CN113893411B - Multi-stage electroosmosis micropump - Google Patents
Multi-stage electroosmosis micropump Download PDFInfo
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- CN113893411B CN113893411B CN202111504557.5A CN202111504557A CN113893411B CN 113893411 B CN113893411 B CN 113893411B CN 202111504557 A CN202111504557 A CN 202111504557A CN 113893411 B CN113893411 B CN 113893411B
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R11/00—Individual connecting elements providing two or more spaced connecting locations for conductive members which are, or may be, thereby interconnected, e.g. end pieces for wires or cables supported by the wire or cable and having means for facilitating electrical connection to some other wire, terminal, or conductive member, blocks of binding posts
- H01R11/11—End pieces or tapping pieces for wires, supported by the wire and for facilitating electrical connection to some other wire, terminal or conductive member
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R9/00—Structural associations of a plurality of mutually-insulated electrical connecting elements, e.g. terminal strips or terminal blocks; Terminals or binding posts mounted upon a base or in a case; Bases therefor
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Structures Of Non-Positive Displacement Pumps (AREA)
- Micromachines (AREA)
Abstract
The invention belongs to the technical field of electroosmosis micropumps, and provides a multistage electroosmosis micropump which comprises a shell, a plurality of electroosmosis micropumps, four metal lead columns and four guide pieces, wherein a cavity is formed in the shell, and four electrode lead grooves and four porous membrane fixing structures are arranged on the wall surface of the cavity; the metal lead posts are arranged in the electrode lead slots in a one-to-one corresponding mode, wherein two metal lead posts are used for being connected with one electrode of the electroosmosis micro pump to form the anode of the electroosmosis micro pump, and the other two metal lead posts are used for being connected with the other electrode of the electroosmosis micro pump to form the cathode of the electroosmosis micro pump; the guiding pieces are connected with the metal lead posts in a one-to-one corresponding mode, one ends of the guiding pieces are connected with the metal lead posts, and the other ends of the guiding pieces are connected with an external power supply. The multistage electroosmosis micropump is provided with the metal lead column in the high-density multistage series electroosmosis micropump, and the micropump driving electrode is electrically led out through the guide piece, so that the multistage electroosmosis micropump is compact in structure and few in electric leads.
Description
Technical Field
The invention belongs to the technical field of electroosmosis micropumps, and particularly relates to a multistage electroosmosis micropump.
Background
This section provides background information related to the present disclosure only and is not necessarily prior art.
In the aspect of drug delivery, the electroosmosis micropump does not have a mechanical moving part, so that the medicine effect is reduced without causing structural damage to medicine macromolecules, and the electroosmosis micropump has very good application potential. By accurately regulating and controlling the driving voltage, the electroosmosis micropump can not only provide precise dosage, but also be used for precise targeted drug delivery treatment of chronic diseases such as diabetes, hypertension and the like under the monitoring feedback of blood sugar and blood pressure. However, the electroosmosis micropump designed by the traditional porous membrane structure has low pump pressure, and is often difficult to meet the requirement of human body percutaneous puncture drug delivery, mainly because the porous membrane electroosmosis driving pore channel has extremely short length (generally several to dozens of micrometers), and cannot generate the pump drug driving force of high pump pressure.
The serial design of the porous film, increasing the effective length of the electroosmosis driving pore passage is a common solution for improving the pumping pressure of the electroosmosis micropump, but when the microelectrodes on two sides of the porous film are integrated in series, the volume of the pump body is greatly increased by leading out and integrating the electrode leads, and the packaging difficulty of the pump body is also increased.
Disclosure of Invention
The invention aims to at least solve the problem that the electroosmosis micropump in the prior art is not compact enough, and the aim is realized by the following technical scheme:
the invention provides a multistage electroosmosis micropump, which comprises:
the electrode lead wire comprises a shell, wherein a cavity is formed in the shell, and the wall surface of the cavity is provided with a plurality of electrode lead wire grooves and a plurality of porous membrane fixing structures;
the electroosmosis micropumps are arranged in the cavity, and the porous membrane fixing structure is used for fixing the porous membrane of the electroosmosis micropumps;
the metal lead posts are arranged in the electrode lead grooves in a one-to-one corresponding mode, part of the metal lead posts are used for being connected with one electrode of the electroosmosis micro pump to form a positive electrode of the electroosmosis micro pump, and the other part of the metal lead posts are used for being connected with the other electrode of the electroosmosis micro pump to form a negative electrode of the electroosmosis micro pump;
the guide pieces are connected with the metal lead posts in a one-to-one correspondence mode, the first ends of the guide pieces are connected with the metal lead posts, the second ends of the guide pieces penetrate out of the shell, and the guide pieces are used for connecting the electroosmosis micropump with an external power supply.
The invention provides a multistage electroosmosis micropump, wherein a metal lead post is arranged in a micropump with a high-density multistage series electrode-porous film-electrode sandwich structure, and a micropump driving electrode is electrically led out through a guide piece. The metal lead column is easy to prepare and convenient to integrate, and solves the problems of large pump body size, unreliable electrical interconnection and the like caused by the fact that a large number of metal leads penetrate through a micro-pump shell to conduct electrical leading-out on a traditional high-density series micro-pump electrode.
In addition, the multistage electroosmotic micropump according to the present invention may also have the following additional technical features:
in some embodiments of the present invention, the metal lead column is provided with at least four electrode grooves along an axial direction thereof, a depth direction of the electrode grooves is arranged along a radial direction of the metal lead column, a plurality of the electroosmosis micro pumps are arranged along the axial direction of the metal lead column, the electroosmosis micro pumps comprise two electrodes and a porous film, the electrodes are inserted into the electrode grooves, and the porous film is inserted into the film grooves.
In some embodiments of the present invention, the housing includes a casing and two sealing covers, a cavity is formed inside the casing, two axial ends of the cavity are open, the two sealing covers are respectively sealed at two axial ends of the cavity, four electrode lead slots are disposed on a wall surface of the cavity, the four electrode lead slots extend in an axial direction of the cavity and are arranged at intervals in a circumferential direction of the cavity, the metal lead posts are disposed in the electrode lead slots in a one-to-one correspondence manner, a radial width of the electrode lead slots is greater than twice a radial width of the metal lead posts, a porous membrane fixing structure is disposed on a cavity wall of the cavity, the porous membrane fixing structure includes a plurality of membrane slots distributed in the axial direction of the cavity, a depth direction of the membrane slots is parallel to the circumferential direction of the cavity, a position of the membrane slot in the axial direction of the cavity is located between two adjacent electrode slots, the membrane slots are arranged to be communicated with the electrode lead slots, fluid ports are disposed on the sealing covers, and the cavity is communicated with the outside through the fluid ports.
In some embodiments of the present invention, the electroosmotic micropump includes two electrodes and a porous membrane, the electrodes include an electrode body and four tabs connected to an outer edge of the electrode body, the electrode body is in a porous disk structure, the porous membrane includes a membrane body and four petals connected to an outer edge of the membrane body, the membrane body is in a porous disk structure, the four tabs of the electrodes are inserted into the electrode grooves of the four metal lead posts in a one-to-one correspondence manner, and the four petals of the porous membrane are inserted into the membrane grooves of the four porous membrane fixing structures in a one-to-one correspondence manner.
In some embodiments of the present invention, the guiding member includes fastening pins, locking members, and lead connectors, the metal lead post is provided with a first connecting hole, the sealing covers are provided with four second connecting holes, the positions of the second connecting holes correspond to the positions of the first connecting holes, the fastening pins are inserted into the first connecting holes and the second connecting holes of the two sealing covers, the head end of each fastening pin abuts against one of the sealing covers, the locking member is connected with the tail end of the fastening pin, the locking member abuts against the other sealing cover, and the lead connectors are connected with the end portions of the fastening pins.
In some embodiments of the present invention, the metal lead post includes a post body and a connecting portion, at least four electrode slots are disposed on the post body along an axial direction of the post body, the connecting portion is connected to a side end of the post body, the connecting portion is provided with the first connecting hole, the housing is further provided with four insertion holes, the positions of the insertion holes correspond to those of the connecting portion, and the connecting portion is inserted into the insertion holes.
In some embodiments of the present invention, the multistage electroosmotic micropump further comprises a flexible electrical connection element disposed within the first connection hole, the flexible electrical connection element abutting between a hole wall of the first connection hole and the fastening nail.
In some embodiments of the present invention, the terminal body has a serpentine-shaped bent structure, and the electrode slot is adapted to the serpentine-shaped bent structure.
In some embodiments of the present invention, the housing further includes four fixing holes penetrating all the membrane grooves of a single porous membrane fixing structure, and the multistage electroosmosis micro pump further includes a porous membrane fixing pin penetrating the fixing holes and the through holes of the porous membrane.
In some embodiments of the invention, the end of the sealing cover facing the cavity is provided with a funnel-shaped fluid cavity.
Drawings
Various additional advantages and benefits will become apparent to those of ordinary skill in the art upon reading the following detailed description of the preferred embodiments. The drawings are only for purposes of illustrating the preferred embodiments and are not to be construed as limiting the invention. Also, like parts are designated by like reference numerals throughout the drawings. In the drawings:
FIG. 1 schematically illustrates a schematic structural view of a first embodiment of a multistage electroosmotic micropump according to an embodiment of the present invention;
FIG. 2 is a schematic view of an exploded structure of the multi-stage electroosmotic micropump shown in FIG. 1;
FIG. 3 schematically illustrates a structural schematic of a second embodiment of a multi-stage electroosmotic micropump in accordance with an embodiment of the present invention;
FIG. 4 schematically illustrates a schematic structural view of a first example of a housing of a multistage electroosmotic micropump according to an embodiment of the present invention;
FIG. 5 schematically illustrates a schematic structural view of a second example of a housing of a multistage electroosmotic micropump according to an embodiment of the present invention;
FIG. 6 schematically illustrates a structural view of a first example of a metal lead post of a multistage electroosmotic micropump according to an embodiment of the present invention;
FIG. 7 schematically illustrates a structural view of a second example of a metal lead post of a multi-stage electroosmotic micropump, in accordance with an embodiment of the present invention;
FIG. 8 is a schematic diagram illustrating a third example of a metal lead post of a multi-stage electroosmotic micro-pump in accordance with an embodiment of the present invention;
FIG. 9 is a schematic view showing the structure of a fourth example of a metal lead post of the multistage electroosmotic micro pump according to the embodiment of the invention;
FIG. 10 is a schematic diagram illustrating a fifth embodiment of a metal lead post of a multistage electroosmotic micro-pump according to an embodiment of the present invention;
FIG. 11 is a schematic view showing the structure of a sixth example of a metal lead post of the multistage electroosmotic micro pump according to the embodiment of the invention;
FIG. 12 schematically illustrates a partial structural view of a multi-stage electroosmotic micropump in accordance with an embodiment of the present invention;
FIG. 13 schematically illustrates a schematic structural view of an electrode of a multistage electroosmotic micropump according to an embodiment of the present invention;
FIG. 14 schematically illustrates a structural view of a porous membrane of a multistage electroosmotic micropump according to an embodiment of the present invention;
FIG. 15 is a schematic view illustrating a structure of a sealing cover of a multistage electroosmotic micro pump according to an embodiment of the present invention from a first perspective;
FIG. 16 is a schematic view illustrating a structure of a sealing cover of a multistage electroosmotic micro pump according to an embodiment of the present invention from a second perspective;
in the drawings, the reference numerals denote the following:
10: a housing, 11: electrode lead groove, 12: porous membrane-fixing structure, 13: film tank, 14: lead post body, 15: electrode tank, 16: connecting part, 17: first connection hole, 18: second connection hole, 19: inserting hole, 20: fixing hole, 21: sealing cover, 22: fastening nail, 23: locking piece, 24: lead tab, 25: electrode, 26: flap, 28: fluid port, 29: fluid chamber, 30: porous membrane fixing pin, 31: and (3) tab, 32: a porous membrane.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.
It is to be understood that the terminology used herein is for the purpose of describing particular example embodiments only, and is not intended to be limiting. As used herein, the singular forms "a", "an" and "the" may be intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms "comprises," "comprising," "including," and "having" are inclusive and therefore specify the presence of stated features, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and/or groups thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring their performance in the particular order discussed or illustrated, unless specifically identified as an order of performance. It should also be understood that additional or alternative steps may be used.
Although the terms, second, third, etc. may be used herein to describe various elements, components, regions, layers and/or sections, these elements, components, regions, layers and/or sections should not be limited by these terms. These terms may be only used to distinguish one element, component, region, layer or section from another region, layer or section. Terms such as "second" and other numerical terms when used herein do not imply a sequence or order unless clearly indicated by the context. Thus, an element, component, region, layer or section discussed below could be termed a second element, component, region, layer or section without departing from the teachings of the example embodiments.
For convenience of description, spatially relative terms, such as "inner", "outer", "inner", "side", "lower", "below", "upper", "above", and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. This spatially relative term is intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "below" or "beneath" other elements or features would then be oriented "above" or "over" the other elements or features. Thus, the example term "at 8230; \8230; below" may include both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
As shown in fig. 1 to 16, the present invention provides a multi-stage electroosmosis micropump, including a housing, a plurality of electroosmosis micropumps, a plurality of metal lead posts and a plurality of guides, wherein a cavity is formed in the housing, and a plurality of electrode lead grooves 11 and a plurality of porous membrane fixing structures 12 are disposed on a wall surface of the cavity; the electroosmosis micropump is arranged in the cavity, and the porous membrane fixing structure 12 is used for fixing the porous membrane 32 of the electroosmosis micropump; the metal lead columns are arranged in the electrode lead groove 11 in a one-to-one corresponding mode, wherein part of the metal lead columns are used for being connected with one electrode of the electroosmosis micro pump to form an anode of the electroosmosis micro pump, and the other part of the metal lead columns are used for being connected with the other electrode of the electroosmosis micro pump to form a cathode of the electroosmosis micro pump; the guide piece is connected with the metal lead posts in a one-to-one corresponding mode, the first end of the guide piece is connected with the metal lead posts, the second end of the guide piece penetrates out of the shell, and the guide piece is used for connecting the electroosmosis micropump with an external power supply.
Specifically, the metal lead posts are preferably four, and accordingly, the number of the electrode lead grooves 11 and the leads is also four.
It is understood that the electroosmotic micropump includes a porous membrane 32 and electrodes, and a pair of electrodes are disposed on both sides of the porous membrane 32 as the positive and negative electrodes of the electroosmotic driving module, so as to form a potential difference in the micro/nano channels of the porous membrane 32, and drive the fluid in the micro/nano channels to generate electroosmotic flow.
The porous film 32 can be made of polycarbonate, polyurethane, polyethylene terephthalate, polyimide and other biological materials by mechanical micromachining, chemical corrosion micromachining, ion etching micromachining and other processes, the film thickness is hundreds of nanometers to hundreds of micrometers, the micro/nano pore channel structure on the porous film 32 can be a round hole, a square hole or a polygonal hole, and the equivalent diameter of the hole is dozens of nanometers to dozens of micrometers.
The electrode can be selected from titanium, platinum, gold, platinum-iridium alloy, or a composite structure which takes certain metal, glass, ceramic or polymer as a framework or a substrate and is plated with a platinum or gold film layer, wherein the metal can be titanium, stainless steel or the like, the glass can be quartz glass or the like, the ceramic can be aluminum oxide, zirconium dioxide or the like, and the polymer can be polyimide, polycarbonate or the like;
the electrode is a porous structure and can be formed by weaving and punching metal wires, or can be formed by punching a metal or glass or ceramic or polymer film through processes such as mechanical micromachining, chemical corrosion, etching and the like to form a porous structure and then modifying a layer of inert biocompatible platinum or gold on the porous framework or the substrate through processes such as electroplating, sputtering, deposition and the like to form a final electrode; in the process flow, a layer of inert biocompatible platinum or gold can be modified on a metal or glass or ceramic or polymer film through the processes of electroplating, sputtering, deposition and the like, and then the porous structure of the electrode can be formed through the processes of mechanical micro-processing, chemical corrosion, etching and the like;
the thickness of the electrode is not less than that of the porous film 32, and the maximum thickness is several millimeters; the electrode pore structure can be round, square, diamond, triangle or polygon, the equivalent diameter size of the pore is not less than that of the porous film 32 micron/nanometer pore, and the maximum equivalent diameter size is several millimeters.
The electrode lead groove 11 is arranged on the inner wall of the shell, the electrode lead groove 11 is used for fixing electrodes of the electroosmosis micropump and leading out the electrodes, and comprises a positive electrode lead groove 11 and a negative electrode lead groove 11, a metal lead column and a hollow groove are arranged in the electrode lead groove 11, the metal lead column is fixed in the electrode lead groove 11 in a gluing mode and the like, and the hollow groove is a groove which is close to the metal lead column on the inner wall of the shell.
The metal lead post can be made of titanium or platinum iridium or platinized stainless steel and other materials, can be a snake-shaped bent spring, and also can be a round, quadrilateral, triangular or polygonal metal post with a blade groove, a tab 31 is firstly placed in the hollow groove in the electrode assembling process, then the electrode is rotated to the metal lead post position to the corresponding groove through the hollow groove position, finally conductive adhesive is filled in the spring gap and the blade groove, the electrode tab 31 is fixed, and the electrical contact between the electrode tab 31 and the metal lead post is kept;
the electroosmosis micropump provided by the invention is characterized in that a metal lead post is arranged in the micropump with a high-density multistage series electrode-porous film 32-electrode sandwich structure, and the micropump driving electrode is electrically led out through a guide piece. The metal lead column is easy to prepare and convenient to integrate, and solves the problems of large pump body size, unreliable electrical interconnection and the like caused by the fact that a large number of metal leads penetrate through a micro-pump shell to conduct electrical leading-out on a traditional high-density series micro-pump electrode.
In some embodiments of the present invention, the metal lead column is provided with at least four electrode grooves 15 along the axial direction thereof, the depth direction of the electrode grooves 15 is parallel to the radial direction of the metal lead column, a plurality of electroosmotic micro pumps are arranged along the axial direction of the metal lead column, the electroosmotic micro pumps comprise two electrodes and a porous film 32, the porous film 32 is arranged between the two electrodes, the electrodes are inserted into the electrode grooves 15 on the same plane of the four metal lead columns, and the porous film 32 is inserted into the film groove 13.
In some embodiments of the present invention, the housing includes a casing 10 and two sealing covers 21, a cavity is formed inside the casing 10, two axial ends of the cavity are open, the two sealing covers 21 are respectively sealed at the two axial ends of the cavity, four electrode lead slots 11 are disposed on a wall surface of the cavity, the four electrode lead slots 11 extend in an axial direction of the cavity and are arranged at intervals in a circumferential direction of the cavity, metal lead posts are disposed in the electrode lead slots 11 in a one-to-one correspondence manner, a radial width of the electrode lead slots 11 is greater than twice a radial width of the metal lead posts, a porous membrane fixing structure 12 is disposed on a wall of the cavity, the porous membrane fixing structure 12 includes a plurality of thin membrane slots 13 distributed in the axial direction of the cavity, a depth direction of the thin membrane slots 13 is parallel to the circumferential direction of the cavity, a position of the thin membrane slot 13 in the axial direction of the cavity is located between two adjacent electrode slots 15, the thin membrane slot 13 forms a notch on a radial sidewall of the electrode lead slot 11, a fluid port 28 is disposed on the sealing cover 21, and the cavity is communicated with the outside through the fluid port 28.
The casing is composed of a shell 10 and a sealing cover 21, plays a role in fixing components such as an internal electrode of the micro pump, a porous film 32, a metal lead post and the like, can be made of quartz glass, polymethyl methacrylate, alumina ceramic, polytetrafluoroethylene and other biological materials through mechanical micromachining.
The thin film groove 13 is a sheet-shaped groove on the inner wall of the shell 10 and is used for fixing the porous thin film 32, the thin film groove 13 is not on the same horizontal plane with the metal lead groove in the axial direction of the shell 10, and the thin film groove 13 and the metal lead groove are sequentially arranged in a staggered mode in a mode of electrode groove 15-thin film groove 13-electrode groove 15-thin film groove 13-electrode groove 15, wherein the distance between the adjacent electrode grooves 15-electrode groove 15 is not smaller than the distance between the electrode groove 15 and the electrode groove 15 which sandwich the thin film groove 13 in the middle, so that the contact short circuit of the electrodes on two sides of the porous thin film 32 can be avoided on one hand, and the electrolytic reaction can be generated when the adjacent two electrodes on the surface are too close to each other; wherein the electrodes are spaced from the porous film 32 in the range of tens of nanometers to hundreds of micrometers.
In some embodiments of the present invention, the electroosmotic micropump includes two electrodes 25 and a porous membrane 32, wherein the electrodes 25 include an electrode body and four tabs 31 connected to the outer edge of the electrode body, the electrode body is in a porous disk-shaped structure, the porous membrane 32 includes a membrane body and four petals 26 connected to the outer edge of the membrane body, the membrane body is in a porous disk-shaped structure, the four tabs 31 of the electrodes 25 are inserted into the electrode grooves 15 of the four metal lead posts in a one-to-one correspondence manner, and the four petals 26 of the porous membrane 32 are inserted into the membrane grooves 13 of the four porous membrane fixing structures 12 in a one-to-one correspondence manner.
In the electrode assembling process, the tab 31 is firstly placed in the hollow groove, then is rotated to the metal lead post position to the corresponding groove through the hollow groove, and finally the spring gap and the blade groove are filled with conductive adhesive to fix the electrode tab 31 and keep the electrical contact between the electrode tab 31 and the metal lead post;
after the electrical extraction is completed, the hollow groove can be filled with silica gel or not as a fluid filling channel, so that the whole cavity can be conveniently filled with fluid, and the porous film 32 has a pore canal of micro/nano magnitude and large filling fluid resistance.
In some embodiments of the present invention, the guiding member includes fastening pins 22, locking members 23, and lead tabs 24, the metal lead post is provided with a first connection hole 17, the sealing covers 21 are provided with four second connection holes 18, the positions of the second connection holes 18 correspond to the positions of the first connection holes 17, the fastening pins 22 are inserted through the first connection holes 17 and the second connection holes 18 of the two sealing covers 21, the head end of the fastening pin 22 abuts against one of the sealing covers 21, the locking members 23 are connected to the tail end of the fastening pin 22, the locking members 23 abut against the other sealing cover 21, and the lead tabs 24 are connected to the end of the fastening pins 22.
It can be understood that the guide is used for fixing the sealing cover 21 to the housing 10, the fastening nail 22 may be a screw, the sealing cover 21 and the housing have screw holes, and the screw passes through the screw holes to fix the sealing cover 21 to two sides of the housing 10; in order to ensure the reliability of the sealing performance, waterproof glue can be coated on the sealing surface of the sealing cover 21 and the shell 10 or a waterproof rubber pad can be placed on the sealing surface;
the fastening nail 22 may be made of a metal material such as titanium or platinum-plated stainless steel, and the screw may be fastened and fixed by a nut or may be fixed by welding.
Furthermore, the fastening nail 22 can be used as one of the electrode lead wires for the middle lead of the metal lead post and the pump external electric lead.
In some embodiments of the present invention, the metal lead post includes a lead post body 14 and a connecting portion 16, at least 4 electrode grooves 15 are disposed on the lead post body 14 along an axial direction thereof, the connecting portion 16 is connected to a side end of the lead post body 14, a first connecting hole 17 is disposed on the connecting portion 16, four insertion holes 19 are further disposed on the housing 10, the insertion holes 19 correspond to positions of the connecting portion 16, and the connecting portion 16 is inserted into the insertion holes 19.
In some embodiments of the present invention, the multistage electroosmotic micropump further comprises a flexible electrical connection element disposed within the first connection aperture 17, the flexible electrical connection element abutting between the aperture wall of the first connection aperture 17 and the fastening pegs 22. After the screw is inserted into the screw hole and fixed, the screw is electrically connected with the metal lead post through the flexible electric connection element and the electrode; for reliable electrical connection of the screw with the electrical connection element, the electrical connection element is designed to be clamped in the screw hole in a cylindrical structure with a spring piece.
In some embodiments of the present invention, the lead post body 14 has a serpentine folded structure, and the electrode groove 15 is formed according to the serpentine folded structure.
In some embodiments of the present invention, the housing 10 is further provided with four fixing holes 20, the fixing holes 20 penetrate all the membrane grooves 13 of the single porous membrane fixing structure 12, and the multistage electroosmotic micropump further includes a porous membrane fixing needle 30, and the porous membrane fixing needle 30 is inserted into the fixing holes 20 and the through holes of the porous membrane 32.
Specifically, the porous membrane fixing needle 30 is used for fixing the porous membrane 32, so that the porous membrane 32 is ensured not to be displaced in the pump, a fixed distance is kept between the porous membrane and an electrode, and stable electroosmotic flow driving with small fluctuation is generated; the porous membrane fixing pin 30 may be made of a metal material such as titanium or platinized stainless steel, or made of a metal coated with a film of a biomaterial such as polytetrafluoroethylene, polyurethane, or parylene, or made of a non-metal biomaterial such as polytetrafluoroethylene, glass, or ceramic, and fixed in the fixing hole 20 of the housing 10 by means of adhesion.
In some embodiments of the invention, the end of the sealing cover 21 facing the chamber is provided with a fluid chamber 29 in the shape of a funnel. The flow effect of the fluid is improved.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are also included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (8)
1. A multistage electroosmotic micropump, comprising:
the electrode lead wire comprises a shell, wherein a cavity is formed in the shell, and the wall surface of the cavity is provided with a plurality of electrode lead wire grooves and a plurality of porous membrane fixing structures;
the electroosmosis micropumps are arranged in the cavity, and the porous membrane fixing structure is used for fixing the porous membrane of the electroosmosis micropumps;
the metal lead posts are arranged in the electrode lead grooves in a one-to-one corresponding mode, part of the metal lead posts are used for being connected with one electrode of the electroosmosis micro pump to form a positive electrode of the electroosmosis micro pump, and the other part of the metal lead posts are used for being connected with the other electrode of the electroosmosis micro pump to form a negative electrode of the electroosmosis micro pump;
a plurality of guides connected to the metal lead posts in a one-to-one correspondence, a first end of the guides being connected to the metal lead posts, a second end of the guides passing through the housing, the guides for connecting the electroosmotic micropump to an external power source;
the metal lead column is provided with at least four electrode grooves along the axial direction, the depth direction of the electrode grooves is arranged along the radial direction of the metal lead column, a plurality of electroosmosis micro pumps are arranged along the axial direction of the metal lead column, each electroosmosis micro pump comprises two electrodes and a porous film, and the electrodes are inserted into the electrode grooves;
the shell comprises a shell and two sealing covers, a cavity is formed inside the shell, the two axial ends of the cavity are open, the two sealing covers are respectively sealed at the two axial ends of the cavity, four electrode lead grooves are formed in the wall surface of the cavity and extend along the axial direction of the cavity and are arranged at intervals along the circumferential direction of the cavity, the metal lead posts are arranged in the electrode lead grooves in a one-to-one correspondence mode, the radial width of each electrode lead groove is larger than twice the radial width of each metal lead post, a porous membrane fixing structure is arranged on the cavity wall of the cavity and comprises a plurality of membrane grooves distributed along the axial direction of the cavity, the depth direction of each membrane groove is parallel to the circumferential direction of the cavity, the membrane grooves are located between the two adjacent electrode grooves at the axial positions of the cavity, the membrane grooves are communicated with the electrode lead grooves, fluid ports are formed in the sealing covers, and the cavity is communicated with the outside through the fluid ports.
2. The multistage electroosmotic micropump of claim 1, wherein said electrode comprises an electrode body and four tabs connected to the outer edge of said electrode body, said electrode body is a porous disk-shaped structure, said porous membrane comprises a membrane body and four petals connected to the outer edge of said membrane body, said membrane body is a porous disk-shaped structure, said four tabs of said electrode are inserted into said electrode grooves of said four metal lead posts in a one-to-one correspondence, and said four petals of said porous membrane are inserted into said membrane grooves of said four porous membrane fixing structures in a one-to-one correspondence.
3. The multistage electroosmotic micropump of claim 1, wherein the guide member comprises a fastening pin, a locking member and a lead tab, wherein a first connection hole is formed on the metal lead post, four second connection holes are formed on the sealing cover, the positions of the second connection holes correspond to the positions of the first connection holes, the fastening pin is inserted through the first connection hole and the second connection holes on the two sealing covers, the head end of the fastening pin abuts against one of the sealing covers, the locking member is connected with the tail end of the fastening pin, the locking member abuts against the other sealing cover, and the lead tab is connected with the end of the fastening pin.
4. The multistage electroosmotic micropump according to claim 3, wherein the metal lead column comprises a terminal body and a connecting portion, at least four of the electrode grooves are provided on the terminal body along an axial direction thereof, the connecting portion is connected to a side end of the terminal body, the connecting portion is provided with the first connecting hole, the casing is further provided with four insertion holes corresponding to positions of the connecting portion, and the connecting portion is inserted into the insertion holes.
5. The multistage electroosmotic micropump of claim 3, further comprising a flexible electrical connection element disposed within said first connection hole, said flexible electrical connection element abutting between a hole wall of said first connection hole and said fastening pin.
6. The multistage electroosmotic micropump of claim 4, wherein said terminal body has a serpentine-shaped bent structure, and said electrode groove is adapted to said serpentine-shaped bent structure.
7. The multistage electroosmotic micropump of any one of claims 2 to 6, wherein said housing further has four fixing holes formed therein, said fixing holes penetrating all of said membrane grooves of a single said porous membrane fixing structure, said multistage electroosmotic micropump further comprising porous membrane fixing needles, said porous membrane fixing needles being inserted into said fixing holes and through holes of said porous membranes.
8. The multistage electroosmotic micropump of any one of claims 2 to 6, wherein an end of the sealing cover facing the cavity is provided with a fluid chamber having a funnel shape.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7785158B1 (en) * | 2007-11-30 | 2010-08-31 | Brunswick Corporation | Electrode connection platform |
| CN105337058A (en) * | 2014-07-16 | 2016-02-17 | 珠海格力节能环保制冷技术研究中心有限公司 | Binding post structure of compressor and compressor |
| CN106711633A (en) * | 2017-01-19 | 2017-05-24 | 郑州凌达压缩机有限公司 | Compressor terminal connector and compressor |
| CN107436365A (en) * | 2017-08-14 | 2017-12-05 | 中北大学 | A kind of graphene wind speed wind direction sensor |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100591432B1 (en) * | 2004-05-31 | 2006-06-22 | 삼성에스디아이 주식회사 | Secondary battery |
| US20100244585A1 (en) * | 2009-03-26 | 2010-09-30 | General Electric Company | High-temperature capacitors and methods of making the same |
| CN106644238B (en) * | 2016-11-11 | 2020-04-03 | 中国电子科技集团公司第四十八研究所 | Film differential pressure core |
| CN206931551U (en) * | 2017-05-08 | 2018-01-26 | 中国科学院电子学研究所 | Lead interior crossing type multi-level depressurization collector |
| CN207851102U (en) * | 2017-08-14 | 2018-09-11 | 中北大学 | A kind of graphene wind speed wind direction sensor |
| CN210198972U (en) * | 2019-04-17 | 2020-03-27 | 华研环科(北京)科技有限公司 | Lithium battery in-situ microscopic imaging device and in-situ high-temperature microscopic imaging device |
| CN211877292U (en) * | 2020-03-31 | 2020-11-06 | 中北大学 | Cross beam structure graphite alkene high temperature pressure sensor |
| CN111918506B (en) * | 2020-09-30 | 2021-01-26 | 杭州未名信科科技有限公司 | Connecting structure of film electrode and shell |
-
2021
- 2021-12-10 CN CN202111504557.5A patent/CN113893411B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7785158B1 (en) * | 2007-11-30 | 2010-08-31 | Brunswick Corporation | Electrode connection platform |
| CN105337058A (en) * | 2014-07-16 | 2016-02-17 | 珠海格力节能环保制冷技术研究中心有限公司 | Binding post structure of compressor and compressor |
| CN106711633A (en) * | 2017-01-19 | 2017-05-24 | 郑州凌达压缩机有限公司 | Compressor terminal connector and compressor |
| CN107436365A (en) * | 2017-08-14 | 2017-12-05 | 中北大学 | A kind of graphene wind speed wind direction sensor |
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Inventor after: Zhang Zebo Inventor after: Gao Meng Inventor before: Zhang Zebo Inventor before: Gao Meng Inventor before: Ye Le |