix Codonopsis, 14 parts of Radix Rhodiolaes, 180 parts of bright Fructus Hippophae, best results.
Present composition tool replenishes special dietary, anti-anoxic, and radioresistance is removed the effects such as tired, raising immunity. Regular dosage form lozenge, tablet, capsule have preserves advantage convenient, taking convenience. Lozenge of the present invention contains when dextrose plus saccharose is particularly suitable for the highlands tourism to be taken; Containing different maltulose alcohol person, to be suitable for the plains region edible; And it is little, easy to carry that lozenge of the present invention has a volume, taking convenience (not needing boiling water to take), the characteristics such as mouthfeel is good, and compliance is good.
Claims (10)
1. a compositions of preventing and treating altitude sickness is characterized in that, it contains the following weight proportion raw material and is prepared from: 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, 80～280 parts of Fructus Hippophae.
2. compositions of preventing and treating altitude sickness according to claim 1 is characterized in that, it is prepared from by the following weight proportion raw material: 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, 80～280 parts of Fructus Hippophae.
3. compositions of preventing and treating altitude sickness according to claim 2 is characterized in that, it is prepared from by the following weight proportion raw material: 40～50 parts of Radix Codonopsis, 12～15 parts of Radix Rhodiolaes, 170～190 parts of Fructus Hippophae.
4. compositions of preventing and treating altitude sickness according to claim 3 is characterized in that, it is prepared from by the following weight proportion raw material: 45 parts of Radix Codonopsis, 14 parts of Radix Rhodiolaes, 180 parts of Fructus Hippophae.
5. according to each described compositions of preventing and treating altitude sickness of claim 1～4, it is characterized in that described Fructus Hippophae is bright Fructus Hippophae.
6. according to each described compositions of preventing and treating altitude sickness of claim 1～4, it is characterized in that it is to be active component with Radix Codonopsis, Radix Rhodiolae, Fructus Hippophae, add pharmaceutically, on the health product, acceptable auxiliary is prepared from the food preparation.
7. compositions of preventing and treating altitude sickness according to claim 6 is characterized in that, described preparation is buccal tablet, tablet, capsule, granule or oral liquid.
8. compositions of preventing and treating altitude sickness according to claim 7, it is characterized in that the adjuvant of described buccal tablet is made up of following components in weight percentage: 25～200 parts of one or more in hydroxyl isomaltulose, glucose or the sucrose, 0.05～1 part of Mentholum.
9. compositions of preventing and treating altitude sickness according to claim 8 is characterized in that, described buccal tablet adjuvant weight proportion is: 50 parts of one or more in hydroxyl isomaltulose, glucose or the sucrose, 0.3 part of Mentholum.
10. one kind prepares the described method for compositions of preventing and treating altitude sickness of claim 1, and it comprises the steps:
A, take by weighing the following weight proportion raw material: 80～280 parts of 18～100 parts of Radix Codonopsis, 6～25 parts of Radix Rhodiolaes, bright Fructus Hippophae or dry Fructus Hippophae;
B, get bright Fructus Hippophae and squeeze the juice, filter, filtrate is concentrated into thick paste;
Or get dry Fructus Hippophae and boil with ethanol or decocting, filtering, filtrate is concentrated into thick paste;
C, get Radix Codonopsis, Radix Rhodiolae boils with ethanol or decocting, filters, filtrate is concentrated into thick paste;
D, get step b and c gained thick paste, mix, add pharmaceutically, on the health product, acceptable auxiliary preparation on the food, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100223787A CN101190249B (en) | 2006-11-30 | 2006-11-30 | Composition for preventing and controlling high-altitude disease and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100223787A CN101190249B (en) | 2006-11-30 | 2006-11-30 | Composition for preventing and controlling high-altitude disease and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN101190249A CN101190249A (en) | 2008-06-04 |
| CN101190249B true CN101190249B (en) | 2011-05-18 |
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| CN109985107A (en) * | 2019-05-07 | 2019-07-09 | 西藏中孚医药科技有限公司 | It is a kind of for altitude erythrocytosis prevention and treatment compound ginseng return piece and preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130531A (en) * | 1995-12-07 | 1996-09-11 | 青海省老年医学研究所 | Medicine for preventing and curing altitude disease |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1130531A (en) * | 1995-12-07 | 1996-09-11 | 青海省老年医学研究所 | Medicine for preventing and curing altitude disease |
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