CN113908787A - Micro-reaction channel structure and acoustic micro-reactor and chemical production system based on same - Google Patents
Micro-reaction channel structure and acoustic micro-reactor and chemical production system based on same Download PDFInfo
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- CN113908787A CN113908787A CN202111400924.7A CN202111400924A CN113908787A CN 113908787 A CN113908787 A CN 113908787A CN 202111400924 A CN202111400924 A CN 202111400924A CN 113908787 A CN113908787 A CN 113908787A
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- 238000006243 chemical reaction Methods 0.000 title claims abstract description 34
- 238000012824 chemical production Methods 0.000 title claims abstract description 19
- 239000007787 solid Substances 0.000 claims abstract description 58
- 239000007788 liquid Substances 0.000 claims abstract description 41
- 239000000919 ceramic Substances 0.000 claims abstract description 15
- 239000000758 substrate Substances 0.000 claims abstract description 14
- 239000012530 fluid Substances 0.000 claims description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- -1 polydimethylsiloxane Polymers 0.000 claims description 5
- 229910052710 silicon Inorganic materials 0.000 claims description 5
- 239000010703 silicon Substances 0.000 claims description 5
- 239000004793 Polystyrene Substances 0.000 claims description 4
- 229920002223 polystyrene Polymers 0.000 claims description 4
- 239000011521 glass Substances 0.000 claims description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 claims description 3
- 239000004926 polymethyl methacrylate Substances 0.000 claims description 3
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 3
- 238000005728 strengthening Methods 0.000 claims description 3
- 239000000126 substance Substances 0.000 abstract description 9
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 229920000642 polymer Polymers 0.000 abstract 1
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- 239000011859 microparticle Substances 0.000 description 3
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0053—Details of the reactor
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Abstract
The invention discloses a micro-reaction channel structure, an acoustic micro-reactor based on the micro-reaction channel structure and a chemical production system, and relates to the field of manufacturing and application of chemical reaction equipment. The design working scheme of the acoustic microreactor comprises the following steps: the micro-channel is characterized in that a substrate and a polymer block with a groove are combined to form a micro-channel with a micron or millimeter scale, at least two liquid inlets are formed in the micro-channel, and one or more free solid microstructures with a certain opening degree are arranged in the micro-channel. When the mixed liquid flows through the solid microstructure, micro bubbles are generated at the opening of the solid microstructure due to the action of surface tension. By arranging the piezoelectric ceramic transducer near the micro-channel, the micro-bubbles resonate at a certain working frequency to generate acoustic current, so that the liquid mixing and reaction processes are promoted. The invention solves the technical problems of single controllability and low efficiency of the micro-reactor chemical equipment, and can achieve the purpose of improving the chemical production efficiency and quality.
Description
Technical Field
The invention belongs to the technical field of manufacturing and application of chemical reaction equipment, and particularly relates to a micro-reaction channel structure, and an acoustic micro-reactor and a chemical production system based on the micro-reaction channel structure.
Background
Mixing and reaction equipment is one of the devices commonly used in the chemical field. The traditional macroscopic chemical production equipment has the problems of long mixing and reaction time, low raw material utilization rate, high energy consumption and low yield due to low heat and mass transfer efficiency, and the development of the chemical industry is severely limited.
In recent years, microreactors have received increasing attention from researchers as a kind of micro-device manufactured by means of microfabrication technology. Compared with the traditional macroscopic chemical production equipment, the microreactor with the narrow microchannel has the main advantages of large specific surface area, and the increase of the specific surface area can not only shorten the heat and mass transfer distance, but also strengthen the mixing and reaction process, thereby having very important significance for improving the development level of the chemical industry. However, most of the existing microreactors have lower Reynolds numbers, so that the liquid in the microchannel is in a laminar flow state, which is not beneficial to improving the chemical production efficiency. In addition, the existing micro-reactor chemical equipment also has the technical problems of single controllability, low efficiency and the like, and in order to achieve the purpose of improving the chemical production efficiency and quality, the channel structure and the operating conditions of the micro-reactor must be designed and improved in a targeted manner.
The sound wave has shown great application potential in the biomedical field due to the advantages of no contact, controllable energy density, good biocompatibility and the like. Patent CN107533056A indicates that surface acoustic waves can be used for manipulating particles in liquid media, and antigen binding and antibody in-situ modification are performed by using the surface acoustic waves, so that a new idea is provided for immunoassay and biological detection. In addition, acoustic waves have been shown to resonate micro-scale solids, liquids, and gases at certain operating frequencies. In particular, for microbubbles in a liquid medium, the friction generated at the gas-liquid interface by the oscillation of the microbubbles can cause the liquid to generate a strong circulation around the microbubbles. The phenomenon has great application potential in the liquid mixing and reaction process, but at present, effective micro-bubble-based acoustic micro-reactor equipment is not only lacked, but also no precedent is tried in the chemical production field.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a micro-reaction channel structure, and an acoustic micro-reactor and a chemical production system based on the micro-reaction channel structure. The invention solves the problems of single controllability and low efficiency commonly existing in the traditional macroscopic chemical production equipment and the existing micro chemical reactor, and can achieve the purpose of improving the chemical production efficiency and quality.
In order to achieve the purpose, the invention adopts the following technical scheme to realize the purpose:
the invention provides a micro-reaction channel structure, which comprises a substrate, wherein a micro-channel with the characteristic dimension of 0.1mm-3mm is arranged on the substrate, and one or more free solid microstructures are arranged in the micro-channel; one end of the micro-channel is provided with a liquid inlet, and the other end is provided with a liquid outlet;
the free solid microstructures are positioned in the micro-channel or arranged on two side walls of the micro-channel; the width of the free solid microstructure is 1/5-4/5 of the width of the micro channel;
the shape of the free solid microstructure is one or a combination of several of arrow-shaped, L-shaped, circular, crescent or V-shaped;
the free solid microstructure has a flare of 10 to 170 degrees.
Further, the free solid microstructures and microchannels are made of polydimethylsiloxane, polymethylmethacrylate, polyvinyl chloride, or polystyrene.
Further, the substrate is made of glass or silicon wafer.
Furthermore, the shape of the micro-channel is one or a combination of several of straight shape, arc shape, fold line shape, S shape, wave shape, ring shape or spiral shape.
Furthermore, the number of the liquid inlets is at least two, Y-shaped, T-shaped, U-shaped or psi-shaped is formed between different liquid inlets, and the mixed liquid enters the microchannel through the liquid inlets.
The invention also discloses an acoustic micro-reactor consisting of the micro-reaction channel structure, wherein the acoustic micro-reactor adopts one or more piezoelectric ceramic transducers as an active strengthening module, and the linear distance between the piezoelectric ceramic transducers and the micro-channel is not more than 3cm and is arranged on the same substrate; the working frequency of the piezoelectric ceramic transducer is 3 kHz-300 KHz.
Further, the total flow rate of the mixing fluid in the micro-channel in the acoustic micro-reactor is 0.001 mL/min-20 mL/min.
The invention also discloses a chemical production system which comprises the acoustic microreactor.
Compared with the prior art, the invention has the following beneficial effects:
compared with the traditional microreactor channel, the micro-reaction channel structure provided by the invention has the characteristic dimension of 0.1-3 mm, so that the volume of a single microreactor device is greatly reduced; the micro-channel is internally provided with a free solid microstructure, when mixed liquid flows through the solid microstructure, micro-bubbles are generated at the opening of the solid microstructure under the action of surface tension and vibrate under the excitation of a sound field, so that different liquids are vigorously mixed, and the reaction efficiency is improved.
The invention also provides an acoustic micro-reactor based on the micro-reaction channel structure, one or more piezoelectric ceramic transducers are used as an active strengthening module, mixed liquid generates micro-bubbles after flowing through a free solid microstructure, and the micro-bubbles resonate to generate acoustic current under a certain working frequency of the ceramic ring energy device, so that the heat and mass transfer efficiency is greatly improved; meanwhile, due to the strong stirring action of the sounding bubbles, solid products in the micro-channel are easy to remove from the micro-channel, so that the problem of blockage of the micro-reactor is effectively solved, and the aim of improving the chemical production efficiency and quality is fulfilled; in addition, the acoustic microreactor can control the mixing degree by adjusting the flow velocity, and can adjust the mixing degree by applying a frequency value, a frequency type and a working voltage to the piezoelectric ceramic transducer, so that the flexibility and the diversity of micro-chemical control are realized.
Drawings
FIG. 1 is a schematic diagram of a micro-reaction channel having a solid microstructure with a free arrowhead shape in a straight micro-reaction channel according to the present invention;
FIG. 2 is a schematic diagram of a micro-reaction channel having a solid microstructure with a free arrowhead shape in an arc-shaped micro-reaction channel according to the present invention;
FIG. 3 is an acoustic micro-reaction channel structure with different shapes of free solid microstructures in the micro-reaction channel according to the present invention;
wherein A-L is shaped; b-circular ring shape; c-crescent shape; D-V shape;
FIG. 4 is a schematic representation of an acoustic microreactor having solid microstructures in the form of free arrowheads in straight microreactor channels in some embodiments of the present invention in the absence of a fluid;
FIG. 5 is a schematic representation of an acoustic microreactor having solid microstructures in the form of free arrowheads in straight microreactor channels in some embodiments of the present invention in the presence of microbubbles formed in a fluid;
FIG. 6 is a fluid mixing process of an acoustic microreactor having a solid microstructure with a free arrowhead shape in a straight microreactor channel under soundless field conditions in some embodiments of the invention;
FIG. 7 is a fluid mixing process of an acoustic microreactor having a solid microstructure with a free arrowhead shape in a straight microreactor channel under an acoustic field condition in some embodiments of the present invention;
FIG. 8 is a particle motion trajectory of an acoustic microreactor having a solid microstructure in the shape of a free arrow in a straight microreactor channel under soundless field conditions in some embodiments of the invention;
FIG. 9 is a particle motion trajectory of an acoustic microreactor having a free arrowhead-shaped solid microstructure in a straight microreactor channel under an acoustic field condition in some embodiments of the present invention;
wherein: 1-a substrate; 2-a microchannel; 3-free solid microstructure; 4-microbubbles; the openness of the alpha-free solid microstructure; d-solid microstructure width; d-microchannel width; the liquid A and the liquid B can be polar solutions and nonpolar solutions of any chemical reagents or chemical raw materials.
Detailed Description
In order to make the technical solutions of the present invention better understood, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that the terms "first," "second," and the like in the description and claims of the present invention and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
The invention is described in further detail below with reference to the accompanying drawings:
example 1:
in a typical embodiment of the present application, as shown in fig. 1, a micro-reaction channel structure comprises a substrate 1 made of glass, a polydimethylsiloxane straight micro-channel 2 made of polydimethylsiloxane, and free arrow-shaped solid microstructures 3 free from the micro-channel on two side walls of the micro-channel. After the chemical production liquid flows through the free solid microstructure, micro-bubbles 4 are generated due to surface tension, the arrow-shaped solid microstructure is distributed in the center of the inside of the micro-channel, the opening degree alpha is 30 degrees, the maximum width D of the solid microstructure is about 1/3 of the width D of the micro-channel, and Y-shaped structures are formed among different liquid inlets 5.
A piezoelectric ceramic transducer is closely arranged in the micro-reaction channel, the working frequency of the transducer is 5.5kHz, the transducer is driven by a signal amplifier and a signal generator, and the total flow rate of the mixed liquid in the micro-channel 2 is 0.001mL/min, so that an acoustic micro-reactor is formed.
Example 2:
example 2 is essentially the same as the device system of example 1, except that: as shown in fig. 2, arc-shaped micro-channels 2 are formed from polydimethylsiloxane, and free arrowhead-shaped solid microstructures 3 are dispersed inside the arc-shaped micro-channels 2.
Example 3:
example 3 is essentially the same as the device system of example 1, except that: as shown in fig. 3A, the free solid microstructure 3 is L-shaped.
Example 4:
example 4 is essentially the same as the device system of example 1, except that: as shown in fig. 3B, the free solid microstructure 3 is circular.
Example 5:
example 5 is essentially the same as the device system of example 1, except that: as shown in fig. 3C, the free solid microstructure 3 is crescent-shaped.
Example 6:
example 6 is essentially the same as the device system of example 1, except that: as shown in fig. 3D, the free solid microstructures 3 are V-shaped.
Example 7:
example 7 is essentially the same as the device system of example 1, except that: the substrate 1 is made of a silicon wafer, the polymethyl methacrylate-shaped wavy micro-channel 2 and the opening degree alpha of the free solid microstructure 3 are 120 degrees.
Example 8:
example 8 is essentially the same as the device system of example 2, except that: the maximum width D of the free solid microstructure 3 is 4/5 of the width D of the micro-channel, and the working frequency of the piezoelectric ceramic transducer is 95 kHz.
Example 9:
example 9 is essentially the same as the device system of example 3, except that: polymethyl methacrylate forms spiral microchannels 2 and the shape of the free solid microstructures 3 are arrow-shaped and V-shaped.
Example 10:
example 10 is essentially the same as the device system of example 4, except that: the solid microstructures 3 are irregularly distributed in the inside of the microchannel, the shape of the microchannel 2 is S-shaped, and the maximum width D of the free solid microstructures 3 is 1/5 of the width D of the microchannel 2.
Example 11:
a micro-reaction channel structure comprises a substrate 1 made of a silicon wafer, a polyvinyl chloride zigzag-shaped micro-channel 2, and free arrow-shaped solid micro-structures 3 which are free from the micro-channel and are arranged on two side walls of the micro-channel. After the chemical production liquid flows through the arrow-shaped solid microstructure 3, micro-bubbles 4 are generated due to surface tension, the arrow-shaped solid microstructure 3 is randomly distributed in the microchannel 2, the opening degree alpha is 10 degrees, the maximum width D of the solid microstructure is 1/5 of the width D of the microchannel, and a T shape is formed between the liquid inlets 5.
A piezoelectric ceramic transducer is arranged near the micro-reaction channel structure, the working frequency of the transducer is 300kHz, the transducer is driven by a signal amplifier and a signal generator, and the total flow rate of the mixed liquid in the micro-channel 2 is 20mL/min, so that an acoustic micro-reactor is formed.
Example 12:
a micro-reaction channel structure comprises a substrate 1 made of a silicon wafer, a polystyrene annular micro-channel 2 and free crescent solid microstructures 3 which are free from the micro-channel and are arranged on two side walls of the micro-channel. After the chemical production liquid flows through the crescent solid microstructures 3, micro-bubbles 4 are generated due to surface tension, the crescent solid microstructures 3 are randomly distributed in the micro-channel 2, the opening degree alpha is 170 degrees, the maximum width D of each solid microstructure is 4/5 of the width D of the micro-channel, and a U shape is formed between the liquid inlets 5.
A piezoelectric ceramic transducer is arranged at the position 3cm away from the micro-reaction channel structure, the working frequency of the transducer is 3kHz, the transducer is driven by a signal amplifier and a signal generator, and the total flow rate of the mixed liquid in the micro-channel 2 is 0.001mL/min, so that an acoustic micro-reactor is formed.
Example 13
Example 8 is essentially the same as the device system of example 2, except that: the material is a polystyrene arc-shaped micro-channel 2, and two side walls of the micro-channel are provided with free circular solid micro-structures 3 which are free from the micro-channel. The opening degree alpha of the free solid microstructure 3 is 80 degrees, a psi shape is formed between the liquid inlets 5, the working frequency of the piezoelectric ceramic transducer is 100kHz, and the total flow rate of the mixed liquid in the microchannel 2 is 10 mL/min.
Experiments using the acoustic microreactor of example 1 are shown in fig. 4, where there are relatively distinct free arrowhead-shaped solid microstructures 3 in microchannel 2 in the absence of solution. When liquid is injected into the microchannel 2, as shown in fig. 5, due to the action of surface tension, the gas in the microchannel 2 is retained in the space formed by the free solid microstructures 3 and the inner wall of the microchannel 2 to form microbubbles 4.
In the experiment using the acoustic microreactor in example 1, under soundfield-free conditions, as shown in fig. 6, the solutions a and B were in a laminar state in the microchannel 2, and no significant mixing was observed. When the sound field is generated by driving of the signal amplifier and the signal generator, instantaneous mixing of the solution a and the solution B can be achieved in the microchannel 2 as shown in fig. 7.
Experiments were performed using the acoustic microreactor of example 1, illustrating chemical mixing and reaction processes by tracing the path of the microparticles within microchannel 2. As shown in FIG. 8, the micro-particles have a distinct linear motion track in the micro-channel under the soundless field condition, which indicates that the liquid in the micro-channel 2 is in a laminar state under the soundless field condition, and there is no distinct mixing effect. As shown in fig. 9, when the sound field is generated by the driving of the signal amplifier and the signal generator, the micro-particles generate a distinct circular motion track near the micro-bubbles 4 in the micro-channel 2, which indicates that a strong sound flow can be generated in the micro-channel under the action of the sound field, so that the liquid in the micro-channel can be instantly mixed.
The above-mentioned contents are only for illustrating the technical idea of the present invention, and the protection scope of the present invention is not limited thereby, and any modification made on the basis of the technical idea of the present invention falls within the protection scope of the claims of the present invention.
Claims (8)
1. A micro-reaction channel structure is characterized by comprising a substrate (1), wherein a micro-channel (2) with the characteristic dimension of 0.1mm-3mm is arranged on the substrate (1), and one or more free solid micro-structures (3) are arranged in the micro-channel (2); one end of the micro-channel (2) is provided with a liquid inlet (5), and the other end is provided with a liquid outlet (6);
the free solid microstructures (3) are positioned in the micro-channel (2) or arranged on two side walls of the micro-channel (2); the width of the free solid microstructure (3) is 1/5-4/5 of the width of the microchannel (2);
the shape of the free solid microstructure (3) is one or a combination of several of arrow-shaped, L-shaped, circular, crescent-shaped and V-shaped;
the free solid microstructure (3) has an opening degree of 10-170 degrees.
2. A micro-channel structure according to claim 1, wherein the free solid microstructures (3) and the micro-channels (2) are made of polydimethylsiloxane, polymethylmethacrylate, polyvinyl chloride or polystyrene.
3. A micro-reaction-channel-structure according to claim 1, characterized in that the substrate (1) is made of glass or silicon wafer.
4. A micro-channel structure according to claim 1, wherein the micro-channel (2) is in the shape of one or a combination of straight, curved, zigzag, S-shaped, wavy, circular or spiral.
5. The microchannel structure of claim 1, wherein the number of the liquid inlets (5) is at least two, and different liquid inlets (5) form a Y-shape, a T-shape, a U-shape or a psi-shape therebetween, and the mixed liquid is introduced into the microchannel (2) through the liquid inlets (5).
6. An acoustic microreactor composed of the micro-reaction channel structure according to any one of claims 1 to 5, wherein the acoustic microreactor adopts one or more piezoelectric ceramic transducers as active strengthening modules, and the linear distance between the piezoelectric ceramic transducers and the microchannel (2) is not more than 3cm and is on the same substrate (1); the working frequency of the piezoelectric ceramic transducer is 3 kHz-300 KHz.
7. An acoustic microreactor according to claim 6, wherein the total flow rate of the mixing fluid in the microchannel (2) of the acoustic microreactor is between 0.001mL/min and 20 mL/min.
8. A chemical production system comprising the acoustic microreactor of claim 6 or 7.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2623589A1 (en) * | 2012-02-06 | 2013-08-07 | Centre National de la Recherche Scientifique | Method of forming a multilayer aggregate of objects |
| WO2015006684A2 (en) * | 2013-07-11 | 2015-01-15 | The Penn State Research Foundation | Apparatuses and methods for modulating fluids using acoustically oscillating solid structures |
| CN111647012A (en) * | 2020-04-24 | 2020-09-11 | 浙江大学 | Method for preparing alkylaluminoxane by using microreactor |
| CN111686665A (en) * | 2019-03-15 | 2020-09-22 | 南京延长反应技术研究院有限公司 | Micro-interface enhanced reaction system |
-
2021
- 2021-11-19 CN CN202111400924.7A patent/CN113908787A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2623589A1 (en) * | 2012-02-06 | 2013-08-07 | Centre National de la Recherche Scientifique | Method of forming a multilayer aggregate of objects |
| WO2015006684A2 (en) * | 2013-07-11 | 2015-01-15 | The Penn State Research Foundation | Apparatuses and methods for modulating fluids using acoustically oscillating solid structures |
| CN111686665A (en) * | 2019-03-15 | 2020-09-22 | 南京延长反应技术研究院有限公司 | Micro-interface enhanced reaction system |
| CN111647012A (en) * | 2020-04-24 | 2020-09-11 | 浙江大学 | Method for preparing alkylaluminoxane by using microreactor |
Non-Patent Citations (2)
| Title |
|---|
| PO-HSUN HUANG: "A spatiotemporally controllable chemical gradient generator via acoustically oscillating sharp-edge structures", 《LAB ON A CHIP》 * |
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Application publication date: 20220111 |