CN113865277A

CN113865277A - Production device and production method of thesium chinense (lyophilized) powder

Info

Publication number: CN113865277A
Application number: CN202111236202.2A
Authority: CN
Inventors: 荆铭灿; 荆晓玉; 荆全梅; 李磊
Original assignee: Henan Hongyi Pharmaceutical Co ltd
Current assignee: Henan Hongyi Pharmaceutical Co ltd
Priority date: 2021-10-22
Filing date: 2021-10-22
Publication date: 2021-12-31

Abstract

The invention discloses a production device and a production method of thesium chinense (freeze-dried) powder, which comprises a drying box body, wherein the inside of the drying box body is of a cavity structure, a step-shaped discharge hole communicated with the inside is formed in the front end of the drying box body, a sealing door matched with the discharge hole is connected to the front end of the drying box body in a sliding mode, the sealing door slides to the discharge hole along the vertical direction and is in sealing cover fit with the discharge hole, and a slotted connecting rod mechanism used for applying extrusion force to the end face of the sealing door in the cover fit state is further arranged above the discharge hole in the front end of the drying box body. The thesium Chinese in the invention is dried at low temperature by adopting a vacuum freeze drying technology before being crushed, a plurality of heat-sensitive substances can not be denatured or inactivated, the loss of volatile components is small, and the original effective active components of the medicine are kept. The freeze drying can remove more than 95-99% of water, so that the dried medicine can be stored for a long time without deterioration. The freeze-dried medicine is porous, and has good rehydration and high drug effect.

Description

Production device and production method of thesium chinense (lyophilized) powder

Technical Field

The invention relates to the field of thesium preparations, in particular to a production device and a production method of thesium chinense (freeze-dried) powder.

Background

Thesium chinense is a hemiparasitic plant, and has less wild resources. Due to excessive collection, the wild resources of the thesium Chinese are increasingly reduced, and the market demand is increasingly large because the thesium Chinese has wide application, so that the change of the production process and the improvement of the product utilization rate are important.

In the processing process of the thesium Chinese schltr, the thesium Chinese schltr needs to be dried, but the drying or the drying is generally adopted for drying the thesium Chinese schltr in the prior art, but by adopting the drying mode, a plurality of heat-sensitive substances in the thesium Chinese schltr can be denatured or inactivated, the loss of volatile components is large, and a large amount of original effective active components in the thesium Chinese schltr are caused to be lost, so that the treatment effect of the medicine is greatly reduced, and the waste of resources is also caused. In view of the above situation, the present invention provides an apparatus for producing thesium powder and a method for preparing the same.

Disclosure of Invention

The invention aims to provide a production device and a production method of thesium powder, which aim to solve the problems in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme: the device comprises a drying box body, wherein the inside of the drying box body is of a cavity structure, a discharge hole which is communicated with the inside of the drying box body and is in a step shape is formed in the front end of the drying box body, a sealing door matched with the discharge hole is connected to the front end of the drying box body in a sliding mode, the sealing door slides to the discharge hole in the vertical direction and is in sealing cover fit with the discharge hole, and a slotted link mechanism used for applying extrusion force to the end face of the sealing door in the cover fit state is further arranged above the discharge hole in the front end of the drying box body.

Preferably, fluting link mechanism is including fixing the mount pad at dry box front end, the top fixed mounting of mount pad has the cylinder, the output of cylinder is connected with the piston rod, the terminal fixedly connected with sleeve pipe of piston rod, the front end of dry box is located the articulated seat of the fixedly connected with of sheathed tube bilateral symmetry, the inboard of every articulated seat all articulates there is the briquetting, the slope has been seted up on the briquetting and has been link up the groove, sheathed tube inside has been followed its axial fixation cover and has been connect the connecting rod, the both ends of connecting rod are followed its axial extension and are run through two respectively and link up the groove, and the connecting rod all with corresponding groove sliding connection that links up.

Preferably, the front end of the drying box body is located the both sides of drain hole and is provided with the slide rail along vertical direction, and the inboard of every slide rail all is formed with the gliding second spout of confession sealing door along vertical direction, and the sealing door is embedded to be installed between two slide rails and with second spout sliding connection, and the inboard position department that corresponds the drain hole of slide rail still is formed with the gliding first spout of confession sealing door along drain hole degree of depth direction, and first spout is linked together with the second spout.

Preferably, the inside of drying box is located the equidistant flitch that holds of a plurality of seconds of placing in top of drain hole, the inside of drying box is located equidistant a plurality of first flitchs that hold of placing in the below of drain hole, the equal fixedly connected with support in the bottom four corners department of every first flitch that holds, and in two adjacent first flitchs that hold, the first flitch that holds that is located the top passes through the support to be supported on the first flitch that holds of below, electric telescopic handle is installed to bottom center department in the cavity of drying box, electric telescopic handle's expansion end fixedly connected with adsorption plate, adsorption plate and support, the lower terminal surface of the second flitch that holds adsorbs fixedly.

Preferably, the inside both sides of cavity of drying box correspond the position department of the flourishing flitch of second or the first flourishing flitch all to be provided with spacing post, spacing post is the step shape structure towards the one end of drying box cavity center department, the other end extends to in the inner wall of drying box, and spacing post is located the slip of one end center department of drying box inner wall and has cup jointed the guide post, the spring has been cup jointed in the outside of guide post, the one end of spring links to each other with the inner wall of drying box, the other end links to each other with the one end of spacing post, the guide post is kept away from the one end center department fixedly connected with spliced pole of spacing post, fixedly connected with sprocket behind the inner wall that the spliced pole outwards extended through drying box, spacing post and spliced pole all rotate with the inner wall of drying box and are connected.

Preferably, the top ends of two sides and the bottom end of the outside of the drying box body are fixedly provided with motors, the output end of each motor is connected with a driving chain wheel, the two driving chain wheels positioned above are respectively sleeved with a second chain, the chain wheels corresponding to two sides of the second material containing plate above the discharging port are respectively meshed with the corresponding second chains, the driving chain wheels positioned below are respectively sleeved with a first chain, and the chain wheels corresponding to two sides of the second material containing plate below the discharging port are respectively meshed with the corresponding first chains.

The invention also provides a preparation method of the thesium powder, which comprises the following steps:

step one, taking thesium chinense, cleaning, cutting into sections, dishing up, and putting into a freeze dryer for vacuum freeze drying;

step two, crushing the dried thesium chinense, and finishing granules to obtain thesium chinense particles;

step three, taking the polyethylene oxide WSR303 in the prescription amount and the thesium granules prepared in the step two, uniformly mixing to prepare an intermediate, and tabletting the intermediate to obtain thesium powder.

Compared with the prior art, the invention provides a production device and a production method of thesium powder, which have the following beneficial effects:

(1) the thesium Chinese in the invention is dried at low temperature by adopting a vacuum freezing technology before being crushed, and because the vacuum freezing drying is low-temperature drying, a plurality of heat-sensitive substances can not be denatured or inactivated, the loss of volatile components is small, and the original effective active components of the medicine are kept. During the freeze-drying process, the growth of microorganisms and the action of enzymes cannot be carried out, so that the original properties such as color, smell and the like can be maintained. Since the drying is carried out under vacuum, oxygen is very little, and thus some easily oxidizable substances are protected. The freeze drying can remove more than 95-99% of water, so that the dried medicine can be stored for a long time without deterioration. The freeze-dried medicine is porous, and has good rehydration and high drug effect. The thesium Chinese adopts a freeze drying method to improve the drug effect, and the superfine grinding after drying can reduce the dosage, improve the utilization rate of the drug and save resources when being taken orally.

(2) According to the invention, the piston rod is driven to extend out by the air cylinder, the connecting rod slides along the through groove on the pressing block, the connecting rod extrudes the pressing block along with the continuous downward extension of the piston rod, the pressing block rotates by taking the hinge seat as the center, the other end of the pressing block acts on the end surface of the sealing door, and the sealing door is tightly pressed at the discharge opening, so that the whole device has a good sealing effect.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention without limiting the invention in which:

FIG. 1 is a schematic view of the overall structure of the entire apparatus of the present invention;

FIG. 2 is a schematic structural diagram of the whole device at the position of a sealing door;

FIG. 3 is a schematic view of the entire apparatus of the present invention with the sealing door removed;

FIG. 4 is a schematic view of the entire device with the back shell removed;

FIG. 5 is a schematic front view of the structure of FIG. 4;

FIG. 6 is a schematic view of the assembly of the sealing door and the sliding track;

FIG. 7 is a schematic structural view of a slide rail;

fig. 8 is a schematic sectional view of the assembly of the limiting column and the wall of the drying box.

In the figure: 1. drying the box body; 2. a mounting seat; 3. a cylinder; 4. briquetting; 5. a sealing door; 6. a slide rail; 61. a first chute; 62. a second chute; 7. a sprocket; 8. a first chain; 9. a motor; 10. a first material containing plate; 11. a support; 12. a second material containing plate; 13. an electric telescopic rod; 14. a limiting column; 15. A hinged seat; 16. a piston rod; 17. a sleeve; 18. a connecting rod; 19. a through groove; 20. a handle; 21. A discharging port; 22. a guide post; 23. connecting columns; 24. a spring; 25. and a second chain.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the embodiments of the present invention, it should be understood that the terms "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience in describing embodiments of the present invention and simplifying the description, but do not indicate or imply that the device or element referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus should not be construed as limiting the embodiments of the present invention.

The embodiment discloses a production device of thesium chinense (freeze-dried) powder. As shown in fig. 1-8, the drying box 1 is included, the inside of the drying box 1 is a cavity structure, a discharge port 21 which is communicated with the inside of the drying box 1 and is in a step shape is formed at the front end of the drying box 1, a sealing door 5 which is matched with the discharge port 21 is connected to the front end of the drying box 1 in a sliding manner, the sealing door 5 slides to the discharge port 21 along the vertical direction and is sealed and covered with the discharge port, a slotted link mechanism which is used for applying extrusion force to the end face of the sealing door 5 in a covering state is further arranged above the discharge port 21 at the front end of the drying box 1, and after the sealing door 5 in the step shape is covered on the discharge port 21, the sealing door 5 is applied with extrusion force through the slotted link mechanism, so that the sealing door and the sealing door are tightly combined, the sealing performance of the whole drying box 1 is ensured, and the drying efficiency of the thesium chinense is improved.

Further, the slotted link mechanism in this embodiment includes an installation base 2 fixed at the front end of the drying box 1, a cylinder 3 is fixedly installed at the top of the installation base 2, an output end of the cylinder 3 is connected with a piston rod 16, a sleeve 17 is fixedly connected to the end of the piston rod 16, hinge bases 15 are symmetrically and fixedly connected to both sides of the sleeve 17 at the front end of the drying box 1, a pressing block 4 is hinged to the inner side of each hinge base 15, a through groove 19 is obliquely formed on the pressing block 4, a connecting rod 18 is fixedly sleeved inside the sleeve 17 along the axial direction thereof, two ends of the connecting rod 18 respectively penetrate through the two through grooves 19 along the axial direction thereof, the connecting rod 18 is slidably connected with the corresponding through groove 19, the piston rod 16 is driven to extend by the cylinder 3, the connecting rod 18 slides along the through groove 19 on the pressing block 4, and the through groove 19 has the shape shown in fig. 2, so as the piston rod 16 continuously extends downwards, connecting rod 18 extrusion briquetting 4 makes it rotate with articulated seat 15 as the center, and the briquetting 4 other end acts on the terminal surface of sealing door 5, and then makes the inseparable pressfitting of sealing door 5 in drain hole 21 department, and when needs opened sealing door 5, the piston rod 16 of cylinder 3 withdraws, and briquetting 4 is rotatory to be broken away from sealing door 5, and outside pulling handle 20 and the sealing door 5 that slides downwards can.

The front end of drying box 1 is located the both sides of drain hole 21 and is provided with slide rail 6 along vertical direction, the inboard of every slide rail 6 all is formed with supplies sealing door 5 along the gliding second spout 62 of vertical direction, sealing door 5 embedded type is installed between two slide rails 6 and with second spout 62 sliding connection, the inboard position department that corresponds drain hole 21 of slide rail 6 still is formed with and supplies sealing door 5 along the gliding first spout 61 of drain hole 21 degree of depth direction, first spout 61 is linked together with second spout 62, when opening sealing door 5, outside pulling handle 20 makes sealing door 5 get into to in the second spout 62, then make sealing door 5 the lapse can in second spout 62.

In addition, in this embodiment, a plurality of second flourishing flitch 12 of placing that are located the top equidistant of drain hole 21 in the inside of drying box 1, the inside of drying box 1 is located the below equidistant of drain hole 21 and has placed a plurality of first flourishing flitch 10, the equal fixedly connected with support 11 in bottom four corners department of every first flourishing flitch 10, and in two adjacent first flourishing flitchs 10, the first flourishing flitch 10 that is located the top supports on the first flourishing flitch 10 of below through support 11, electric telescopic handle 13 is installed to the center department in the cavity internal bottom of drying box 1, electric telescopic handle 13's expansion end fixedly connected with adsorption plate, adsorption plate and support 11, the lower terminal surface of second flourishing flitch 12 adsorbs fixedly, all realize through electric telescopic handle 13 placing of first flourishing flitch 10 and second flourishing flitch 12.

Specifically, as shown in fig. 5 and 8, the two sides inside the cavity of the drying box 1 corresponding to the second material containing plate 12 or the first material containing plate 10 are provided with a limiting post 14, one end of the limiting post 14 facing the center of the cavity of the drying box 1 is in a building structure, the other end extends into the inner wall of the drying box 1, the limiting post 14 is located at the center of one end of the inner wall of the drying box 1 and is slidably sleeved with a guide post 22, the outer side of the guide post 22 is sleeved with a spring 24, one end of the spring 24 is connected with the inner wall of the drying box 1, the other end is connected with one end of the limiting post 14, the center of one end of the guide post 22 far away from the limiting post 14 is fixedly connected with a connecting post 23, the connecting post 23 extends outwards to penetrate through the inner wall of the drying box 1 and is fixedly connected with a chain wheel 7, the limiting post 14 and the connecting post 23 are both rotatably connected with the inner wall of the drying box 1, the initial state of each limiting post 14 is described with reference to fig. 5, the initial state of the position-limiting columns 14 at both sides of the first material-containing plate 10 is shown in fig. 5, the initial state of the position-limiting columns 14 at both sides of the second material-containing plate 12 is rotated by 180 degrees as shown in fig. 5, when drying and discharging, the second material-containing plate 12 is placed through the electric telescopic rod 13, the position-limiting columns 14 are extruded at both sides of the second material-containing plate 12, the position-limiting columns 14 slide along the guide columns 22 and retract and compress the springs 24, after the second material-containing plate 12 slides over the position-limiting columns 14, the electric telescopic rod 13 retracts, the position-limiting columns 14 recover to the initial position under the action of the springs 24, at this time, the position-limiting columns 14 support and fix the second material-containing plate 12, when placing the first material-containing plate 10, the movable end of the electric telescopic rod 13 extends to the position of the discharge port 21, then the first material-containing plate 10 is placed on the adsorption plate in sequence, because the adsorption plate and the first material-containing plate 10 are adsorbed and fixed, the electric telescopic rod 13 retracts and drives the first material-containing plate 10 to move downwards, after the first material containing plate 10 slides over the limiting post 14, the electric telescopic rod 13 continues to retract, the limiting post 14 returns to the initial position under the action of the spring 24, at this time, the limiting post 14 and the electric telescopic rod 13 jointly support and fix the first material containing plate 10, a second first material containing plate 10 is continuously put in, finally, the second first material containing plate 10 is supported and fixed between the upper limiting post 14 and the lower limiting post 14, when the material needs to be taken out after drying is finished, the electric telescopic rod 13 extends through the rotating chain wheel 7 eighty degrees, the first material containing plate 10 at the top end extrudes the limiting post 14 again and slides over, a person takes out the telescopic rod from the material discharge port 21, after all the first material containing plates 10 are taken out, the electric telescopic rod 13 continues to extend and adsorb and fix the second material containing plate 12 at the bottom, at this time, the limiting posts 14 corresponding to two sides of the second material containing plate 12 rotate 180 degrees as shown in fig. 5, then the electric telescopic rod 13 retracts to drive the second material containing plate 12 to move downwards to the discharging port 21.

As a preferred embodiment, the top ends and the bottom ends of two sides of the outside of the drying box 1 are fixedly provided with motors 9, the output end of each motor 9 is connected and fixedly connected with a driving sprocket, the two driving sprockets above are respectively sleeved with a second chain 25, the sprockets 7 corresponding to two sides of the second material containing plate 12 above the discharging port 21 are respectively meshed with the corresponding second chains 25, the driving sprockets below are respectively sleeved with a first chain 8, the sprockets 7 corresponding to two sides of the second material containing plate 12 below the discharging port 21 are respectively meshed with the corresponding first chains 8, the rotation of all the limiting columns 14 is driven by the motor 9, the motor 9 drives the driving sprockets to rotate, the first chains 8, the second chains 25 rotate through the driving sprockets respectively to drive the corresponding sprockets 7 to rotate, and further, the synchronous rotation of the sprocket 7 on one side is realized.

In the description of the present invention, the terms "first", "second", "another", and "yet" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more features. In the description of the embodiments of the present invention, "a plurality" means two or more unless specifically limited otherwise.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.

While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

Claims

1. The utility model provides a apparatus for producing of thesium chinense (freeze-drying) powder, a serial communication port, including drying box (1), the inside of drying box (1) is cavity structures, the front end of drying box (1) is formed with inside intercommunication and be echelonment drain hole (21) within with, the front end sliding connection of drying box (1) has sealing door (5) with drain hole (21) looks adaptation, sealing door (5) slide to drain hole (21) department and with it sealed lid closes along vertical direction, the front end of drying box (1) is located the top of drain hole (21) and still is provided with the fluting link mechanism that is used for applying the extrusion force to sealing door (5) terminal surface that is in the lid and closes the state.

2. The production device of thesium chinense (freeze-dried) powder according to claim 1, wherein the slotted link mechanism comprises a mounting seat (2) fixed at the front end of the drying box body (1), a cylinder (3) is fixedly mounted at the top of the mounting seat (2), the output end of the cylinder (3) is connected with a piston rod (16), the tail end of the piston rod (16) is fixedly connected with a sleeve (17), the front end of the drying box body (1) is positioned at two symmetrical hinged seats (15) at two sides of the sleeve (17), the inner side of each hinged seat (15) is hinged with a pressing block (4), the pressing block (4) is obliquely provided with a through groove (19), a connecting rod (18) is fixedly sleeved inside the sleeve (17) along the axial direction thereof, two ends of the connecting rod (18) respectively penetrate through the two through grooves (19) along the axial direction thereof, and the connecting rods (18) are all connected with the corresponding through grooves (19) in a sliding way.

3. A thesium Chinese (freeze-dried) powder production device according to claim 2, characterized in that slide rails (6) are vertically arranged at two sides of the discharge port (21) at the front end of the drying box body (1), a second slide groove (62) for the sealing door (5) to slide along the vertical direction is formed at the inner side of each slide rail (6), the sealing door (5) is embedded between the two slide rails (6) and is slidably connected with the second slide groove (62), a first slide groove (61) for the sealing door (5) to slide along the depth direction of the discharge port (21) is further formed at the position of the inner side of each slide rail (6) corresponding to the discharge port (21), and the first slide groove (61) is communicated with the second slide groove (62).

4. A production device of thesium chinense (r) (freeze-dried) powder according to any one of claims 2-3, characterized in that a plurality of second material containing plates (12) are placed in the drying box body (1) above the discharging port (21) at equal intervals, a plurality of first material containing plates (10) are placed in the drying box body (1) below the discharging port (21) at equal intervals, a bracket (11) is fixedly connected to the four corners of the bottom of each first material containing plate (10), in two adjacent first material containing plates (10), the first material containing plates (10) above are supported on the first material containing plates (10) below through the brackets (11), an electric telescopic rod (13) is installed in the center of the bottom in the cavity of the drying box body (1), an adsorption plate is fixedly connected to the movable end of the electric telescopic rod (13), and the adsorption plate and the bracket (11), The lower end face of the second material containing plate (12) is fixed in an adsorption mode.

5. The device for producing thesium chinense (freeze-dried) powder according to claim 4, wherein the two sides inside the cavity of the drying box body (1) are provided with limiting columns (14) corresponding to the positions of the second material containing plate (12) or the first material containing plate (10), one ends of the limiting columns (14) facing the center of the cavity of the drying box body (1) are of a building structure, the other ends of the limiting columns extend into the inner wall of the drying box body (1), the centers of the ends of the limiting columns (14) located on the inner wall of the drying box body (1) are sleeved with guide columns (22) in a sliding mode, the outer sides of the guide columns (22) are sleeved with springs (24), one ends of the springs (24) are connected with the inner wall of the drying box body (1), the other ends of the springs are connected with one ends of the limiting columns (14), the centers of the ends of the guide columns (22) far away from the limiting columns (14) are fixedly connected with connecting columns (23), the connecting columns (23) extend outwards through the inner wall of the drying box body (1) and then are fixedly connected with chain wheels (7), the limiting column (14) and the connecting column (23) are rotatably connected with the inner wall of the drying box body (1).

6. The production device of thesium chinense (freeze-dried) powder according to claim 5, characterized in that the top and bottom ends of the two sides of the outside of the drying box body (1) are fixedly provided with motors (9), the output end of each motor (9) is fixedly connected with a driving sprocket, the two driving sprockets above are respectively sleeved with a second chain (25), the sprockets (7) corresponding to the two sides of the second material containing plate (12) above the discharging port (21) are respectively meshed with the corresponding second chains (25), the driving sprockets below are respectively sleeved with a first chain (8), and the sprockets (7) corresponding to the two sides of the second material containing plate (12) below the discharging port (21) are respectively meshed with the corresponding first chains (8).

7. A process for the preparation of thesium powder, using a plant for the production of thesium (lyophilized) powder as claimed in any one of claims 1-6, 5 and 6, characterized in that it comprises the following steps:

step one, taking thesium chinense, cleaning, cutting into sections, dishing up, and placing thesium chinense (freeze-dried) powder in a production device for vacuum freeze drying;

and step two, crushing the dried thesium chinense, and grading to obtain thesium chinense particles.