CN113786351A - Novel use of clofazimine as hair dye - Google Patents
Novel use of clofazimine as hair dye Download PDFInfo
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- CN113786351A CN113786351A CN202111167736.4A CN202111167736A CN113786351A CN 113786351 A CN113786351 A CN 113786351A CN 202111167736 A CN202111167736 A CN 202111167736A CN 113786351 A CN113786351 A CN 113786351A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/10—Preparations for permanently dyeing the hair
Abstract
The invention discloses a new application of clofazimine as a hair dye, and relates to the field of hair dyes. Preparing saturated solution from clomazone by using a polar solvent, uniformly coating the saturated solution on hair or animal hair, drying the hair at normal temperature, and determining whether the hair is subjected to re-dyeing and the number of the re-dyeing according to the dyeing depth of the hair to be dyed; the polar solvent is ethanol and/or DMSO. Adding 1-10 wt.% penetration enhancer selected from one or more of Borneolum Syntheticum, Mentholum and laurocapram into the saturated solution; the invention provides a new application of clofazimine, namely the clofazimine is used for dyeing hair or animal hair as a hair dye, meanwhile, the invention adds different agents absorbed through skin, such as borneol, menthol and/or laurocapram, so that the problem of poor solubility of the clofazimine is solved, and the clofazimine preparation is applied to the fields of hair dyeing and hair dyeing by means of changing the pH value, multiple counterdyeing and the like.
Description
Technical Field
The invention relates to the field of hair dyes, in particular to a novel application of clofazimine as a hair dye.
Background
Clofazimine was synthesized by Barry et al in 1954, and Browne et al in 1962 demonstrated a positive therapeutic effect on leprosy, which was recommended by WHO in 1982 as a treatment for polymicrobial leprosy and leprosy nodules. Has antibacterial, antiinflammatory and immunosuppressive effects. The traditional Chinese medicine composition is mainly clinically applied to treating various leprosy patients with positive bacteria detection, and can control recurrent leprosy reaction. It has certain curative effect on leprosy of tumor type and other types, is also effective on leprosy of sulfone type, and is often combined with rifampicin, ethionamide or prothioconamide for application. In addition, the medicine has good curative effects on tuberculosis, erythema nodosum, pyoderma, pemphigoid, discoid lupus erythematosus, palmoplantar pustulosis, vasculitis, pyoderma gangrenosum, acute febrile Zhongxing facial granuloma, aseptic pustulosis, pigmentary abnormal skin diseases, mycobacterial infectious skin diseases, Melkersson-Rosenthal syndrome or granulomatous cheilitis, acne vulgaris and the like.
Hair dye is a cosmetic having an effect of changing the color of hair. In addition to the pursuit of many old-aged hair dyeing people to dye white hair into black hair, modern young people emphasize distinctiveness for highlighting individuality and often change the single hair color of the modern young people into various colors such as brown, red and the like.
Many pet breeders also tend to dye beautiful hair when beautifying their pets.
It is known that most of the existing hair dyes have the defects of sensitization, carcinogenesis and the like. Foreign studies have shown that the incidence of breast cancer, skin cancer, leukemia, bladder cancer in people who often have hair dyes is increased. Therefore, the safety of the hair dye is important.
The clofazimine used as the medicine has wide clinical application, the dosage of 50-400mg per day is proved to be safe and effective, and the side effects with different degrees can be generated after continuous large-dosage administration for 2-4 weeks. At present, no application of clofazimine in hair dyeing and hair dyeing is available.
Disclosure of Invention
In view of the above problems in the prior art, the present invention provides a novel use of clofazimine as a hair dye.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows:
the new use of clofazimine as hair dye, prepare clofazimine into saturated solution with polar solvent, and apply the saturated solution on hair or animal's hair evenly, after blow-drying at the normal temperature, determine whether to dye and the number of times of dyeing again according to the dyeing depth that needs to dye hair; the polar solvent is ethanol and/or DMSO.
Further, the clofazimine is prepared into a saturated solution by using 30-100% ethanol by volume percentage.
Further, clofazimine is prepared into a saturated solution by using 30-100% volume percent of ethanol and DMSO.
Preferably, the volume percent of ethanol is 75-100%.
Further, the volume ratio of ethanol to DMSO is 1: 1.
Further, the saturated solution is not adjusted in pH value or is adjusted in pH value to 2-3 by using a pH regulator.
Further, the pH regulator is an acid neutralizer selected from one or more of hydrochloric acid, sulfuric acid, oxalic acid, acetic acid, pyruvic acid, glycolic acid, lactic acid, citric acid, tartaric acid, succinic acid, gluconic acid and sulfamic acid.
Furthermore, a penetration enhancer is added into the saturated solution.
Further, the concentration of the penetration enhancer in the saturated solution is 1-10 wt.%.
Further, the penetration enhancer is one or more selected from borneol, menthol and laurocapram.
A clofazimine hair dye comprises the following components: clofazimine, polar solvent and penetration enhancer; preparing clofazimine into a saturated solution by using a polar solvent to prepare a clofazimine hair dye; the polar solvent is ethanol and/or DMSO; the penetration enhancer is selected from one or more of borneol, menthol and laurocapram; the concentration of the penetration enhancer in the saturated solution is 1-10 wt.%.
Compared with the prior art, the invention has the beneficial effects that: the invention provides a new application of clofazimine, namely the clofazimine is used for dyeing hair or animal hair as a hair dye, meanwhile, different agents absorbed through skin, such as borneol, menthol and/or laurocapram, are added, the problem of poor solubility of the clofazimine is solved, and the clofazimine preparation is applied to the fields of hair dyeing and hair dyeing by means of changing the pH value, multiple counterdyeing and the like.
Drawings
FIG. 1 is a graph showing the results of dyeing hair with a 75% ethanol saturated solution formulation of clofazimine; in the figure, No. 1 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 2 shows the result of dyeing the hair for 1 time by using a clofazimine 75% ethanol saturated solution preparation, and the hair is dyed with golden color by contrasting with a hair dyeing card number 7/33; no. 3 shows that the hair dyeing result of the clofazimine 75% ethanol saturated solution preparation is 2 times, and the hair dyeing card number is 7/43, orange yellow; no. 4 shows that the hair dyeing result of the clofazimine 75% ethanol saturated solution preparation is 3 times, and the hair dyeing card number is 7/43, orange yellow; no. 5 shows that the clofazimine 75% ethanol saturated solution preparation has hair dyeing for 4 times, and the hair dyeing card number is 7/43, orange yellow; no. 6 shows that the hair dyeing result of the clofazimine 75% ethanol saturated solution preparation is 5 times, and the hair dyeing card number is 7/43, orange yellow;
FIG. 2 is a graph showing the results of dyeing hair with clofazimine 100% ethanol saturated solution formulation; in the figure, No. 1 shows the result of dyeing hair for 1 time by using a clofazimine 100% ethanol saturated solution preparation, and the hair is orange yellow compared with a dyed hair card number 7/43; no. 2 shows that the clofazimine 100% ethanol saturated solution preparation has the result of dyeing for 2 times, and the dyeing card number 7/43 is orange yellow; no. 3 shows that the hair dyeing result of the clofazimine 100 percent ethanol saturated solution preparation is 3 times, and the hair dyeing card number is 7/43 which is orange yellow; no. 4 shows the result of dyeing hair for 4 times by using a clofazimine 100% ethanol saturated solution preparation, and the hair is orange red according to the dyed hair card number 6/43; no. 5 shows the result of dyeing 5 times by using a clofazimine 100% ethanol saturated solution preparation, and the hair is orange red according to the dyed hair card number 6/43;
FIG. 3 is a graph showing wool dyeing results of a clofazimine 100% ethanol saturated solution formulation; in the figure, the result that No. 1 is the wool dyed by the clofazimine 100 percent ethanol preparation for 1 time is compared with the dyed hair dye number 8/43, and the color is light orange yellow; no. 2 shows that the wool is dyed for 2 times by the clofazimine 100 percent ethanol preparation, and the wool is dyed in light orange yellow according to the dyeing card number 8/43; no. 3 shows that the wool is dyed for 1 time by a clofazimine 100% ethanol preparation (PH 3 is regulated by citric acid), and the color is dyed in a pink brown color according to the color card number 6/76;
FIG. 4 is a diagram of the hair dyeing results of a saturated solution of clofazimine in 100% ethanol or a saturated solution preparation prepared by 100% ethanol and DMSO; in the figure, No. 1 is primary hair, and is dyed with a hair color card number 22/0 in black; no. 2 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 3 is a hair dyeing result of 1 time of chlorine method zimine 100% ethanol saturated solution preparation (PH is adjusted to be 3 by citric acid), and the hair is orange red according to the dyed hair card number 6/43; no. 4 is that the clofazimine is prepared into saturated solution by 100 percent ethanol and DMSO (V: V is 1: 1), and the hair is dyed for 1 time, and compared with the hair dyeing card number 7/43, the color is orange yellow; no. 5 shows that the hair is dyed for 1 time by a clofazimine 100 percent ethanol saturated solution preparation (the PH is regulated to be 3 by citric acid), and the hair is dyed in orange red according to the hair dyeing card number 6/43; no. 6 shows that the clofazimine 100% ethanol saturated solution preparation (PH 3 is adjusted by citric acid) has 2 times of hair dyeing, and is orange red according to the dyeing hair card number 6/43; no. 7 is that clofazimine is prepared into saturated solution by 100 percent ethanol to DMSO (V: V is 1: 1), (PH 3 is adjusted by citric acid) and the hair is dyed for 1 time, and is orange red according to the dyeing card number 6/43;
FIG. 5 is a graph of the hair dyeing results with laurocapram added and no acid; in the figure, No. 1 is primary hair, and is dyed with a hair color card number 22/0 in black; no. 2 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 3 shows the result of adding 2% laurocapram for dyeing for 1 time, and contrasting with the dyeing card number 7/33 to be golden; no. 4 shows the result of adding 2% laurocapram for dyeing for 2 times, and contrasting with the dyeing card number 7/33 to be golden; no. 5 shows the result of 1 time of hair dyeing by adding 5% laurocapram, and the hair is dyed with 7/33 color card number in a contrast manner to be golden; no. 6 shows the result of adding 5% laurocapram for dyeing for 2 times, and contrasting with the dyeing card number 7/33 to be golden; no. 7 shows the result of adding 8% laurocapram for dyeing for 1 time, and the dyeing card number is 7/33, golden; no. 8 shows the result of adding 8% laurocapram for dyeing for 2 times, and contrasting with the dyeing card number 7/33 to be golden;
FIG. 6 is a graph showing the hair dyeing results with laurocapram added and acid added; in the figure, No. 1 is primary hair, and is dyed with a hair color card number 22/0 in black; no. 2 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 3 shows the result of dyeing hair for 1 time by adding 2% of laurocapram (PH 3 is adjusted by acetic acid), and the dyeing hair is golden according to the dyeing hair card number 7/33; no. 4 shows that 2% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 2 times, and the hair is light orange yellow according to the dyeing card number 8/43; no. 5 shows that 5% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 1 time, and the dyeing card number is 7/43 and is orange yellow; no. 6 shows that 5% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 2 times, and the dyeing card number is 6/43 and is orange red; no. 7 shows that 8% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 1 time, and the dyeing card number is 7/43 and is orange yellow; no. 8 shows the result of adding 8% laurocapram (adjusting PH 3 with acetic acid) for dyeing for 2 times, and comparing with the dyeing card number 6/43, orange red;
FIG. 7 is a diagram showing the result of hair dyeing with borneol or menthol; in the figure, No. 1 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 2 shows that the hair is dyed for 1 time by adding 2 percent borneol, and compared with the dyed hair card number 7/43, the hair is orange yellow; no. 3 shows that the hair is dyed for 2 times by adding 2 percent borneol, and compared with the dyed hair card number 7/43, the hair is orange yellow; no. 4 shows that the hair is dyed for 1 time by adding 2 percent menthol, and the hair is dyed orange by contrasting with a hair-dyeing card number 7/43; no. 5 shows that the hair is dyed for 2 times by adding 2 percent menthol, and the hair is dyed orange by contrasting with a hair-dyeing card number 7/43;
FIG. 8 is a map of a specifically dyed hair clip.
Detailed Description
The invention is further described with reference to specific examples.
Treating human hair or animal hair with hair whitening agent and hydrogen peroxide milk (6-12 deg.) for half an hour, cleaning after color fading, and air drying or blow drying.
Example 1
Preparing saturated solution from clomazone with 75% ethanol, uniformly coating the solution on hair, blow-drying at room temperature, re-dyeing for 1 time, blow-drying, if deeper color is required, dyeing for several times, blow-drying, washing off loose color with clear water, and blow-drying. The hair dyeing result of the saturated solution prepared by the clofazimine with 75% ethanol is shown in figure 1; no. 1 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 2 shows the result of dyeing the hair for 1 time by using a clofazimine 75% ethanol saturated solution preparation, and the hair is dyed with golden color by contrasting with a hair dyeing card number 7/33; no. 3 shows that the hair dyeing result of the clofazimine 75% ethanol saturated solution preparation is 2 times, and the hair dyeing card number is 7/43, orange yellow; no. 4 shows that the hair dyeing result of the clofazimine 75% ethanol saturated solution preparation is 3 times, and the hair dyeing card number is 7/43, orange yellow; no. 5 shows that the clofazimine 75% ethanol saturated solution preparation has hair dyeing for 4 times, and the hair dyeing card number is 7/43, orange yellow; no. 6 shows the result of 5 times of hair dyeing by using a clofazimine 75% ethanol saturated solution preparation, and the hair dyeing card number is 7/43, and the color is orange yellow.
Example 2
Preparing saturated solution from clomazone with 100% ethanol, uniformly coating the solution on hair, blow-drying at room temperature, re-dyeing for 1 time, blow-drying, if deeper color is required, dyeing for several times, blow-drying, washing off loose color with clear water, and blow-drying. The hair dyeing result of the saturated solution prepared by the clofazimine with 100 percent ethanol is shown in figure 2; no. 1 shows the result of dyeing hair for 1 time by using a clofazimine 100% ethanol saturated solution preparation, and the hair is orange yellow according to the dyed hair card number 7/43; no. 2 shows that the clofazimine 100% ethanol saturated solution preparation has the result of dyeing for 2 times, and the dyeing card number 7/43 is orange yellow; no. 3 shows that the hair dyeing result of the clofazimine 100 percent ethanol saturated solution preparation is 3 times, and the hair dyeing card number is 7/43 which is orange yellow; no. 4 shows the result of dyeing hair for 4 times by using a clofazimine 100% ethanol saturated solution preparation, and the hair is orange red according to the dyed hair card number 6/43; no. 5 shows the result of dyeing 5 times by using a clofazimine 100% ethanol saturated solution preparation, and the hair is orange red according to the dyed hair card number 6/43.
Example 3
Preparing saturated solution from chlorine method with 100% ethanol, uniformly coating the solution on wool, blow-drying at normal temperature, re-dyeing for 1 time, blow-drying, if deeper color is required, re-dyeing for several times, blow-drying, washing off loose color with clear water, and blow-drying. The wool dyeing result of the chlorine method zimine prepared into a saturated solution by 100 percent ethanol is shown in figure 3; dyeing wool for 1 time by using a No. 1 clofazimine 100% ethanol preparation, and contrasting with a dyed hair card number 8/43, wherein the dyed hair card number is light orange yellow; no. 2 shows that the wool is dyed for 2 times by the clofazimine 100 percent ethanol preparation, and the wool is dyed in light orange yellow according to the dyeing card number 8/43; no. 3 shows the result of dyeing wool for 1 time by a 100% ethanol preparation of clofazimine (PH 3 is adjusted by citric acid), and the result is compared with the dyeing color card number 6/76, which is pink brown.
Example 4
Preparing saturated solution from chlorine method with 100% ethanol, or preparing saturated solution from 100% ethanol and DMSO (V: V is 1: 1), directly dyeing without adding acid, or adjusting pH value of the solution to 2-3, uniformly coating the solution on hair, blow-drying at room temperature, re-dyeing for 1 time, blow-drying, if deeper color is required, dyeing for several times, blow-drying, washing off loose color with clear water, and blow-drying. The hair dyeing results are shown in figure 4; number 1 is original hair, and the hair is dyed with 22/0 color card number in black; no. 2 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 3 is a hair dyeing result of 1 time of chlorine method zimine 100% ethanol saturated solution preparation (PH is adjusted to 3 by citric acid), and the hair is dyed orange red according to the hair dyeing card number 6/43; no. 4 is that the clofazimine is prepared into saturated solution by 100 percent ethanol and DMSO (V: V is 1: 1), and the hair is dyed for 1 time, and compared with the hair dyeing card number 7/43, the color is orange yellow; no. 5 shows that the hair is dyed for 1 time by a clofazimine 100 percent ethanol saturated solution preparation (the PH is regulated to be 3 by citric acid), and the hair is dyed in orange red according to the hair dyeing card number 6/43; no. 6 is a clofazimine 100% ethanol saturated solution preparation (PH is adjusted to 3 by citric acid) for dyeing 2 times, and is orange red according to the dyeing hair card number 6/43; no. 7 is that clofazimine is prepared into saturated solution by 100 percent ethanol: DMSO (V: V is 1: 1), and hair is dyed for 1 time by regulating PH 3 with citric acid, and the hair is dyed with orange red according to the hair-dyeing card number 6/43.
Example 5
Preparing saturated solution from clofazimine with 75% ethanol mixed solution (containing laurocapram), uniformly coating the solution on hair, blow-drying at normal temperature, re-dyeing for 1 time, blow-drying, dyeing again if deeper color is required, blow-drying, washing off loose color with clear water, and blow-drying. The results are shown in FIG. 5; number 1 is original hair, and the hair is dyed with 22/0 color card number in black; no. 2 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 3 shows the result of adding 2% laurocapram for dyeing for 1 time, and contrasting with the dyeing card number 7/33 to be golden; no. 4 shows the result of adding 2% laurocapram for dyeing for 2 times, and contrasting with the dyeing card number 7/33 to be golden; no. 5 shows the result of 1 time of hair dyeing by adding 5% laurocapram, and the hair is dyed with 7/33 color card number in a contrast manner to be golden; no. 6 shows the result of adding 5% laurocapram for dyeing for 2 times, and contrasting with the dyeing card number 7/33 to be golden; no. 7 shows the result of adding 8% laurocapram for dyeing for 1 time, and the dyeing card number is 7/33, golden; number 8 shows the result of 2 hair dyes with 8% laurocapram added, compared to the color card number 7/33, gold.
Example 6
Preparing saturated solution from clofazimine with 100% ethanol mixed solution (containing laurocapram), adjusting pH to 2-3 with acid before use, uniformly spreading the solution on hair, blow-drying at room temperature, re-dyeing for 1 time, blow-drying, re-dyeing if dark color is required, blow-drying, washing off loose color with clear water, and blow-drying. The results are shown in FIG. 6; number 1 is original hair, and the hair is dyed with 22/0 color card number in black; no. 2 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 3 shows the result of dyeing hair for 1 time by adding 2% of laurocapram (PH 3 is adjusted by acetic acid), and the dyeing hair is golden according to the dyeing hair card number 7/33; no. 4 shows that 2% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 2 times, and the hair is light orange yellow according to the dyeing card number 8/43; no. 5 shows that 5% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 1 time, and the dyeing card number is 7/43 and is orange yellow; no. 6 shows that 5% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 2 times, and the dyeing card number is 6/43 and is orange red; no. 7 shows that 8% laurocapram (pH 3 adjusted by acetic acid) is added for dyeing for 1 time, and the dyeing card number is 7/43 and is orange yellow; no. 8 shows the result of dyeing 2 times by adding 8% laurocapram (pH 3 adjusted with acetic acid), and comparing with 6/43, orange red.
Example 7
Preparing a saturated solution from a mixed solution of 100% ethanol (containing 2 wt.% of borneol or 2 wt.% of menthol), uniformly coating the saturated solution on hair, drying at normal temperature, re-dyeing for 1 time, and drying. And (4) after blow-drying, washing with clear water to remove loose color, and blow-drying. The specific implementation result is shown in FIG. 7; no. 1 is fading hair after primary hair is treated by a whitening agent and hydrogen peroxide, and the fading cream is compared with a dyeing card number 0/00; no. 2 shows that the hair is dyed for 1 time by adding 2 percent borneol, and compared with the dyed hair card number 7/43, the hair is orange yellow; no. 3 shows that the hair is dyed for 2 times by adding 2 percent borneol, and compared with the dyed hair card number 7/43, the hair is orange yellow; no. 4 shows that the hair is dyed for 1 time by adding 2 percent menthol, and the hair is dyed orange by contrasting with a hair-dyeing card number 7/43; no. 5 shows the result of dyeing with 2% menthol for 2 times, which is orange yellow compared with the dyeing card number 7/43.
Example 8
Substantially the same results as in example 7 were obtained, except that 2 wt.% borneol or 2 wt.% menthol was replaced by 8 wt.% borneol or 8 wt.% menthol.
Example 9
Substantially the same results as in example 7 were obtained except that 100% ethanol was replaced with 30% ethanol.
The preferred embodiments of the present invention have been described above in detail, but the present invention is not limited thereto. Within the scope of the technical idea of the invention, many simple modifications can be made to the technical solution of the invention, including combinations of various technical features in any other suitable way, and these simple modifications and combinations should also be regarded as the disclosure of the invention, and all fall within the scope of the invention.
Claims (10)
1. The new use of clofazimine as hair dye is characterized in that the clofazimine is prepared into saturated solution by polar solvent, the saturated solution is evenly smeared on hair or animal hair, and after the hair is dried at normal temperature, whether the hair is redyed or not and the redyed times are determined according to the dyeing depth of the hair dye; the polar solvent is ethanol and/or DMSO.
2. The novel use of clofazimine as a hair dye according to claim 1, wherein the clofazimine is formulated into a saturated solution with 30-100% volume percent ethanol.
3. The novel use of clofazimine as a hair dye according to claim 1, wherein the clofazimine is formulated into a saturated solution with 30-100% volume percent ethanol and DMSO.
4. The novel use of clofazimine as a hair dye according to claim 3, wherein the volume ratio of ethanol to DMSO is 1: 1.
5. The novel use of clofazimine as a hair dye according to claim 1, wherein the saturated solution is not adjusted in pH or is adjusted in pH to 2 to 3 with a pH adjuster.
6. The novel use of clofazimine as a hair dye according to claim 5, wherein the pH regulator is an acid neutralizer selected from one or more of hydrochloric acid, sulfuric acid, oxalic acid, acetic acid, pyruvic acid, glycolic acid, lactic acid, citric acid, tartaric acid, succinic acid, gluconic acid and sulfamic acid.
7. The novel use of clofazimine as a hair dye according to claim 1, wherein a penetration enhancer is added to the saturated solution.
8. The novel use of clofazimine as a hair dye according to claim 7, wherein the concentration of said penetration enhancer in the saturated solution is 1-10 wt.%.
9. The novel use of clofazimine as a hair dye according to claim 7, wherein the penetration enhancer is one or more selected from borneol, menthol and laurocapram.
10. The clofazimine hair dye is characterized by comprising the following components: clofazimine, polar solvent and penetration enhancer; preparing clofazimine into a saturated solution by using a polar solvent to prepare a clofazimine hair dye; the polar solvent is ethanol and/or DMSO; the penetration enhancer is selected from one or more of borneol, menthol and laurocapram; the concentration of the penetration enhancer in the saturated solution is 1-10 wt.%.
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| US5224964A (en) * | 1985-01-07 | 1993-07-06 | Shami Farouk M | Method for lightening and permanently coloring hair |
| US20160066578A1 (en) * | 2014-08-13 | 2016-03-10 | Akeso Biomedical, Inc. | Antimicrobial compounds and compositions, and uses thereof |
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