CN113769267A - Implantable electrode capable of monitoring conductivity signal and device for inhibiting cell division - Google Patents
Implantable electrode capable of monitoring conductivity signal and device for inhibiting cell division Download PDFInfo
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- CN113769267A CN113769267A CN202110982261.8A CN202110982261A CN113769267A CN 113769267 A CN113769267 A CN 113769267A CN 202110982261 A CN202110982261 A CN 202110982261A CN 113769267 A CN113769267 A CN 113769267A
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- A—HUMAN NECESSITIES
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
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Abstract
The embodiment of the application provides an implantable electrode capable of monitoring a conductivity signal and a cell division inhibiting device. The implantable electrode comprises a bearing main body, at least one electrode plate, a flexible lead and a conductivity probe; the electrode slice is arranged on the bearing main body and is used for generating an alternating electric field; one end of the flexible lead is connected with the electrode plate and is used for transmitting an electric signal to the electrode plate; the conductivity probe is disposed on the carrier body, electrically connected with the conductivity converter, and configured to transmit the detected conductivity signal to the conductivity converter. In the embodiment, the conductivity probe is arranged on the implanted electrode, and the conductivity probe is used for detecting the conductivity signal so as to obtain the conductivity of the tissue around the implanted electrode, so that the electric signal transmitted to the electrode plate can be adjusted to obtain a better treatment effect; and the conductivity probe is arranged on the bearing main body, so that the conductivity probe and the bearing main body can be implanted into the body of a patient together, and the operation difficulty is reduced.
Description
Technical Field
The application relates to the field of tumor treatment fields, in particular to an implantable electrode capable of monitoring a conductivity signal and a cell division inhibiting device.
Background
Tumor electric field therapy (TTFields) is a novel Tumor therapy method, and the principle is that a low-intensity intermediate-frequency alternating electric field acts on tubulin proliferating pathological cells to interfere mitosis of the pathological cells, so that the affected pathological cells are apoptotic, and growth of the pathological cells is inhibited.
TTFields, one embodiment of which uses implantable electrodes, i.e., electrodes implanted in a patient's body such that an electric field is applied directly to a lesion, have fewer side effects than conventional treatments such as surgery, radiation, and medication, and have the advantages of being lighter in weight, causing no irritation to the patient's skin, and having low power.
However, the environment inside the body of the patient is complex, and many factors influence the application effect of the electric field and even influence the treatment effect.
Disclosure of Invention
The implanted electrode capable of monitoring the conductivity signal and the cell division inhibiting device are provided aiming at the defects of the existing mode, the conductivity of the electrode implantation part of a patient can be monitored, so that the applied electric field can be adjusted according to the conductivity, and a better treatment effect can be obtained.
In a first aspect, embodiments of the present application provide an implantable electrode capable of monitoring a conductivity signal, the implantable electrode including a carrier body, at least one electrode pad, a flexible lead, and a conductivity probe;
the electrode plate is arranged on the bearing main body and is used for generating an alternating electric field;
one end of the flexible lead is connected with the electrode plate and is used for transmitting an electric signal to the electrode plate;
the conductivity probe is disposed on the carrier body for electrical connection with a conductivity converter to transmit a detected conductivity signal to the conductivity converter.
Optionally, the electrode sheet is a flexible electrode sheet.
Optionally, the implantable electrode comprises a plurality of flexible electrode pieces, and the flexible electrode pieces are arranged on the bearing main body in an array manner.
Optionally, the implantable electrode further comprises a thermistor disposed on the carrier body, the thermistor being configured to be electrically connected to a temperature converter, and to transmit the detected temperature signal to the temperature converter.
Optionally, the bearing main body includes a base layer and a cover layer, the flexible electrode sheet is disposed between the base layer and the cover layer, and a first through hole is disposed on the cover layer, and an orthogonal projection of the first through hole on the base layer is located in an orthogonal projection of the flexible electrode sheet on the base layer.
Optionally, the electrode plates are provided with third through holes, one side of each electrode plate, which is close to the substrate layer, is provided with one conductivity probe or one thermistor, and an orthographic projection of the third through hole on the substrate layer is located in an orthographic projection of the conductivity probe on the substrate layer, or an orthographic projection of the third through hole on the substrate layer is located in an orthographic projection of the conductivity probe on the substrate layer.
Optionally, the thermistor and the conductivity probe are arranged between the substrate layer and the covering layer and between adjacent flexible electrode plates, and one thermistor or one conductivity probe is arranged between two adjacent flexible electrode plates; the covering layer is provided with a second through hole, and the orthographic projection of the second through hole on the base layer is positioned in the orthographic projection of the conductivity probe on the base layer, or the orthographic projection of the second through hole on the base layer is positioned in the orthographic projection of the heat-sensitive probe on the base layer.
Optionally, the load bearing body is a flexible load bearing body.
Optionally, the electrode plate includes a conductive sheet and a dielectric layer coated on the conductive sheet, the conductive sheet is electrically connected to the flexible wire, and the dielectric layer is made of a biocompatible material.
Optionally, the implantable electrode further comprises a joint, the joint is connected with the other end of the flexible lead and is used for implanting the implantable electrode and suturing the biological epidermis.
In a second aspect, embodiments of the present application provide a device for inhibiting cell division, comprising:
the implantable electrodes, which are implanted into a target site of a patient according to a preset manner, wherein each pair of the implantable electrodes are oppositely arranged;
the main controller comprises a voltage generation module and a signal conversion module, the voltage generation module is electrically connected with the other end of the flexible lead and is used for generating an electric signal, the signal conversion module comprises the conductivity converter, and the conductivity converter is used for generating the real-time conductivity of the target part of the patient according to a conductivity signal.
Optionally, when the implantable electrode comprises a thermistor, the signal conversion module further comprises a temperature converter for producing a real-time temperature of the target site of the patient from the temperature signal.
Optionally, the main controller further comprises a housing, and the voltage generation module and the signal conversion module are located in the housing, and the material of the housing has biocompatibility.
Optionally, the master controller further comprises a signal processing module, and the signal processing module is electrically connected to the voltage generation module and the signal conversion module respectively; the signal processing module is used for adjusting the electric signal generated by the voltage generation module according to the real-time conductivity generated by the conductivity converter, and controlling the voltage generation module to stop generating the electric signal when the real-time temperature is higher than a set temperature.
Optionally, the voltage generation module is a pulse voltage generation module or an AC voltage generation module.
Optionally, the implantable electrode is implanted in a patient, the master being located outside the patient.
Optionally, the implantable electrode and the master are both implanted in the patient.
The technical scheme provided by the embodiment of the application has the following beneficial technical effects:
1. according to the implantable electrode capable of monitoring the conductivity signal, the conductivity probe is arranged on the implantable electrode, the conductivity probe is used for detecting the conductivity signal and transmitting the conductivity signal to the conductivity converter, so that the conductivity of the tissue around the implantable electrode is obtained, and the electric signal transmitted to the electrode plate is adjusted conveniently, so that a better treatment effect is obtained; the conductivity probe is arranged on the bearing main body, so that the conductivity probe and the bearing main body can be implanted into a patient body together, and the operation difficulty is reduced;
2. the implantable electrode capable of monitoring the conductivity signal, provided by the embodiment of the application, further comprises a thermistor arranged on the bearing main body, wherein the thermistor can measure the temperature of the focus of a patient and can timely acquire the temperature information of the focus of the patient so as to avoid danger caused by overhigh temperature of the focus of the patient;
3. according to the implantable electrode capable of monitoring the conductivity signal, the connector is arranged, and the connector is sewn with the biological epidermis after the flexible electrode plate is implanted, so that the flexible lead can be prevented from penetrating through the skin of a patient for many times, the operation difficulty can be reduced, and the risk of infection of the patient can be reduced;
4. the device for inhibiting cell division provided by the embodiment comprises a main controller and an implanted electrode, wherein the main controller comprises a voltage generation module and a signal conversion module, the voltage generation module is used for generating an electric signal and transmitting the electric signal to the electrode sheet of the corresponding implanted electrode through a flexible lead, so that each implanted electrode has a corresponding voltage, and a voltage difference exists between voltages on a pair of oppositely arranged implanted electrodes, so that an electric field acting on a target part of a patient can be formed.
Additional aspects and advantages of the present application will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the present application.
Drawings
The foregoing and/or additional aspects and advantages of the present application will become apparent and readily appreciated from the following description of the embodiments, taken in conjunction with the accompanying drawings of which:
fig. 1 is a schematic structural diagram of an implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 2 is a schematic diagram of another implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present disclosure;
FIG. 3 is a schematic structural diagram of another implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 4 is a schematic cross-sectional view of the implantable electrode of FIG. 3 along line A-A, capable of monitoring a conductivity signal;
FIG. 5 is a schematic diagram of another implantable electrode capable of monitoring a conductivity signal according to an embodiment of the present application;
FIG. 6 is a schematic cross-sectional view of the implantable electrode of FIG. 5 along line B-B, wherein the implantable electrode is capable of monitoring a conductivity signal;
FIG. 7 is a schematic view of an embodiment of a device for inhibiting cell division;
FIG. 8 is a schematic diagram of a cell division inhibiting device according to an embodiment of the present disclosure;
fig. 9 is a schematic structural diagram of a frame of a signal conversion module in the device for inhibiting cell division according to the embodiment of the present disclosure.
Reference numerals:
1-a load bearing body; 11-a base layer; 12-a cover layer; 121 — a first via; 122-a second via;
2-electrode slice; 21-a conductive layer; 22-a dielectric layer;
3-a flexible wire;
4-conductivity probe;
5-a thermistor;
6-a linker;
7-a first signal line;
8-a second signal line;
100-an implantable electrode;
200-a master controller; 2001-a housing; 2002-a voltage generation module; 2003-a signal processing module; 2004-signal conversion module.
Detailed Description
Reference will now be made in detail to the present application, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar parts or parts having the same or similar functions throughout. In addition, if a detailed description of the known art is not necessary for illustrating the features of the present application, it is omitted. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present application and are not to be construed as limiting the present application.
It will be understood by those within the art that, unless otherwise defined, all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
TTfields act on tubulin which proliferates pathological cells through a low-intensity medium-frequency alternating electric field, interfere mitosis of the pathological cells, cause apoptosis of affected pathological cells and inhibit growth of the pathological cells. And adopt the mode of implantable electrode, implant the electrode in vivo to make to exert the electric field directly to the focus of a disease to the patient, compare with traditional treatment methods such as operation, radiotherapy and drug therapy, TTfields's side effect is less to have light, can not cause advantages such as stimulation, power are low to patient's skin.
However, the environment inside the body of the patient is complex, and many factors influence the application effect of the electric field and even influence the treatment effect. For example, the electrical signal at the implanted electrode is constant, but the conductivity at the patient's lesion changes, such that the electric field applied to the patient's lesion changes, which affects the therapeutic effect.
The application provides an implantable electrode and a cell division inhibition device capable of monitoring a conductivity signal, and aims to solve the technical problems in the prior art.
The following describes the technical solutions of the present application and how to solve the above technical problems with specific embodiments.
An implantable electrode capable of monitoring a conductivity signal is provided in an embodiment of the present application, and as shown in fig. 1, the implantable electrode provided in this embodiment includes a carrier main body 1, at least one electrode pad 2, a flexible lead 3, and a conductivity probe 4.
The electrode slice 2 is arranged on the bearing main body 1 and is used for generating an alternating electric field; one end of the flexible lead 3 is connected with the electrode plate 2 and is used for transmitting an electric signal to the electrode plate 2; a conductivity probe 4 is provided on the carrier body for electrical connection with the conductivity converter to transmit a detected conductivity signal to the conductivity converter.
In the embodiment, the conductivity probe 4 is arranged on the implanted electrode, and the conductivity probe 4 is used for detecting the conductivity signal and transmitting the conductivity signal to the conductivity converter, so that the conductivity of the tissue around the implanted electrode is obtained, and the electric signal transmitted to the electrode slice 2 is adjusted to obtain a better treatment effect; and the conductivity probe 4 is arranged on the bearing main body, so that the conductivity probe 4 can be implanted into the body of a patient together with the bearing main body 1, and the operation difficulty is reduced.
It should be noted that the conductivity converter is used to convert the conductivity signal detected by the conductivity probe into a real-time conductivity signal so as to adjust the electrical signal according to the real-time conductivity signal, and the conductivity converter will be described in detail in the following embodiments of the device for inhibiting cell division.
Specifically, as shown in fig. 1, in the implantable electrode provided by the present application, the electrode pad 2 is a flexible electrode pad.
Specifically, in the implantable electrode provided in this embodiment, the material of the carrier body 1 includes silicon gel. The silica gel is soft and has good biocompatibility. The flexible electrode slice and the flexible bearing main body 1 can better adapt to the requirements of different positions of a patient, so that the adaptability of the implanted electrode is improved.
Specifically, as shown in fig. 1, in the implantable electrode provided by the present application, the electrode plate 2 is circular, and the diameter of the electrode plate 2 is 0.5cm to 1.5 cm. The size of the electrode plate 2 can be designed according to factors such as the type of the tumor to be treated, the volume of the tumor, the position of the tumor and the like, so that implanted electrodes of different types can be manufactured to meet the requirements of the market and patients.
Since the electrode sheet 2 having a circular shape may not have a standard circular shape due to process limitations, the term "the electrode sheet 2 having a circular shape" as used herein means that the electrode sheet 2 has a standard circular shape or an approximately circular shape.
For example, the flexible electrode sheet 21 having a nearly circular shape may have an elliptical shape, but the ratio of the minor axis to the major axis has a greater effect than 0.8, wherein the minor axis has a length of 0.5cm to 1.5 cm. Alternatively, the flexible electrode sheet 21 having a nearly circular shape may be a regular polygon (the number of sides n is greater than or equal to 10), for example, a regular icosagon, in which the length of twice the radius of the regular icosagon is 0.5cm to 1.5 cm.
Optionally, as shown in fig. 2, the implantable electrode provided in this embodiment includes a plurality of electrode pads 2, and the electrode pads 2 are arranged on the carrier body 1 in an array manner. Specifically, the electrode pads 2 are arranged in an array of m rows and n columns, where m and n are integers greater than or equal to 2, and in the implantable electrode shown in fig. 2, the electrode pads 21 are arranged in 5 rows and 3 columns.
Alternatively, as shown in fig. 2, in the implantable electrode provided in this embodiment, the electrode pads 21 are connected in series.
Specifically, as shown in fig. 2, in the implantable electrode provided in this embodiment, the thickness of the supporting body 1 is 0.01cm to 0.5cm, the length of the supporting body 1 is 3cm to 9cm, and the width of the supporting body 1 is 1cm to 5 cm.
Specifically, as shown in fig. 2, in the implantable electrode provided in this embodiment, the material of the carrier body 1 is silica gel, and the silica gel material is relatively soft and has biocompatibility.
In this embodiment, arrange 2 arrays of electrode slice, can design the electrode according to patient's condition to more adapt to patient's demand, promote treatment.
Optionally, as shown in fig. 2, the implantable electrode provided in the present embodiment further includes a thermistor 5 disposed on the bearing body 1, and the thermistor 5 is used for electrically connecting with a temperature converter (not shown in fig. 2) to transmit a detected temperature signal to the temperature converter.
The thermistor 5 can measure the temperature of the focus of the patient, and can acquire the temperature information of the focus of the patient in time so as to avoid danger caused by overhigh temperature of the focus of the patient.
Optionally, as shown in fig. 2, the implantable electrode provided in this embodiment further includes a connector 6, and the connector 6 is connected to the other end of the flexible lead 3 and is used for suturing with the bio-epidermis.
Specifically, the joint 6 may be of a plug-in type or a press type, as long as the joint 6 can be connected to the electric field generating device conveniently.
It should be noted that the surface of the joint 6 is made of a material that is also chosen to be biocompatible to avoid injury to the patient.
In this embodiment, through setting up joint 6 to sew up joint 6 and biological epidermis after implanting flexible electrode piece 2, so can avoid flexible wire 3 to pass patient's skin many times, can reduce the operation degree of difficulty and reduce the risk that the patient infects.
Alternatively, as shown in fig. 3 and 4, the implantable electrode carrier body 1 provided by the present embodiment includes a base layer 11 and a cover layer 12, the electrode pad 2 is disposed between the base layer 11 and the cover layer 12, and the cover layer 12 is provided with a first through hole 121, and an orthographic projection of the first through hole 121 on the base layer 11 is located within an orthographic projection of the electrode pad 2 on the base layer 11.
In the implantable electrode provided by the embodiment, the carrier body 1 can arrange and fix the electrode slices 2 well, so that the formed electric field is designed to obtain a required electric field.
Alternatively, as shown in fig. 3 and 4, in the implantable electrode provided in the present embodiment, the thermistor 5 and the conductivity probe 4 are disposed between the substrate layer 11 and the covering layer 12 and between the adjacent electrode pieces 2, and one thermistor 5 or one conductivity probe 4 is disposed between two adjacent electrode pieces 2. The cover layer 12 is provided with a second through hole 122, and the orthographic projection of the second through hole 122 on the substrate layer 11 is positioned in the orthographic projection of the conductivity probe 4 on the substrate layer 11, or the orthographic projection of the second through hole 122 on the substrate layer 11 is positioned in the orthographic projection of the thermistor 5 on the substrate layer 11.
It should be noted that, although fig. 3 and 4 show that the conductivity probe 4 and the thermistor 5 and the flexible conductive wire 3 are overlapped, in practical design, the flexible conductive wire 3 may avoid the conductivity probe 4 and the thermistor 5, and specifically, "the flexible conductive wire 3 avoids the conductivity probe 4 and the thermistor 5" means that the orthographic projection of the flexible conductive wire 3 on the substrate layer 11 is not intersected with the orthographic projection of the conductivity probe 4 and the thermistor 5 on the substrate.
Further, in order to improve the measurement effect of the conductivity and the temperature, when designing the positions of the conductivity probe 4 and the thermistor 5, the conductivity probe 4 and the thermistor 5 should be arranged in a staggered manner, for example, in the implantable electrode shown in fig. 3, the conductivity probe 4 is arranged between the electrode plate 2 in the first row and the first column and the electrode plate 2 in the first row and the second column, the thermistor 5 is arranged between the electrode plate 2 in the first row and the second column and the electrode plate 2 in the first row and the second column, and the thermistor 5 is also arranged between the electrode plate 2 in the second row and the first column and the electrode plate 2 in the second row and the second column. By thus alternately arranging the conductivity probes 4 and the thermistors 5, more accurate conductivity information and temperature information can be obtained.
In the implantable electrode provided by the embodiment, the thermistor 5 and the conductivity probe 4 are arranged between the electrode plates 2, so that the conductivity and the temperature near an electric field formed by the electrode plates 2 can be measured in real time, a relatively accurate measurement result can be obtained, and the treatment effect of the implantable electrode is improved.
Alternatively, as shown in fig. 5 and fig. 6, in the implantable electrode provided in this embodiment, the electrode pads 2 are provided with third through holes 23, one conductivity probe 4 or one thermistor 5 is provided on a side of each electrode pad 2 close to the substrate layer 12, and an orthogonal projection of the third through hole 23 on the substrate layer 11 is located in an orthogonal projection of the conductivity probe 4 on the substrate layer 11, or an orthogonal projection of the third through hole 23 on the substrate layer 11 is located in an orthogonal projection of the conductivity probe 4 on the substrate layer 11.
Further, in order to improve the measurement effect of the conductivity and the temperature, when the positions of the conductivity probe 4 and the thermistor 5 are designed, the conductivity probe 4 and the thermistor 5 should be arranged in a staggered manner, for example, in the implantable electrode shown in fig. 5, the conductivity probe 4 is arranged below the electrode sheet 2 in the first row and the first column, and the thermistor 5 is arranged below the electrode sheet 2 in the first row and the second column adjacent to the electrode sheet 2 in the first row and the first column and the electrode sheet 2 in the second row and the first column. By thus alternately arranging the conductivity probes 4 and the thermistors 5, more accurate conductivity information and temperature information can be obtained.
In the implantable electrode provided by the embodiment, the thermistor 5 and the conductivity probe 4 are arranged below the electrode plate 2, so that the conductivity and the temperature near an electric field formed by the electrode plate 2 can be measured in real time, and a relatively accurate measurement result can be obtained, thereby improving the treatment effect of the implantable electrode; and the arrangement mode is favorable for the arrangement design of the electrode plates 2 and the reduction of the volume of the implanted electrode.
Specifically, as shown in fig. 4 and 6, the electrode sheet 2 includes a conductive layer 21 and a dielectric layer 22 wrapping the conductive layer 21, and the material of the dielectric layer 22 has biocompatibility. Wherein, the conductive layer 21 coated with the dielectric layer 21 can be coupled into a capacitor.
As shown in fig. 4 and 6, the material of the dielectric layer 22 includes: filler Ba1-xRxTiO3And biocompatible polymer, filler Ba1-xRxTiO3Dispersed in biocompatible polymer, wherein R is one of nickel, zinc, manganese and iron. The dielectric layer 22 provided by the present embodiment has good dielectric properties, so that the electrode plates 2 can be equivalent to a capacitor to form a corresponding electric field, and the material has biocompatibility.
Based on the same inventive concept, an apparatus for inhibiting cell division is further provided in the embodiments of the present application, as shown in fig. 7, the apparatus for inhibiting cell division includes at least two pairs of the implantable electrodes 100 in the embodiments described above, which has the beneficial effects of the implantable electrodes 100 in the embodiments described above, and will not be described herein again.
Specifically, as shown in fig. 7, implantable electrodes 100 are implanted at a target site in a patient in a predetermined manner, with each pair of implantable electrodes 100 being oppositely disposed. Wherein, the target part of the patient is the focus of the patient, namely the part of the patient with tumor. "implantable electrode 100 is oppositely disposed" refers to the relative disposition of the sub-electrodes in implantable electrode 100, for example, when carrier body 1 includes base layer 11 and cover layer 12, "implantable electrode 100 is oppositely disposed" refers to the relative disposition of cover layer 12 in implantable electrode 100.
Alternatively, as shown in fig. 7 and 8, in the device for inhibiting cell division provided in this embodiment, the voltage generation module 2002 is a pulse voltage generation module 2002 or an AC voltage generation module 2002. Specifically, the pulse voltage generation module 2002 generates a pulse voltage and transmits the pulse voltage to the electrode plate 2 through the flexible lead 3, so that the implanted electrode 100 arranged oppositely generates a pulse electric field; and the AC voltage generating module 2002 generates and transmits an alternating voltage to the electrode patch 2 through the flexible wire 3, so that the implanted electrode 100 disposed opposite generates an alternating electric field. The pulse electric field or the alternating electric field acts on the tumor cells to inhibit the division of the tumor cells, thereby achieving the purpose of tumor treatment.
For a dividing cell, when the cell is in the metaphase of cell division, an electric field acts on the cell, electric field lines induced in the cell are gathered at the equatorial plate, and the organelle is subjected to an electric field force directed to the equatorial plate, so that the organelle is limited to move towards two poles, and the cell division can be inhibited to a certain extent.
Furthermore, as the degree of cell division is deepened (i.e. the equatorial plate is narrowed), the electric field lines at the equatorial plate become more dense at the end of cell division, and the increased electric field can pull the organelle toward the equatorial plate to block the formation of the cell plate, thereby inhibiting cell division and even inducing cell rupture or apoptosis.
Further, the cellular organelles are gathered at the equatorial plate, which leads to an increase in the pressure near the equatorial plate, which may burst the cell membrane, especially in a state of narrowing of the equatorial plate. And the electric field force applied to the organelles also affects the structures of the organelles, so that the disintegration or the rupture of the organelles can be induced, and the cell rupture or the apoptosis can be induced.
Specifically, as shown in fig. 8, the device for inhibiting cell division provided in this embodiment further includes a main controller 200, the main controller 200 includes a voltage generation module 2002 and a signal conversion module 2004, the voltage generation module 2002 is electrically connected to the other end of the flexible lead 3 and is configured to generate an electrical signal, and the signal conversion module 2004 includes a conductivity converter configured to obtain real-time conductivity of the target region of the patient according to the conductivity signal.
The device for inhibiting cell division provided by the present embodiment includes a master controller 200 and an implantable electrode 100, wherein the master controller 200 includes a voltage generation module 2002 and a signal conversion module 2004, the voltage generation module 2002 is configured to generate an electrical signal and transmit the electrical signal to a sub-electrode of a corresponding implantable electrode 100 through a flexible lead 3, so that each implantable electrode 100 has a corresponding voltage, and a voltage difference exists between voltages on a pair of oppositely disposed implantable electrodes 100, so as to form an electric field acting on a target site of a patient.
Specifically, as shown in fig. 8, in the device for inhibiting cell division provided in this embodiment, the main controller 200 further includes a housing 2001, the voltage generation module 2002 and the signal conversion module 2004 are located in the housing 2001, and the material of the housing 2001 has biocompatibility. The biocompatible material can reduce the damage of the patient and improve the safety of the cell division inhibiting device.
As shown in fig. 8, the present embodiment provides a device for inhibiting cell division, in which the implantable electrode 100 is implanted in a patient and the main controller 200 is located outside the patient. This may be accomplished by merely implanting the implantable electrode 100 in the patient, and by providing the housing 2001 of the master 200 with biocompatibility.
As shown in fig. 8, this embodiment provides a device for inhibiting cell division, in which both implantable electrode 100 and master 200 are implanted in a patient. In this case, the housing 2001 of the master 200 must be biocompatible.
Optionally, as shown in fig. 8 and fig. 9, in the device for inhibiting cell division provided in this embodiment, the master controller 200 further includes a signal processing module 2003, and the signal processing module 2003 is electrically connected to the voltage generating module 2002 and the signal converting module 2004 respectively; the signal processing module 2003 is used for adjusting the electrical signal generated by the voltage generation module 2002 according to the real-time conductivity acquired by the conductivity converter. Specifically, the conductivity converter and the conductivity probe 4 are electrically connected through the first signal line 7.
Alternatively, as shown in fig. 8 and 9, in the device for inhibiting cell division provided by the present embodiment, when the implantable electrode 100 includes the thermistor 5, the signal conversion module 2004 further includes a temperature converter, and the temperature converter generates the real-time temperature according to the temperature signal detected by the thermistor 5. Based on this, the signal processing module 2003 in the device for suppressing cell division provided in the present embodiment is further configured to control the voltage generation module to stop generating the electric signal when the real-time temperature generated by the temperature converter is greater than the set temperature. Specifically, the temperature converter and the thermistor 5 are electrically connected through a second signal line 8.
The device for inhibiting cell division provided by the embodiment comprises a temperature converter, the temperature converter generates real-time temperature according to the temperature signal detected by the thermistor 5, and the voltage generation module 2002 stops generating the electric signal once the real-time temperature exceeds the set temperature, so that the damage to the patient caused by overhigh temperature is avoided.
It should be noted that the flexible lead 3, the first signal line 7, and the second signal line 8 all include a metal lead and an insulating layer coated on the surface of the metal lead, and the insulating layer has biocompatibility.
By applying the embodiment of the application, at least the following beneficial effects can be realized:
1. according to the implantable electrode capable of monitoring the conductivity signal, the conductivity probe is arranged on the implantable electrode, the conductivity probe is used for detecting the conductivity signal and transmitting the conductivity signal to the conductivity converter, so that the conductivity of the tissue around the implantable electrode is obtained, and the electric signal transmitted to the electrode plate is adjusted conveniently, so that a better treatment effect is obtained; the conductivity probe is arranged on the bearing main body, so that the conductivity probe and the bearing main body can be implanted into a patient body together, and the operation difficulty is reduced;
2. the implantable electrode capable of monitoring the conductivity signal, provided by the embodiment of the application, further comprises a thermistor arranged on the bearing main body, wherein the thermistor can measure the temperature of the focus of a patient and can timely acquire the temperature information of the focus of the patient so as to avoid danger caused by overhigh temperature of the focus of the patient;
3. according to the implantable electrode capable of monitoring the conductivity signal, the connector is arranged, and the connector is sewn with the biological epidermis after the flexible electrode plate is implanted, so that the flexible lead can be prevented from penetrating through the skin of a patient for many times, the operation difficulty can be reduced, and the risk of infection of the patient can be reduced;
4. the device for inhibiting cell division provided by the embodiment comprises a main controller and an implanted electrode, wherein the main controller comprises a voltage generation module and a signal conversion module, the voltage generation module is used for generating an electric signal and transmitting the electric signal to the sub-electrodes of the corresponding implanted electrodes through flexible leads, so that each implanted electrode has a corresponding voltage, and a voltage difference exists between the voltages on a pair of oppositely arranged implanted electrodes, so that an electric field acting on a target part of a patient can be formed.
In the description of the present application, it is to be understood that the terms "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience in describing the present application and for simplifying the description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, should not be construed as limiting the present application.
The terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present application, "a plurality" means two or more unless otherwise specified.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In the description herein, particular features, structures, materials, or characteristics may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is only a partial embodiment of the present application, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present application, and these modifications and decorations should also be regarded as the protection scope of the present application.
Claims (17)
1. An implantable electrode capable of monitoring a conductivity signal, which is characterized by comprising a bearing main body, at least one electrode plate, a flexible lead and a conductivity probe;
the electrode plate is arranged on the bearing main body and is used for generating an alternating electric field;
one end of the flexible lead is connected with the electrode plate and is used for transmitting an electric signal to the electrode plate;
the conductivity probe is disposed on the carrier body for electrical connection with a conductivity converter to transmit a detected conductivity signal to the conductivity converter.
2. The implantable electrode capable of monitoring a conductivity signal according to claim 1, wherein said electrode pad is a flexible electrode pad.
3. The implantable electrode capable of monitoring conductivity signals according to claim 2, comprising a plurality of flexible electrode pads, wherein the flexible electrode pads are arranged on the carrier body in an array manner.
4. The implantable electrode capable of monitoring a conductivity signal according to claim 3, further comprising a thermistor disposed on said carrier body, said thermistor being adapted to be electrically connected to a temperature transducer for transmitting a detected temperature signal to said temperature transducer.
5. The implantable electrode capable of monitoring conductivity signals according to claim 4, wherein the carrier body comprises a base layer and a cover layer, the flexible electrode sheet is disposed between the base layer and the cover layer, and a first through hole is disposed on the cover layer, and an orthographic projection of the first through hole on the base layer is located within an orthographic projection of the flexible electrode sheet on the base layer.
6. The implantable electrode capable of monitoring conductivity signals according to claim 5, wherein the electrode pads are provided with third through holes, one conductivity probe or one thermistor is provided on one side of each electrode pad close to the substrate layer, and an orthographic projection of the third through hole on the substrate layer is located within an orthographic projection of the conductivity probe on the substrate layer, or an orthographic projection of the third through hole on the substrate layer is located within an orthographic projection of the conductivity probe on the substrate layer.
7. The implantable electrode capable of monitoring a conductivity signal according to claim 5, wherein said thermistor and said conductivity probe are disposed between said base layer and said cover layer and between adjacent ones of said flexible electrode sheets, one said thermistor or one said conductivity probe being disposed between two adjacent ones of said flexible electrode sheets;
the covering layer is provided with a second through hole, and the orthographic projection of the second through hole on the base layer is positioned in the orthographic projection of the conductivity probe on the base layer, or the orthographic projection of the second through hole on the base layer is positioned in the orthographic projection of the heat-sensitive probe on the base layer.
8. The implantable electrode capable of monitoring a conductivity signal according to claim 1, wherein the carrier body is a flexible carrier body.
9. The implantable electrode capable of monitoring conductivity signals according to any one of claims 1-8, wherein the electrode plate comprises a conductive sheet and a dielectric layer coated on the conductive sheet, the conductive sheet is electrically connected with the flexible conducting wire, and the material of the dielectric layer is biocompatible.
10. The implantable electrode capable of monitoring a conductivity signal according to any one of claims 1-8, further comprising a connector connected to the other end of the flexible wire for implanting the implantable electrode sutured to the bio-skin.
11. A device for inhibiting cell division, comprising:
at least two pairs of the implantable electrodes of any one of claims 1-10 implanted at a target site in a patient in a predetermined manner, each pair of the implantable electrodes being oppositely disposed;
the main controller comprises a voltage generation module and a signal conversion module, the voltage generation module is electrically connected with the other end of the flexible lead and is used for generating an electric signal, the signal conversion module comprises the conductivity converter, and the conductivity converter is used for generating the real-time conductivity of the target part of the patient according to a conductivity signal.
12. The device of claim 11, wherein when the implantable electrode comprises a thermistor, the signal conversion module further comprises a temperature converter for producing a real-time temperature of the target site of the patient from the temperature signal.
13. The device for inhibiting cell division according to claim 12, wherein the master controller further comprises a housing, the voltage generation module and the signal conversion module being located within the housing, the housing being made of a biocompatible material.
14. The device for inhibiting cell division according to claim 13, wherein the master controller further comprises a signal processing module electrically connected to the voltage generation module and the signal conversion module, respectively;
the signal processing module is used for adjusting the electric signal generated by the voltage generation module according to the real-time conductivity generated by the conductivity converter, and controlling the voltage generation module to stop generating the electric signal when the real-time temperature is higher than a set temperature.
15. The device for suppressing cell division according to claim 12, wherein the voltage generation module is a pulse voltage generation module or an AC voltage generation module.
16. The device for inhibiting cell division according to any one of claims 11-15, wherein the implantable electrode is implanted in a patient and the master is located outside the patient.
17. The device for inhibiting cell division according to any one of claims 13-15, wherein both the implantable electrode and the master are implanted in the patient.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110982261.8A CN113769267B (en) | 2021-08-25 | Implantable electrode capable of monitoring conductivity signal and device for inhibiting cell division |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110982261.8A CN113769267B (en) | 2021-08-25 | Implantable electrode capable of monitoring conductivity signal and device for inhibiting cell division |
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| Publication Number | Publication Date |
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| CN113769267A true CN113769267A (en) | 2021-12-10 |
| CN113769267B CN113769267B (en) | 2024-04-26 |
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