CN112972757A - Perfluorodecalin hydrogel healing-promoting dressing and preparation method and application thereof - Google Patents
Perfluorodecalin hydrogel healing-promoting dressing and preparation method and application thereof Download PDFInfo
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
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- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/202—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with halogen atoms, e.g. triclosan, povidone-iodine
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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Abstract
The invention provides a perfluorodecalin-containing hydrogel healing-promoting dressing which comprises the following components in parts by weight: PBS buffer solution, sodium hyaluronate, perfluorodecalin, stabilizer and emulsifier. The preparation method comprises the following steps: a. firstly, dissolving sodium hyaluronate in a PBS buffer solution, then adding an emulsifier and stirring at a constant speed to obtain sodium hyaluronate hydrogel containing the emulsifier; b. and (b) adding perfluorodecalin liquid into the sodium hyaluronate hydrogel containing the emulsifier obtained in the step a, stirring at a constant speed at room temperature, finally adding a stabilizer, and stirring until the mixture is uniform, thus obtaining the perfluorodecalin-containing hydrogel healing-promoting dressing. The perfluorodecalin hydrogel dressing is a novel intelligent hydrogel wound dressing with accelerated healing and safety, and can be applied to wounds such as chronic wounds, trauma, burns, scalds, ulcers, bedsores and the like.
Description
Technical Field
The invention belongs to the technical field of hydrogel, and particularly relates to a perfluorodecalin hydrogel healing-promoting dressing as well as a preparation method and application thereof.
Background
With the growing aging population and the increasing number of diabetic patients, chronic wounds have become a major challenge in the global medical field; one important reason for the difficulty in healing chronic wounds, such as diabetic feet, is that local hypoxia at the wound site is an important factor limiting wound healing; currently, oxygen therapy is mainly divided into two types, one is hyperbaric oxygen therapy, and the other is local oxygen therapy. Local oxygen therapy is a novel wound treatment technology, and can realize low-cost and portable oxygen delivery to wounds.
Research shows that perfluorodecalin is a compound with high safety, is colorless, tasteless and nontoxic transparent liquid at normal temperature, has high density, low surface tension and stable chemical property, and does not metabolize in vivo. More importantly, the perfluorodecalin has good gas carrying capacity, the solubility to oxygen is about 20 times that of water and 2-3 times that of whole blood, and the solubility to carbon dioxide is more than 3 times that of water; and has wound repairing, antibacterial, antioxidant, and antiinflammatory effects. Perfluorodecalin has good histocompatibility and biological inertia, and has been used in the biomedical field for a long time, but because perfluorodecalin is insoluble in water, has poor stability, low bioavailability and other characteristics, it has great difficulty in being used in wound dressing.
Therefore, a hydrogel dressing which can actively supply oxygen and has a simple process is urgently needed at present, an oxygen-rich environment is provided for wounds, and the problem that wound cells are slowly healed due to oxygen deficiency is solved.
Disclosure of Invention
The invention aims to solve the defects in the prior art, and provides a perfluorodecalin hydrogel healing-promoting dressing which is simple in process, controllable in cost and capable of accelerating wound healing, a preparation method and application thereof.
The technical scheme adopted by the invention is as follows: a hydrogel healing-promoting dressing containing perfluorodecalin comprises the following components in parts by weight: 100 parts of PBS buffer solution, 1-2 parts of sodium hyaluronate, 1-3 parts of perfluorodecalin, 1-2 parts of stabilizer and 1-3 parts of emulsifier.
Preferably, the composition comprises the following components in parts by weight: 100 parts of PBS buffer solution, 1.5-2 parts of sodium hyaluronate, 1.5-2 parts of perfluorodecalin, 1-1.5 parts of stabilizer and 2-3 parts of emulsifier.
Preferably, the molecular weight of the sodium hyaluronate is 200-600w, the stabilizer is xanthan gum, and the emulsifier is any one of poloxamer, tween-80 or tween-20.
The preparation method of the hydrogel healing-promoting dressing comprises the following steps:
a. firstly, dissolving sodium hyaluronate in a PBS buffer solution, then adding an emulsifier, stirring at a constant speed, and stirring at room temperature for 0.5-1 h to obtain sodium hyaluronate hydrogel containing the emulsifier;
b. and (b) adding perfluorodecalin liquid into the sodium hyaluronate hydrogel containing the emulsifier obtained in the step a, stirring at a constant speed at room temperature, finally adding a stabilizer, and stirring until the mixture is uniform, thus obtaining the perfluorodecalin-containing hydrogel healing-promoting dressing.
The application of the perfluorodecalin-containing hydrogel healing-promoting dressing can improve the oxygen concentration and the humidity on the surface of a wound through oxygen evolution, and can be applied to chronic wounds, trauma, burns, scalds, ulcers or bedsore wounds.
Preferably, the dressing is suitable for wounds at the site of recurrent activity of the elbow, wrist, knee or ankle.
Preferably, the dressing is suitable for chronic wounds.
The beneficial effects obtained by the invention are as follows: the perfluorodecalin hydrogel dressing is white and viscous, is a novel intelligent hydrogel wound dressing with accelerated healing and safety, can be applied to wounds such as chronic wounds, trauma, burns, scalds, ulcers, bedsores and the like, and particularly has a better effect on diabetic foot type chronic wounds.
(1) The perfluorodecalin contained in the hydrogel dressing has strong oxygen dissolving capacity and good moisture retention and air permeability. After being applied to the wound surface, the dressing can isolate the wound surface from the external environment, so that the wound is not contacted with pathogens in the environment, the continuous oxygen supply environment of the wound surface is maintained, the epithelial regeneration is accelerated, and the safety is high; the oxygen concentration and the humidity on the surface of the wound can be effectively improved through oxygen evolution, the improvement of the oxygen concentration directly enhances the wound healing, the improvement of the humidity is favorable for the permeation and the diffusion of gas on the surface of the wound, and the wound healing is promoted through a wet healing mode.
(2) The emulsifier selected by the invention has good wetting dispersibility, can disperse perfluorodecalin in the hydrogel in an oil-in-water form, enables the perfluorodecalin to exist stably, overcomes the defects of water insolubility and poor stability of perfluorodecalin, and can slowly release oxygen when being applied to wounds.
(3) The stabilizing agent selected by the invention has good suspension effect on insoluble solids and oil drops, and can form a hydrogel dressing into a colloidal structure to form a stable gel form.
(4) The invention adopts an oil-in-water emulsion template method to prepare perfluorodecalin hydrogel dressing; firstly, the emulsifier is dissolved in the sodium hyaluronate as a water phase, the perfluorodecalin is dispersed in the gel containing the emulsifier, and the mixture is mixed to form an oil-in-water emulsion system.
(5) The perfluorodecalin hydrogel dressing has good mechanical property, good flexibility and elasticity, can form good adhesion with skin, and is suitable for wound surfaces of different parts of a body, in particular to frequently moving parts such as elbows, wrists, knees, ankles and the like.
Drawings
FIG. 1 is a therapeutic schematic of a wound repair dressing of the present invention;
FIG. 2 is a graph of an acute wound healing rate experiment in accordance with the present invention;
FIG. 3 is a graph of a chronic wound healing experiment according to the present invention;
FIG. 4 is a 400-fold magnified optical micrograph of a hydrogel sample according to example 1 of the present invention;
FIG. 5 is a 400-fold magnified optical micrograph of a perfluorodecalin-free hydrogel sample according to the present invention;
FIG. 6 is a photograph of a sample hydrogel dressing of the present invention applied to a skin surface;
figure 7 is a shape diagram of a sample perfluorodecalin hydrogel dressing of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
Example 1: a hydrogel healing-promoting dressing containing perfluorodecalin comprises the following components in parts by weight: 100 parts of PBS buffer solution, 1 part of sodium hyaluronate with molecular weight of 200w, 1 part of perfluorodecalin, 1 part of xanthan gum and 1 part of poloxamer.
The preparation method of the hydrogel healing-promoting dressing comprises the following steps: a. firstly, dissolving sodium hyaluronate in a PBS buffer solution, then adding an emulsifier, stirring at a constant speed, and stirring at room temperature for 0.5h to obtain sodium hyaluronate hydrogel containing the emulsifier; b. and (b) adding perfluorodecalin liquid into the emulsifier-containing sodium hyaluronate hydrogel obtained in the step (a), uniformly stirring at room temperature for 24 hours, finally adding a stabilizer, and manually stirring for 20 minutes or magnetically stirring at a rotating speed of 2000 rpm until the mixture is uniform, thus obtaining the perfluorodecalin-containing hydrogel healing-promoting dressing.
Example 2: a hydrogel healing-promoting dressing containing perfluorodecalin comprises the following components in parts by weight: 100 parts of PBS buffer solution, 2 parts of sodium hyaluronate with molecular weight of 200-.
The preparation method of the hydrogel healing-promoting dressing comprises the following steps: a. firstly, dissolving sodium hyaluronate in a PBS buffer solution, then adding an emulsifier, stirring at a constant speed, and stirring at room temperature for 1h to obtain sodium hyaluronate hydrogel containing the emulsifier; b. and (b) adding perfluorodecalin liquid into the emulsifier-containing sodium hyaluronate hydrogel obtained in the step a, stirring at a constant speed for 24 hours at room temperature, finally adding a stabilizer, and manually stirring for 20 minutes or magnetically stirring at a rotating speed of 5000 rpm until the mixture is uniform, thus obtaining the perfluorodecalin-containing hydrogel healing-promoting dressing.
Example 3: a hydrogel healing-promoting dressing containing perfluorodecalin comprises the following components in parts by weight: 100 parts of PBS buffer solution, 1.5 parts of sodium hyaluronate with molecular weight of 200-.
The preparation method of the hydrogel healing-promoting dressing comprises the following steps: a. firstly, dissolving sodium hyaluronate in a PBS buffer solution, then adding an emulsifier, stirring at a constant speed, and stirring at room temperature for 0.8h to obtain sodium hyaluronate hydrogel containing the emulsifier; b. and (b) adding perfluorodecalin liquid into the emulsifier-containing sodium hyaluronate hydrogel obtained in the step (a), stirring at a constant speed for 24 hours at room temperature, finally adding a stabilizer, and manually stirring for 20 minutes or magnetically stirring at a rotating speed of 3000 rpm until the mixture is uniform, thus obtaining the perfluorodecalin-containing hydrogel healing-promoting dressing.
The shape of perfluorodecalin hydrogel dressings of the present invention was tested as exemplified in example 3
The blank control group was a non-diabetic group and healed naturally; the diabetic group was diabetic mice and healed naturally; the hydrogel group is a diabetic mouse and wound is coated with a dressing which does not contain perfluorodecalin gel; the perfluorodecalin hydrogel group was diabetic mice and wounds were coated with the dressing containing perfluorodecalin gel of example 3 of the present invention.
An animal assay method for a control hydrogel healing-promoting dressing comprising the steps of: a. the aged mice are firstly bred to adapt to the environment for 7 days, and the acute wound group feed is high-fat and high-sugar; b. cutting a wound with the diameter of about 1cm on the back of the mouse, and coating a hydrogel dressing and a control group reagent; c. preparation of hydrogel without perfluorodecalin: firstly, dissolving sodium hyaluronate in PBS buffer solution, then adding emulsifier and uniformly stirring, uniformly stirring at room temperature for 24h, finally adding stabilizer, manually stirring for 20 min or magnetically stirring at the rotating speed of 3000 r/min until the mixture is uniform, thus obtaining the hydrogel dressing without perfluorodecalin. d. The wound healing curves were prepared by changing the dressing on time each day, measuring the wound length on time and recording, as shown in fig. 2.
The acute wound healing rate experiment of example 3 was compared to the comparative example described above, as shown in figure 2; and example 3 was compared to the above comparative example for a chronic wound healing rate experiment, as shown in figure 3.
Experiments show that the wound healing speed of the dressing is obviously superior to that of gel products without perfluorodecalin and natural healing speed.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. A perfluorodecalin-containing hydrogel healing-promoting dressing characterized by: the paint comprises the following components in parts by weight: 100 parts of PBS buffer solution, 1-2 parts of sodium hyaluronate, 1-3 parts of perfluorodecalin, 1-2 parts of stabilizer and 1-3 parts of emulsifier.
2. The perfluorodecalin-containing hydrogel healing-promoting dressing according to claim 1, wherein: the paint comprises the following components in parts by weight: 100 parts of PBS buffer solution, 1.5-2 parts of sodium hyaluronate, 1.5-2 parts of perfluorodecalin, 1-1.5 parts of stabilizer and 2-3 parts of emulsifier.
3. The perfluorodecalin-containing hydrogel healing-promoting dressing according to claim 1 or 2, wherein: the molecular weight of the sodium hyaluronate is 200-600w, the stabilizer is xanthan gum, and the emulsifier is any one of poloxamer, tween-80 or tween-20.
4. The preparation method of the hydrogel healing-promoting dressing is characterized in that: the method comprises the following steps:
a. firstly, dissolving sodium hyaluronate in a PBS buffer solution, then adding an emulsifier, stirring at a constant speed, and stirring at room temperature for 0.5-1 h to obtain sodium hyaluronate hydrogel containing the emulsifier;
b. and (b) adding perfluorodecalin liquid into the sodium hyaluronate hydrogel containing the emulsifier obtained in the step a, stirring at a constant speed at room temperature, finally adding a stabilizer, and stirring until the mixture is uniform, thus obtaining the perfluorodecalin-containing hydrogel healing-promoting dressing.
5. Use of a perfluorodecalin-containing hydrogel healing-promoting dressing characterized by: the perfluorodecalin in the dressing can improve the oxygen concentration and the humidity on the surface of a wound through oxygen evolution, and can be applied to chronic wounds, trauma, burns, scalds, ulcers or bedsore wounds.
6. Use of a perfluorodecalin-containing hydrogel healing-promoting dressing according to claim 5, wherein: the dressing is suitable for wounds on the frequently active parts of the elbows, wrists, knees or ankles.
7. Use of a perfluorodecalin-containing hydrogel healing-promoting dressing according to claim 5, wherein: the dressing is suitable for chronic wounds.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
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| CN202110245136.9A CN112972757A (en) | 2021-03-05 | 2021-03-05 | Perfluorodecalin hydrogel healing-promoting dressing and preparation method and application thereof |
| PCT/CN2022/079138 WO2022184150A1 (en) | 2021-03-05 | 2022-03-03 | Perfluorodecalin hydrogel healing-promoting dressing, preparation method therefor and use thereof |
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| CN202110245136.9A CN112972757A (en) | 2021-03-05 | 2021-03-05 | Perfluorodecalin hydrogel healing-promoting dressing and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113797380A (en) * | 2021-08-30 | 2021-12-17 | 佛山职业技术学院 | Oxygen release dressing and preparation method and application thereof |
| WO2022184150A1 (en) * | 2021-03-05 | 2022-09-09 | 江苏君隽生物科技有限公司 | Perfluorodecalin hydrogel healing-promoting dressing, preparation method therefor and use thereof |
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| CN109847089A (en) * | 2019-01-30 | 2019-06-07 | 郑岩 | A kind of high molecular material is the wound oxygen supply dressing of carrier multiple film composition |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972757A (en) * | 2021-03-05 | 2021-06-18 | 江苏菌均君隽生物科技有限公司 | Perfluorodecalin hydrogel healing-promoting dressing and preparation method and application thereof |
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- 2021-03-05 CN CN202110245136.9A patent/CN112972757A/en active Pending
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- 2022-03-03 WO PCT/CN2022/079138 patent/WO2022184150A1/en active Application Filing
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| US6235796B1 (en) * | 2000-06-26 | 2001-05-22 | Sarfaraz K. Niazi | Use of fluorocarbons for the prevention of surgical adhesions |
| KR20040064165A (en) * | 2003-01-09 | 2004-07-16 | 김재용 | The stability technology of using the technology of nano spherical particles including perfluorodecalin which is effective for anti-wrinkle and the components of cosmetics including the nano spherical particles and the method of manufacturing the components. |
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| CN104010662A (en) * | 2011-08-16 | 2014-08-27 | 凯诗薇有限责任公司 | Dermal rejuvenation compositions and methods |
| CN102949709A (en) * | 2011-08-18 | 2013-03-06 | 中国科学院大连化学物理研究所 | External gel used for treating diabetic foot, and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2022184150A1 (en) * | 2021-03-05 | 2022-09-09 | 江苏君隽生物科技有限公司 | Perfluorodecalin hydrogel healing-promoting dressing, preparation method therefor and use thereof |
| CN113797380A (en) * | 2021-08-30 | 2021-12-17 | 佛山职业技术学院 | Oxygen release dressing and preparation method and application thereof |
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| WO2022184150A1 (en) | 2022-09-09 |
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Address after: Room 501-9, building C6, Jiangsu life science and Technology Park, No. 9, Weidi Road, Xianlin street, Qixia District, Nanjing, Jiangsu 210046 Applicant after: Jiangsu Junjun Biotechnology Co.,Ltd. Address before: 210000 C6, Jiangsu Life Science Park, Qixia District, Nanjing City, Jiangsu Province Applicant before: Jiangsu junjunjun Biotechnology Co.,Ltd. |