CN113811314A - Composition containing vitamin B12 - Google Patents

Composition containing vitamin B12 Download PDF

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Publication number
CN113811314A
CN113811314A CN202080034923.2A CN202080034923A CN113811314A CN 113811314 A CN113811314 A CN 113811314A CN 202080034923 A CN202080034923 A CN 202080034923A CN 113811314 A CN113811314 A CN 113811314A
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vitamin
class
weight
composition
compositions
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金本美穗
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Kobayashi Pharmaceutical Co Ltd
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Kobayashi Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Birds (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
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  • Rheumatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
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Abstract

The invention aims to provide a vitamin B-containing food12And capable of inhibiting vitamin B formation due to light exposure12And (d) decomposed compositions of the same. By including vitamin B12The composition contains polyoxyethylene sorbitan fatty acid ester and is set relative to vitamin B12The amount of the polyoxyethylene sorbitan fatty acid ester is 10 parts by weight or less based on 1 part by weight, whereby vitamin B can be inhibited even when the light exposure is performed under severe conditions12The decomposition of the vitamin B is remarkably exerted12And (3) light stabilization effect of the class.

Description

Composition containing vitamin B12
Technical Field
The present invention relates to a vitamin B-containing food12And can inhibit vitamin B caused by light exposure12And (d) decomposed compositions of the same.
Background
Vitamin B12The group is one of water-soluble vitamins, and is an essential nutrient for life maintenance. Vitamin B is known12Para-vitamin B12Preventing or improving symptoms such as atony, megaloblastic anemia, taeniasis lata, pernicious anemia, malabsorption syndrome, asthenopia, nutritional anemia, anemia of pregnancy, and neuralgiaThe agent is effective in improving rough skin, and can be used in foods, beverages, oral care products, pharmaceuticals, cosmetics, etc. On the other hand, vitamin B is known12The product is easily decomposed by light exposure, and contains vitamin B12The product of the class I is made into vitamin B12It is essential that the class possess photostability.
In the past, for vitamin B12Various techniques have been reported for preparing formulations having photostability. For example, patent document 1 discloses that vitamin B is contained12And butanol can be used for vitamin B12Imparting light stability. Patent document 2 discloses that vitamin B is contained12And a vitamin stabilizer having a specific phenylpropenoyl carbonyl structure can be used for vitamin B12Imparting light stability. Patent document 3 discloses vitamin B12Adding cyclodextrin or its derivative to make vitamin B12Light stabilization is achieved.
Thus, the conventional attempts to seek vitamin B12Although the technology of photostabilizing preparations has been studied, in recent years, there has been an increasing demand for diversification of products and improvement in quality, and in order to meet such a demand, development of vitamin B12A new technique of light stabilization of the class.
Documents of the prior art
Patent document
Patent document 1: international publication No. 2008/113483
Patent document 2: japanese laid-open patent publication No. 2007-125018
Patent document 3: japanese laid-open patent publication No. 4-49239
Disclosure of Invention
Problems to be solved by the invention
The invention aims to provide a vitamin B-containing food12And capable of inhibiting vitamin B formation due to light exposure12And (d) decomposed compositions of the same.
The present inventors have conducted intensive studies to solve the above problems and as a result, have found that vitamin B is contained in a vitamin B-containing composition12Compositions of the class (I) contain a polyoxyethylene sorbitan fatty acid ester and are formulated to be specific to vitamin B12The amount of the polyoxyethylene sorbitan fatty acid ester is 10 parts by weight or less based on 1 part by weight, whereby vitamin B can be inhibited even when the light exposure is performed under severe conditions12Breakdown of the class, to vitamin B12The light stabilizing effect of the class is particularly remarkable. The present invention has been completed by further studies based on the above findings.
That is, the present invention provides the inventions of the following disclosed embodiments.
Item 1. A composition containing vitamin B12A composition according to (a) is characterized in that,
the vitamin B is contained12Compositions of the class comprising vitamin B12And polyoxyethylene sorbitan fatty acid ester, and relative to vitamin B12Class 1 parts by weight, and the polyoxyethylene sorbitan fatty acid ester is 10 parts by weight or less.
Item 2 vitamin B containing according to item 112A composition of the class wherein,
the vitamin B is contained12Compositions of class also contain vitamin E.
Item 3 vitamin B containing according to item 212A composition of the class wherein,
relative to vitamin B121 part of vitamin E, and 0.00125-1000 parts of vitamin E.
Item 4 the vitamin B containing compound according to any one of items 1 to 312A composition of the class wherein,
the vitamin B is contained12Compositions of the class are aqueous compositions.
Effects of the invention
According to the present invention, vitamin B caused by light exposure can be suppressed12The vitamin B can be increased by decomposing the above substances12Storage stability of various products of the class.
Detailed Description
121. Compositions containing vitamin B
Vitamin B of the present invention12Compositions of the class are characterized by containing vitamin B12And polyoxyethylene sorbitan fatty acid ester, and relative to vitamin B12Class 1 parts by weight, and the polyoxyethylene sorbitan fatty acid ester is 10 parts by weight or less. Hereinafter, vitamin B is contained in the present invention12Compositions of the class are described in detail.
[ vitamin B ]12Class I]
Vitamin B12The group is vitamin B12(cyanocobalamin), derivatives thereof, and salts thereof. Vitamin B for use in the present invention12The type of the group is not particularly limited as long as the group can be incorporated into products such as foods, drinks, oral care products, pharmaceuticals, and cosmetics. For example as vitamin B12Examples of the derivative of (3) include methylcobalamin, hydroxocobalamin, adenosylcobalamin (adenosylcobalamin), hydrocobalamin, and the like. In addition, as vitamin B12Examples of the salts of the derivatives thereof include carboxylates such as acetate, trifluoroacetate, butyrate, palmitate, stearate, fumarate, maleate, succinate, malonate, lactate, tartrate and citrate; organic sulfonates such as methanesulfonate, toluenesulfonate and p-toluenesulfonate; inorganic acid salts such as hydrochloride, sulfate, nitrate and phosphate; organic amine salts such as methylamine, triethylamine, and triethanolamine; alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium and magnesium; ammonium salts, and the like.
These vitamin B compounds12The types of the above-mentioned compounds may be 1 type alone or 2 or more types in combination.
These vitamin B compounds12Among them, cyanocobalamin is preferably used.
Vitamin B-containing compositions according to the invention12Vitamin B in compositions of the class12Concentration of the vitamin B in the composition12The shape of the composition and the product form may be appropriately set, and for example, the amount of the composition is 0.0001 to 0.2% by weight, preferably 0.0002 to 0.02% by weight, and more preferably 0.0002 to 0.002% by weight.
[ polyoxyethylene sorbitan fatty acid ester ]
To seek vitamin B12Photostabilization of the vitamin B-containing compounds of the invention12Compositions of the class in relation to vitamin B12The component (1) contains polyoxyethylene sorbitan fatty acid ester in a proportion of 10 parts by weight or less.
The polyoxyethylene sorbitan fatty acid ester is a compound obtained by condensing ethylene oxide with a sorbitan fatty acid ester which is a monoester, diester, or triester of a fatty acid and sorbitan. The number of carbon atoms of the fatty acid constituting the polyoxyethylene sorbitan fatty acid ester is, for example, 8 to 30, preferably 10 to 22, and more preferably 12 to 18. The average number of moles of ethylene oxide added to the polyoxyethylene sorbitan fatty acid ester is, for example, 6 to 160, preferably 6 to 60, and more preferably 6 to 30. Specific examples of the polyoxyethylene sorbitan fatty acid ester include polysorbate 20 (polyoxyethylene (20) sorbitan monopalmitate), polysorbate 40 (polyoxyethylene (20) sorbitan monolaurate), polysorbate 60 (polyoxyethylene (20) sorbitan monostearate), polysorbate 65 (polyoxyethylene (20) sorbitan tristearate), polysorbate 80 (polyoxyethylene (20) sorbitan monooleate), polysorbate 85 (polyoxyethylene (20) sorbitan trioleate), PEG-6 sorbitan stearate, PEG-20 sorbitan isostearate, PEG-6 sorbitan oleate, and polysorbate 85.
These polyoxyethylene sorbitan fatty acid esters may be used alone in 1 kind, or may be used in combination in 2 or more kinds.
Among these polyoxyethylene sorbitan fatty acid esters, vitamin B is further effectively sought for12From the viewpoint of light stabilization, polysorbate 80 is preferably used.
Vitamin B in the present invention12In compositions of the class (I), as vitamin B12The ratio of the fatty acid esters to the polyoxyethylene sorbitan fatty acid ester in the presence of vitamin B12The polyoxyethylene sorbitan fatty acid ester may be used in an amount of 10 parts by weight or less based on 100 parts by weight of the surfactant, but is preferably 1 to 10 parts by weight, more preferably 2.5 to 10 parts by weight.
In addition, vitamin B is contained in the present invention12The concentration of the polyoxyethylene sorbitan fatty acid ester in the composition of the class (iii) may be appropriately set within a range satisfying the above ratio, and for example, the concentration is 0.001 to 0.1% by weight, preferably 0.0025 to 0.1% by weight, and more preferably 0.005 to 0.1% by weight.
[ vitamin E group ]
Vitamin B in the present invention12Compositions of the class except vitamin B12And polyoxyethylene sorbitan fatty acid ester, and vitamin E. By further containing vitamin E in this way, vitamin B can be more effectively sought12Light stabilization of the class.
Vitamin E refers to vitamin E (tocopherol, tocotrienol) and its derivatives. The type of the vitamin E used in the present invention is not particularly limited as long as it can be incorporated into products such as foods, drinks, oral care products, pharmaceuticals, and cosmetics. For example, tocopherol and tocotrienol may be any of α -, β -, γ -, and δ -, and may be any of d-isomer or dl-isomer. Examples of the vitamin E derivative include tocopherol organic acid esters such as tocopherol acetate, tocopherol succinate, tocopherol linoleate, tocopherol linolenate, tocopherol nicotinate, and tocopherol (linoleic acid/oleic acid) ester.
These vitamin E compounds may be used alone in 1 kind, or in combination of 2 or more kinds.
Among these vitamin E compounds, vitamin B is sought for more effectively12From the viewpoint of light stabilization of the group, a derivative of tocopherol is preferably used, and tocopherol acetate is more preferably used.
In the present invention, vitamin B is contained12When vitamin E is contained in the composition, vitamin B is used12Ratio of class to vitamin E classExamples of the ratio include: relative to vitamin B121 part by weight of the vitamin E compound, 0.00125 to 1000 parts by weight of the vitamin E compound, preferably 0.025 to 250 parts by weight, and more preferably 2.5 to 250 parts by weight.
In addition, the vitamin B-containing compositions of the present invention12When vitamin E is contained in the composition, vitamin B is contained12The concentration of the vitamin E in the composition of the type (I) is, for example, 0.00025 to 0.1% by weight, preferably 0.0005 to 0.05% by weight, more preferably 0.0005 to 0.005% by weight.
[ chelating agent ]
Vitamin B of the present invention12Compositions of class (d) may further comprise a chelating agent. The type of the chelating agent used in the present invention is not particularly limited as long as it can be incorporated into products such as foods, drinks, oral care products, pharmaceuticals, and cosmetics, and examples thereof include edetic acid, citric acid, succinic acid, and salts thereof. Examples of the salt form include alkali metal salts such as sodium salt and potassium salt. These chelating agents may be used alone in 1 kind, or may be used in combination in 2 or more kinds.
Among these chelating agents, edetic acid and salts thereof are preferable, and sodium edetate is more preferable.
In addition, the vitamin B-containing compositions of the present invention12In the case where the composition of class (III) contains a chelating agent, vitamin B is contained12The concentration of the chelating agent in the composition of the class is not particularly limited, and may be, for example, 0.001 to 0.3% by weight, preferably 0.005 to 0.1% by weight, more preferably 0.01 to 0.1% by weight.
[ polyhydric alcohol ]
Vitamin B of the present invention12Compositions of the class may further comprise a polyol. Examples of the polyhydric alcohol used in the present invention include ethylene glycol, 1, 3-butanediol, propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polypropylene glycol, and glycerin. These polyols may be used alone in 1 kind, or in combination with 2 or more kinds.
Among these polyols, propylene glycol is preferably used.
In addition, the vitamin B-containing compositions of the present invention12When the composition of class (III) contains a polyhydric alcohol, vitamin B is contained12The concentration of the polyol in the composition of the type is not particularly limited, and may be, for example, 0.01 to 10% by weight, preferably 0.1 to 5% by weight, and more preferably 0.1 to 1% by weight.
[ other ingredients ]
Vitamin B in the present invention12In addition to the above components, the compositions may contain vitamin B12The composition contains various ingredients such as pharmacological ingredients, food materials, additives, etc. in terms of shape and product form. Such ingredients are only required to contain vitamin B12The shape and product form of the composition may be appropriately selected from usable components, and examples thereof include water, pharmacological components, coolants, surfactants (other than polyoxyethylene sorbitan fatty acid esters), oils and fats, waxes, hydrocarbons, fatty acids, higher alcohols, esters, water-soluble polymers, metal soaps, monohydric lower alcohols, pH regulators, buffers, antioxidants, ultraviolet screening agents, preservatives, perfumes, powders, thickeners, and pigments. These components can be used alone in 1, in addition to the combination of more than 2. The concentrations of these components may be appropriately set according to the kind of the components to be used, the shape of the composition, the product form, and the like.
[ vitamin B ] containing12The shape and product form of the composition]
Vitamin B of the present invention12The composition of class may be either an aqueous composition or a non-aqueous composition. In general, vitamin B12The group has a tendency to be easily decomposed by light exposure in an aqueous composition, but according to the present invention, vitamin B caused by light exposure can be effectively suppressed even in an aqueous composition12And (5) decomposing the class. In view of the effects of the present invention, vitamin B is contained as the present invention12Preferred examples of the composition of the class include aqueous compositions.
Aqueous compositions refer to compositions containing water. The concentration of water in the aqueous composition is, specifically, 50% by weight or more, preferably 50 to 99.99% by weight, and more preferably 50 to 99.8% by weight. Examples of the form of the aqueous composition include a liquid, a gel, and a paste.
In the presence of vitamin B12When the composition of the type (b) is an aqueous composition, the pH thereof is, for example, 4.0 to 8.0, preferably 5.0 to 7.7, and more preferably 5.5 to 7.0.
The nonaqueous composition means a composition containing substantially no water other than water inevitably contained due to moisture absorption of the components to be blended. Examples of the shape of the nonaqueous composition include powder, granule, tablet, pill, and paste.
Vitamin B-containing compositions according to the invention12The product form of the composition is not particularly limited, and examples thereof include foods and beverages, oral care products, pharmaceutical products, and cosmetics.
Examples of the foods and beverages include beverages such as soft drinks, alcoholic beverages, nutritional beverages, coffee, tea, milk, fruit juice beverages, and soft drinks; supplements such as tablet, granule, powder, gel, powder, suspension, syrup, and capsule (soft capsule, hard capsule); auxiliary vegetables such as cheese, wiener sausage, ham and seafood processed product; snacks such as ice cream, cookies, cake, jelly, pudding, candy, chewing gum, yogurt, gummy candy, chocolate, and biscuit.
Examples of the oral care product include dentifrices such as toothpaste, powder dentifrice, and liquid dentifrice; a tooth paste; mouth washes such as mouth washes and gargles; oral paste, oral spray, orally disintegrating film, gel, lozenge, tablet, chewable tablet, oral ointment, etc.
Examples of the pharmaceutical products include oral pharmaceutical products such as powders, granules, tablets, capsules, pills, and solutions; a drug for subcutaneous, intravascular or intraperitoneal administration such as an infusion solution or an injection; liquid preparations (including lotion, spray, aerosol and emulsion), water-soluble ointment, greasy ointment, cream, foam, gel, patch, eye drop, eye lotion, etc.
Examples of the cosmetic include basic cosmetics such as ointments, creams, lotions, face masks, and gels; makeup cosmetics such as foundation, eye shadow, lipstick, and blush.
Examples
The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples.
Test example 1
Aqueous compositions of the compositions shown in table 1 were prepared. 500ml of the aqueous composition thus obtained was filled in a transparent container (made of polyethylene terephthalate) having a capacity of 500ml, and the container was left standing for 35 days in a room (a place 10cm away from a window on the south side) where sunlight was directly emitted in the daytime. After standing for 35 days, the appearance of the aqueous composition was visually observed, and the storage stability of cyanocobalamin was evaluated according to the following criteria. In addition, since cyanocobalamin has a pink hue and fades when decomposed, the more fading in this test indicates that the decomposition of cyanocobalamin proceeds more.
< storage stability of cyanocobalamin >
Very good: the color tone was equivalent to that immediately after production.
O: slight discoloration was observed as compared with immediately after production, but was within the allowable range.
X: significant discoloration was observed and was not allowed as compared with immediately after production.
X: the discoloration was significant and became almost colorless.
The results are shown in Table 1. As a result, in the aqueous composition, even when cyanocobalamin and polysorbate 80 were coexisted, decomposition of cyanocobalamin by light exposure could not be inhibited in the case where polysorbate 80 exceeded 10 parts by weight relative to 1 part by weight of cyanocobalamin. On the other hand, it was confirmed that decomposition of cyanocobalamin due to light exposure could be suppressed when polysorbate 80 was co-present with cyanocobalamin in the aqueous composition and polysorbate 80 was 10 parts by weight or less based on 1 part by weight of cyanocobalamin. In addition, it is also clear that: in the case where the aqueous composition contains cyanocobalamin and polysorbate 80 in an amount of 10 parts by weight or less relative to 1 part by weight of cyanocobalamin, and also contains tocopherol acetate, the decomposition of cyanocobalamin by light exposure can be suppressed particularly effectively.
[ Table 1]
Figure BDA0003346781800000101
Formulation examples
Aqueous compositions of the compositions shown in table 2 were prepared. The storage stability of cyanocobalamin was evaluated for the obtained aqueous composition in the same manner as in test example 1, and as a result, the decomposition of cyanocobalamin by light exposure was effectively suppressed.
[ Table 2]
Figure BDA0003346781800000111

Claims (4)

1. Vitamin B-containing food12A composition according to (a) is characterized in that,
the vitamin B is contained12Compositions of the class comprising vitamin B12And polyoxyethylene sorbitan fatty acid ester, and relative to vitamin B12Class 1 parts by weight, and the polyoxyethylene sorbitan fatty acid ester is 10 parts by weight or less.
2. Vitamin B according to claim 112A composition of the class wherein,
the vitamin B is contained12Compositions of class also contain vitamin E.
3. Vitamin B according to claim 212A composition of the class wherein,
relative to vitamin B12Class 10.00125 to 1000 parts by weight of vitamin E.
4. Vitamin B according to any one of claims 1 to 312A composition of the class wherein,
the vitamin B is contained12Compositions of the class are aqueous compositions.
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