CN113908792A - Equipment and method for preparing nicotinamide ribose - Google Patents
Equipment and method for preparing nicotinamide ribose Download PDFInfo
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- CN113908792A CN113908792A CN202111251718.4A CN202111251718A CN113908792A CN 113908792 A CN113908792 A CN 113908792A CN 202111251718 A CN202111251718 A CN 202111251718A CN 113908792 A CN113908792 A CN 113908792A
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- JLEBZPBDRKPWTD-TURQNECASA-O N-ribosylnicotinamide Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=C1 JLEBZPBDRKPWTD-TURQNECASA-O 0.000 title claims abstract description 30
- 238000000034 method Methods 0.000 title claims abstract description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 141
- 238000002156 mixing Methods 0.000 claims abstract description 19
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 238000003756 stirring Methods 0.000 claims abstract description 14
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims description 20
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 18
- 235000020956 nicotinamide riboside Nutrition 0.000 claims description 10
- 239000011618 nicotinamide riboside Substances 0.000 claims description 10
- 238000000926 separation method Methods 0.000 claims description 7
- 239000012043 crude product Substances 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 claims description 3
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims description 3
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims description 3
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 239000004519 grease Substances 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 3
- 230000008859 change Effects 0.000 abstract description 2
- 238000009792 diffusion process Methods 0.000 abstract 1
- 239000003643 water by type Substances 0.000 abstract 1
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 8
- 229950006238 nadide Drugs 0.000 description 8
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 5
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 239000005515 coenzyme Substances 0.000 description 3
- 210000001503 joint Anatomy 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- 108090000698 Formate Dehydrogenases Proteins 0.000 description 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 108010028658 Leucine Dehydrogenase Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- -1 hydrogen ions Chemical class 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000000627 niacin group Chemical class 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000003303 reheating Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0006—Controlling or regulating processes
- B01J19/0013—Controlling the temperature of the process
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00092—Tubes
Abstract
The invention relates to the technical field of medicine preparation, and discloses equipment and a method for preparing nicotinamide ribose, wherein the equipment comprises a shell component, a connecting component, a treatment component, a water circulation component I, a water circulation component II, a water tank and a mixing component; the shell assembly comprises a base, a barrel body and a feeding pipe, the barrel body is arranged at the top of the base, the feeding pipe is connected with the top of the barrel body, the processing assembly is arranged at the top of the base, and the connecting assembly is arranged at the top of the barrel body; through the work of motor, it is rotatory to drive the axis body and stir the leaf, in rotatory, to water circulation subassembly one in inject low temperature's water or high temperature, can change the liquid temperature in the staving fast, consequently utilized the rotation of (mixing) shaft, liquid temperature in the control bucket to in water circulation subassembly one work, by the cooperation of water circulation subassembly two, with the outside internal diffusion of the temperature follow staving of water circulation subassembly two internal waters.
Description
Technical Field
The invention relates to the technical field of medicine preparation, in particular to equipment and a method for preparing nicotinamide ribose.
Background
Nicotinamide riboside is a derivative of vitamin B3, can form nicotinamide adenine dinucleotide (NAD, also called coenzyme I) and nicotinamide adenine dinucleotide phosphate (NADP, also called coenzyme II) with phosphate and adenine, is a precursor of an important coenzyme NAD +, and plays an important role in the generation of energy in human cells, and is involved in the synthesis of intracellular nicotinamide adenine dinucleotide (an important coenzyme for cellular energy conversion). Nicotinamide adenine dinucleotide is a coenzyme for the transfer of protons (more precisely, hydrogen ions) which occurs in many metabolic reactions in cells, involved in the breakdown of proteins, carbohydrates and fats, such as: chiral reductions catalyzed by leucine dehydrogenase, ammonia formate dehydrogenase, and glucose dehydrogenase all require the aid of nicotinamide adenine dinucleotide to complete the entire reaction, as does oxidation. As the cells age or become diseased, the amount of NADP decreases. Therefore, the nicotinamide riboside is supplemented, the content of nicotinamide adenine dinucleotide is increased, and the basic metabolic activity of cells can be improved, so that the cell activity is obviously improved, and the physiological functions of various aspects of a human body are improved.
The existing equipment for preparing nicotinamide ribose has dispersed functions, so that the preparation progress is influenced.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides equipment and a method for preparing nicotinamide ribose, which have the advantage of multiple functions and solve the problem that the preparation progress is influenced by function dispersion.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: an apparatus for preparing nicotinamide riboside comprises a housing assembly, a connecting assembly, a treatment assembly, a water circulation assembly I, a water circulation assembly II, a water tank and a mixing assembly;
the shell assembly comprises a base, a barrel body and a feeding pipe, the barrel body is arranged at the top of the base, the feeding pipe is connected with the top of the barrel body, the treatment assembly is arranged at the top of the base, the connecting assembly is arranged at the top of the barrel body, the water circulation assembly II is arranged inside the barrel body, and the water tank is arranged inside the base;
the mixing assembly comprises a motor, a first gear, a second gear, a shaft body and a stirring blade, the motor is arranged inside the base, the output shaft of the motor is connected with the first gear, the base is connected with the shaft body in a rotating mode, the outer side wall of the shaft body is connected with the second gear, the second gear is connected with the first gear in a meshed mode, the stirring blade is arranged on the outer side wall of the shaft body in a regular mode, the water circulation assembly is arranged inside the shaft body and the stirring blade, and the motor is electrically connected with an external power supply.
Preferably, the water circulation assembly II comprises a second circulation part and a second connecting end, the two second circulation parts are arranged in the barrel body, one end of the second circulation part is connected with the second circulation part, and the other end of the second circulation part is connected with the water tank.
Preferably, the first water circulation assembly comprises a sixth pipe body, a water guide part, a first circulation part, a seventh pipe body and a first connecting end, the sixth pipe body is arranged inside the shaft body, the first circulation part is arranged inside the stirring blade, the sixth pipe body is connected with the first circulation part through the water guide part, the seventh pipe body is arranged at the top of the sixth pipe body, and the seventh pipe body is connected with the first connecting end.
Preferably, coupling assembling includes disk body, collector pipe, body one and body two, the inside top surface of staving is provided with the disk body, body seven is located the inside of staving, the top of staving is provided with the disk body, the inside wall sliding connection of disk body the collector pipe, the lateral wall symmetry of collector pipe is provided with body one with body two.
Preferably, the outer side wall of the water collecting pipe is provided with a clamping block, the outer side wall of the tray body is provided with a bulge matched with the clamping block, and the bottom of the water collecting pipe is provided with a telescopic pipe and a spring.
Preferably, the treatment assembly comprises a box body, a drying box, a third pipe body, a fourth pipe body, a separation column, a groove, a ring pipe and a fifth pipe body, the box body is arranged at the top of the base, the groove is formed in the top of the box body, the separation column is arranged in the groove, the drying box is arranged in the box body, the third pipe body is arranged at the top of the drying box, the ring pipe is arranged around the outer side wall of the drying box, the ring pipe is connected with the sixth pipe body through the fourth pipe body, and the ring pipe is connected with the water tank through the fifth pipe body.
A method for preparing nicotinamide riboside equipment, comprising the following steps:
s1: preparing an intermediate: distributing the raw materials into the barrel body, controlling the mixing assembly to work, putting solution ribose in the mixing process, injecting water at the temperature of two into the water circulation assembly II to increase the temperature of the liquid in the barrel body, adding silicone grease when the liquid in the barrel body reaches the temperature, replacing the water at the temperature, and reheating the barrel body by the two pairs of the water circulation assemblies;
s2: mixing the intermediate with methanol: injecting low-temperature water into the water circulation assembly I, reducing the temperature in the barrel body to the temperature, adding methanol in a funnel mode to obtain a nicotinamide ribose crude product, and obtaining high-purity nicotinamide ribose by adopting the work of the treatment assembly.
(III) advantageous effects
Compared with the prior art, the invention provides equipment and a method for preparing nicotinamide ribose, which have the following beneficial effects:
1. according to the equipment and the method for preparing nicotinamide ribose, the shaft body and the stirring blades are driven to rotate through the work of the motor, low-temperature water or high-temperature water is injected into the water circulation component I while the shaft body and the stirring blades rotate, and the temperature of liquid in the barrel can be rapidly changed, so that the rotation of the stirring shaft is utilized to control the temperature of the liquid in the barrel, and the temperature of the water in the water circulation component II is diffused inwards from the outer side of the barrel by the cooperation of the water circulation component II while the water circulation component I works, and the temperature of the liquid in the barrel is rapidly changed by the cooperation of the water circulation component I;
2. according to the equipment and the method for preparing the nicotinamide ribose, through the arrangement of the treatment component, when high-temperature water is injected into the water circulation component I, the water can be introduced into the circular pipe, the drying box is heated, the temperature of the water is further utilized, and the drug can be conveniently dried in the preparation process.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic view of the internal structure of the present invention;
FIG. 3 is an enlarged view of the structure at A in FIG. 2 according to the present invention;
fig. 4 is a partial structural diagram of the inside of the case in the present invention.
In the figure: 1. a housing assembly; 11. a base; 12. a barrel body; 13. a feed pipe; 2. a connecting assembly; 21. a tray body; 22. a water collection pipe; 23. a clamping block; 24. a first pipe body; 25. a second pipe body; 26. a telescopic pipe; 27. a spring; 28. a protrusion; 3. a processing component; 31. a box body; 32. a drying oven; 33. a pipe body III; 34. a pipe body IV; 35. a separation column; 36. a groove; 37. a ring pipe; 38. a pipe body V; 4. a water circulation component I; 41. a sixth pipe body; 42. a water guide part; 43. a first circulating part; 44. a pipe body seven; 45. a first connecting end; 5. a water circulation component II; 51. a second circulating part; 52. a second connecting end; 6. a water tank; 7. a mixing assembly; 71. a motor; 72. a first gear; 73. a second gear; 74. a shaft body; 75. stirring the leaves.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-4, an apparatus for preparing nicotinamide riboside includes a housing assembly 1, a connecting assembly 2, a treating assembly 3, a water circulation assembly 4, a water circulation assembly 5, a water tank 6 and a mixing assembly 7;
the shell assembly 1 comprises a base 11, a barrel body 12 and a feeding pipe 13, wherein the barrel body 12 is arranged at the top of the base 11, the feeding pipe 13 is connected with the top of the barrel body 12, the treatment assembly 3 is arranged at the top of the base 11, the connecting assembly 2 is arranged at the top of the barrel body 12, a water circulation assembly II 5 is arranged inside the barrel body 12, and a water tank 6 is arranged inside the base 11;
the mixing assembly 7 comprises a motor 71, a first gear 72, a second gear 73, a shaft body 74 and a mixing blade 75, the motor 71 is arranged inside the base 11, an output shaft of the motor 71 is connected with the first gear 72, the shaft body 74 is rotatably connected on the base 11 and the barrel body 12, the second gear 73 is connected to the outer side wall of the shaft body 74, the second gear 73 is meshed with the first gear 72, the mixing blades 75 are regularly arranged on the outer side wall of the shaft body 74, a first water circulation assembly 4 is arranged inside the shaft body 74 and the mixing blade 75, and the motor 71 is electrically connected with an external power supply.
In this embodiment, specifically, the water circulation component two 5 includes a circulation part two 51 and a connection end two 52, two circulation parts two 51 are disposed inside the barrel body 12, one end of the circulation part two 51 is connected to the circulation part two 51, and the other end is connected to the water tank 6;
the water circulation assembly II 5 is additionally arranged on the inner container layer of the barrel body 12, water is injected into the connecting assembly 2, the water surrounds the outer side wall of the barrel body 12 through the circulation portion II 51, the temperature in the barrel body 12 is changed, and after the circulation portion II is surrounded, the water is guided into the water tank 6 to be concentrated.
In this embodiment, specifically, the first water circulation assembly 4 includes a tube body six 41, a water guide portion 42, a circulation portion one 43, a tube body seven 44 and a connection end one 45, the tube body six 41 is disposed inside the shaft body 74, the circulation portion one 43 is disposed inside the stirring blade 75, the tube body six 41 is connected with the circulation portion one 43 through the water guide portion 42, the tube body seven 44 is disposed at the top of the tube body six 41, and the tube body seven 44 is connected with the connection end one 45;
the water circulation component I4 is added on the basis of the water circulation component II 5, when the circulation part II 51 works, water is injected into the pipe body seven 44, the pipe body seven 44 collects the water into the pipe body six 41, the pipe body six 41 disperses the water into the water guide part 42, the water guide part 42 disperses the water into the two circulation part I43, in the introducing process, the circulation part I43 is in a rotating state, when the circulation part I43 rotates to the water outlet of the water guide part 42, water flow is introduced into the circulation part I43, the water flow passes through the circulation part I43 for one circle and then is introduced into the water guide part 42 again, finally the water is discharged through the pipe body six 41, the water guide part 42 is of a hollow cylinder structure, and four liquid outlet holes are symmetrically formed in the outer side wall.
In this embodiment, specifically, the connection assembly 2 includes a tray body 21, a water collection pipe 22, a first pipe body 24 and a second pipe body 25, the tray body 21 is arranged on the top surface inside the barrel body 12, the seventh pipe body 44 is located inside the barrel body 12, the tray body 21 is arranged on the top of the barrel body 12, the inner side wall of the tray body 21 is slidably connected with the water collection pipe 22, and the first pipe body 24 and the second pipe body 25 are symmetrically arranged on the outer side wall of the water collection pipe 22;
be provided with coupling assembling 2 between two hydrologic cycle subassemblies, when using hydrologic cycle subassembly two 5, with two 25 butt joint end two 52 of body, when using hydrologic cycle subassembly one 4, rotatory and press collector pipe 22, with a 24 butt joint end 45 of body, make hydrologic cycle subassembly one 4 obtain work to adopt two hydrologic cycle subassemblies of mode fast switch-over that rotatory was pressed, be convenient for the temperature of the interior liquid of quick change staving 12.
In this embodiment, specifically, a fixture block 23 is disposed on an outer side wall of the water collecting pipe 22, a protrusion 28 matched with the fixture block 23 is disposed on an outer side wall of the tray body 21, and an extension pipe 26 and a spring 27 are disposed at the bottom of the water collecting pipe 22;
when the water collecting pipe 22 is rotated and pressed, the spring 27 and the extension pipe 26 are deformed, the clamping block 23 is clamped in the protrusion 28, so that the water collecting pipe 22 is stable, and when the water collecting pipe is switched to the second water circulation assembly 5, the water collecting pipe 22 is quickly reset by the elastic reset of the spring 27 and the assistance of the extension pipe 26, and is in butt joint with the second water circulation assembly 5.
In this embodiment, specifically, the processing assembly 3 includes a box 31, a drying box 32, a tube body three 33, a tube body four 34, a separation column 35, a groove 36, a ring pipe 37, and a tube body five 38, the box 31 is disposed on the top of the base 11, the groove 36 is disposed on the top of the box 31, the separation column 35 is disposed in the groove 36, the drying box 32 is disposed inside the box 31, the tube body three 33 is disposed on the top of the drying box 32, the ring pipe 37 is surrounded on the outer side wall of the drying box 32, the ring pipe 37 is connected with the tube body six 41 through the tube body four 34, and the ring pipe 37 is connected with the water tank 6 through the tube body five 38;
when the water in the six 41 pipe bodies is led out, the water has a certain temperature, the water is led into the circular pipe 37 through the four 34 pipe bodies, the drying box 32 is heated, the temperature in the drying box 32 is increased, and the drying box 32 is used for drying the nicotinamide ribose crude product.
A method for preparing nicotinamide riboside equipment, comprising the following steps:
s1: preparation of intermediate 2: the raw materials are distributed into the barrel body 12, the mixing assembly 7 is controlled to work, dissolving liquid ribose is put in the mixing process, water with the temperature of 12 ℃ is injected into the water circulation assembly II 5, the temperature of the liquid in the barrel body 12 is increased, when the liquid in the barrel body 12 reaches 12 ℃, silicone grease is added, the water with the temperature of 50 ℃ is replaced, and the barrel body 12 is heated again through the water circulation assembly II 5;
s2: intermediate 2 was mixed with methanol: injecting low-temperature water into the water circulation assembly I4, reducing the temperature in the barrel body 12 to 25 ℃, adding methanol in a funnel mode to obtain a nicotinamide ribose crude product, and obtaining high-purity nicotinamide ribose by adopting the work of the treatment assembly 3.
The working principle is as follows: when the water circulation component II 5 works, the water collection pipe 22 is pressed and rotated to enable the two pipe bodies 24 to be respectively butted with the two first connecting ends 45 and to enable the water to be led into the water collection pipe 22 again, the water is led into the water collection pipe 22, the pipe bodies 24 are respectively butted with the two first connecting ends 45, the water is led into the water collection pipe 22 again, the pipe bodies 25 and the second connecting ends 52 are not in a butted state, the water is led into the pipe body seven 44, the pipe body seven 44 concentrates the water into the pipe body six 41, and the water is dispersed into the first circulating part 43 through the water guide part 42, the liquid in the staving 12 is heated to the water in the circulation portion 43, and by the rotation of axis body 74, with the temperature in the circulation portion 43 disperse to liquid fast in, when the water in the six 41 of body is derived, the constant temperature in the water still, lead into the ring pipe 37 through the four 34 of body with water, heat drying cabinet 32, make temperature rise in the drying cabinet 32, finally through the five 38 of body, lead into water tank 6 with water, but the user real time control water of water tank 6, lead into in water circulation subassembly 4 or water circulation subassembly two 5 with the water in the water tank 6.
In the present embodiment, the first and second electrodes are,
although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. An apparatus for preparing nicotinamide riboside, characterized in that: the device comprises a shell component (1), a connecting component (2), a processing component (3), a water circulation component I (4), a water circulation component II (5), a water tank (6) and a mixing component (7);
the shell assembly (1) comprises a base (11), a barrel body (12) and a feeding pipe (13), the barrel body (12) is arranged at the top of the base (11), the feeding pipe (13) is connected with the top of the barrel body (12), the treatment assembly (3) is arranged at the top of the base (11), the connecting assembly (2) is arranged at the top of the barrel body (12), the water circulation assembly II (5) is arranged inside the barrel body (12), and the water tank (6) is arranged inside the base (11);
the mixing assembly (7) comprises a motor (71), a first gear (72), a second gear (73), a shaft body (74) and stirring blades (75), the motor (71) is arranged in the base (11), an output shaft of the motor (71) is connected with the first gear (72), the base (11) and the barrel body (12) are connected with the shaft body (74) in a rotating mode, the outer side wall of the shaft body (74) is connected with the second gear (73), the second gear (73) is meshed with the first gear (72) and is connected with the first gear (72), the stirring blades (75) are arranged on the outer side wall of the shaft body (74) in a regular mode, the first water circulation assembly (4) is arranged in the shaft body (74) and the stirring blades (75), and the motor (71) is electrically connected with an external power supply.
2. The apparatus for producing nicotinamide ribose according to claim 1, wherein: the water circulation assembly II (5) comprises a circulation part II (51) and a connecting end II (52), two circulation part II (51) are arranged in the barrel body (12), one end of the circulation part II (51) is connected with the circulation part II (51), and the other end of the circulation part II (51) is connected with the water tank (6).
3. The apparatus for producing nicotinamide riboside of claim 2, wherein: the water circulation assembly I (4) comprises a pipe body six (41), a water guide portion (42), a circulation portion I (43), a pipe body seven (44) and a connecting end I (45), the pipe body six (41) is arranged inside the shaft body (74), the circulation portion I (43) is arranged inside the stirring blade (75), the pipe body six (41) and the circulation portion I (43) are connected through the water guide portion (42), the pipe body seven (44) is arranged at the top of the pipe body six (41), and the pipe body seven (44) is connected with the connecting end I (45).
4. The apparatus for producing nicotinamide riboside of claim 3, wherein: coupling assembling (2) include disk body (21), collector pipe (22), body one (24) and body two (25), the inside top surface of staving (12) is provided with disk body (21), body seven (44) are located the inside of staving (12), the top of staving (12) is provided with disk body (21), the inside wall sliding connection of disk body (21) collector pipe (22), the lateral wall symmetry of collector pipe (22) is provided with body one (24) with body two (25).
5. The apparatus for producing nicotinamide riboside of claim 4, wherein: the outer side wall of the water collecting pipe (22) is provided with a clamping block (23), the outer side wall of the tray body (21) is provided with a bulge (28) matched with the clamping block (23), and the bottom of the water collecting pipe (22) is provided with an expansion pipe (26) and a spring (27).
6. The apparatus for producing nicotinamide ribose according to claim 5, wherein: the treatment component (3) comprises a box body (31), a drying box (32), a pipe body III (33), a pipe body IV (34), a separation column (35), a groove (36), a ring pipe (37) and a pipe body V (38), wherein the box body (31) is arranged at the top of the base (11), the groove (36) is formed in the top of the box body (31), the separation column (35) is arranged in the groove (36), the drying box (32) is arranged in the box body (31), the pipe body III (33) is arranged at the top of the drying box (32), the ring pipe (37) is encircled on the outer side wall of the drying box (32), the ring pipe (37) is connected with the pipe body VI (41) through the pipe body IV (34), and the ring pipe (37) is connected with the water tank (6) through the pipe body V (38).
7. A method for producing nicotinamide ribose comprising the apparatus for producing nicotinamide ribose of any one of claims 1 to 6, comprising the steps of:
s1: preparation of intermediate 2: distributing the raw materials into a barrel body (12), controlling a mixing assembly (7) to work, putting solution ribose in the mixing process, injecting water at the temperature of 12 ℃ into a water circulation assembly II (5), so that the temperature of the liquid in the barrel body (12) is increased, adding silicone grease when the liquid in the barrel body (12) reaches 12 ℃, replacing the water at the temperature of 50 ℃, and heating the barrel body (12) again by the water circulation assembly II (5);
s2: intermediate 2 was mixed with methanol: injecting low-temperature water into the water circulation assembly I (4), reducing the temperature in the barrel body (12) to 25 ℃, adding methanol in a funnel mode to obtain a nicotinamide ribose crude product, and obtaining high-purity nicotinamide ribose by adopting the work of the treatment assembly (3).
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| CN202111251718.4A CN113908792A (en) | 2021-10-25 | 2021-10-25 | Equipment and method for preparing nicotinamide ribose |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB580290A (en) * | 1943-06-26 | 1946-09-03 | British Thomson Houston Co Ltd | Improvements in and relating to heat exchangers such as surface condensers |
| CN2830828Y (en) * | 2005-03-25 | 2006-10-25 | 黄兴耀 | Full automatic shaft-type multi-way control valve |
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