CN113907871A - Tumor ablation microwave device for multi-nuclide MRI real-time detection and using method - Google Patents
Tumor ablation microwave device for multi-nuclide MRI real-time detection and using method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1869—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument interstitially inserted into the body, e.g. needles
Abstract
The invention provides a tumor ablation microwave device for multi-core MRI real-time detection and a use method thereof, the ablation microwave device comprises a heat-conducting nonmagnetic shielding case, a control panel, a master control module, a power supply module and a microwave generation module are sequentially arranged in the shielding case from top to bottom, the shielding case is provided with a power supply input port and a microwave power output port, the power supply input port is connected with the input end of the power supply module through an EMI filter, the output end of the power supply module is respectively and electrically connected with the control panel, the microwave generation module and the master control module, the master control module is electrically connected with the microwave generation module, the output end of the microwave generation module is connected with the microwave power output port, and the microwave power output port is connected with a microwave ablation needle through an isolator; when in use, the temperature obtained by the MRI temperature measurement sequence is corrected based on the system temperature deviation table. The invention is compatible with a magnetic resonance imaging system and realizes real-time noninvasive temperature measurement of a tumor ablation area and peripheral tissues.
Description
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a tumor ablation microwave device for multi-core MRI real-time detection and a using method thereof.
Background
The existing MRI imaging devices are single-frequency single-nuclear-element imaging systems, the information contained in the existing MRI imaging devices is single, and the existing MRI imaging devices cannot reflect multi-molecular events generated by tumors in organisms; the multi-nuclide multi-frequency magnetic resonance synchronous imaging system can detect multi-molecule events which drive the tumor to generate and develop together, such as dynamic balance of tumor ions, energy metabolism, change of molecular targets, change of tumor microenvironment and the like, and can obtain more direct, comprehensive and accurate image data compared with the traditional MRI in the prior art.
Compared with the imaging technologies such as X-ray, CT, ultrasound and the like, MRI has prominent advantages, mainly including: multiple parameters of MRI have temperature dependence and can detect the temperature change at body temperature noninvasively; monitoring the change of tumor signals in the ablation process in real time and evaluating the ablation effect; multi-parameter imaging, functional imaging, soft tissue resolution and contrast are better; the relation between the focus and the normal tissue can be clearly displayed, and the damage to nerves and blood vessels can be avoided to the maximum extent by MR guidance; ultrafast imaging sequences such as gradient echo (GRE), FLASH imaging, Echo Planar Imaging (EPI), single shot fast spin echo, etc., make MR images reach the goal of near real-time display.
MRI has now been widely used for image guidance of microwave ablation because of its above-mentioned advantages. However, the conventional microwave ablation system and the magnetic resonance imaging system are not compatible, and some key components and signal transmission modes in the conventional microwave ablation system and the magnetic resonance imaging system can generate electromagnetic interference when working in connection with MRI, so that the image quality and the ablation effect are influenced. The existing real-time temperature measurement for tumor microwave ablation is realized by installing a temperature measurement module in a microwave ablation instrument and realizing real-time temperature feedback in an ablation process through a temperature sensor. However, this mode of operation feeds back the temperature at the interface only at the local temperature of the ablation antenna tip, not the bulk temperature of the tumor ablation region, which will also have the following effect: if the tumor volume is large, only the needle tip part and the tumor tissues around the needle tip part are completely ablated when the tumor volume reaches the set temperature, but the tumor tissues at the far end cannot reach the set ablation temperature, so that the tumor tissues are not completely killed; if the tumor is completely ablated, the microwave power or the ablation time must be increased, however, no matter whether the microwave power or the ablation time is increased or not, the microwave power or the ablation time reaches a certain level, and even local carbonization of tissues around the needle tip occurs, so that a good ablation effect cannot be realized.
Real-time non-invasive thermometry is also one of the advantages of magnetic resonance imaging. The ideal result of tumor thermal ablation is to completely inactivate tumor tissue and maximize the protection of surrounding healthy tissue, and real-time monitoring and control of tissue temperature during thermal ablation is essential. The accurate temperature control technology can guide an operator to timely adjust parameters of the heating equipment and stop heating time points, so that healthy tissues around the tumor can be protected to the maximum extent, and the ablation efficiency is improved. MRI has multiple temperature-related imaging parameters, allowing real-time measurement of temperature data of the lesion and surrounding tissue. The existing temperature measuring methods comprise the following steps: utilizing a temperature dependence on Diffusion Coefficient (DC); utilizing a temperature dependence on Proton Resonance Frequency (PRF); the temperature dependence of the longitudinal relaxation time T1 is used. The PRF is the most deeply researched, has high space-time resolution, presents a stable linear relation with temperature and is not changed due to different tissue types, but has low temperature measurement precision, so that an operator can easily introduce wrong evaluation to influence the ablation effect.
Therefore, a microwave ablation instrument which is completely compatible with MRI and a method which can accurately monitor the temperature of a tumor ablation area in real time in the ablation process are realized, and the method is of great importance for realizing good ablation effect. Aiming at the technical problems, the invention designs the tumor ablation microwave device for the real-time detection of the multi-nucleotide MRI and the use method thereof, so that the accuracy and the safety of the tumor microwave ablation are improved.
Disclosure of Invention
The invention provides a tumor ablation microwave device for multi-core MRI real-time detection and a using method thereof, which are compatible with a magnetic resonance imaging system and realize real-time noninvasive temperature measurement of a tumor ablation area and peripheral tissues.
The technical scheme of the invention is realized as follows:
many nuclide MRI real-time detection's tumour melts microwave device, including the heat conduction does not have the magnetic shielding machine case, control panel has set gradually from top to bottom in the shielding machine case, host system, power module, microwave generation module, be equipped with power input port and microwave power output port on the shielding machine case, power input port passes through the EMI wave filter and links to each other with power module's input, power module's output respectively with control panel, microwave generation module and host system electricity are connected, host system is connected with microwave generation module electricity, microwave generation module's output and microwave power output port are connected, microwave power output port passes through the isolator and connects the microwave ablation needle, host system is connected with control panel electricity, the last magnetism compatible display touch-sensitive screen that is provided with of control panel.
In contrast, a magnetically compatible infusion bottle support is arranged on the shielding case, the display touch screen is located at the upper end of the shielding case, universal wheels are arranged at four corners of the lower end of the shielding case, and a transverse handle is arranged on the front side of the shielding case.
Furthermore, an optical fiber transmitter connected with the main control module is further arranged in the shielding case, the optical fiber transmitter is connected with the display touch screen through a waveguide tube, and the display touch screen displays the microwave ablation power in real time.
Furthermore, the microwave generation module comprises a power control communication module, a transistor type solid microwave source, an amplifier, an output matching network circuit and a directional coupler which are sequentially connected, and the power control communication module is communicated with the main control module.
Furthermore, the main control module comprises a power control communication module, a microprocessor and a display communication module which are sequentially connected, the main control module is connected with the power control communication module of the microwave module, and the display communication module is connected with the display touch screen.
Furthermore, water tanks are arranged between the peripheries of the main control module, the power supply module and the microwave generation module and the inner wall of the shielding case, and radiators corresponding to the positions of the water tanks are arranged on the peripheries of the outer wall of the shielding case.
The use method of the tumor ablation microwave device for multi-nuclide MRI real-time detection comprises the following steps: firstly, preparing an agar imitation, placing the agar imitation in a radio frequency coil, heating the agar imitation by utilizing microwave ablation of a microwave ablation device, measuring the temperature of the agar imitation at the periphery of a microwave ablation needle by adopting an MRI temperature measurement sequence and a temperature measurement probe, selecting a pixel set closest to the temperature measurement probe as an ROI (region of interest) during MRI temperature measurement, then averaging phase values of pixels in the ROI, calculating a temperature value of the temperature measurement result as a PRF temperature measurement result based on the dependency relationship between proton resonance frequency and temperature, and combining the temperature measurement result with the temperature measurement result measured by the temperature measurement probe to construct a system temperature deviation table; and correcting the temperature obtained by the MRI thermometry sequence based on the system temperature deviation table.
The invention has the beneficial effects that:
(1) the movable microwave ablation device integrating the microwave ablation instrument host and the microwave ablation needle can adjust the position of the device according to the ablation requirements of different parts of different patients, thereby reducing the body position limitation in the ablation process; the display touch screen arranged above the case is more visual in observation and more convenient and faster in operation, and the position of the ablation needle can be determined through MRI images.
(2) No matter the whole microwave ablation device is a generation module or a part, the whole microwave ablation device is made of magnetic compatible or non-magnetic materials and can be placed between magnets, the influence on the uniformity of a magnetic resonance field is avoided, the real temperature of a tumor area is monitored in real time by an MRI method, ablation parameters can be adjusted timely and as required in the ablation process, and the safety is improved.
(3) Compared with the traditional microwave ablation instrument, the temperature measuring module can only measure the temperature of local tumor tissue in a needle point area, the temperature measuring device can monitor the temperature of the tumor area in real time and the temperature of the tissue around the tumor in real time, does not need an additional temperature sensor, is non-invasive, and can avoid the potential influence of the temperature sensor on the distribution of a microwave field.
(4) The multi-nuclide MRI real-time detection adopts four-nuclide synchronous imaging, the detection is performed from a molecular level, the imaging is more accurate, the tumor region and the development period can be accurately positioned, the noninvasive operation can be repeatedly performed for many times, and the invasive property of the traditional tissue biopsy and the space-time heterogeneity of tumor tissues are avoided; meanwhile, the tumor ablation process is monitored by using the MRI temperature measurement method, the method is noninvasive, a temperature measurement probe is not needed, the potential influence of the temperature measurement probe on a microwave field is effectively avoided, the real-time adjustment of microwave parameters is facilitated, and the accuracy and the safety of microwave ablation are improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a general construction of an ablation microwave device;
FIG. 2 is a schematic flow diagram of the interior of a shielded enclosure;
FIG. 3 is a flow chart of the control of the main control module and the microwave module;
FIG. 4 is a top view of a top view ablation microwave device;
fig. 5 is an overall flow chart of tumor tissue temperature correction.
The device comprises a shielding case 1, a transverse handle 2, a transfusion bottle bracket 3, a display touch screen 4, a control panel 5, a main control module 6, a power module 7, a microwave generation module 8, a water tank 9 and a radiator 10.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive effort based on the embodiments of the present invention, are within the scope of the present invention.
The tumor ablation microwave device for multi-core MRI real-time detection shown in FIG. 1 is integrally designed into an integrated movable shielding case 1 made of a heat-conducting nonmagnetic copper-zinc alloy, and a transverse handle 2 made of hard plastic is arranged in front of the shielding case 1, so that the whole device can be pulled conveniently; a transfusion bottle bracket 3 made of nickel-chromium alloy with magnetic compatibility is arranged on the side of the shielding case 1, so that the magnetic field cannot be interfered when a certain strength is ensured to bear the gravity and the pulling force of a transfusion bottle; a magnetic compatible embedded display touch screen 4 is arranged above the shielding case 1, so that the ablation power is displayed in real time and is convenient to adjust in time; four universal wheels with fixing devices are arranged below the shielding case 1, the main body is made of hard plastic, and other parts are made of non-magnetic materials and magnetically compatible materials. In consideration of the ablation conditions of different parts, after the coaxial cable is connected with the microwave ablation needle, the coaxial cable can be curled and bent, and the deformation force can deviate the position of the microwave ablation needle in the body, so that the integrated movable microwave ablation machine is designed, the position of the microwave device can be conveniently adjusted according to the ablation requirement, and the adaptability of the device is improved. Because the whole device is completely magnetic compatible, the device can be directly arranged between the magnets, time and labor are saved, and the operation safety is improved.
As shown in fig. 2, a control panel 5, a main control module 6, a power module 7, and a microwave generation module 8 are vertically arranged in the shielding case 1 from top to bottom. The power module 7 is electrically connected with the control panel 5, the microwave generation module 8 and the main control module 6 respectively in the middle to supply power for the three. The main control module 6 is electrically connected with the microwave generating module 8 and is used for controlling the power of the microwave generating module 8. And a power input port and a microwave power output port are arranged outside the shielding case 1. The power input port is electrically connected with the input end of the power module 7 through the EMI filter; the power output end of the power module 7 is provided with three groups of outputs which respectively supply power to the control panel 5, the microwave generation module 8 and the main control module 6 after being connected with the feedthrough capacitors. The microwave power output port is connected with the output end of the microwave generation module 8, and is connected with a microwave ablation needle made of titanium alloy through an isolator in order to isolate electromagnetic interference brought by a microwave power transmission line. An optical fiber transmitter electrically connected with the main control module 6 is further arranged in the shielding case 1, a waveguide tube interface is arranged on the shielding case 1, an optical fiber of the optical transmitter penetrates through the waveguide tube interface and is connected with a matched optical receiver, and the optical receiver converts an optical signal into an electric signal and transmits the electric signal to a display.
As shown in fig. 3, the microwave generating module 8 includes a transistor-type solid microwave source, an amplifier, an output matching network circuit, a directional coupler, a power control communication module and a power management module, wherein the power control communication module, the transistor-type solid microwave source, the amplifier, the output matching network circuit and the directional coupler are sequentially connected; the microwave generation module 8 adopts a 2450MHz transistor type solid microwave source to replace a magnetron, has narrow bandwidth, more stable power, PLL + VCO control and higher frequency stability, and has better magnetic compatibility and electromagnetic compatibility than the traditional magnetron mode, thereby reducing the interference of electromagnetic signals to MRI imaging signals; the amplifier can be divided into a pre-stage amplification, an intermediate amplification, a third stage amplification and a tail end amplification. The power control communication module is communicated with the main control module 6, and outputs microwaves according to required power under the control of the main control module 6, and the main control module 6 transmits the microwave power to a display through an optical transmitter and an optical fiber to display the power of the transistor type solid microwave source in real time.
The main control module 6 comprises a microprocessor, a power control communication module, a display communication module and a power management module, the power control communication module, the microprocessor and the display communication module are sequentially connected, and the power control communication module of the main control module 6 is connected with the power control communication module of the microwave module. The microprocessor is the core of the main control module 6 and mainly completes the functions of display communication, microwave control module communication and control. And the power control communication module is mainly used for finishing the power control function of the microwave module. The display communication module is connected with the display touch screen 4 and mainly completes the communication function with the display screen.
Considering the importance of heat dissipation in electronic devices, poor heat dissipation can cause poor operation of the machine and even damage, which can cause economic loss and even certain risk to patients, the following design is adopted (as shown in fig. 4): the main control module 6, the power module 7 and the microwave generation module 8 are all tightly attached to four water tanks 9 made of heat-conducting nonmagnetic materials between the periphery of the inner wall of the shielding case 1, four radiators 10 made of heat-conducting nonmagnetic materials are all attached to the periphery of the outer wall of the shielding case 1, the water tanks 9 correspond to the radiators 10 in position, heat generated during work is taken away in and out, and the influence of the heat accumulated locally during work on the three modules and the internal components is effectively avoided. The reason for using the water tank 9 is: in common liquid and solid, the specific heat capacity of water is the largest, and the temperature of unit mass of water rises by 1 ℃, so that more heat needs to be absorbed. Copper has a good heat transfer capacity although it does not store heat strongly. The surface of copper is treated by a special process, so that the copper can be waterproof, oxidation-resistant and corrosion-resistant. By utilizing the good heat conduction capability of pure copper materials and the good heat absorption capability of water, the heat generated by the instrument during working can be taken away at the highest speed, and in addition, the raised temperature in the water tank 9 can be gradually cooled along with the external radiator 10, so that the influence on the temperature reduction of the instrument caused by the temperature of the water tank 9 exceeding a certain range is avoided.
Because the multi-nuclide MRI has the advantages of accurately detecting the occurrence of tumors, guiding microwave ablation in real time and realizing real-time noninvasive temperature measurement of tumor ablation areas, the invention can compensate the technical defects in the existing single-nuclide single-channel MRI real-time image guided microwave ablation process.
FIG. 5 shows a flowchart of the temperature calibration process, which uses an agar phantom to correct the temperature measurement accuracy of MRI.
The use method of the tumor ablation microwave device for multi-nuclide MRI real-time detection comprises the following steps:
(1) acquiring the temperature deviation of the system for MRI temperature measurement, specifically as follows:
firstly, preparing an agar imitation body, placing the imitation body in a coil after the imitation body reaches a stable state, inserting an ablation antenna, connecting a microwave ablation instrument, and carrying out microwave heating on the imitation body. In order to make the experimental result more accurate, the position of the temperature measuring probe inside the simulated body is found by pre-scanning during MRI temperature measurement, a pixel set adjacent to the temperature measuring probe is selected as an ROI, then the average value of phase values of pixels in the ROI is taken, and the temperature value is calculated as the temperature measuring result of the PRF. The heating time and the corresponding temperatures measured by the two methods are recorded and plotted in tables 1 and 2, respectively, and then the temperature deviations of the two methods are recorded and stored as system deviations in another table 3.
And 3, the temperature obtained by correcting the MRI temperature measurement sequence based on the system temperature deviation table is shown as the system temperature deviation, the temperature of the ablation area and the temperature of the peripheral tissues obtained by correcting the MRI temperature measurement sequence based on the system deviation table is measured in real time by continuously and repeatedly scanning the MRI temperature measurement sequence in the use process of the microwave ablation needle, namely the microwave ablation process of the tumor tissues. According to the change condition of the tumor temperature, the ablation power is adjusted in real time, the termination time is determined, and the ablation efficiency and safety are improved.
(2) The multi-nuclide MRI system accurately scans and determines the position of a tumor, and the method specifically comprises the following steps:
a multi-nuclide MRI system is used for synchronously imaging Na, H, F and P nuclides in a target area or combination of more than two nuclides in the target area, the multi-nuclide event which drives the tumor to generate and develop together at four different levels of molecular targets, energy metabolism abnormality, ion balance disorder and an acid microenvironment is integrally detected, the multi-molecular action mechanism in the tumor is monitored, the tumor area is determined, the development condition of the tumor is mastered in real time, and early accurate detection and positioning of the tumor are realized. And (3) melting in the real-time temperature monitoring process by using a microwave device compatible with an MRI system and based on an MRI temperature measurement sequence.
(3) Delineating tumor region and determining needle falling position of microwave ablation needle
Tumor location determination by multi-nuclide MRI accurate scanning, injection specificity if necessary19F-targeting probe for delineating tumor tissue region, determining needle insertion path, and application thereof1And H structure image, monitoring the needle inserting direction and the needle point position, and scanning in multiple directions again to confirm the relationship between the needle point and the tumor and the surrounding important tissue structures. After the needle is determined, connectingAnd the microwave ablation instrument is used for setting ablation power and ablation time.
(4) Alternating repetitive scanning thermography sequence and T2WI sequence
And scanning the GRE family sequence in the microwave ablation process to perform PRF temperature imaging of the tumor area. Correcting the temperature data obtained after PRF temperature measurement through the drawn system deviation table 3 to obtain the real temperature of the whole tumor tissue in the ablation process (as shown in figure 5); the range of the thermal coagulability bad dead zone with low signal visible in the T2WI dynamic scanning process is gradually enlarged from the center to the periphery along with the time progress, and the ablation effect is verified in an auxiliary mode. By means of tumor temperature feedback, ablation power is adjusted in real time, termination time is determined, and ablation efficiency and safety are improved.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.
Claims (7)
1. The tumor ablation microwave device for multi-nuclide MRI real-time detection is characterized in that: including the heat conduction nonmagnetic shielding machine case, control panel has set gradually from top to bottom in the shielding machine case, host system, power module, microwave generation module, be equipped with power input port and microwave power output port on the shielding machine case, power input port passes through the EMI wave filter and links to each other with power module's input, power module's output respectively with control panel, microwave generation module and host system electricity are connected, host system is connected with microwave generation module electricity, microwave generation module's output is connected with microwave power output port, microwave power output port passes through the isolator and connects the microwave ablation needle, host system is connected with control panel electricity, the last magnetism compatible display touch-sensitive screen that is provided with of control panel.
2. The microwave device for tumor ablation with multi-nucleotide MRI real-time detection according to claim 1, characterized in that: a magnetically compatible infusion bottle support is arranged on the shielding case, the display touch screen is located at the upper end of the shielding case, universal wheels are arranged at four corners of the lower end of the shielding case, and a transverse handle is arranged on the front side of the shielding case.
3. The microwave device for tumor ablation with multi-nucleotide MRI real-time detection according to claim 1, characterized in that: and an optical fiber transmitter connected with the main control module is further arranged in the shielding case, the optical fiber transmitter is connected with the display touch screen through a waveguide tube, and the display touch screen displays the microwave ablation power in real time.
4. The microwave device for tumor ablation with multi-nucleotide MRI real-time detection according to claim 1, characterized in that: the microwave generation module comprises a power control communication module, a transistor type solid microwave source, an amplifier, an output matching network circuit and a directional coupler which are sequentially connected, and the power control communication module is communicated with the main control module.
5. The microwave device for tumor ablation with multi-nucleotide MRI real-time detection according to claim 4, characterized in that: the main control module comprises a power control communication module, a microprocessor and a display communication module which are sequentially connected, the main control module is connected with the power control communication module of the microwave module, and the display communication module is connected with the display touch screen.
6. The microwave device for tumor ablation with multi-nucleotide MRI real-time detection according to claim 1, characterized in that: water tanks are arranged between the peripheries of the main control module, the power supply module and the microwave generation module and the inner wall of the shielding case, and radiators corresponding to the positions of the water tanks are arranged on the peripheries of the outer wall of the shielding case.
7. The method for using the multi-polynucleotide MRI real-time detection tumor ablation microwave device according to any one of claims 1 to 6, characterized by comprising the following steps: firstly, preparing an agar imitation, placing the agar imitation in a radio frequency coil, heating the agar imitation by utilizing microwave ablation of a microwave ablation device, measuring the temperature of the agar imitation at the periphery of a microwave ablation needle by adopting an MRI temperature measurement sequence and a temperature measurement probe, selecting a pixel set closest to the temperature measurement probe as an ROI during MRI temperature measurement, then averaging phase values of pixels in the ROI, calculating a temperature value of the temperature measurement result as a PRF temperature measurement result based on the dependency relationship between proton resonance frequency and temperature, and combining the temperature measurement result with the temperature measurement result measured by the temperature measurement probe to construct a system temperature deviation table; and correcting the temperature obtained by the MRI thermometry sequence based on the system temperature deviation table.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533247A (en) * | 2022-01-12 | 2022-05-27 | 康达洲际医疗器械有限公司 | Three-dimensional magnetic heat control method and system based on photoacoustic imaging guidance |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107095719A (en) * | 2017-04-22 | 2017-08-29 | 安徽硕金医疗设备有限公司 | A kind of microwave ablation instrument of magnetic resonance compatible |
| CN109171955A (en) * | 2018-10-23 | 2019-01-11 | 宁波穿山甲机电有限公司 | A kind of microwave ablation instrument of magnetic resonance compatible |
| CN111714097A (en) * | 2020-06-30 | 2020-09-29 | 杭州佳量医疗科技有限公司 | Bimodal magnetic resonance temperature measurement method based on multi-gradient echo sequence |
| US20210208225A1 (en) * | 2020-01-08 | 2021-07-08 | University Of Virginia Patent Foundation | Systems and methods for magnetic resonance based skull thermometry |
| CN113331815A (en) * | 2020-03-02 | 2021-09-03 | 哈尔滨医科大学 | Multi-core radio frequency coil transceiving and ultrasonic array unit synchronous control device and method |
-
2021
- 2021-09-13 CN CN202111069099.7A patent/CN113907871A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107095719A (en) * | 2017-04-22 | 2017-08-29 | 安徽硕金医疗设备有限公司 | A kind of microwave ablation instrument of magnetic resonance compatible |
| CN109171955A (en) * | 2018-10-23 | 2019-01-11 | 宁波穿山甲机电有限公司 | A kind of microwave ablation instrument of magnetic resonance compatible |
| US20210208225A1 (en) * | 2020-01-08 | 2021-07-08 | University Of Virginia Patent Foundation | Systems and methods for magnetic resonance based skull thermometry |
| CN113331815A (en) * | 2020-03-02 | 2021-09-03 | 哈尔滨医科大学 | Multi-core radio frequency coil transceiving and ultrasonic array unit synchronous control device and method |
| CN111714097A (en) * | 2020-06-30 | 2020-09-29 | 杭州佳量医疗科技有限公司 | Bimodal magnetic resonance temperature measurement method based on multi-gradient echo sequence |
Non-Patent Citations (1)
| Title |
|---|
| 赵智勇: "基于磁共振成像测温技术的方法学和应用研究", 《中国优秀博士学位论文全文数据库 基础科学辑》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533247A (en) * | 2022-01-12 | 2022-05-27 | 康达洲际医疗器械有限公司 | Three-dimensional magnetic heat control method and system based on photoacoustic imaging guidance |
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