CN113842368A - 一种具有防脱发保健功效的中药组合物滴丸及其制备方法 - Google Patents
一种具有防脱发保健功效的中药组合物滴丸及其制备方法 Download PDFInfo
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Abstract
本发明属于保健食品技术领域,具体涉及一种具有防脱发保健功效的中药组合物滴丸,由组合物提取液、基质、增塑剂、交联剂、VB族维生素和水组成,其中,各组分的质量比为组合物提取液∶基质∶增塑剂∶交联剂∶VB族维生素∶水为20~60∶3~15∶0.2~3∶0.01~1∶2~15∶20~70,所述组合物提取液为具有防脱发保健功效的组合物的提取液,具有补肝益肾、强健筋骨,改善体内血液微循环、增强免疫能力。本发明还公开了所述滴丸的制备方法。本发明设备简单、工艺条件易于控制,生产效率高,可实现工业化生产,质量稳定,剂量准确,稳定性高等优点;滴丸剂型易于携带,相对于内服汤剂,服用更加简便,口感更好,更容易被广大消费者接受。
Description
技术领域
本发明属于保健食品技术领域,具体涉及一种具有防脱发保健功效的中药组合物滴丸及其制备方法。
背景技术
随着经济社会的发展,生活节奏加快,人们在生活和工作上的压力越来越大,另外还由于环境污染等原因,脱发问题开始成为较为普遍的健康问题,困扰着广大群众。
从医学角度讲,脱发分为暂时性脱发与永久性脱发。暂时性脱发是指各种原因导致头部皮肤局部神经代谢时功能发生紊乱或障碍,产生毛囊的生理机能退化或营养不良而引起的脱发症状(但未引起毛囊结构的坏死或脱落)。一般经过对症治疗或体外有针对性的刺激反应,能重新恢复其机能,使其再生。永久脱发是指头发不再生长也不再脱落,是不可逆性脱发,不可恢复。
利用植物资源丰富的优势,结合现代技术,开发具有明确功效的产品已经成为发展的趋势之一。在分析日常生活中导致人们产生脱发现象原因的基础上,结合对症下药的中医理论,有针对性地选取部分活性成分,通过刺激毛囊,促进血液微循环,提供头发生长养分等手段,从而达到防脱发的作用。
分析目前具有治疗和保健功效的防脱发产品、专利文献资料,发现内服具有治疗或保健功效的中药主要以汤剂为主。但是对于很多人来说,汤剂存在煎煮、保存、携带等诸多不便,而且口感不佳,部分人难以长期坚持服用。外用含有治疗或保健功效的洗护产品,都要求使用者每次使用时长至少需要20-30分钟才能起作用,存在使用不方便的问题。甚至人们在使用有防脱发保健功效的日化洗护产品时,大多会在短时间揉搓后便冲洗干净,无法取得应有的疗效。这就导致了使用外用的产品,无法充分发挥其防脱发功效。
发明内容
针对以上问题,本发明的一个目的是公开一种具有防脱发保健功效的中药组合物滴丸。
一种具有防脱发保健功效的组合物滴丸,由组合物提取液、基质、增塑剂、交联剂、VB族维生素和水组成,其中,各组分的质量比为组合物提取液∶基质∶增塑剂∶交联剂∶VB族维生素∶水为20~60∶3~15∶0.2~3∶0.01~1∶2~15∶20~70,优选30~50∶4~12∶0.5~2∶0.03~0.6∶4~10∶40~60;所述组合物提取液为具有防脱发保健功效的组合物的提取液。
本发明较优公开例中,所述基质为明胶、卡拉胶、结冷胶、海藻酸钠、琼脂、黄原胶中的一种或多种混合,优选卡拉胶、结冷胶与海藻酸钠以任意比的组合物。
本发明较优公开例中,所述增塑剂为丙三醇、聚乙二醇200、聚乙二醇400、山梨糖醇中的一种或多种混合,优选丙三醇。
本发明较优公开例中,所述交联剂为氯化钾、氯化钙、乙二醛、双醛淀粉中的一种或多种混合,优选氯化钾或氯化钙。
本发明较优公开例中,所述VB族维生素为烟酸(维生素B3)、盐酸吡哆素(维生素B6)、生物素(维生素B7)中的一种或多种混合。
本发明较优公开例中,所述具有防脱发保健功效的组合物,包括以下原料及质量分数:何首乌10%~30%、黄芪10%~30%、川芎5%~30%、女贞子5%~20%、当归5%~20%、熟地黄5%~20%、白芷5%~20%、白芨5%~20%、牡丹皮5%~20%,总质量分数为100%。
本发明较优公开例中,所述具有防脱发保健功效的组合物提取液,其制备步骤包括:
(1)按质量配比准确称取各组分,清水洗净后,进行粗破碎处理,得到碎片;
(2)将原料碎片按质量体积比1g:4~20mL浸泡于水中0.5~2h,以100℃煎煮1~4h,过滤收集;滤渣中加入其质量4~20倍的水重复煎煮2~3次,每次煎煮时间0.5~2 h,合并滤液,即得组合物提取液;用水定容,使其浓度为10~300 g/L,优选50~200 g/L,备用。
本发明的另一个目的,是公开所述组合物滴丸的制备方法。
一种具有防脱发保健功效的组合物滴丸的制备方法,包括如下步骤:
(1)按比例称量组合物原料提取液、基质、增塑剂、交联剂、VB族维生素、水,加入到具有加热夹层的反应釜中70~95℃搅拌溶解,待混合物料搅拌溶解完全后,静置脱泡;
(2)将所述混合物料加入到滴丸机的具有加热夹层的储罐中,在70~80℃温度下,以滴丸机滴头,控制滴速,滴入冷凝液中凝固成型,获得初步成型的湿丸,其中所述冷凝液为液体石蜡或辛癸酸甘油酯,冷凝液温度4~8℃;
(3)收集湿丸,用水洗去表面的冷凝液,干燥后即得。
根据中医药理论并结合现代分析技术,本发明所提出的中药组合物含有二苯乙烯苷、蒽醌类、磷脂类、苯丙素类、黄酮类、生物碱、挥发油、有机酸和多糖等多种有效成分,具有补肝益肾、强健筋骨,改善体内血液微循环、增强免疫能力。通过对身体机能的调整,起到防脱固发、乌须生发的保健功效。另外本发明在抗衰老、抗氧化、抗肿瘤、保护神经以及改善血管功能等方面也有良好的保健效果。
有益效果
本发明公开的一种防脱发保健功效中药组合物滴丸的制备方法,具有设备简单、工艺条件易于控制,生产效率高, 可实现工业化生产,质量稳定,剂量准确,稳定性高等优点;滴丸剂型易于携带,相对于内服汤剂,服用更加简便,口感更好,更容易被广大消费者接受。
具体实施方式
下面结合实施例对本发明进行详细说明,以使本领域技术人员更好地理解本发明,但本发明并不局限于以下实施例。
实施例1
1、一种具有防脱发保健功效的组合物,包括以下组合物原料及质量份数:何首乌16%、黄芪16%、川芎8%、女贞子15%、当归12%、熟地黄10%、白芷9%、白芨9%、牡丹皮5%。
具有一定浓度的组合物原料提取液由如下步骤制备:
(1)按重量配比准确称取所述组合物原料,用清水洗净后,进行粗破碎处理,得到所述组合物原料碎片;
(2)将所述组合物原料碎片按质量体积比加入10倍的水浸泡1 h,再进行煎煮3 h,煎煮温度 100℃,过滤得到滤液;将滤渣重复煎煮3次,每次煎煮时间1 h,将滤液合并,即得组合物原料提取液;
(3)将所述组合物原料提取液用水定容,使所述组合物原料提取液的浓度为150g/L,备用。
2、一种具有防脱发保健功效的组合物滴丸包含物料质量之比为:组合物原料提取液∶基质∶增塑剂∶交联剂∶VB族维生素∶水的质量比为40∶5∶1∶0.4∶8∶45.6。
所述基质为结冷胶、琼脂、海藻酸钠混合组成,其质量比为:结冷胶∶琼脂∶海藻酸钠=67∶32∶1。所述增塑剂为丙三醇。所述交联剂为氯化钾。所述VB族维生素为烟酸(维生素B3)、盐酸吡哆素(维生素B6)、生物素(维生素B7)混合组成,其质量比为:烟酸∶盐酸吡哆素∶生物素=60∶20∶20。
所述一种具有防脱发保健功效的组合物滴丸通过以下步骤进行制备:
(1)按上述比例准确称量组合物原料提取液、基质、增塑剂、交联剂、VB族维生素、水,加入到具有加热夹层的反应釜中搅拌溶解,加热温度在80℃,待混合物料搅拌溶解完全后,静置脱泡;
(2)将所述混合物料加入到滴丸机的具有加热夹层的储罐中,在70~80℃温度下,通过滴丸机滴头,控制滴速,滴入冷凝液中凝固成型,获得初步成型的湿丸。所述冷凝液为辛癸酸甘油酯,所述冷凝液温度为4~8℃。
(3)收集湿丸,并用水冲洗以除去湿丸表面的冷凝液,将湿丸干燥后即得所述一种具有防脱发保健功效的组合物滴丸。
实施例2
1、一种具有防脱发保健功效的组合物,包括以下组合物原料及质量份数:何首乌14%、黄芪14%、川芎12%、女贞子8%、当归8%、熟地黄8%、白芷12%、白芨12%、牡丹皮12%。
具有一定浓度的组合物原料提取液由如下步骤制备:
(1)按重量配比准确称取所述组合物原料,用清水洗净后,进行粗破碎处理,得到所述组合物原料碎片;
(2)将所述组合物原料碎片按质量体积比加入15倍的水浸泡1 h,再进行煎煮3 h,煎煮温度 100℃,过滤得到滤液;将滤渣重复煎煮3次,每次煎煮时间1 h,将滤液合并,即得组合物原料提取液;
(3)将所述组合物原料提取液用水定容,使所述组合物原料提取液的浓度为200g/L,备用。
2、一种具有防脱发保健功效的组合物滴丸包含物料质量之比为:组合物原料提取液∶基质∶增塑剂∶交联剂∶VB族维生素∶水的质量比为50∶8∶1∶0.6∶10∶30.4。
所述基质为卡拉胶、结冷胶、海藻酸钠混合组成,其质量比为:卡拉胶∶结冷胶∶海藻酸钠=68∶30∶2,所述增塑剂为丙三醇,所述交联剂为氯化钾,所述VB族维生素为烟酸(维生素B3)、盐酸吡哆素(维生素B6)、生物素(维生素B7)混合组成,其质量比为:烟酸∶盐酸吡哆素∶生物素=50∶25∶25。
所述一种具有防脱发保健功效的组合物滴丸通过以下步骤进行制备:
(1)按上述比例准确称量组合物原料提取液、基质、增塑剂、交联剂、VB族维生素、水,加入到具有加热夹层的反应釜中搅拌溶解,加热温度在90℃,待混合物料搅拌溶解完全后,静置脱泡;
(2)将所述混合物料加入到滴丸机的具有加热夹层的储罐中,在70~80℃温度下,通过滴丸机滴头,控制滴速,滴入冷凝液中凝固成型,获得初步成型的湿丸。所述冷凝液为液体石蜡,所述冷凝液温度为4~8℃。
(3)收集湿丸,并用水冲洗以除去湿丸表面的冷凝液,将湿丸干燥后即得所述一种具有防脱发保健功效的组合物滴丸。
以上所述仅为本发明的实施例,并非因此限制本发明的专利范围,凡是利用本发明说明书所作的等效结构或等效流程变换,或直接或间接运用在其他相关的技术领域,均同理包括在本发明的专利保护范围内。
Claims (10)
1.一种具有防脱发保健功效的组合物滴丸,由组合物提取液、基质、增塑剂、交联剂、VB族维生素和水组成,其特征在于:各组分的质量比为组合物提取液:基质:增塑剂:交联剂:VB族维生素:水为20~60:3~15:0.2~3:0.01~1:2~15:20~70,所述组合物提取液为具有防脱发保健功效的组合物的提取液。
2.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于:各组分的质量比为组合物提取液:基质:增塑剂:交联剂:VB族维生素:水为30~50:4~12:0.5~2:0.03~0.6:4~10:40~60。
3.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于:所述基质为明胶、卡拉胶、结冷胶、海藻酸钠、琼脂、黄原胶中的一种或多种混合,卡拉胶、结冷胶与海藻酸钠以任意比的组合物。
4.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于:所述增塑剂为丙三醇、聚乙二醇200、聚乙二醇400、山梨糖醇中的一种或多种混合。
5.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于:所述增塑剂为丙三醇。
6.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于:所述交联剂为氯化钾、氯化钙、乙二醛、双醛淀粉中的一种或多种混合,优选氯化钾或氯化钙。
7.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于:所述VB族维生素为维生素B3、维生素B6、维生素B7中的一种或多种混合。
8.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于,所述具有防脱发保健功效的组合物,包括以下原料及质量分数:何首乌10%~30%、黄芪10%~30%、川芎5%~30%、女贞子5%~20%、当归5%~20%、熟地黄5%~20%、白芷5%~20%、白芨5%~20%、牡丹皮5%~20%,总质量分数为100%。
9.根据权利要求1所述具有防脱发保健功效的组合物滴丸,其特征在于,所述具有防脱发保健功效的组合物提取液,其制备步骤包括:
(1)按质量配比准确称取各组分,清水洗净后,进行粗破碎处理,得到碎片;
(2)将原料碎片按质量体积比1g:4~20mL浸泡于水中0.5~2h,以100℃煎煮1~4 h,过滤收集;滤渣中加入其质量4~20倍的水重复煎煮2~3次,每次煎煮时间0.5~2 h,合并滤液,即得组合物提取液;用水定容,使其浓度为10~300 g/L,优选50~200 g/L,备用。
10.一种如上述权利要求1-9任一所述组合物滴丸的制备方法,其特征在于,包括如下步骤:
(1)按比例称量组合物原料提取液、基质、增塑剂、交联剂、VB族维生素、水,加入到具有加热夹层的反应釜中70~95℃搅拌溶解,待混合物料搅拌溶解完全后,静置脱泡;
(2)将所述混合物料加入到滴丸机的具有加热夹层的储罐中,在70~80℃温度下,以滴丸机滴头,控制滴速,滴入冷凝液中凝固成型,获得初步成型的湿丸,其中所述冷凝液为液体石蜡或辛癸酸甘油酯,冷凝液温度4~8℃;
(3)收集湿丸,用水洗去表面的冷凝液,干燥后即得。
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