CN113808100A - Device for identifying rough calcification of breast nodules - Google Patents
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- 230000002308 calcification Effects 0.000 title claims abstract description 125
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- 208000004434 Calcinosis Diseases 0.000 claims abstract description 126
- 238000002604 ultrasonography Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000010276 construction Methods 0.000 claims abstract description 7
- 238000000605 extraction Methods 0.000 claims abstract description 6
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- 238000003709 image segmentation Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 238000003064 k means clustering Methods 0.000 description 1
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- 238000012285 ultrasound imaging Methods 0.000 description 1
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- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
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Abstract
The invention relates to a device for identifying rough calcification of breast nodules, which comprises: an image acquisition module: for acquiring an ultrasound image with a breast nodule; the interesting nodule image extraction module: the method comprises the steps that a breast nodule boundary of the ultrasonic image is intercepted in a mode of selecting a plurality of interested coordinate points, and an interested nodule image is obtained; a calcification identification module: for passing Bayesian ExcelleIdentifying calcifications in the interesting nodule image by a chemical algorithm to obtain an image Icals_grow(ii) a Calcification geometric descriptor construction module: for according to image Icals_growTo construct a calcification geometric descriptor; coarse calcification identification module: for identifying the image I by the calcification geometry descriptorcals_growWhether the medium calcification is coarse calcification. The method and the device can effectively identify the coarse calcification in the ultrasonic image.
Description
Technical Field
The invention relates to the technical field of auxiliary medical diagnosis, in particular to a device for identifying rough calcification of breast nodules.
Background
Nowadays, with the increasing demand for rapid and accurate diagnosis and the shortage of clinical staff, computer analysis methods have been increasingly applied to support routine clinical diagnosis and show good results.
It is expected that breast cancer will become the second leading cancer of life in women in recent years with a mortality rate of 15%. These statistics indicate that diagnosis of breast cancer is critical to improving life expectancy, especially in women. As a common clinical tool, ultrasound imaging is a non-invasive, non-radiative, low-cost cancer diagnostic technique. However, due to the low image quality, identifying breast lesions and detecting signs of cancer from ultrasound is a challenging task.
The growth and progression of malignant tumors can be reflected by their direction, appearance, texture, composition, and many other factors. As a well-used tool, grayscale Ultrasound (US) images can visualize many of these factors, helping physicians to better view and understand breast nodules. However, in current clinical practice, the features observed in ultrasound breast images can only be assessed subjectively or semi-subjectively, which limits the widespread use of ultrasound images. Therefore, automated accurate breast nodule quantitative analysis criteria are crucial for accurate cancer diagnosis.
The breast imaging report and data system (BI-RADS) is a guideline for scientific measurement and reporting of breast nodules. Unfortunately, there is currently no study of quantifying the BI-RADS features to improve the diagnostic performance of breast cancer classification.
Disclosure of Invention
The invention aims to provide a device for identifying rough calcification of a breast nodule, which can effectively identify the rough calcification in an ultrasonic image.
The technical scheme adopted by the invention for solving the technical problems is as follows: provided is a device for identifying rough calcification of a breast nodule, including:
an image acquisition module: for acquiring an ultrasound image with a breast nodule;
the interesting nodule image extraction module: the method comprises the steps that a breast nodule boundary of the ultrasonic image is intercepted in a mode of selecting a plurality of interested coordinate points, and an interested nodule image is obtained;
a calcification identification module: the method is used for identifying calcifications in the interested nodule image through a convolutional neural network to obtain an image Icals_grow;
Calcification geometric descriptor construction module: for according to image Icals_growTo construct a calcification geometric descriptor;
coarse calcification identification module: for identifying the image I by the calcification geometry descriptorcals_growWhether the medium calcification is coarse calcification.
A construction calcification geometric descriptor in the calcification geometric descriptor construction module, comprising:
calculating the image Icals_growThe area of each calcification in (a);
and constructing a calcification geometric descriptor according to the calculated area of each calcification point.
Computing the image I in the calcification geometry descriptor construction modulecals_growThe area of each calcification point in (a), the formula is:wherein S isCCIndicates the area of calcifications, XCCSet of pixel coordinates representing a calcification, (x, y) representing image Icals_growThe coordinates of the pixel points in (1).
The calcification geometric descriptor constructing module constructs a calcification geometric descriptor according to the calculated area of each calcification point, and the formula is as follows:
wherein, CirCCIndicating the roundness of the calcifications, SCCIndicates the area of calcifications, XCCSet of pixel coordinates, X ', representing calcification points'CCSet of pixel coordinates, P, representing erosion by a butterfly-shaped structuring element of 1-pixel width within a calcificationCCShowing the perimeter of the calcified area (x, y)Display image Icals_growThe coordinates of the pixel points in (1).
Identifying the image I by the calcification geometry descriptor in the coarse calcification identification modulecals_growWhether the medium calcification is coarse calcification or not is specifically as follows: if the area S of the calcified pointCC>tSAnd the roundness Cir of the calcified pointCC>tCirThen, it indicates that the calcified point is coarse calcified point, tSDenotes the area threshold, tCirIndicating the roundness threshold.
Advantageous effects
Due to the adoption of the technical scheme, compared with the prior art, the invention has the following advantages and positive effects: according to the invention, a calcification geometric descriptor is constructed according to calcification points detected in an ultrasonic image, and effective identification of coarse calcification is realized through the calcification geometric descriptor; the invention can facilitate doctors to accurately judge the pathological part and provide effective data support for doctors to accurately judge the pathological part better, faster and more accurately.
Drawings
FIG. 1 is a flow chart of an embodiment of the present invention;
FIG. 2 is a schematic diagram of superpixel segmentation according to an embodiment of the present invention;
fig. 3 is a schematic diagram of a coarse calcification identification result according to the embodiment of the present invention.
Detailed Description
The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Further, it should be understood that various changes or modifications of the present invention may be made by those skilled in the art after reading the teaching of the present invention, and such equivalents may fall within the scope of the present invention as defined in the appended claims.
The embodiment of the present invention relates to a device for identifying rough calcification of breast nodules, referring to fig. 1, including:
an image acquisition module: for acquiring an ultrasound image with a breast nodule;
the interesting nodule image extraction module: the method comprises the steps that a breast nodule boundary of the ultrasonic image is intercepted in a mode of selecting a plurality of interested coordinate points, and an interested nodule image is obtained;
a calcification identification module: identifying calcification points in the nodule image of interest through a Bayesian optimization algorithm to obtain an image Icals_grow;
Calcification geometric descriptor construction module: for according to image Icals_growTo construct a calcification geometric descriptor;
coarse calcification identification module: for identifying the image I by the calcification geometry descriptorcals_growWhether the medium calcification is coarse calcification.
The invention is described in detail below by means of a specific embodiment:
in this embodiment, the calcification identification module further includes a calcification candidate detection module before the calcification identification module, and the calcification candidate detection module is configured to remove a boundary mask from the nodule image of interest to obtain an image I'erodeDividing the image into a plurality of superpixels, detecting calcification candidate points from each superpixel according to the contrast and the brightness to obtain an image Icals_raw。
The calcification candidate point detection module specifically comprises: the image I 'is divided by an image segmentation method of a k-means clustering method'erodeIs divided into 200 super pixels to obtain an image I'SP200And from said image I'SP200The super-pixel 100 before the average brightness is selected.
Will be from picture I'SP200The selected superpixel of which the average luminance is 100 th before is divided into 300 superpixels to obtain an image I'SP300And from said image I'SP300The super pixel 150 before the average brightness is selected.
Will be from picture I'SP300The selected superpixel 150 before the average brightness is divided into 750 superpixels to obtain an image I'SP750And from said image I'SP750The superpixel of contrast variance 375 ahead is selected and finally image I 'is further eroded by 6-pixel or 10-pixel (depending on nodule size) wide dish-shaped structuring elements'SP750Is limited byA mask for removing the potential false calcification candidate points detected at the edge to obtain an image I with the calcification candidate pointscals_raw。
As for the super-pixel segmentation, fig. 2 may be referred to, where (a) in fig. 2 is a nodule image of interest, and (b) in fig. 2 shows an image after the super-pixel segmentation.
For image Icals_rawAnd (3) cutting each connected domain (namely, the pixel point set of the region occupied by the calcifications) independently. Further, for image Icals_rawAnd (3) extracting the features of each connected domain which is cut separately, extracting two features which are respectively a histogram feature expressing the brightness feature expression of the candidate region and a gray level co-occurrence matrix feature expressing the texture feature expression of the candidate region, and combining the histogram feature and the gray level co-occurrence matrix feature to express that the total number is 6+14 to 20. The reasonable interval for extracting the characteristic value is determined by the statistical analysis of the characteristic expression difference between the true calcification and the false calcification and the Bayesian optimization algorithm. Carrying out feature extraction on each candidate calcification region by a Bayesian optimization algorithm, checking the feature extraction with the determined reasonable interval, and if the feature value is out of the defined interval, carrying out verification on the image Icals_rawDeleting the non-calcified area to obtain an image Icals_fine. This embodiment also applies to image I by a region growing methodcals_fineThe calcified points in the image are subjected to regional growth, the growing regions of the calcified points are limited through the energy range calibrated by the SURF descriptor, and finally a calcified image I is generatedcals_grow。
Based on clinical experience, coarse calcifications generally suggest a lower malignancy potential of the nodule than micro calcifications, and therefore identification of coarse and micro calcifications is required.
The coarse calcifications often appear in the ultrasonic image in a strip-shaped pattern, and based on this, in the calcific geometric descriptor constructing module, the size and roundness information of the calcifications are identified by constructing the calcific geometric descriptor, which specifically includes:
(one) calculating the image Icals_growThe area of each calcification point in (a), the formula is:
wherein S isCCIndicates the area of calcifications, XCCSet of pixel coordinates representing a calcification, (x, y) representing image Icals_growThe coordinates of the pixel points in (1).
(II) constructing a calcification geometric descriptor according to the calculated area of each calcification point, wherein the formula is as follows:
wherein, CirCCIndicating the roundness of the calcifications, SCCIndicates the area of calcifications, XCCSet of pixel coordinates, X ', representing calcification points'CCSet of pixel coordinates, P, representing erosion by a butterfly-shaped structuring element of 1-pixel width within a calcificationCCThe perimeter of the calcified region, (x, y) the image Icals_growThe coordinates of the pixel points in (1).
Due to CirCC∝SCCTherefore, it should be noted that the circularity Cir of the connected domain with smaller size is larger than the circularity Cir of the connected domain with larger size (i.e. the set of pixels in the region occupied by the calcifications)CCAnd is smaller. Therefore, in applying roundness CirCCWhen making measurements, it is necessary to set a minimum size limit, since smaller connected domains are less likely to be coarse calcifications. That is, in the coarse calcification identification module, if the area S of the calcification pointCC>tSAnd the roundness Cir of the calcified pointCC>tCirThen, it indicates that the calcified point is coarse calcified point, tSDenotes the area threshold, tCirIndicating the roundness threshold. Through experiments, the present embodiment sets the area threshold to be: t is tS95; the roundness threshold is set to: t is tCir=0.78。
Fig. 3 (a) shows calcifications detected from the ultrasound image, which are three punctiform calcifications and one bar-shaped calcifications, respectively, and the bright white calcifications in fig. 3 (b) are linear calcifications, i.e., coarse calcifications.
Therefore, the invention constructs the calcification geometric descriptor according to the calcification points detected in the ultrasonic image, and realizes effective identification of coarse calcification through the calcification geometric descriptor.
Claims (5)
1. A device for identifying rough calcification of breast nodules, comprising:
an image acquisition module: for acquiring an ultrasound image with a breast nodule;
the interesting nodule image extraction module: the method comprises the steps that a breast nodule boundary of the ultrasonic image is intercepted in a mode of selecting a plurality of interested coordinate points, and an interested nodule image is obtained;
a calcification identification module: identifying calcification points in the nodule image of interest through a Bayesian optimization algorithm to obtain an image Icals_grow;
Calcification geometric descriptor construction module: for according to image Icals_growTo construct a calcification geometric descriptor;
coarse calcification identification module: for identifying the image I by the calcification geometry descriptorcals_growWhether the medium calcification is coarse calcification.
2. The apparatus for identifying rough calcification of breast nodules according to claim 1, wherein the constructing a calcification geometric descriptor in the calcification geometric descriptor constructing module comprises:
calculating the image Icals_growThe area of each calcification in (a);
and constructing a calcification geometric descriptor according to the calculated area of each calcification point.
3. The apparatus for identifying rough calcification of breast nodules according to claim 2, wherein said calculating said image I in said calcification geometric descriptor constructing modulecals_growThe area of each calcification point in (a), the formula is:wherein S isCCIndicates the area of calcifications, XCCSet of pixel coordinates representing a calcification, (x, y) representing image Icals_growThe coordinates of the pixel points in (1).
4. The apparatus for identifying rough calcification of breast nodules according to claim 2, wherein the calcification geometric descriptor constructing module constructs a calcification geometric descriptor according to the calculated area of each calcification, and the formula is as follows:
wherein, CirCCIndicating the roundness of the calcifications, SCCIndicates the area of calcifications, XCCSet of pixel coordinates, X ', representing calcification points'CCSet of pixel coordinates, P, representing erosion by a butterfly-shaped structuring element of 1-pixel width within a calcificationCCThe perimeter of the calcified region, (x, y) the image Icals_growThe coordinates of the pixel points in (1).
5. The apparatus according to claim 1, wherein the coarse calcification identification module identifies the image I by the calcification geometric descriptorcals_growWhether the medium calcification is coarse calcification or not is specifically as follows: if the area S of the calcified pointCC>tSAnd the roundness Cir of the calcified pointCC>tCirThen, it indicates that the calcified point is coarse calcified point, tSDenotes the area threshold, tCirIndicating the roundness threshold.
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