CN113769024B - Compound essential oil for improving mood and preparation method and application thereof - Google Patents

Compound essential oil for improving mood and preparation method and application thereof Download PDF

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CN113769024B
CN113769024B CN202111121415.0A CN202111121415A CN113769024B CN 113769024 B CN113769024 B CN 113769024B CN 202111121415 A CN202111121415 A CN 202111121415A CN 113769024 B CN113769024 B CN 113769024B
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essential oil
parts
compound
vetiver
bergamot
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CN113769024A (en
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林少敏
蒋智方
刘静
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Guangzhou Creates Cosmetics Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/738—Rosa (rose)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Abstract

The invention relates to a compound essential oil for improving emotion, which comprises the following components in parts by weight: 1-20 parts of cananga essential oil, 1-20 parts of damask rose essential oil, 2-10 parts of bergamot essential oil, 2-10 parts of vetiver essential oil, 2-10 parts of basil essential oil and 1-5 parts of thymol and thyme essential oil. According to the formula compatibility principle of the monarch, minister, assistant and guide of the traditional Chinese medicine, the cananga essential oil is taken as the monarch, the bergamot essential oil is taken as the minister, the vetiver essential oil and the thyme essential oil of thymol are taken as the assistants, the damask rose essential oil and the basil essential oil are taken as the guides, the reasonable compounding is carried out, the scientific proportion is combined, the synergistic effect is achieved, and the good effect of improving the mood is achieved.

Description

Compound essential oil for improving mood and preparation method and application thereof
Technical Field
The invention relates to the technical field of natural product application, in particular to a compound essential oil for improving emotion and a preparation method and application thereof.
Background
Modern society is competitive, the rhythm of work and life is fast, many people are in a state of high tension for a long time and often can not be adjusted in time, and many people have emotional depression, dysphoria, uneasiness and the like.
The essential oil is a volatile aromatic substance extracted from flowers, leaves, stems, roots or fruits of plants, inherits from Chinese traditional medicine health preservation, plays an important treatment role in more traditional Chinese medicines, and is an indispensable effective component.
At present, most of compound essential oil sold in the market adopts sedative and tranquilizing medicines, such as spina date seed essential oil and the like, so as to achieve the effects of relieving emotion, relaxing and decompressing, tranquilizing and assisting sleep, but the compound essential oil is easy to cause a drowsy feeling after being used and cannot be used in daily working period.
Disclosure of Invention
Based on the above, one of the purposes of the invention is to provide the compound essential oil for improving emotion, which is prepared by reasonably compounding various essential oils and combining with scientific proportion, so that a synergistic effect is achieved, and a good effect of improving emotion is achieved.
The invention also aims to provide a preparation method of the compound essential oil for improving emotion.
The invention also aims to provide application of the compound essential oil for improving emotion in preparation of products with effects of relaxing nerves, soothing emotion, calming nerves and helping sleep.
In order to achieve the purpose of the invention, one of the purposes of the invention adopts the following technical scheme:
The compound essential oil for improving emotion comprises the following components in parts by weight:
1-20 parts of cananga essential oil, 1-20 parts of damask rose essential oil, 2-10 parts of bergamot essential oil, 2-10 parts of vetiver essential oil, 2-10 parts of basil essential oil and 1-5 parts of thymol and thyme essential oil.
The compound essential oil is scientifically blended according to the formula compatibility principle of monarch, minister, assistant and guide in traditional Chinese medicine, cananga odorata essential oil is taken as a monarch, secretion of various neurotransmitters in the brain is promoted, epinephrine is regulated, the nervous system is relaxed, strong appeasing power is given to a person, and the person can have happy and romantic inner feeling; the bergamot essential oil is taken as a minister, so that the excitation of sympathetic nerves can be promoted, and the bergamot essential oil, like a naturally-genuine and exuberant child, brings people to a pure and happy world and leaves a depressed life; the vetiver essential oil and the thyme essential oil are used as assistants, the vetiver essential oil can stabilize nerves, relieve tension, give people strength from the land continuously, help people who feel unconscious to wrap up the people without feeling confidence to establish some deeper psychological problems of confidence, the thyme essential oil has the liveness of promoting nerve conduction, and has the effects of improving emotion and courage in mind, so that the emotion is further adjusted on the basis of monarch and minister to achieve the effect of improving emotion; the essential oil of the rosa damascena and the essential oil of basil are used as the guiding materials, and the effects of relaxing nerves and soothing mood are finally achieved.
Further, the compound essential oil for improving mood comprises the following components in parts by weight:
5-10 parts of cananga essential oil, 5-10 parts of damask rose essential oil, 2-5 parts of bergamot essential oil, 2-5 parts of vetiver essential oil, 2-5 parts of basil essential oil and 1-2 parts of thymol and thyme essential oil.
Further, the weight ratio of the cananga essential oil, the bergamot essential oil, the vetiver essential oil and the thymol and thyme essential oil is 5: 2: 2: 1.
wherein the cananga odorata essential oil mainly contains monoterpene alcohol (linalool, geraniol), sesquiterpene (germacrene, alpha-farnesene), benzyl ester (benzyl acetate), and sesquiterpene alcohol. The damascus rose essential oil mainly contains citronellol, geraniol, nerol, linalool, geranyl acetate and other components. The bergamot essential oil is citrus essential oil rich in monoterpene alcohol (linalool, nerol, geraniol, etc.), monoterpene (limonene, terpinene), linalyl acetate, etc. The vetiver essential oil mainly contains sesquiterpene molecules (mainly vetiver), acids such as benzoic acid, alcohols such as vetiverol, aldehydes such as furfural, and ketones such as vetiverone. The basil essential oil mainly contains methyl ether betel phenol, methyl eugenol, linalool, abutilon citronellol, linalool, piemarker ester, sinenses ester acetate, etc. The essential oil mainly comprises thymol, carvacrol, p-cymene, gamma-terpinene, linalool, borneol + alpha terpineol, alpha-arborvitae, arborvitae alcohol, methyl ether thymol, methyl carvacrol, camphor, etc.
Further, the cananga odorata essential oil contains 5-15 wt% of geraniine, the bergamot essential oil contains 4-8 wt% of monoterpene, and the thymol and thyme essential oil contains 1-8 wt% of gamma-terpinene.
Further, the vetiver essential oil contains 1-3 wt% of sesquiterpene molecules.
Further, the essential oil of the rosa damascena contains 10 wt% -20 wt% of linalool.
Furthermore, the basil essential oil contains 0.5-1 wt% of fennel acetate.
Wherein, the main effective components of the cananga essential oil are the monoterpene, the main effective components of the thyme essential oil are the gamma-terpinene, the main effective components of the vetiver essential oil are the sesquiterpene molecules, the main effective components of the rose essential oil are the linalool, and the main effective components of the basil essential oil are the fennel acetate, and the wall breaking technology and the molecular membrane activation orientation technology are adopted for extraction, so that the maximum amount of the effective components can be extracted, the activity is maintained to the maximum extent, the content and the purity of the effective components are improved, the matter of the macromolecular groups is converted into the micromolecular groups, the effective performance of each effective component is directly maximized, and the lipid solubility of the composition is enhanced, the composition can easily penetrate through a lipid membrane and can quickly permeate into a human body, and the absorption and utilization of each component by the human body are facilitated. The combination of the effective components of the components can effectively improve the conditions of depression, dysphoria, restlessness and the like.
Preferably, the compound essential oil for improving mood comprises the following components in parts by weight:
5 parts of cananga essential oil, 5 parts of damask rose essential oil, 2 parts of bergamot essential oil, 2 parts of vetiver essential oil, 2 parts of basil essential oil and 1 part of thymol and thyme essential oil.
The second purpose of the invention adopts the following technical scheme:
a preparation method of the compound essential oil for improving emotion comprises the following preparation steps:
sequentially placing cananga odorata essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, and uniformly stirring to obtain the compound essential oil.
Further, the stirring speed is 30r/min-50r/min, and the stirring time is 10min-30 min.
The third purpose of the invention adopts the following technical scheme:
application of a compound essential oil for improving emotion in preparation of a product with effects of relaxing nerves, soothing emotion, calming nerves and aiding sleep.
Compared with the prior art, the invention has the beneficial effects that:
according to the formula compatibility principle of the monarch, minister, assistant and guide of the traditional Chinese medicine, the cananga essential oil is taken as the monarch, the bergamot essential oil is taken as the minister, the vetiver essential oil and the thyme essential oil of thymol are taken as the assistants, the damask rose essential oil and the basil essential oil are taken as the guides, the reasonable compounding is carried out, the scientific proportion is combined, the synergistic effect is achieved, and the good effect of improving the mood is achieved.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the following more detailed description. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The following are specific examples of the present invention, and raw materials, equipments and the like used in the following examples can be obtained by purchasing them unless otherwise specified.
Example 1
The compound essential oil for improving emotion comprises the following components in parts by weight:
1 part of cananga odorata essential oil, 1 part of damask rose essential oil, 2 parts of bergamot essential oil, 2 parts of vetiver essential oil, 2 parts of basil essential oil and 1 part of thymol and thyme essential oil. The ylang essential oil contains 10 wt% of geraniine, the bergamot essential oil contains 6 wt% of monoterpene, the thyme essential oil contains 2 wt% of gamma-terpinene, the vetiver essential oil contains 3 wt% of sesquiterpene molecules, the damascus rose essential oil contains 10 wt% of linalool, and the basil essential oil contains 1 wt% of fennel acetate.
The preparation method of the compound essential oil for improving emotion comprises the following preparation steps:
sequentially placing cananga odorata essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, stirring at 30r/min for 10min, and stirring uniformly to obtain the compound essential oil.
Example 2
The compound essential oil for improving emotion comprises the following components in parts by weight:
10 parts of cananga essential oil, 10 parts of damask rose essential oil, 6 parts of bergamot essential oil, 6 parts of vetiver essential oil, 6 parts of basil essential oil and 3 parts of thymol and thyme essential oil. The cananga odorata essential oil contains 10 wt% of geraniine, the bergamot essential oil contains 6 wt% of monoterpene, the thymol thyme essential oil contains 2 wt% of gamma-terpinene, the vetiver essential oil contains 3 wt% of sesquiterpene molecules, the damascus rose essential oil contains 10 wt% of linalool, and the basil essential oil contains 1 wt% of fennel acetate.
The preparation method of the compound essential oil for improving emotion comprises the following preparation steps:
sequentially placing cananga odorata essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, stirring at 30r/min for 10min, and stirring uniformly to obtain the compound essential oil.
Example 3
The compound essential oil for improving emotion comprises the following components in parts by weight:
the essential oil comprises, by weight, 20 parts of cananga essential oil, 20 parts of damask rose essential oil, 10 parts of bergamot essential oil, 10 parts of vetiver essential oil, 10 parts of basil essential oil and 5 parts of thymol and thyme essential oil. The cananga odorata essential oil contains 10 wt% of geraniine, the bergamot essential oil contains 6 wt% of monoterpene, the thymol thyme essential oil contains 2 wt% of gamma-terpinene, the vetiver essential oil contains 3 wt% of sesquiterpene molecules, the damascus rose essential oil contains 10 wt% of linalool, and the basil essential oil contains 1 wt% of fennel acetate.
The preparation method of the compound essential oil for improving emotion comprises the following preparation steps:
sequentially placing cananga odorata essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, stirring at 30r/min for 10min, and stirring uniformly to obtain the compound essential oil.
Example 4
The compound essential oil for improving emotion comprises the following components in parts by weight:
10 parts of cananga essential oil, 10 parts of damask rose essential oil, 5 parts of bergamot essential oil, 5 parts of vetiver essential oil, 5 parts of basil essential oil and 2 parts of thymol and thyme essential oil. The cananga odorata essential oil contains 10 wt% of geraniine, the bergamot essential oil contains 6 wt% of monoterpene, the thymol thyme essential oil contains 2 wt% of gamma-terpinene, the vetiver essential oil contains 3 wt% of sesquiterpene molecules, the damascus rose essential oil contains 10 wt% of linalool, and the basil essential oil contains 1 wt% of fennel acetate.
The preparation method of the compound essential oil for improving emotion comprises the following preparation steps:
sequentially placing cananga odorata essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, stirring at 30r/min for 10min, and stirring uniformly to obtain the compound essential oil.
Example 5
The compound essential oil for improving emotion comprises the following components in parts by weight:
5 parts of cananga essential oil, 5 parts of damask rose essential oil, 2 parts of bergamot essential oil, 2 parts of vetiver essential oil, 2 parts of basil essential oil and 1 part of thymol and thyme essential oil. The cananga odorata essential oil contains 10 wt% of geraniine, the bergamot essential oil contains 6 wt% of monoterpene, the thymol thyme essential oil contains 2 wt% of gamma-terpinene, the vetiver essential oil contains 3 wt% of sesquiterpene molecules, the damascus rose essential oil contains 10 wt% of linalool, and the basil essential oil contains 1 wt% of fennel acetate.
The preparation method of the compound essential oil for improving emotion comprises the following preparation steps:
sequentially placing cananga odorata essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, stirring at 30r/min for 10min, and stirring uniformly to obtain the compound essential oil.
In the above embodiments, each material is not limited to the above components, and each material may also be composed of other single components or multiple components described in the present invention, and the component parts of each material are not limited to the above parts, and the component parts of each material may also be a combination of other component parts described in the present invention, and are not described herein again.
Comparative example 1
The difference from example 1 is that the material of comparative example 1 has no bergamot essential oil added.
Comparative example 2
The difference from example 1 is that basil essential oil was not added to the raw material of comparative example 2.
Comparative example 3
The difference from example 1 is that the raw material of comparative example 3 comprises the following components in parts by weight: 30 parts of cananga essential oil, 5 parts of damask rose essential oil, 15 parts of bergamot essential oil, 1 part of vetiver essential oil, 1 part of basil essential oil and 1 part of thymol and thyme essential oil. The cananga odorata essential oil contains 10 wt% of geraniine, the bergamot essential oil contains 6 wt% of monoterpene, the thymol thyme essential oil contains 2 wt% of gamma-terpinene, the vetiver essential oil contains 3 wt% of sesquiterpene molecules, the damascus rose essential oil contains 10 wt% of linalool, and the basil essential oil contains 1 wt% of fennel acetate.
Comparative example 4
The difference from example 1 is that the raw material of comparative example 4 contains 20 wt% of geraniine and the bergamot essential oil contains 10 wt% of monoterpene.
And (3) performance detection:
first, mild effect determination
1. The experimental method comprises the following steps: for each example, 30 eligible subjects were selected for testing.
Adopting skin closed patch test, selecting patch with area not more than 50mm2And qualified spot test equipment with the depth of about 1 mm.
Placing the experimental product into a spot tester chamber, wherein the dosage is about 0.020mL-0.025mL, applying the spot tester with the tested object to the curved side of the forearm of the tested object by using hypoallergenic adhesive tape, slightly pressing the spot tester with the palm to uniformly apply the spot tester to the skin for 24 hours, and observing the skin reaction for 24 hours according to the skin reaction grading standard of the skin-closed spot test.
2. Subject: examples the prepared compound essential oil.
3. The results of the tests, are given in table 1 below:
TABLE 1
Figure BDA0003276872620000091
Note: + represents no adverse reaction; + represents that a small amount of irritation can be felt but no adverse reaction occurs; the + and + indicates that strong stimulation can be felt, but no adverse reaction occurs; the sign of +++ indicates that strong irritation is felt and adverse reaction occurs.
As can be seen from Table 1, the compound essential oil provided by the invention is mild, safe, non-irritant to skin and reliable to use.
Second, mood improvement test
(1) Selection of population
People who are 25-45 years old and are easy to have depression, dysphoria, restlessness and the like are selected, the total number of people is 180, and 90 people are selected for men and women respectively.
(2) Experiment grouping
Selecting 100 volunteers, matching and mixing men and women, and coating the product of the embodiment of the invention; 80 of the volunteers were selected, matched and mixed, and coated with the product of the comparative example.
(3) Test method
The medicine is applied and massaged, and is uniformly applied on the brain acupuncture points, and is properly massaged to promote absorption, so that the medicine is used in the morning, the noon and the evening.
(4) The experimental results are shown in table 2 below.
TABLE 2
Figure BDA0003276872620000092
Figure BDA0003276872620000101
Note: the table is divided into four conditions of 1, 2, 3 and the like, wherein 0 represents obvious effect and relieves the conditions of depression, dysphoria, restlessness and the like; 1 represents general effect, and has a small part of emotional depression, dysphoria, restlessness and the like; 2 represents no effect; 3 means that there is an adverse reaction, e.g. the inability to fall asleep.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims (8)

1. The compound essential oil for improving emotion is characterized by comprising the following components in parts by weight:
5-10 parts of cananga essential oil, 5-10 parts of damask rose essential oil, 2-5 parts of bergamot essential oil, 2-5 parts of vetiver essential oil, 2-5 parts of basil essential oil and 1-2 parts of thymol and thyme essential oil;
wherein the mass ratio of the cananga essential oil to the bergamot essential oil to the vetiver essential oil is 5: 2: 2: 1.
2. the compound essential oil for improving emotion according to claim 1, wherein the cananga essential oil contains 5 wt% to 15 wt% of geraniine, the bergamot essential oil contains 4 wt% to 8 wt% of monoterpene, and the thymol thyme essential oil contains 1 wt% to 8 wt% of gamma-terpinene.
3. The compound essential oil for improving emotion according to claim 1, wherein the vetiver essential oil contains 1-3 wt% of sesquiterpene molecules.
4. The compound essential oil for improving emotion according to claim 1, wherein linalool is contained in the essential oil of rosa damascena in an amount of 10 wt% to 20 wt%.
5. The compound essential oil for improving emotion according to claim 1, wherein the basil essential oil contains 0.5 wt% to 1 wt% of anisyl acetate.
6. The compound essential oil for improving mood is characterized by comprising the following components in parts by weight:
5 parts of cananga essential oil, 5 parts of damask rose essential oil, 2 parts of bergamot essential oil, 2 parts of vetiver essential oil, 2 parts of basil essential oil and 1 part of thymol and thyme essential oil.
7. The method for preparing the compound essential oil for improving emotion according to any one of claims 1 to 6, comprising the following preparation steps:
sequentially placing cananga essential oil, damask rose essential oil, bergamot essential oil, vetiver essential oil, basil essential oil and thymol and thyme essential oil into a container, and stirring uniformly to obtain the compound essential oil.
8. Use of the mood-improving compound essential oil according to any one of claims 1 to 6 in the preparation of a product having effects of relaxing nerves, soothing mood, soothing nerves and aiding sleep.
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