CN113876641A - 一种具有抗皱紧致功效的化妆品组合物及其应用 - Google Patents
一种具有抗皱紧致功效的化妆品组合物及其应用 Download PDFInfo
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- CN113876641A CN113876641A CN202111305071.9A CN202111305071A CN113876641A CN 113876641 A CN113876641 A CN 113876641A CN 202111305071 A CN202111305071 A CN 202111305071A CN 113876641 A CN113876641 A CN 113876641A
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- percent
- wrinkle
- skin
- cosmetic composition
- cosmetic
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Abstract
本发明公开了一种具有抗皱紧致功效的化妆品组合物及其应用，涉及化妆品技术领域；上述具有抗皱紧致功效的化妆品组合物按质量百分比计，由以下组分组成：透明质酸钠：0.002‑1％；复合物I：0.002‑5％；复合物II：0.002‑5％；化妆品辅料基质：91％‑99.9％；所述复合物I包括以下组分：C12‑15醇苯甲酸酯、三山嵛精、神经酰胺NS/神经酰胺NG、PEG‑10植物甾醇、乳酸和棕榈酰六肽‑12；所述复合物II包括以下组分：水、甘油、PCA钠、水解胶原、赤藓糖、皱波角叉菜、黄原胶、苯甲酸、山梨酸和六肽‑9。本发明的化妆品组合物能淡化肌肤细纹、紧实肌肤增加弹性，强化皮肤屏障减少经皮水份流失。
Description
技术领域
本发明涉及化妆品技术领域，具体涉及一种具有抗皱紧致功效的化妆品组合物及其应用。
背景技术
众所周知，肌肤老化分自然老化和环境因素导致的老化。自然老化是指皮肤细胞自身会随着时间推移而老化，皮肤细胞就像整个人体一样，也有生命周期，随着时间推移，细胞的增殖与分化能力和功能会逐渐衰退，这就被称为细胞的衰老。衰老的细胞虽然依然有活性，但没有能力繁殖。那皮肤作为我们全身上下最大的器官，自然也会随着皮肤细胞的衰老而老化，皱纹、色斑、松弛就是皮肤细胞衰老的结果。不管男性还是女性，一般25岁以后，皮肤的新陈代谢就会日趋缓慢，角质层会渐渐堆积变厚。除了年龄会影响皮肤状况，由于工作、生活压力导致的体内荷尔蒙的变化，环境的污染，紫外线的辐射，不良的饮食习惯吸烟、饮酒以及不恰当的肌肤保养方式均会影响皮肤健康，导致大量自由基的生成，这些活跃的分子基团会引发一系列自由基反应，造成细胞的损伤甚至死亡，从而使肌肤加速衰老。坚持长期正确使用有效的抗衰紧致护肤品在一定程度上可以有效延缓皮肤衰老的速度。
目前，市场上宣称抗衰紧致的护肤品品类繁多、质量也良莠不齐，甚至有些产品使用后不但起不到抗衰紧致的效果，反而带来刺激、瘙痒等肌肤问题，或导致敏感肌肤的出现。随着新法规的落地，开发出真正具有抗衰紧致功效的产品也是很有市场前景的。
发明内容
本发明目的在于为克服现有的技术缺陷，提供一种具有抗皱紧致功效的化妆品组合物及其应用，本发明的化妆品组合物能淡化肌肤细纹、紧实肌肤增加弹性，强化皮肤屏障减少经皮水份流失。
为了解决上述技术问题，本发明提供了以下技术方案：
第一方面，提供了一种具有抗皱紧致功效的化妆品组合物，按质量百分比计，由以下组分组成：
透明质酸钠：0.002-1％；
复合物I：0.002-5％；
复合物II：0.002-5％；
化妆品辅料基质：91％-99.9％；
所述复合物I包括以下组分：C12-15醇苯甲酸酯、三山嵛精、神经酰胺 NS/神经酰胺NG、PEG-10植物甾醇、乳酸和棕榈酰六肽-12；
所述复合物II包括以下组分：水、甘油、PCA钠、水解胶原、赤藓糖、皱波角叉菜、黄原胶、苯甲酸、山梨酸和六肽-9。
进一步地，按质量百分比计，所述复合物I中各组分的含量为：C12-15醇苯甲酸酯：71-74％、三山嵛精：18-22％、神经酰胺NS/神经酰胺NG：3.0-4.5％、 PEG-10植物甾醇：2.0-3.0％、乳酸：0.7-1.0％、棕榈酰六肽-12：0.01-0.04％。
进一步地，按质量百分比计，所述复合物II中各组分的含量为：水：80-90％、甘油：10-15％、PCA钠：1-5％、水解胶原：0.5-3％、赤藓糖：0.5-2％、皱波角叉菜：0.5-1.5％、黄原胶：0.1-0.6％、苯甲酸：0.1-0.3％、山梨酸：0.1-0.2％、六肽-9：0.001-0.1％。
进一步地，按质量百分比计，所述化妆品辅料基质中各组分的含量为：溶剂：20-95％；保湿剂：1-18％；增稠剂：0.01-3％；乳化剂：0-4.5％；润肤剂： 0-65％；防晒剂：0-30％；香精香料：0-0.5％；防腐剂：0.01-2％；
其中，所述防晒剂为物理防晒剂或者化学防晒剂中的一种或多种。
在本发明中，化妆品基质辅料均为化妆品领域常用的基质辅料；优选地，所述化妆品基质辅料选自保湿剂、螯合剂、增稠剂、润肤剂、乳化剂、皮肤调理剂、溶剂、香精香料、防腐剂、水中的一种或多种。
进一步地，所述化妆品辅料基质由以下质量百分比的组分组成：溶剂： 22-90％；保湿剂：1-12％；增稠剂：0.05-2.5％；乳化剂：0-3.5％；润肤剂：0-60％；防晒剂：0-28％；香精香料：0-0.3％；防腐剂：0.05-1.5％。
进一步地，所述保湿剂为山梨醇、甘油、木糖醇、1，2-己二醇、尿素、双丙甘醇、乳酸钠、糖类同分异构体、丙二醇、甜菜碱、PCA钠、透明质酸钠、聚乙二醇-8、丁二醇、透明质酸、甘油丙烯酸酯/丙烯酸酯共聚物、1，2-戊二醇、海藻糖、1，3-丙二醇、乙基己基甘油中的一种或多种。
进一步地，所述防晒剂为苯基苯并咪唑磺酸、聚硅氧烷-15、4-甲基苄亚基樟脑、丁基甲氧基二苯甲酰基甲烷、二甲基PABA乙基己酯、亚甲基双-苯并三唑基四甲基丁基酚、p-甲氧基肉桂酸异戊酯、奥克立林、双-乙基己氧苯酚甲氧苯基三嗪、二乙氨羟苯甲酰基苯甲酸己酯、二苯酮-3、二乙基己基丁酰胺基三嗪酮、乙基己基三嗪酮、水杨酸乙基己酯、苯基二苯并咪唑四磺酸酯二钠、甲氧基肉桂酸乙基己酯、薄荷醇邻氨基苯甲酸酯、二氧化钛、氧化锌中的一种或多种。
进一步地，所述增稠剂为聚丙烯酸酯交联聚合物-6、纤维素及其改性物、结冷胶、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物、聚丙烯酸钠接枝淀粉、聚丙烯酸、羟丙基淀粉磷酸酯、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、卡波姆、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸(酯)类共聚物、聚丙烯酰胺、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物、黄原胶、聚丙烯酸酯-13 中的一种或多种。
进一步地，所述乳化剂为聚山梨醇酯类、脂肪醇聚醚类、脂肪醇磷酸酯类、甘油硬脂酸酯、PEG-20甲基葡糖倍半硬脂酸酯、硬脂酰谷氨酸钠、山梨坦脂肪酸酯类、蔗糖脂肪酸酯类、聚乙二醇硬脂酸酯类、聚甘油脂肪酸酯类、氢化卵磷脂、PEG-40氢化蓖麻油、鲸蜡醇磷酸酯钾、PPG-26-丁醇聚醚-26、鲸蜡硬脂醇橄榄油酸酯、烷基葡糖苷类、聚乙二醇聚硅氧烷类中的一种或多种。
进一步地，所述润肤剂为植物油脂、合成油脂、动物油脂、矿物油脂、合成油脂组合物中的一种或多种。
作为优选的技术方案，本发明中的防腐剂为化妆品领域的常用防腐剂，所述防腐剂为咪唑烷基脲类、苯氧乙醇、尼泊金酯类、有机酸类中的一种或多种。
作为优选的技术方案，本发明中的香精香料为化妆品领域的常用香精香料，所述香精香料选自清香型香精、花香型香精、果香型香精、复合香型香精中的一种或多种。
作为优选的技术方案，本发明中的溶剂为水，所述水为符合化妆品要求的用水。
第二方面，提供了一种如第一方面所述的具有抗皱紧致功效的化妆品组合物在制备化妆品中的应用，所述化妆品具有抗皱紧致功效；所述化妆品的剂型为膏霜、乳液、水剂、精华液、面膜、啫喱、底妆、喷雾和洁面产品。
本发明采用的透明质酸钠(HA)是线型直链状高分子黏多糖，由葡萄糖醛酸和N-乙酰氨基葡萄糖组成的双糖单位重复连接而成，分子量范围从几千到 300万道尔顿不等。透明质酸钠具有高度水亲和性，当HA分子量或浓度达到一定值，HA分子线圈相互缠绕、形成连续、柔韧的三维网状结构，如同“分子海绵”一样，HA可牢牢锁住很多水分。同时HA还具有智能保湿作用，低相对湿度环境下，HA吸湿量最高；高相对湿度环境下，HA吸湿量最低。能实现智能调节，保证肌肤水润。
50％以上HA存在于皮肤中，在真皮层、表皮层、角质层中均含有HA。真皮层较厚，细胞间的胞外空间大，基质多，因此含HA量较多；表皮层较薄，细胞排列紧密，含HA相对较少。在皮肤中透明质酸与其他硫酸化多糖、胶原蛋白、弹性蛋白等纤维性蛋白共同组成含大量水分的胞外胶状基质，维持皮肤水润、有弹性。
本发明采用的复合物I是由Ceramide 2和a matrikine*弹性蛋白的片段 Pal-Val-Gly-Val-Ala-Pro-Gly结合而成，Ceramide 2是角质层成分，皮肤的完整性是由角质层细胞间隙总的神经酰胺来保证的。Ceramide 2可以提升皮肤完整性和皮肤屏障，同时减少水分散失；Matrikine VGVAPG通过趋化性作用，实现弹性蛋白合成的再平衡，激活皮肤受损区域的特定蛋白，趋使受损细胞的清理和新细胞的制备，将修复细胞指引到皮肤损伤区域，在损伤部位的清除过程之后，成纤维母细胞的修复活性被激活，肌肤变得更加平滑，皱纹和细纹数量减少。
本发明采用的复合物II，主要包含海洋的胶原蛋白寡肽，红色海藻提取物，天然发酵的赤藓醇和RSPO甘油，高比例天然来源成分，可生物降解。
皮肤初老的主要特征是：
1、真表皮连接层(基底膜)的扁平化，胶原蛋白IV&XVII减少；
2、老化肌肤表皮变薄；
3、真皮层稀疏、僵硬，弹性下降，胶原蛋白I&III减少。
纤维性胶原是一类提供皮肤抗张强度的胶原蛋白，胶原流失是皮肤老化的重要特征：
1、结构：胶原蛋白I型是真皮中主要的蛋白质，它排列在纤维上，产生强度和阻力；
2、新生：胶原蛋白III型常与I型相伴而行，与皮肤再生密切相关；
3、网络：胶原蛋白IV将表皮锚固到真皮-表皮连接层(DEJ)，形成一个网状结构，使DEJ的结构稳固；
4、信号：胶原蛋白VXII是一种跨膜胶原蛋白，将表皮锚固到细胞外基质 (ECM)，也作为皮肤再生的信号释放，胶原蛋白IV与胶原蛋白VXII共同组成表真皮“锚定"的张力结构。
皮肤延缓衰老是一个动态的多步骤过程，本发明采用的复合物II分别对表皮层、表皮、真表皮连接层(基底膜)和真皮层产生作用，锁水紧致肌肤，促进再生和皮肤屏障修复，提升胶原蛋白IV&XVII、I&III，从而起到抗老的效果。
与现有技术相比，本发明具有以下有益效果：
本发明的具有抗皱紧致功效的化妆品组合物，通过三个维度来达到最终的紧致抗皱效果，一是选用分子量范围从几千到300万道尔顿的透明质酸钠，通过透明质酸钠特殊的保湿作用，能与其他硫酸化多糖、胶原蛋白、弹性蛋白等纤维性蛋白共同组成含大量水分的胞外胶状基质，维持皮肤水润、有弹性；二是利用复合物I，提升皮肤屏障，通过趋化性作用，实现弹性蛋白合成的再平衡，激活皮肤受损区域的特定蛋白，趋使受损细胞的清理和新细胞的制备，使得肌肤变得更加平滑，皱纹和细纹数量减少；三是利用复合物II，分别对表皮层、表皮、真表皮连接层(基底膜)和真皮层产生作用，锁水紧致肌肤，促进再生和皮肤屏障修复，提升胶原蛋白IV&XVII、I&III，从而起到抗老的效果。本发明通过实验意外发现，采用特定比例的透明质酸钠与复合物I、复合物II 配合使用，具有显著的协同增效作用，组合物通过组分间的协同作用，具有显著的抗皱效果。
本发明附加的方面和优点将在下面的描述中部分给出，这些将从下面的描述中变得明显，或通过本发明的实践了解到。
附图说明
此处所说明的附图用来提供对本发明的进一步理解，构成本申请的一部分，并不构成对本发明的不当限定，在附图中：
图1为本发明中抗皱紧致功效测试的测试区域示意图；
图2为本发明中消费者使用测试的测试区域示意图；
图3为实施例1-3和空白例的护肤霜连续使用4周后皱纹改善的测试结果示意图。
具体实施方式
为了更充分的理解本发明的技术内容，下面将结合具体实施例和附图对本发明作进一步介绍和说明；显然，以下所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例；基于本发明中的实施例，本领域技术人员在没有作出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
对于本领域的技术人员来说，通过阅读本说明书公开的内容，本发明的特征、有益效果和优点将变得显而易见。
除非另外指明，所有百分比、分数和比率都是按本发明组合物的总重量计算的。本文术语“重量含量”可用符号“％”表示。
本文中“包括”、“包含”、“含”、“含有”、“具有”或其它变体意在涵盖非封闭式包括，这些术语之间不作区分。术语“包含”是指可加入不影响最终结果的其它步骤和成分。术语“包含”还包括术语“由...组成”和“基本上由...组成”。本发明的组合物和方法/工艺可包含、由其组成和基本上由本文描述的必要元素和限制项以及本文描述的任一的附加的或任选的成分、组分、步骤或限制项组成。
需要说明的是，香精香料、防腐剂为化妆品技术领域的常规添加剂，其用量可由本领域技术人员可依据本申请记载的种类、含量以及化妆品中添加量的规定，根据产品设计需要进行添加。
实施例1-3、对照例1-5及空白例
将本发明提供的具有抗皱紧致功效的化妆品组合物，制成护肤霜，实施例 1-3、对照例1-5及空白例的原料组分配比，如下表1所示。
表1：实施例1-3、对照例1-5和空白例的配方组成(％)
上述复合物I和复合物II，其原料组分配方及含量如下表2和表3所示。
表2：复合物I的原料组分配方
| 组分名称 | 含量(质量％) |
| C12-15醇苯甲酸酯 | 73.08 |
| 三山嵛精 | 20 |
| 神经酰胺NS/神经酰胺NG | 3.5 |
| PEG-10植物甾醇 | 2.5 |
| 乳酸 | 0.9 |
| 棕榈酰六肽-12 | 0.02 |
表3：复合物II的原料组分配方
上述复合物II的总含量为100％。
将表1的化妆品组合物制成护肤霜，其制备方法包括以下步骤：
1、将去离子水、黄原胶、EDTA二钠、甘油、硬脂酰谷氨酸钠、透明质酸钠加入水相锅，搅拌加热到75-80℃，搅拌分散均匀，作为A相；
2、将季戊四醇四(乙基己酸)酯、异壬酸异壬酯、氢化聚异丁烯、牛油果树(BUTYROSPERMUM PARKII)果脂、鲸蜡硬脂醇、甘油硬脂酸酯、 PEG-100硬脂酸酯、鲸蜡硬脂醇、鲸蜡硬脂基葡糖苷、环五聚二甲基硅氧烷、环己硅氧烷、复合物I加入油相锅，搅拌加热到75-80℃，搅拌溶解均匀，作为 B相；
3、将A、B相同时抽入乳化锅中，均质乳化6-8分钟，保温搅拌10-20 分钟，开启降温水；
4、待降温至60℃，往乳化锅加入丙烯酰二甲基牛磺酸铵/VP共聚物，搅拌均质均匀；
5、当乳化锅内料体降温到45℃以下时，将复合物II、香精香料/防腐剂加入乳化锅内，搅拌均匀，得到护肤霜。
经过试验，上述复合物I，还可采用如表4所示的原料组分配方及含量。
表4：
| 组分名称 | 含量(％) |
| C12-15醇苯甲酸酯 | 71-74 |
| 三山嵛精 | 18-22 |
| 神经酰胺NS/神经酰胺NG | 3.0-4.5 |
| PEG-10植物甾醇 | 2.0-3.0 |
| 乳酸 | 0.7-1.0 |
| 棕榈酰六肽-12 | 0.01-0.04 |
上述复合物I的总含量为100％。
本发明的抗皱紧致功效化妆品组合物的配方中，保湿剂、防晒剂和增稠剂还可以采用以下物质组分。
保湿剂还可采用山梨醇、木糖醇、1,2-己二醇、尿素、双丙甘醇、乳酸钠、糖类同分异构体、丙二醇、甜菜碱、PCA钠、透明质酸钠、聚乙二醇-8、丁二醇、透明质酸、甘油丙烯酸酯/丙烯酸酯共聚物、1,2-戊二醇、海藻糖、1,3-丙二醇、乙基己基甘油中的一种或多种。值得注意的是，保湿剂中的透明质酸钠与其他常用的保湿剂一样，用于提高组合物的保湿剂作用，改善皮肤干燥状态，提高皮肤的含水量。
防晒剂还可采用苯基苯并咪唑磺酸、聚硅氧烷-15、4-甲基苄亚基樟脑、丁基甲氧基二苯甲酰基甲烷、二甲基PABA乙基己酯、亚甲基双-苯并三唑基四甲基丁基酚、p-甲氧基肉桂酸异戊酯、奥克立林、双-乙基己氧苯酚甲氧苯基三嗪、二乙氨羟苯甲酰基苯甲酸己酯、二苯酮-3、二乙基己基丁酰胺基三嗪酮、乙基己基三嗪酮、水杨酸乙基己酯、苯基二苯并咪唑四磺酸酯二钠、甲氧基肉桂酸乙基己酯、薄荷醇邻氨基苯甲酸酯、二氧化钛、氧化锌中的一种或多种。
增稠剂还可采用聚丙烯酸酯交联聚合物-6、纤维素及其改性物、结冷胶、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物、聚丙烯酸钠接枝淀粉、聚丙烯酸、羟丙基淀粉磷酸酯、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、卡波姆、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸(酯)类共聚物、聚丙烯酰胺、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物、黄原胶、聚丙烯酸酯-13中的一种或多种。
效果验证试验：
(一)温和性测试
依据《化妆品安全技术规范》(2021版)规定的人体皮肤斑贴试验进行人体皮肤封闭型斑贴测试。
1、测试目的：检测受试物引起人体皮肤不良反应的潜在可能性。
2、测试设计：将加有受试物的斑试器帖敷与受试者背部皮肤，持续24h。受试物为化妆品产品物时，对照孔为空白对照(不置任何物质)，受试物为稀释后的化妆品时，对照孔内使用该化妆品的稀释剂。分别于去除受试物斑试器后 30min(待压痕消失后)、24h、48h按皮肤封闭型斑贴试验皮肤反应分级标准对皮肤进行评分。
3、测试样品：实施例1-3、对照例1-3的产品作为测试样品。
4、测试仪器/材料：分析天平、1mm斑试器、医用胶布、灭菌棉签和1ml 注射器；
5、测试方法：
志愿者要求：选择18-60岁符合试验要求的志愿者作为受试对象，30人；
测试步骤：选用面积不超过50mm2、深度约1mm的合格斑试器材。将受试物放入斑试器小室内，用量约为0.020g-0.025g。对照孔为空白对照。将加有受试物的斑试器用低敏胶带贴敷于受试者的背部，用手掌轻压使之均匀地贴敷于皮肤上，持续24h。
分别于去除受试物斑试器后30min(待压痕消失后)、24h和48h按表2 标准观察皮肤反应，并记录观察结果。
表5：皮肤封闭型斑贴试验皮肤反应分级标准
6、实验结果分析：试验结果如表6所示。
表6：人体皮肤封闭型斑贴试验结果
7、结论：人体皮肤封闭型斑贴试验结果显示，30人中0例出现阳性反应。
从上述人体皮肤封闭型斑贴试验可以看出，本发明实施例1-3、对照例1-3 的具有抗皱紧致功效的化妆品组合物不会引起不良的皮肤反应，非常温和，对人体皮肤无刺激。
(二)抗皱、紧致功效测试
抗皱指有助于减缓皮肤皱纹产生或使皱纹变得不明显。
紧致指有助于保持皮肤的紧实度、弹性。
A、抗皱+紧致组合方案测试
1、测试类型：人体功效评价
2、受试者要求：眼角有细纹者
3、测试仪器：Evaskin，Cutometer；
4、测试区域：眼角鱼尾纹，如图1所示；
5、测试指标：眼角细纹(Evaskin)，皮肤弹性(Cutometer)
6、使用方法：按照正常使用方法使用化妆品，早晚各一次
7、测试周期：8周
8、测试时间点：0，4，8周
9、样品：实施例1-3、对照例1-5、空白例的产品作为测试样品；
10、方法：将受试者随机分为9组，每组30名，对照例1-5分别与实施例 1左右对比测试，空白例与实施例1左右对比测试，实施例1分别与实施例2、3左右对比测试。在开始使用产品前用仪器测量测试指标，即第0周，并记录；连续使用8周，分别在第4周和第8周采集数据，并记录。
11、测试结果：
a、使用实施例1的眼角平均细纹深度随着时间延长明显变小，改善效果均优于对照例1-5和空白例；使用实施例1的眼角皮肤弹性随着时间延长得到逐步提升，8周皮肤弹性值对比使用前0周提升0.7，且对比对照例1-5和空白例皮肤弹性提升最明显；眼角平均细纹深度改善效果最明显，皮肤弹性值提升最大，说明使用实施例1的组合物后，皮肤的抗皱紧致效果最明显。同时，对照例4-5与实施例1的结果说明，本方案中透明质酸钠的选择是具有针对的，并不是组分间的简单添加或替换，采用其他保湿组分进行替换，虽有一定效果，但是效果不及透明质酸钠。具体为：透明质酸钠分子线圈相互缠绕，形成连续、柔韧的三维网状结构，可牢牢锁住很多水分；同时透明质酸钠有促进血液微循环改善代谢，有利于皮肤对营养物质的吸收，更为主要的是，透明质酸钠与其他两种复合物具有协同增效作用，三者共同作用时抗皱紧致功效显著增强，当采用其他保湿组分时，并不具备上述功效。
b、使用实施例1的眼角平均细纹深度改善效果优于实施例2、3，皮肤弹性提升情况对比实施例2高0.3，对比实施例3高0.35，说明使用实施例1的组合物后对皮肤抗皱紧致效果更好，说明在一定范围内，适当增加组合功效成分含量抗皱紧致效果会更好。
c、使用空白例的眼角平均细纹深度、皮肤弹性值前后变化不明显，说明肌肤抗皱紧致几乎无改善。
B、消费者使用测试
具体测试区域如图2所示：
1、将志愿者随机分为4组，每组30名，每组测试区域的位置和面积相同；
2、每组志愿者均分别连续使用4周实施例1产品、实施例2产品、实施例3产品和空白例产品，每组使用时间和用量一致，且测试期间不使用其他功能性化妆品；
3、志愿者自我评价皱纹改善情况和皮肤紧实度。
测试结果如图1所示。
从图1可知，本发明的具有抗皱紧致功效的化妆品组合物，通过组分间的协同作用，具有比较显著的抗皱效果。同时，各组分之间也存在一定的量效关系，在一定范围内，用量越大功效越好。
特别注意的是，在本发明公开的配比范围内，将上述化妆品组合物制成护肤水、护肤精华、护肤乳液、护肤凝胶、防晒乳、防晒霜、防晒凝胶或防晒喷雾等其他剂型的化妆品，其他剂型的化妆品与实施例所证实的效果一样，对人体皮肤温和、无刺激，均可以起到显著的抗皱紧致功效。
在上述实施例中，对各个实施例的描述都各有侧重，某个实施例中没有详细描述的部分，可以参见其他实施例的相关描述。
以上对本发明实施例所提供的技术方案进行了详细介绍，本文中应用了具体个例对本发明实施例的原理以及实施方式进行了阐述，以上实施例的说明只适用于帮助理解本发明实施例的原理；同时，对于本领域的一般技术人员，依据本发明实施例，在具体实施方式以及应用范围上均会有改变之处，综上所述，本说明书内容不应理解为对本发明的限制。
Claims (10)
1.一种具有抗皱紧致功效的化妆品组合物，其特征在于，按质量百分比计，由以下组分组成：
透明质酸钠：0.002-1％；
复合物I：0.002-5％；
复合物II：0.002-5％；
化妆品辅料基质：91％-99.9％；
所述复合物I包括以下组分：C12-15醇苯甲酸酯、三山嵛精、神经酰胺NS/神经酰胺NG、PEG-10植物甾醇、乳酸和棕榈酰六肽-12；
所述复合物II包括以下组分：水、甘油、PCA钠、水解胶原、赤藓糖、皱波角叉菜、黄原胶、苯甲酸、山梨酸和六肽-9。
2.根据权利要求1所述的具有抗皱紧致功效的化妆品组合物，其特征在于，按质量百分比计，所述复合物I中各组分的含量为：C12-15醇苯甲酸酯：71-74％、三山嵛精：18-22％、神经酰胺NS/神经酰胺NG：3.0-4.5％、PEG-10植物甾醇：2.0-3.0％、乳酸：0.7-1.0％、棕榈酰六肽-12：0.01-0.04％。
3.根据权利要求1所述的具有抗皱紧致功效的化妆品组合物，其特征在于，按质量百分比计，所述复合物II中各组分的含量为：水：80-90％、甘油：10-15％、PCA钠：1-5％、水解胶原：0.5-3％、赤藓糖：0.5-2％、皱波角叉菜：0.5-1.5％、黄原胶：0.1-0.6％、苯甲酸：0.1-0.3％、山梨酸：0.1-0.2％、六肽-9：0.001-0.1％。
4.根据权利要求1-3任一项所述的具有抗皱紧致功效的化妆品组合物，其特征在于，按质量百分比计，所述化妆品辅料基质中各组分的含量为：溶剂：20-95％；保湿剂：1-18％；增稠剂：0.01-3％；乳化剂：0-4.5％；润肤剂：0-65％；防晒剂：0-30％；香精香料：0-0.5％；防腐剂：0.01-2％；
其中，所述防晒剂为物理防晒剂或者化学防晒剂中的一种或多种。
5.根据权利要求4所述的具有抗皱紧致功效的化妆品组合物，其特征在于，所述化妆品辅料基质由以下质量百分比的组分组成：溶剂：22-90％；保湿剂：1-12％；增稠剂：0.05-2.5％；乳化剂：0-3.5％；润肤剂：0-60％；防晒剂：0-28％；香精香料：0-0.3％；防腐剂：0.05-1.5％。
6.根据权利要求5所述的具有抗皱紧致功效的化妆品组合物，其特征在于，所述防晒剂为苯基苯并咪唑磺酸、聚硅氧烷-15、4-甲基苄亚基樟脑、丁基甲氧基二苯甲酰基甲烷、二甲基PABA乙基己酯、亚甲基双-苯并三唑基四甲基丁基酚、p-甲氧基肉桂酸异戊酯、奥克立林、双-乙基己氧苯酚甲氧苯基三嗪、二乙氨羟苯甲酰基苯甲酸己酯、二苯酮-3、二乙基己基丁酰胺基三嗪酮、乙基己基三嗪酮、水杨酸乙基己酯、苯基二苯并咪唑四磺酸酯二钠、甲氧基肉桂酸乙基己酯、薄荷醇邻氨基苯甲酸酯、二氧化钛、氧化锌中的一种或多种。
7.根据权利要求5所述的具有抗皱紧致功效的化妆品组合物，其特征在于，所述保湿剂为山梨醇、甘油、木糖醇、1，2-己二醇、尿素、双丙甘醇、乳酸钠、糖类同分异构体、丙二醇、甜菜碱、PCA钠、透明质酸钠、聚乙二醇-8、丁二醇、透明质酸、甘油丙烯酸酯/丙烯酸酯共聚物、1，2-戊二醇、海藻糖、1，3-丙二醇、乙基己基甘油中的一种或多种。
8.根据权利要求5所述的具有抗皱紧致功效的化妆品组合物，其特征在于，所述增稠剂为聚丙烯酸酯交联聚合物-6、纤维素及其改性物、结冷胶、丙烯酸(酯)类/C10-30烷醇丙烯酸酯交联聚合物、聚丙烯酸钠接枝淀粉、聚丙烯酸、羟丙基淀粉磷酸酯、丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、卡波姆、丙烯酰二甲基牛磺酸铵/VP共聚物、丙烯酸(酯)类共聚物、聚丙烯酰胺、丙烯酸钠/丙烯酰二甲基牛磺酸钠共聚物、黄原胶、聚丙烯酸酯-13中的一种或多种。
9.根据权利要求5所述的具有抗皱紧致功效的化妆品组合物，其特征在于，所述乳化剂为聚山梨醇酯类、脂肪醇聚醚类、脂肪醇磷酸酯类、甘油硬脂酸酯、PEG-20甲基葡糖倍半硬脂酸酯、硬脂酰谷氨酸钠、山梨坦脂肪酸酯类、蔗糖脂肪酸酯类、聚乙二醇硬脂酸酯类、聚甘油脂肪酸酯类、氢化卵磷脂、PEG-40氢化蓖麻油、鲸蜡醇磷酸酯钾、PPG-26-丁醇聚醚-26、鲸蜡硬脂醇橄榄油酸酯、烷基葡糖苷类、聚乙二醇聚硅氧烷类中的一种或多种。
10.根据权利要求1-9任一项所述的具有抗皱紧致功效的化妆品组合物在制备化妆品中的应用，其特征在于，所述化妆品具有抗皱紧致功效；所述化妆品的剂型为膏霜、乳液、水剂、精华液、面膜、啫喱、底妆、喷雾和洁面产品。
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