CN113841687A - 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途 - Google Patents

具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途 Download PDF

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Publication number
CN113841687A
CN113841687A CN202111194944.3A CN202111194944A CN113841687A CN 113841687 A CN113841687 A CN 113841687A CN 202111194944 A CN202111194944 A CN 202111194944A CN 113841687 A CN113841687 A CN 113841687A
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CN
China
Prior art keywords
heart
reperfusion
solution
calcium
cardioplegic
Prior art date
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Pending
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CN202111194944.3A
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English (en)
Chinese (zh)
Inventor
D·弗里德
C·怀特
L·许尔施寇
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Tevosol Inc
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Tevosol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2015/050297 external-priority patent/WO2015154193A1/en
Application filed by Tevosol Inc filed Critical Tevosol Inc
Publication of CN113841687A publication Critical patent/CN113841687A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Physiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biophysics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202111194944.3A 2014-10-24 2015-10-23 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途 Pending CN113841687A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462068524P 2014-10-24 2014-10-24
US62/068,524 2014-10-24
PCT/CA2015/050297 WO2015154193A1 (en) 2014-04-10 2015-04-10 Modulation of calcium ion homeostasis in harvested transplantable hearts
CAPCT/CA2015/050297 2015-04-10
CN201580070774.4A CN107105640B (zh) 2014-10-24 2015-10-23 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途

Related Parent Applications (1)

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CN201580070774.4A Division CN107105640B (zh) 2014-10-24 2015-10-23 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途

Publications (1)

Publication Number Publication Date
CN113841687A true CN113841687A (zh) 2021-12-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN202111194944.3A Pending CN113841687A (zh) 2014-10-24 2015-10-23 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途
CN201580070774.4A Active CN107105640B (zh) 2014-10-24 2015-10-23 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途

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CN201580070774.4A Active CN107105640B (zh) 2014-10-24 2015-10-23 具有控制的钙离子水平的新型组合物和溶液以及用于再灌注的相关方法和用途

Country Status (6)

Country Link
EP (1) EP3209128A4 (de)
CN (2) CN113841687A (de)
AU (1) AU2015336862B2 (de)
BR (1) BR112017008076B1 (de)
CA (1) CA2965400C (de)
WO (1) WO2016061700A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600120839A1 (it) * 2016-12-01 2018-06-01 Valentina Valenti Soluzione cardioplegica con attivatori dell'autofagia per l'arresto diastolico del cuore in corso di interventi cardiochirurgici
CN113303325A (zh) * 2021-05-27 2021-08-27 南方医科大学南方医院 一种灌注液和适用于大鼠供体心脏的常温血液机械灌注系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015154193A1 (en) * 2014-04-10 2015-10-15 University Of Manitoba Modulation of calcium ion homeostasis in harvested transplantable hearts

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
FR2785501B1 (fr) * 1998-11-10 2001-01-05 Centre Nat Rech Scient Solution de perfusion et/ou de conservation et/ou de reperfusion lors de la transplantation d'organes
EP1207753A4 (de) * 1999-06-17 2005-11-30 Univ California Kontinuierliche kardiale perfusionskonservierung mit peg-hb für verbesserte hypotherme lagerung
US20030124503A1 (en) * 2001-12-28 2003-07-03 Olivencia-Yurvati Albert H. Pyruvate cardioplegia solutions for administration to the heart during cardiopulmonary surgery and methods of use thereof
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
FR2975869B1 (fr) * 2011-05-31 2017-03-03 Hemarina Composition de preservation d'organe et utilisations
CN103893205B (zh) * 2014-04-15 2016-03-09 青岛大学附属医院 一种包含利多卡因和腺苷的心脏停搏液及其制备方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015154193A1 (en) * 2014-04-10 2015-10-15 University Of Manitoba Modulation of calcium ion homeostasis in harvested transplantable hearts

Also Published As

Publication number Publication date
BR112017008076B1 (pt) 2021-06-29
AU2015336862B2 (en) 2018-08-09
CN107105640B (zh) 2021-10-12
BR112017008076A2 (pt) 2017-12-26
AU2015336862A1 (en) 2017-06-01
EP3209128A4 (de) 2018-04-11
CA2965400C (en) 2023-03-14
EP3209128A1 (de) 2017-08-30
CN107105640A (zh) 2017-08-29
CA2965400A1 (en) 2016-04-28
WO2016061700A1 (en) 2016-04-28

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Application publication date: 20211228