CN113855912A - Micro-pump device for medicine administration - Google Patents
Micro-pump device for medicine administration Download PDFInfo
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- CN113855912A CN113855912A CN202110930491.XA CN202110930491A CN113855912A CN 113855912 A CN113855912 A CN 113855912A CN 202110930491 A CN202110930491 A CN 202110930491A CN 113855912 A CN113855912 A CN 113855912A
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
Landscapes
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Abstract
The invention relates to the technical field of medical instruments, and particularly discloses a drug delivery micropump device which comprises a packaging shell, a driving module, a first driving electrode and a second driving electrode, wherein the driving module, the first driving electrode and the second driving electrode are installed in the packaging shell, two opposite ends of the packaging shell are respectively provided with a liquid medicine inlet and a liquid medicine outlet, a plurality of micro-cavity channels penetrating through two side surfaces of the driving module are formed in the driving module, the liquid medicine inlet is communicated with the liquid medicine outlet through the micro-cavity channels, and the first driving electrode and the second driving electrode are respectively arranged on two side surfaces of the driving module. The invention provides a drug delivery micropump device based on an electroosmosis micro-drive principle, which has a simple and compact structure, only has two core components of a drive electrode and a drive module inside, does not have a mechanical motion friction part, is beneficial to the miniaturization assembly and integration of a pump body in a drug delivery system, can obviously reduce the volume size, and solves the problem of easy failure of a mechanical pump due to mechanical motion.
Description
Technical Field
The invention relates to the technical field of medical instruments, and particularly discloses a drug delivery micropump device.
Background
The drug delivery pump is an indispensable key medical apparatus for clinical transfusion and disease treatment, and is widely applied to the micro-precise delivery of analgesics, insulin, antihypertensive drugs and cancer chemotherapeutics. The medicine is expensive, can achieve the targeted and accurate treatment effect by the transportation of a medicine pump, can improve the use efficiency of the medicine to the maximum extent, reduce the medicine cost, and can also obviously reduce the side effect of the medicine.
In clinical application, mechanical pumps such as gear rotor pumps, screw pumps, turbine pumps, peristaltic pumps and the like are always pumps for drug delivery mainstream regardless of external drug delivery or internal implant drug delivery. Mechanical pumps pump drugs by mechanical motion, which can generate heat due to mechanical friction to cause power dissipation loss and also easily cause mechanical failure; on the other hand, the mechanical moving parts of the mechanical pump are not conducive to miniaturization and integration of the drug delivery system, often resulting in a larger volume of the drug delivery system and easy generation of friction noise.
Disclosure of Invention
The present invention is directed to solving, at least to some extent, the above-mentioned technical problems in the related art. To this end, the present invention proposes a drug delivery micro-pump device solving at least one of the technical problems described above.
In order to achieve the above object, the present invention provides a drug delivery micropump device, including a package housing, a driving module, a first driving electrode and a second driving electrode, wherein the driving module, the first driving electrode and the second driving electrode are installed in the package housing, two opposite ends of the package housing are respectively provided with a drug solution inlet and a drug solution outlet, a plurality of micro channels penetrating through two side surfaces of the driving module are formed in the driving module, the drug solution inlet is communicated with the drug solution outlet through the micro channels, and the first driving electrode and the second driving electrode are respectively disposed on two side surfaces of the driving module.
In addition, the administration micropump device of the present invention may also have the following additional technical features:
according to some embodiments of the invention, the electrode surface of the first driving electrode and the electrode surface of the second driving electrode are disposed in parallel, and the electrode surface of the first driving electrode and the electrode surface of the second driving electrode are perpendicular to the center line of the micro-channel respectively.
According to some embodiments of the invention, the drive module comprises a plurality of capillaries arranged in a stack, each capillary having a microchannel formed therein.
According to some embodiments of the invention, the driving module is a multi-layer structure, and each layer of structure is convexly provided with a plurality of rectangular strips so as to form micro-cavities between two adjacent layers of structures.
According to some embodiments of the invention, the drive module is formed by stacking a plurality of sheets.
According to some embodiments of the invention, the drive module is spirally wound from a sheet.
According to some embodiments of the invention, the drive module is serpentine folded from a sheet.
According to some embodiments of the invention, the sheet has a plurality of through holes.
According to some embodiments of the invention, the first driving electrode and/or the second driving electrode is a mesh structure woven by wires or a thin film porous structure, and the pore size of the single mesh on the first driving electrode and/or the second driving electrode is not smaller than the cross-sectional equivalent diameter size of the single micro-cavity channel.
According to some embodiments of the present invention, the package housing includes a tube body having openings at two ends thereof, and a first end cap and a second end cap disposed at two ends of the tube body, the liquid medicine inlet is disposed on the first end cap, the liquid medicine outlet is disposed on the second end cap, and the driving module is disposed in the tube body.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a drug delivery micropump device based on an electroosmosis micro-drive principle, which has a simple and compact structure, only has two core components of a drive electrode and a drive module inside, does not have a mechanical motion friction part, is beneficial to the miniaturization assembly and integration of a pump body in a drug delivery system, can obviously reduce the volume size, and solves the problem of easy failure of a mechanical pump due to mechanical motion.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
FIG. 1 is an exploded view of a drug delivery micro-pump device in accordance with one embodiment of the present invention;
FIG. 2 is a perspective view of FIG. 1;
FIG. 3 is an exploded view of a drug delivery micro-pump device in accordance with another embodiment of the present invention;
FIG. 4 is an exploded view of a drug delivery micro-pump device in accordance with another embodiment of the present invention;
FIG. 5 is an exploded view of a drug delivery micro-pump device in accordance with another embodiment of the present invention;
FIG. 6 is a schematic view of a portion of the structure of FIG. 5;
FIG. 7a is a side view of a combination of a sheet and rectangular strips in accordance with an embodiment of the present invention;
FIG. 7b is a top view of a combination of a sheet and rectangular strips in accordance with an embodiment of the present invention;
FIG. 8a is a side view of a sheet in combination with rectangular strips and drive electrodes in accordance with an embodiment of the present invention;
FIG. 8b is a top view of a combination of a sheet with rectangular strips and drive electrodes in accordance with an embodiment of the present invention;
FIG. 9a is a side view of a sheet after being apertured in accordance with one embodiment of the present invention;
figure 9b is a top view of a sheet after being apertured in accordance with one embodiment of the present invention.
The implementation, functional features and advantages of the objects of the present invention will be further described with reference to the accompanying drawings.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that all the directional indicators (such as upper, lower, left, right, front and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indicator is changed accordingly.
In addition, the descriptions related to "first", "second", etc. in the present invention are only for descriptive purposes and are not to be construed as indicating or implying relative importance or implying any number of indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present invention, "a plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "connected," "secured," and the like are to be construed broadly, and for example, "secured" may be a fixed connection, a removable connection, or an integral part; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In addition, the technical solutions in the embodiments of the present invention may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the protection scope of the present invention.
The technical solution of the present invention will be described in further detail with reference to specific examples.
Referring to fig. 1 to 9, an embodiment of the present invention provides a drug delivery micro-pump device 100, where the drug delivery micro-pump device 100 includes a package housing 10, a driving module, a first driving electrode 11 and a second driving electrode 12, the driving module, the first driving electrode 11 and the second driving electrode 12 are installed in the package housing 10, two opposite ends of the package housing 10 are respectively provided with a drug solution inlet 101 and a drug solution outlet 102, the drug solution inlet 101 and the drug solution outlet 102 are respectively used for connecting with a liquid storage device of a drug fluid and an infusion catheter or needle, a plurality of micro-channels 13 penetrating through two side faces of the driving module are formed in the driving module, the drug solution inlet 101 is communicated with the drug solution outlet 102 through the micro-channels 13, and the first driving electrode 11 and the second driving electrode 12 are respectively disposed on two side faces of the driving module. Compared with the same type of electroosmosis pump, the design of the administration micropump of the embodiment of the invention ensures the administration effect and has simpler structure.
The package housing 10 includes a tube 103 having openings at two ends, and a first end cap 104 and a second end cap 105 disposed at two ends of the tube 103, wherein the liquid medicine inlet 101 is disposed on the first end cap 104, the liquid medicine outlet 102 is disposed on the second end cap 105, and the driving module is disposed in the tube 103.
It should be noted that the package housing 10 may play a role in fixing and protecting the driving module, the first driving electrode 11, and the second driving electrode 12, the tube 103 wraps the driving module and serves as an outermost layer of the drug fluid channel to prevent the drug fluid from leaking, the tube 103 may be made into a circular shape, a rectangular shape, a rhombic shape, or the like, and the present invention is not limited herein.
Further, the material of the package housing 10 may be quartz glass, ceramic, polymethyl methacrylate, or polytetrafluoroethylene, and is prepared by machining processes such as cutting, stamping, injection molding, laser, 3D printing, and the like.
In addition, after the package housing 10 is assembled with the driving module, the first driving electrode 11 and the second driving electrode 12, permanent sealing may be performed by glue, laser welding, ultrasonic welding, plasma bonding, or thermal compression bonding, or non-permanent sealing may be performed by bolts.
In this embodiment, the first driving electrode 11 may be directly and integrally fixed to the first end cap 104, the second driving electrode 12 may be directly and integrally fixed to the second end cap 105, or may be directly and integrally fixed to two ends of the driving module by sputtering, deposition, gluing, and the like, and the first driving electrode 11 and the second driving electrode 12 are connected to an external power lead through the tube 103 or a gap reserved in the first end cap 104 or the second end cap 105.
With continued reference to fig. 1-6, the electrode surface of the first driving electrode 11 is parallel to the electrode surface of the second driving electrode 12, and the electrode surfaces of the first driving electrode 11 and the second driving electrode 12 are perpendicular to the center line of each micro-channel 13. Specifically, when the electrode surface of the first driving electrode 11 and the electrode surface of the second driving electrode 12 are perpendicular to the center line of each micro-channel 13, the direction of the electric field generated by the first driving electrode 11 and the second driving electrode 12 in the micro-channel 13 is parallel to the flow direction of the fluid, so that the utilization rate of the electric field can reach the highest, a parallel electric field is formed in the micro-channel 13, an electric double layer is formed on the inner and outer wall surfaces of the micro-channel 13, and when the first driving electrode 11 and the second driving electrode 12 are loaded with voltage, the static electricity pushes the electric double layer to slide to form an electroosmotic flow, so that a pump driving force is generated, and further the medicine is driven to flow. Compared with other electroosmotic pumps, under the condition of the same total pump length and space, the effective driving length of the embodiment of the invention is much longer, the flow rate is equivalent to the effective driving length, and the pumping pressure is obviously improved. In addition, the micro-channel designed by the embodiment of the invention can transport medicines in a range from nanometer to micrometer, and besides small molecular medicines, large molecules such as insulin can also be transported.
The first driving electrode 11 and the second driving electrode 12 can be used as a positive electrode and a negative electrode respectively, the first driving electrode 11 and/or the second driving electrode 12 can be a mesh structure or a thin film porous structure woven by a lead to cover the cross section of the drug fluid micro-cavity channel 13 of the driving module to the maximum extent, meshes on the first driving electrode 11 and the second driving electrode 12 are used for drug fluid to pass through, and the pore diameter of a single mesh on the first driving electrode 11 and/or the second driving electrode 12 is not less than the equivalent diameter size of the cross section of the single micro-cavity channel 13.
In this embodiment, the first driving electrode 11 and the second driving electrode 12 may be made of biocompatible platinum, gold, titanium, platinum iridium, or a metal alloy or coating thereof, or may be made by metallizing the metal on a non-metal substrate made of a biomaterial such as quartz glass, ceramic, or polyimide. In addition, the first driving electrode 11 and the second driving electrode 12 can be surface-modified by a bio-coating process, so that the electroosmosis driving effect is improved, the electrode electrolysis reaction and gas generation are eliminated, and the pollution of byproducts to the medicine is avoided.
In some embodiments of the present invention, with continued reference to fig. 1-2, the drive module may include a plurality of capillaries 14 arranged in a stack, with one microchannel 13 formed within each capillary 14. Specifically, the plurality of capillaries 14 are arranged in parallel and connected in parallel, an electric double layer is formed on the inner and outer wall surfaces of each capillary 14, when a voltage is applied to the first driving electrode 11 and the second driving electrode 12, parallel electric fields are generated on the inner and outer wall surfaces of the capillary 14 to generate an electrostatic driving force on the electric double layer, the electric double layer slides on the inner and outer wall surfaces of the capillary 14 under the action of the electrostatic force, and the medicament fluid around the electric double layer is pushed to flow downstream under the action of fluid viscosity, that is, an electroosmotic flow is formed, and a pump driving force is generated to drive the medicament to flow.
The cross section of the capillary 14 can be circular ring-shaped or elliptical ring-shaped, or rectangular ring-shaped or rhombic ring-shaped, etc., the capillary 14 can be prepared by selecting quartz glass, or polymethyl methacrylate, etc., the adjacent capillaries 14 can keep a certain distance gap or not, the equivalent diameter size of the cross section of the capillary 14 is in the range of tens of nanometers to hundreds of micrometers, and the gap between the capillaries 14 is not more than the equivalent diameter size of the cross section of the capillary 14.
In other embodiments of the present invention, the driving module may further have a multi-layer structure, each layer of the structure is provided with a plurality of rectangular strips 15 in a protruding manner to form a micro-cavity channel 13 between two adjacent layers of the structure, the wall surfaces of the rectangular strips 15 may be used as wall surfaces generated by electroosmotic flow to form a driving force of the micro-pump, and the equivalent diameter of the cross section of the micro-cavity channel 13 is in a range from tens of nanometers to hundreds of micrometers.
The rectangular strip 15 can be made of quartz glass, polymethyl methacrylate, polyurethane, polycarbonate, polyimide or other materials, the rectangular strip 15 can be integrated on the sheet 16 after being made by a micro-processing method, and the integration method can also be adhesive, plasma bonding, thermal compression bonding, ultrasonic welding, laser welding or other processes.
With continued reference to fig. 3-9, the driving module may be formed by stacking a plurality of sheets 16, at this time, a micro-cavity channel 13 is formed between two adjacent sheets 16, a plurality of rectangular strips 15 are uniformly arranged on the sheets 16 and are linearly arranged, the driving module may also be formed by spirally winding one sheet 15, at this time, a micro-cavity channel 13 is formed between two adjacent winding layers; the driving module can also be formed by folding a thin sheet 16 in a snake shape, at this time, a micro channel 13 is formed between two adjacent folded layers, the driving principle of the three driving modules is the same as that of fig. 2, and the description of the invention is omitted here.
Further, as shown in fig. 9, the thin sheet 16 may be prepared by spin coating, deposition, sputtering, injection molding, stamping and other micro-processing processes, and a plurality of through holes 160 may be formed on the thin sheet 16 by mechanical punching, mechanical drilling, laser drilling and other methods, so that the entire driving module micro-cavity channel 13 is easily filled with the drug fluid during infusion, and the local pressure inside the micro-cavity channel 13 is released.
When the first driving electrode 11 and the second driving electrode 12 are applied with driving voltages, the drug fluid on the inner wall surface of the micro-channel 13 forms electroosmotic flow to drive the drug fluid to flow, so as to achieve the function of pumping the drug. Compared with a mechanical pump, the medicine pump based on electroosmotic flow driving has a relatively simple structure, is easy to integrate and miniaturize, has no mechanical moving part in the pump, does not generate friction wear and noise, and operates stably; in addition, no mechanical moving part is arranged in the pump, so that the damage of mechanical friction motion to the structure of the medicine, particularly insulin-like large molecular medicine can be avoided, and the pump can be favorable for long-term and efficient targeted drug delivery treatment of chronic diseases such as diabetes, cancer, hypertension and the like.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The utility model provides a micropump device of dosing, its characterized in that, is including encapsulation shell, drive module, first drive electrode and second drive electrode are installed in the encapsulation shell, liquid medicine import and liquid medicine export have been seted up respectively to encapsulation shell's relative both ends, be formed with a plurality of in the drive module and run through the microcavity of drive module both sides face says, the liquid medicine import passes through the microcavity say with liquid medicine export intercommunication, first drive electrode and second drive electrode are located respectively drive module's both sides face.
2. The administration micro pump device according to claim 1, wherein the electrode surface of the first driving electrode is disposed parallel to the electrode surface of the second driving electrode, and the electrode surfaces of the first driving electrode and the second driving electrode are perpendicular to the center line of the micro channel, respectively.
3. The drug delivery micropump device of claim 2, wherein the driving module comprises a plurality of capillaries arranged in a stack, one microcavity channel being formed in each capillary.
4. The drug delivery micropump device according to claim 2, wherein the driving module is a multi-layer structure, and a plurality of rectangular strips are convexly arranged on each layer structure to form a micro-cavity channel between the two adjacent layers of structures.
5. The drug delivery micro-pump device of claim 4, wherein the driving module is formed by stacking a plurality of thin plates.
6. The drug delivery micro-pump device of claim 4, wherein the drive module is spirally wound from a sheet.
7. The drug delivery micropump device of claim 4, wherein the drive module is serpentine folded from a sheet.
8. The administration micro pump device according to any of claims 5 to 7, wherein the sheet is provided with a plurality of through holes.
9. The drug delivery micropump device according to claim 2, wherein the first driving electrode and/or the second driving electrode is a mesh structure woven by a conducting wire or a thin film porous structure, and the pore size of the single mesh on the first driving electrode and/or the second driving electrode is not smaller than the cross-sectional equivalent diameter size of the single microcavity channel.
10. The drug delivery micro-pump device according to claim 2, wherein the package housing comprises a tube body having openings at two ends thereof, and a first end cap and a second end cap disposed at two ends of the tube body, the drug solution inlet is disposed on the first end cap, the drug solution outlet is disposed on the second end cap, and the driving module is disposed in the tube body.
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