CN113786369A - 一种含人参总皂苷的天然抗氧化纳米组合物及其制备方法 - Google Patents
一种含人参总皂苷的天然抗氧化纳米组合物及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种含人参总皂苷的天然抗氧化纳米组合物及其制备方法。本发明处方中重量百分比计含有0.1～20％的抗氧化活性物、0.1～20％的人参总皂苷作为稳定剂及余量的水。本发明制备方法采用人参总皂苷替代现有的常规化学合成类表面活性剂或高分子聚合物作为稳定剂，为纯天然配方，即增加了协同抗氧化作用，又降低了其他添加物带来的副作用等不利影响。工艺简单，剂量准确，不采用有机试剂，适宜于规模化生产。
Description
技术领域
本发明涉及化妆品技术领域，具体涉及一种含人参总皂苷的天然抗氧化纳米组合物及其制备方法。
背景技术
天然存在的抗氧化活性物如白藜芦醇、槲皮素等被证实具有较好的抗氧化作用相对于化学合成类的苯氧肟酸等美白抗氧化剂皮肤副作用更小。但此类天然活性物大多存在水溶性差等问题，从而影响了其实际效果的发挥。
纳米混悬或者纳米晶体由有效成分、稳定剂(一般为表面活性剂或者高分子聚合物)及水组成。此技术体系不采用任何药物载体，因此具有载药量高、副作用小、起效快等优势。它是一种通过提高饱和溶解度及溶出速度并且提高皮肤吸附效果来提升难溶性成分的实际效果。此类纳米体系中的稳定剂往往单纯起稳定作用，无功效作用，有时会带来副作用。
人参总皂苷是人参提取物的主要成分，能扩张皮肤毛细血管，促进皮肤血液循环，增加皮肤营养，调节皮肤的水油平衡，防止皮肤脱水、硬化、起皱，同时其还具有抑制黑色素的还原性能，具有美白抗氧化等作用，对皮肤几乎没有不良刺激。人参总皂苷具有表面活性剂的作用，因此其可以作为天然的稳定剂与其他天然美白抗氧化活性物协同作用。
发明内容
本发明的目的是提供一种含人参总皂苷的天然抗氧化纳米组合物及其制备方法。
本发明，其特征在于：按重量百分比计，其含有0.1～20％的抗氧化活性物、0.1～20％的人参总皂苷作为稳定剂及余量的水。
本发明的天然抗氧化纳米组合物，其粒径范围在适宜皮肤吸收的10～1000nm。
本发明的天然抗氧化纳米组合物制备方法，包括以下制备步骤：
(1)在搅拌下将一种或多种天然存在的抗氧化活性物原料粉末直接加入到含有人参总皂苷作为稳定剂的水溶液或者混悬液中，形成粗混悬液；
(2)将粗混悬液转移至0～5℃预冷的高压均质机中均质，先在500bar下循环5-10次，然后在1000bar～1500bar下循环10-30次，制成纳米组合物。
本发明所述的天然存在的抗氧化活性物为白藜芦醇、光甘草定、槲皮素、姜黄素、维生素A及其衍生物、维生素E及其衍生物、丹皮酚、红没药醇、水飞蓟素、根皮素中的一种或多种。
本发明的优点在于：
(1)天然存在的抗氧化活性物如白藜芦醇、槲皮素等难溶于水，制成纳米后，能够迅速溶解并且加强皮肤吸附。
(2)本发明的制备方法采用人参总皂苷替代现有的常规化学合成类表面活性剂或高分子聚合物作为稳定剂，为纯天然配方，即增加了协同抗氧化作用，又降低了副作用等不利影响。
(3)工艺简单，剂量准确，不采用有机试剂，适宜于规模化生产。
下面实施例仅对本发明作进一步的详细说明，但应注意本发明的保护范围不应受这些实例的任何限制。
实施例1
将1.6g白藜芦醇在搅拌下加入到含有0.4g人参总皂苷的80ml水溶液中，形成粗混悬液。将粗混悬液转移至0～5℃预冷的高压均质机中均质，先在500bar下循环5次，然后在1300bar下循环15次，即得纳米组合混悬液，测得纳米组合混悬液的平均粒径为511nm。
实施例2
将1.6g槲皮素在搅拌下加入到含有0.4g人参总皂苷的80ml水溶液中，形成粗混悬液。将粗混悬液转移至0～5℃预冷的高压均质机中均质，先在500bar下循环5次，然后在1300bar下循环15次，即得纳米组合混悬液，测得纳米组合混悬液的平均粒径为373nm。
实施例3
将1.6g姜黄素在搅拌下加入到含有0.4g人参总皂苷的80ml水溶液中，形成粗混悬液。将粗混悬液转移至0～5℃预冷的高压均质机中均质，先在500bar下循环5次，然后在1300bar下循环15次，即得纳米组合混悬液，测得纳米组合混悬液的平均粒径为679nm。
实施例4
将4.8g白藜芦醇、姜黄素、槲皮素(1：1：1)在搅拌下加入到含有0.4g人参总皂苷的80ml水溶液中，形成粗混悬液。将粗混悬液转移至0～5℃预冷的高压均质机中均质，先在500bar下循环5次，然后在1300bar下循环15次，即得纳米组合混悬液，测得纳米组合混悬液的平均粒径为355nm。
实施例4纳米组合物的抗氧化作用的测试(DPPH测试)
基于自由基DPPH(1，1-二苯基-2-苦基腙(1，1-diphenyl-2-picrylhydrazyl))的还原所引起的吸光度变化，通过测定对DPPH氧化抑制作用评价上述制备得到的纳米组合物的抗氧化活性。
从纳米组合物样品中取50μl，加无水乙醇定容至25ml，得高浓度供试液；从上述组合物样品中取33μl，加无水乙醇定容至100ml，得低浓度供试液。取2.5mgDPPH，无水乙醇定容至50ml，得DPPH溶液。取0.5ml高浓度供试液加入3ml无水乙醇和2.5mlDPPH溶液。另取0.5ml低浓度供试液加入3ml无水乙醇和2.5mlDPPH溶液。另取一空瓶，加入3ml无水乙醇和3mlDPPH溶液作为空白组。上述均混匀后于室温暗处避光反应30min，以无水乙醇为背景，在517nm测定吸光度，计算可得高浓度供试液DPPH清除率为75％，低浓度供试液DPPH清除率为20％，表明随着待测样品中活性物质量浓度增加，其对DPPH自由基的清除能力增加，这说明在样品的制备过程中保持了有效的抗氧化活性。
Claims (3)
1.一种含人参总皂苷的天然抗氧化纳米组合物，其特征在于，按重量百分比计，其含有0.1～20％的抗氧化活性物、0.1～20％的人参总皂苷作为稳定剂及余量的水。
2.根据权利要求1所述的含人参总皂苷的天然抗氧化纳米组合物，其特征在于包括以下制备步骤：
(1)在搅拌下将一种或多种天然存在的抗氧化活性物原料粉末直接加入到含有人参总皂苷作为稳定剂的水溶液或者混悬液中，形成粗混悬液；
(2)将粗混悬液转移至0～5℃预冷的高压均质机中均质，先在500bar下循环5-10次，然后在1000bar～1500bar下循环10-30次，制成纳米组合物。
3.本发明所述的天然存在的抗氧化活性物为白藜芦醇、光甘草定、槲皮素、姜黄素、维生素A及其衍生物、维生素E及其衍生物、丹皮酚、红没药醇、水飞蓟素、根皮素中的一种或多种。
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| CN103271891A (zh) * | 2013-04-28 | 2013-09-04 | 福建南方制药股份有限公司 | 人参皂苷纳米胶束及其制备方法、应用和药物组合物 |
| CN106619163A (zh) * | 2016-12-24 | 2017-05-10 | 青岛科技大学 | 光甘草定纳米混悬剂及其制备方法 |
| WO2017095138A1 (en) * | 2015-11-30 | 2017-06-08 | Gil Medical Center | Curcumin-containing lipid nanoparticle complex comprising ginsenosides |
| CN108904316A (zh) * | 2018-08-17 | 2018-11-30 | 江西中医药大学 | 天然美白抗氧化组合物及由其制备的纳米凝胶化妆品 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271891A (zh) * | 2013-04-28 | 2013-09-04 | 福建南方制药股份有限公司 | 人参皂苷纳米胶束及其制备方法、应用和药物组合物 |
| WO2017095138A1 (en) * | 2015-11-30 | 2017-06-08 | Gil Medical Center | Curcumin-containing lipid nanoparticle complex comprising ginsenosides |
| CN106619163A (zh) * | 2016-12-24 | 2017-05-10 | 青岛科技大学 | 光甘草定纳米混悬剂及其制备方法 |
| CN108904316A (zh) * | 2018-08-17 | 2018-11-30 | 江西中医药大学 | 天然美白抗氧化组合物及由其制备的纳米凝胶化妆品 |
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