CN113817326A - Multifunctional catechol hydrogel dressing and preparation method and application thereof - Google Patents
Multifunctional catechol hydrogel dressing and preparation method and application thereof Download PDFInfo
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- CN113817326A CN113817326A CN202110748169.5A CN202110748169A CN113817326A CN 113817326 A CN113817326 A CN 113817326A CN 202110748169 A CN202110748169 A CN 202110748169A CN 113817326 A CN113817326 A CN 113817326A
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- hydrogel
- catechol
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- polyphenol
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- 238000002360 preparation method Methods 0.000 title claims abstract description 6
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Abstract
The invention discloses a multifunctional catechol hydrogel dressing, a preparation method and application thereof, wherein the hydrogel comprises the following components: light curing agent, hydrophilic colloid, polyphenol, copper salt and photoinitiator. According to the invention, on one hand, the mechanical property of the hydrogel is enhanced by introducing copper ions, and on the other hand, polyphenol and Cu are fully utilized2+The biological synergistic effect of the components shows enhanced biological functions of antibiosis, antioxidation, angiogenesis promotion and the like. The hydrogel dressing is simple to prepare, provides a moist wound healing microenvironment, and has good biocompatibility. These advantages are very highGreatly promotes the healing of the chronic wound and relieves the pain of patients.
Description
Technical Field
The invention belongs to the technical field of medical hydrogel dressings, and particularly relates to a multifunctional catechol hydrogel dressing and a preparation method and application thereof.
Background
The hydrogel is a high molecular network system rich in a large number of water molecules, is soft in property and can keep a certain shape. Compared with the traditional dressing, the hydrogel is used as the wound dressing, so that the wound surface can be kept moist, wound exudate can be absorbed, the gas exchange between the wound and the outside can be kept, the wound surface adhesion is not easy to occur, and medicines or bioactive components can be loaded to promote the healing of the wound. Based on the advantages, the hydrogel dressing has great clinical medical value in the aspect of healing of skin wound, and particularly in the application research of chronic wound healing. However, the complex formation mechanism of the chronic wound, the small mechanical strength and single function of the hydrogel dressing greatly limit the application of the hydrogel dressing.
Chronic wounds are those wounds that do not heal orderly and in time under normal conditions, and usually mainly include vascular ulcers (venous and arterial), diabetic ulcers and pressure sores, and are characterized by the following features: excessive levels of reactive oxygen compounds (ROS), pro-inflammatory cytokines, proteases, and senescent cells, persistent infections, formation of resistant microbial membranes, and stem cell deficiencies or dysfunctions. Wherein, the ROS existing in a large amount in tissues around the wound can cause oxidative stress, thereby greatly promoting chronic inflammation and preventing the healing of the chronic wound. The appearance of chronic wounds, often accompanied by infection and water loss, seriously affects the quality of life of people and can even lead to disability or death.
Hydrogel dressings with biological functions that can be used for chronic wound healing are yet to be further developed.
Disclosure of Invention
The first technical problem to be solved by the invention is as follows:
a multifunctional catechol hydrogel is provided.
The second technical problem to be solved by the invention is:
provides a method for preparing the multifunctional catechol hydrogel.
The third technical problem to be solved by the invention is:
the multifunctional catechol hydrogel is applied to hydrogel dressings.
In order to solve the first technical problem, the invention adopts the technical scheme that:
the multifunctional catechol hydrogel comprises the following preparation raw materials in parts by weight:
12.87 to 25.17 parts of light curing agent, 0.85 to 0.42 part of hydrophilic colloid, 0.42 to 2.15 parts of polyphenol, 0.42 to 4.3 parts of copper salt and 0.04 to 0.008 part of photoinitiator.
According to an embodiment of the present invention, the hydrophilic colloid is at least one of carrageenan, galactomannan, pectin, alginate and xanthan gum.
The metal ions in the copper salt and the polyphenol can be rapidly self-assembled into the metal-polyphenol functional material.
According to one embodiment of the present invention, the polyphenol comprises epigallocatechin gallate (EGCG).
According to an embodiment of the present invention, the light curing agent includes methacrylate-modified silk fibroin.
The light curing agent has photosensitive groups and can be cured by light crosslinking.
The epigallocatechin gallate (EGCG) is used as the main component of catechol, is a bioactive polyphenol compound extracted from green tea, and has strong antioxidant and free radical scavenging effects.
The EGCG also has antibacterial, antioxidant, repercussive, antiinflammatory, antithrombotic and antitumor effects.
According to an embodiment of the present invention, the copper salt includes at least one of a copper chloride solution, a copper nitrate solution, and a copper sulfate.
According to an embodiment of the present invention, the photoinitiator includes at least one of lithium phenyl-2, 4, 6-trimethylbenzoylphosphinate and 2-hydroxy-2-methyl-1- [4- (2-hydroxyethoxy) phenyl ] -1-propanone.
According to an embodiment of the present invention, the methacrylate functional group grafting ratio in the methacrylate-modified silk fibroin is 20 to 40%.
The reason why the graft ratio of the methacrylate functional group is selected to be 20 to 40% is that if the graft ratio concentration is too low, the hydrogel dressing prepared by the above method is insufficient in mechanical strength and is liable to break; and when the concentration is too high, the solubility is higher than that of silk fibroin, the viscosity of the prepolymer is increased, the molecular structure of the silk fibroin is folded, and the silk fibroin is self-assembled into a colloidal material.
In order to solve the second technical problem, the invention adopts the technical scheme that:
a method for preparing the multifunctional catechol hydrogel comprises the following steps:
s1 mixing the silk fibroin modified by methacrylate, a photoinitiator and deionized water to obtain Sil-MA solution;
s2, sequentially adding the polyphenol and the hydrophilic colloid into the Sil-MA solution to obtain a mixed solution, and carrying out ultraviolet curing and crosslinking on the mixed solution to obtain hydrogel;
s3, placing the hydrogel into the metal salt aqueous solution to obtain the multifunctional catechol hydrogel.
According to an embodiment of the present invention, the step of transferring the mixed solution in S2 to a concave glass plate having a height of 0.5 to 3.0mm before the reaction to obtain the hydrogel.
According to an embodiment of the present invention, the step of reacting the hydrogel in S2 includes placing the mixed solution transferred to the concave glass plate in an ultraviolet curing chamber to cure and crosslink the mixed solution to obtain the hydrogel.
According to an embodiment of the present invention, the light irradiation time of the mixed solution in the ultraviolet curing box is 5s to 10 min.
According to an embodiment of the present invention, the step of placing the hydrogel in the aqueous solution of metal salt in S3 includes immersing the hydrogel in the aqueous solution of metal salt for 15 to 120 min.
According to an embodiment of the invention, the mass volume concentration of the methacrylate-modified silk fibroin in the Sil-MA solution is 15-35%.
According to an embodiment of the present invention, the mass volume concentration of the polyphenol is 0.5 to 3.0%.
In yet another aspect of the present invention, there is provided a use of the multifunctional catechol hydrogel in a hydrogel dressing.
One of the above technical solutions has at least the following advantages or beneficial effects:
the invention adopts the combination of the ultraviolet crosslinking method and the soaking method to prepare the multifunctional catechol hydrogel, has simple process and low cost, and regulates and controls the mechanical property and the biological function of the hydrogel by regulating the factors such as component concentration, crosslinking time and the like.
According to the invention, the hydrogel adsorbs bioactive copper ions, so that the mechanical strength of the hydrogel is enhanced, and the hydrogel dressing has more biological functions through the chelating effect of polyphenol and metal ions, wherein the biological functions comprise a drug slow release effect; regulating and controlling the microenvironment of the cells; regulating cell behaviors such as proliferation, growth, differentiation and the like of cells; antibacterial action; when Glutathione (GSNO) is contained in body fluids, it acts as a catalyst to produce NO physiological molecules.
The invention makes full use of EGCG and Cu2+The hydrogel dressing shows enhanced biological functions of antibiosis, antioxidation, angiogenesis promotion and the like. The advantages greatly promote the healing of the chronic wound and relieve the pain of patients.
The hydrogel dressing can be used for nursing and treating wounds which are difficult to heal, such as soft tissue contusion, surgical wounds, scalds and the like, shortening the healing time of the wounds and relieving the pain of patients.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the invention and together with the description serve to explain the invention and not to limit the invention.
FIG. 1 is a structural view of the internal appearance of the above hydrogel dressing as observed by SEM. FIG. 1(A) shows Cu2+SEM image of hydrogel dressing before treatment; FIG. 1(B) shows Cu2+SEM image of treated hydrogel dressing.
Fig. 2 is a graph showing a compression performance test of the hydrogel dressing.
FIG. 3 is an antibacterial test chart of the hydrogel dressing using Escherichia coli as a model. FIG. 3(A) shows Cu2+A pre-treatment hydrogel dressing; FIG. 3(B) shows Cu2+A treated hydrogel dressing.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout.
The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, if there are first, second, third, etc. described only for the purpose of distinguishing technical features, it is not to be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.
In the description of the present invention, it should be understood that the orientation or positional relationship referred to in the description of the orientation, such as the upper, lower, left, right, etc., is based on the orientation or positional relationship shown in the drawings, and is only for convenience of description and simplicity of description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that unless otherwise explicitly defined, terms such as arrangement, installation, connection and the like should be broadly understood, and those skilled in the art can reasonably determine the specific meanings of the terms in the present invention in combination with the detailed contents of the technical solutions.
Example 1
Firstly, 0.4g of Sil-MA with the grafting rate of the functional group of 25 percent is weighed in a beaker, added into 2ml of deionized water, stirred and dissolved at room temperature to obtain a Sil-MA solution with the mass volume concentration of 20 percent, and 0.05 percent of photoinitiator LAP is added. Then, 0.04g of EGCG (2% by mass/volume) was added to the above Sil-MA solution, and dissolved by stirring at room temperature.
Then, 0.02g of carrageenan (1% by mass/volume) was added, dissolved by stirring, and mixed uniformly. Transferring the prepared mixed solution to a concave glass plate with the height of 1.5mm, then placing the concave glass plate in an ultraviolet curing box, irradiating for 10 minutes by ultraviolet light, and curing and crosslinking to prepare hydrogel; carefully taking out the hydrogel, soaking the hydrogel in 0.2M copper chloride aqueous solution for 30min, taking out the hydrogel, carefully washing off residual liquid on the surface by using deionized water, wiping off surface moisture by using filter paper, and finally obtaining the multifunctional catechol hydrogel dressing.
Example 2
Firstly, 0.6g of Sil-MA with the grafting rate of functional groups of 30 percent is weighed in a beaker, added into 2ml of deionized water, stirred and dissolved at room temperature to obtain a Sil-MA solution with the mass volume concentration of 30 percent, and added with 0.05 percent of photoinitiator LAP. Then, 0.02g of EGCG (1% by mass/volume) was added to the above Sil-MA solution, and dissolved by stirring at room temperature.
Then, 0.02g of carrageenan (1% by mass/volume) was added, dissolved by stirring, and mixed uniformly. Transferring the prepared mixed solution to a concave glass plate with the height of 1.0mm, then placing the concave glass plate in an ultraviolet curing box, irradiating the concave glass plate for 20 minutes by ultraviolet light, and curing and crosslinking to prepare hydrogel; carefully taking out the hydrogel, soaking the hydrogel in 0.2M copper chloride aqueous solution for 60min, taking out the hydrogel, carefully washing off residual liquid on the surface by using deionized water, wiping off surface moisture by using filter paper, and finally obtaining the multifunctional catechol hydrogel dressing.
Example 3
Firstly, 0.5g of Sil-MA with the grafting rate of functional groups of 30 percent is weighed in a beaker, added into 2ml of deionized water, stirred and dissolved at room temperature to obtain a Sil-MA solution with the mass volume concentration of 25 percent, and 0.1 percent of photoinitiator LAP is added. Then, 0.04g of EGCG (2% by mass/volume) was added to the above Sil-MA solution, and dissolved by stirring at room temperature.
Then, 0.02g of carrageenan (1% by mass/volume) was added, dissolved by stirring, and mixed uniformly. Transferring the prepared mixed solution to a concave glass plate with the height of 1.5mm, then placing the concave glass plate in an ultraviolet curing box, irradiating the concave glass plate for 20 minutes by ultraviolet light, and curing and crosslinking to prepare hydrogel; carefully taking out the hydrogel, soaking the hydrogel in 0.2M copper chloride aqueous solution for 90min, taking out the hydrogel, carefully washing off residual liquid on the surface by using deionized water, wiping off surface moisture by using filter paper, and finally obtaining the multifunctional catechol hydrogel dressing.
The hydrogels prepared in the above examples 1 to 3 all showed good mechanical properties, controllable biodegradability, good biocompatibility, and have a variety of functional effects such as antibacterial, antioxidant, and angiogenesis promoting.
As shown in figure 1, the internal appearance structure of the prepared hydrogel dressing before and after the treatment of the copper salt solution presents an irregular porous structure, and the hydrogel dressing can adsorb effusion at a wound and is beneficial to gas exchange.
The results of the compression test of figure 2 show that as the treatment time of the copper salt solution increases, the compressive resistance of the hydrogel increases, and both the compressive modulus and the amount of compressive deformation increase significantly.
Fig. 3 is an antibacterial test result of the hydrogel dressing prepared by using escherichia coli as a model, and it can be seen from the result that after the prepared hydrogel is treated by a copper salt solution, the number of escherichia coli is obviously reduced, a better antibacterial effect is exhibited, and the biological synergistic antibacterial property of the combination of EGCG and copper ions is illustrated.
The above description is only an example of the present invention and is not intended to limit the scope of the present invention, and all equivalent modifications made by the present invention as described in the specification of the present invention or directly or indirectly applied to the related technical fields are included in the scope of the present invention.
Claims (10)
1. A multifunctional catechol hydrogel is characterized in that: the preparation method comprises the following raw materials in parts by weight:
12.87 to 25.17 parts of light curing agent, 0.85 to 0.42 part of hydrophilic colloid, 0.42 to 2.15 parts of polyphenol, 0.42 to 4.3 parts of copper salt and 0.04 to 0.008 part of photoinitiator.
2. The multifunctional catechol hydrogel of claim 1, wherein: the hydrophilic colloid is at least one of K-carrageenan, galactomannan, pectin, alginate and xanthan gum.
3. The multifunctional catechol hydrogel of claim 1, wherein: the polyphenol comprises epigallocatechin gallate.
4. The multifunctional catechol hydrogel of claim 1, wherein: the light curing agent comprises methacrylate modified silk fibroin.
5. The multifunctional catechol hydrogel of claim 1, wherein: the copper salt comprises at least one of copper chloride, copper nitrate and copper sulfate.
6. The multifunctional catechol hydrogel of claim 1, wherein: the photoinitiator comprises at least one of phenyl-2, 4, 6-trimethyl benzoyl lithium phosphinate and 2-hydroxy-2-methyl-1- [4- (2-hydroxyethoxy) phenyl ] -1-acetone.
7. The multifunctional catechol hydrogel of claim 4, wherein: the grafting rate of methacrylate functional groups in the methacrylate-modified silk fibroin is 20-40%.
8. A method for preparing the multifunctional catechol hydrogel of any one of claims 1 to 7, wherein: the method comprises the following steps:
s1 mixing the silk fibroin modified by methacrylate, a photoinitiator and deionized water to obtain Sil-MA solution;
s2, sequentially adding the polyphenol and the hydrophilic colloid into the Sil-MA solution to obtain a mixed solution, and carrying out ultraviolet curing and crosslinking on the mixed solution to obtain hydrogel;
s3, placing the hydrogel into the metal salt aqueous solution to obtain the multifunctional catechol hydrogel.
9. The method for preparing a multifunctional catechol hydrogel according to claim 8, wherein: the mass volume concentration of the silk fibroin modified by the methacrylate in the Sil-MA solution is 15-35%.
10. Use of a multifunctional catechol hydrogel of any one of claims 1 to 7 in a hydrogel dressing.
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