CN113769003A - Medicine for treating hyperplasia of mammary glands and breast tumor and preparation method thereof - Google Patents
Medicine for treating hyperplasia of mammary glands and breast tumor and preparation method thereof Download PDFInfo
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- CN113769003A CN113769003A CN202111025690.2A CN202111025690A CN113769003A CN 113769003 A CN113769003 A CN 113769003A CN 202111025690 A CN202111025690 A CN 202111025690A CN 113769003 A CN113769003 A CN 113769003A
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- ginseng
- selfheal
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Abstract
The invention relates to the field of medicament formulas, in particular to a medicament for treating hyperplasia of mammary glands and breast tumors, which is prepared from the following medicinal materials in parts by weight: 20-30 parts of radix rehmanniae, 10-20 parts of pseudo-ginseng, 10-15 parts of snakegourd fruit, 5-10 parts of radix bupleuri, 5-20 parts of cortex albiziae, 5-15 parts of angelica sinensis, 5-10 parts of radix paeoniae alba, 5-10 parts of poria cocos, 5-20 parts of tribulus terrestris, 5-10 parts of radix aconiti lateralis preparata, 5-15 parts of pangolin scales, 3-15 parts of actinidia root, 5-20 parts of rhizoma cyperi, 5-10 parts of radix sophorae flavescentis, 5-10 parts of cyclocarya paliurus, 5-15 parts of selfheal and 3-5 parts of liquorice. The invention has the functions of soothing liver-qi stagnation, relieving swelling and pain, promoting blood circulation to cure carbuncle, inhibiting the growth of tumor cells, promoting the apoptosis of tumor cells and improving the immunity of organisms, has obvious curative effect on treating hyperplasia of mammary glands and breast cancer, and has no obvious side effect.
Description
Technical Field
The invention relates to the field of medicament formulas, in particular to a medicament for treating hyperplasia of mammary glands and breast tumors and a preparation method thereof.
Background
The hyperplasia of mammary glands refers to one or more benign hyperplasia of mammary ducts, lobules of mammary glands, acinar epithelium and fibrous tissues, takes periodically aggravated breast distending pain and multiple breast lumps as main clinical characteristics, is the most common breast disease of women, and is easy to develop into breast tumor by serious people, thus seriously affecting the physical and psychological health of women. The incidence of the disease has been increasing year by year in recent years, and the age has been getting lower.
The etiology and pathogenesis of the disease are not fully understood in modern medicine, and most scholars consider the disease to be related to endocrine dysfunction and mental factors, and the reduction of progesterone secretion and the relative increase of estrogen are important reasons for the disease. The drug treatment is mainly hormone preparations, has good effect in the near term, can obviously relieve symptoms, but has unstable curative effect and easy relapse after drug withdrawal, can interfere the balance among human hormones after long-term application, causes side effects such as menstrual disorder, secondary sexual characteristic change and the like, and increases the risk of canceration, so the drug is generally not suitable to be used as a conventional drug and is only considered to be applied when the symptoms are serious. The operation therapy is suitable for patients with severe hyperplasia and malignant tendency, but is easy to cause body injury and easy to relapse. Meanwhile, the curative effect of the existing oral administration medicine of the traditional Chinese medicine is not ideal. At present, no specific medicine for treating the disease exists.
Disclosure of Invention
In order to solve the technical problems, the invention provides a medicament for treating hyperplasia of mammary glands and breast tumors and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a medicine for treating hyperplasia of mammary glands and breast tumor is prepared from the following medicinal materials in parts by weight: 20-30 parts of radix rehmanniae, 10-20 parts of pseudo-ginseng, 10-15 parts of snakegourd fruit, 5-10 parts of radix bupleuri, 5-20 parts of cortex albiziae, 5-15 parts of angelica sinensis, 5-10 parts of radix paeoniae alba, 5-10 parts of poria cocos, 5-20 parts of tribulus terrestris, 5-10 parts of radix aconiti lateralis preparata, 5-15 parts of pangolin scales, 3-15 parts of actinidia root, 5-20 parts of rhizoma cyperi, 5-10 parts of radix sophorae flavescentis, 5-10 parts of cyclocarya paliurus, 5-15 parts of selfheal and 3-5 parts of liquorice.
Preferably, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 20 parts of radix rehmanniae, 10 parts of pseudo-ginseng, 10 parts of snakegourd fruit, 5 parts of radix bupleuri, 5 parts of cortex albiziae, 5 parts of angelica, 5 parts of radix paeoniae alba, 5 parts of poria cocos, 5 parts of tribulus terrestris, 5 parts of monkshood, 5 parts of pangolin scales, 3 parts of Chinese actinidia root, 5 parts of rhizoma cyperi, 5 parts of radix sophorae flavescentis, 5 parts of cyclocarya paliurus, 5 parts of selfheal and 3 parts of liquorice.
Preferably, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 30 parts of radix rehmanniae, 20 parts of pseudo-ginseng, 15 parts of snakegourd fruit, 10 parts of radix bupleuri, 20 parts of cortex albiziae, 15 parts of angelica, 10 parts of radix paeoniae alba, 10 parts of poria cocos, 20 parts of tribulus terrestris, 10 parts of monkshood, 15 parts of pangolin scales, 15 parts of Chinese actinidia root, 20 parts of rhizoma cyperi, 10 parts of radix sophorae flavescentis, 10 parts of cyclocarya paliurus, 15 parts of selfheal and 5 parts of liquorice.
Preferably, the traditional Chinese medicine composition is prepared from the following medicinal materials in parts by weight: 25 parts of dried rehmannia root, 15 parts of pseudo-ginseng, 12.5 parts of snakegourd fruit, 7.5 parts of Chinese thorowax root, 12.5 parts of silktree albizzia bark, 10 parts of Chinese angelica, 7.5 parts of white paeony root, 7.5 parts of Indian buead, 12.5 parts of tribulus terrestris, 7.5 parts of prepared common monkshood daughter root, 10 parts of stir-baked pangolin scales, 9 parts of Chinese actinidia root, 12.5 parts of nutgrass galingale rhizome, 7.5 parts of lightyellow sophora root, 7.5 parts of cyclocarya paliurus, 10 parts of common selfheal fruit-spike and 4 parts of liquoric root.
The invention also provides a preparation method of the medicine for treating hyperplasia of mammary glands and breast tumors, which comprises the following steps:
s1, weighing the medicinal materials according to the formula;
s2, grinding weighed radix rehmanniae, pseudo-ginseng, snakegourd fruit, radix bupleuri, cortex albiziae, angelica sinensis, radix paeoniae alba, poria cocos, tribulus terrestris, monkshood, pangolin scales, actinidia chinensis, rhizoma cyperi, radix sophorae flavescentis, cyclocarya paliurus, selfheal and liquorice root into 200 meshes, adding 10-15 times of water, carrying out electromagnetic cracking treatment for 3 times, 2.5-3.5 min each time, and filtering to obtain an extracting solution and filter residues;
s3, placing filter residues in an extraction tank, sequentially extracting with 5-10 times of 20-30% ethanol, 35-50% ethanol and 55-90% ethanol for 0.5-3 h respectively, filtering, recovering ethanol, and combining three ethanol extracts to obtain an extracting solution;
s4, combining the extracting solutions obtained in the step S2 and the step S3, concentrating the extracting solutions at the temperature of 30-60 ℃ under reduced pressure to 1/5-1/100 of the original volume, and drying the extracting solutions at the temperature of 30-60 ℃ under reduced pressure for 5-18 hours to obtain the compound.
The invention has the functions of soothing liver-qi stagnation, relieving swelling and pain, promoting blood circulation to cure carbuncle, inhibiting the growth of tumor cells, promoting the apoptosis of tumor cells and improving the immunity of organisms, has obvious curative effect on treating hyperplasia of mammary glands and breast cancer, and has no obvious side effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A medicine for treating hyperplasia of mammary glands and breast tumor is prepared by the following steps:
s1, weighing the following components in parts by weight: 20 parts of radix rehmanniae, 10 parts of pseudo-ginseng, 10 parts of snakegourd fruit, 5 parts of radix bupleuri, 5 parts of cortex albiziae, 5 parts of angelica, 5 parts of radix paeoniae alba, 5 parts of poria cocos, 5 parts of tribulus terrestris, 5 parts of monkshood, 5 parts of pangolin scales, 3 parts of Chinese actinidia root, 5 parts of rhizoma cyperi, 5 parts of radix sophorae flavescentis, 5 parts of cyclocarya paliurus, 5 parts of selfheal and 3 parts of liquorice;
s2, crushing weighed radix rehmanniae, pseudo-ginseng, snakegourd fruit, radix bupleuri, cortex albiziae, angelica sinensis, radix paeoniae alba, poria cocos, tribulus terrestris, monkshood, pangolin scales, actinidia chinensis, rhizoma cyperi, radix sophorae flavescentis, cyclocarya paliurus, selfheal and liquorice to 200 meshes, adding 10-15 times of water, carrying out electromagnetic cracking treatment for 3 times with the power frequency of 180 Hz for 2.5-3.5 min each time, and filtering to obtain an extracting solution and filter residues;
s3, placing filter residues in an extraction tank, sequentially extracting with 5-10 times of 20-30% ethanol, 35-50% ethanol and 55-90% ethanol for 0.5-3 h respectively, filtering, recovering ethanol, and combining three ethanol extracts to obtain an extracting solution;
s4, combining the extracting solutions obtained in the step S2 and the step S3, concentrating the extracting solutions at the temperature of 30-60 ℃ under reduced pressure to 1/5-1/100 of the original volume, and drying the extracting solutions at the temperature of 30-60 ℃ under reduced pressure for 5-18 hours to obtain the compound.
Example 2
A medicine for treating hyperplasia of mammary glands and breast tumor is prepared by the following steps:
s1, weighing the following components in parts by weight: 30 parts of radix rehmanniae, 20 parts of pseudo-ginseng, 15 parts of snakegourd fruit, 10 parts of radix bupleuri, 20 parts of cortex albiziae, 15 parts of angelica, 10 parts of radix paeoniae alba, 10 parts of poria cocos, 20 parts of tribulus terrestris, 10 parts of monkshood, 15 parts of pangolin scales, 15 parts of Chinese actinidia root, 20 parts of rhizoma cyperi, 10 parts of radix sophorae flavescentis, 10 parts of cyclocarya paliurus, 15 parts of selfheal and 5 parts of liquorice;
s2, crushing weighed radix rehmanniae, pseudo-ginseng, snakegourd fruit, radix bupleuri, cortex albiziae, angelica sinensis, radix paeoniae alba, poria cocos, tribulus terrestris, monkshood, pangolin scales, actinidia chinensis, rhizoma cyperi, radix sophorae flavescentis, cyclocarya paliurus, selfheal and liquorice to 200 meshes, adding 10-15 times of water, performing electromagnetic cracking treatment for 3 times at the power frequency of 200 Hz for 2.5-3.5 min each time, and filtering to obtain an extracting solution and filter residues;
s3, placing filter residues in an extraction tank, sequentially extracting with 5-10 times of 20-30% ethanol, 35-50% ethanol and 55-90% ethanol for 0.5-3 h respectively, filtering, recovering ethanol, and combining three ethanol extracts to obtain an extracting solution;
s4, combining the extracting solutions obtained in the step S2 and the step S3, concentrating the extracting solutions at the temperature of 30-60 ℃ under reduced pressure to 1/5-1/100 of the original volume, and drying the extracting solutions at the temperature of 30-60 ℃ under reduced pressure for 5-18 hours to obtain the compound. .
Example 3
A medicine for treating hyperplasia of mammary glands and breast tumor is prepared by the following steps:
s1, weighing the following components in parts by weight: 25 parts of dried rehmannia root, 15 parts of pseudo-ginseng, 12.5 parts of snakegourd fruit, 7.5 parts of radix bupleuri, 12.5 parts of cortex albiziae, 10 parts of angelica, 7.5 parts of white peony root, 7.5 parts of poria cocos, 12.5 parts of tribulus terrestris, 7.5 parts of monkshood, 10 parts of pangolin scales, 9 parts of Chinese actinidia root, 12.5 parts of rhizoma cyperi, 7.5 parts of radix sophorae flavescentis, 7.5 parts of cyclocarya paliurus, 10 parts of selfheal and 4 parts of liquorice;
s2, crushing weighed radix rehmanniae, pseudo-ginseng, snakegourd fruit, radix bupleuri, cortex albiziae, angelica sinensis, radix paeoniae alba, poria cocos, tribulus terrestris, monkshood, pangolin scales, actinidia chinensis, rhizoma cyperi, radix sophorae flavescentis, cyclocarya paliurus, selfheal and liquorice to 200 meshes, adding 10-15 times of water, performing electromagnetic cracking treatment for 3 times at the power frequency of 220 Hz for 2.5-3.5 min each time, and filtering to obtain an extracting solution and filter residues;
s3, placing filter residues in an extraction tank, sequentially extracting with 5-10 times of 20-30% ethanol, 35-50% ethanol and 55-90% ethanol for 0.5-3 h respectively, filtering, recovering ethanol, and combining three ethanol extracts to obtain an extracting solution;
s4, combining the extracting solutions obtained in the step S2 and the step S3, concentrating the extracting solutions at the temperature of 30-60 ℃ under reduced pressure to 1/5-1/100 of the original volume, and drying the extracting solutions at the temperature of 30-60 ℃ under reduced pressure for 5-18 hours to obtain the compound. .
Toxicity test
120 mice (60 males and females) with the weight of 18-22 g were selected and divided into 3 groups, 10 males and females in each group were fed with the drugs obtained in examples 1, 2 and 3, respectively, and the drugs were administered at a daily dose of 5g for 30 days. During the administration period and 1 week after the withdrawal, the growth state and active diet of the mice were observed to identify hematology, blood biochemistry, organ organization, and urinary system. The result shows that all mice survive healthily without any toxic and side effect; the hemogram, liver function and organ tissue state are observed in an anatomical way, and the difference is avoided compared with a normal white mouse. Experiments prove that the traditional Chinese medicine preparation provided by the invention is nontoxic and safe and reliable to use.
Test of drug efficacy
120 patients are treated in all cases, the patients are 20-50 years old, the average age is 35 years old, the course of disease is 4 months-5 years old, all the patients have breast vague pain or distending pain symptoms of different degrees, and the B-ultrasonic examination shows that the mammary glands are hyperplastic with different degrees, the texture is medium, and the boundary is unclear. All cases meet the diagnosis standard of the clinical research guideline of new Chinese medicine.
The patients were divided into 3 groups, each group was treated with the oral preparations prepared in examples 1, 2 and 3, 3 times a day, 1 time 10g, 15 days as one treatment course, and 4 treatment courses were continuously administered.
Standard of therapeutic effect
Is formulated according to the therapeutic effect standard of the Chinese medicine industry Standard of the people's republic of China issued by the State administration of traditional Chinese medicine. Remarkably: the lump in the breast disappears, the texture becomes soft, the pain disappears, the ultrasonic examination prompts that the shadow disappears, and the near infrared examination is a normal mammary image; the method has the following advantages: the texture of the breast becomes soft, the tumor is reduced, the ultrasonic examination indicates that the shadow is slightly reduced, and the near infrared examination is better than that before the treatment; and (4) invalidation: the lump is not reduced, the breast pain is not reduced, and the near infrared ray examination is not obviously improved.
After 4 courses of treatment, the treatment effect of the hyperplasia of mammary glands of 35 people in the first group of 40 people is obvious, and the treatment effect of 5 people is effective; the treatment effect of the hyperplasia of mammary glands of 37 persons in the second group of 40 persons is obvious, and the treatment effect of 3 persons is effective; in the third group of 40 people, the treatment effect of the hyperplasia of mammary glands of 38 people is obvious, and the treatment effect of 2 people is effective.
The MTT method and flow cytometry are used for detecting the influence of the medicines obtained in the examples 1, 2 and 3 on the proliferation and apoptosis of MDA-MB-231 cells and MCF-7 cells at different concentrations, and the results show that: the medicines obtained in the examples 1, 2 and 3 can obviously inhibit the proliferation of breast cancer cells MDA-MB-231 and MCF-7 and obviously induce the breast cancer cells to generate apoptosis.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that those skilled in the art can make various improvements and modifications without departing from the principle of the present invention, and these improvements and modifications should also be construed as the protection scope of the present invention.
Claims (5)
1. A medicine for treating hyperplasia of mammary glands and breast tumor is characterized in that: the traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 20-30 parts of radix rehmanniae, 10-20 parts of pseudo-ginseng, 10-15 parts of snakegourd fruit, 5-10 parts of radix bupleuri, 5-20 parts of cortex albiziae, 5-15 parts of angelica sinensis, 5-10 parts of radix paeoniae alba, 5-10 parts of poria cocos, 5-20 parts of tribulus terrestris, 5-10 parts of radix aconiti lateralis preparata, 5-15 parts of pangolin scales, 3-15 parts of actinidia root, 5-20 parts of rhizoma cyperi, 5-10 parts of radix sophorae flavescentis, 5-10 parts of cyclocarya paliurus, 5-15 parts of selfheal and 3-5 parts of liquorice.
2. The medicament for the treatment of mammary gland hyperplasia and mammary gland tumor of claim 1, wherein: the traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 20 parts of radix rehmanniae, 10 parts of pseudo-ginseng, 10 parts of snakegourd fruit, 5 parts of radix bupleuri, 5 parts of cortex albiziae, 5 parts of angelica, 5 parts of radix paeoniae alba, 5 parts of poria cocos, 5 parts of tribulus terrestris, 5 parts of monkshood, 5 parts of pangolin scales, 3 parts of Chinese actinidia root, 5 parts of rhizoma cyperi, 5 parts of radix sophorae flavescentis, 5 parts of cyclocarya paliurus, 5 parts of selfheal and 3 parts of liquorice.
3. The medicament for the treatment of mammary gland hyperplasia and mammary gland tumor of claim 1, wherein: the traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 30 parts of radix rehmanniae, 20 parts of pseudo-ginseng, 15 parts of snakegourd fruit, 10 parts of radix bupleuri, 20 parts of cortex albiziae, 15 parts of angelica, 10 parts of radix paeoniae alba, 10 parts of poria cocos, 20 parts of tribulus terrestris, 10 parts of monkshood, 15 parts of pangolin scales, 15 parts of Chinese actinidia root, 20 parts of rhizoma cyperi, 10 parts of radix sophorae flavescentis, 10 parts of cyclocarya paliurus, 15 parts of selfheal and 5 parts of liquorice.
4. The medicament for the treatment of mammary gland hyperplasia and mammary gland tumor of claim 1, wherein: the traditional Chinese medicine is prepared from the following medicinal materials in parts by weight: 25 parts of dried rehmannia root, 15 parts of pseudo-ginseng, 12.5 parts of snakegourd fruit, 7.5 parts of Chinese thorowax root, 12.5 parts of silktree albizzia bark, 10 parts of Chinese angelica, 7.5 parts of white paeony root, 7.5 parts of Indian buead, 12.5 parts of tribulus terrestris, 7.5 parts of prepared common monkshood daughter root, 10 parts of stir-baked pangolin scales, 9 parts of Chinese actinidia root, 12.5 parts of nutgrass galingale rhizome, 7.5 parts of lightyellow sophora root, 7.5 parts of cyclocarya paliurus, 10 parts of common selfheal fruit-spike and 4 parts of liquoric root.
5. A preparation method of a medicine for treating hyperplasia of mammary glands and breast tumor is characterized in that: the method comprises the following steps:
s1, weighing the medicinal materials according to the formula of any one of claims 1 to 4;
s2, grinding weighed radix rehmanniae, pseudo-ginseng, snakegourd fruit, radix bupleuri, cortex albiziae, angelica sinensis, radix paeoniae alba, poria cocos, tribulus terrestris, monkshood, pangolin scales, actinidia chinensis, rhizoma cyperi, radix sophorae flavescentis, cyclocarya paliurus, selfheal and liquorice root into 200 meshes, adding 10-15 times of water, carrying out electromagnetic cracking treatment for 3 times, 2.5-3.5 min each time, and filtering to obtain an extracting solution and filter residues;
s3, placing filter residues in an extraction tank, sequentially extracting with 5-10 times of 20-30% ethanol, 35-50% ethanol and 55-90% ethanol for 0.5-3 h respectively, filtering, recovering ethanol, and combining three ethanol extracts to obtain an extracting solution;
s4, combining the extracting solutions obtained in the step S2 and the step S3, concentrating the extracting solutions at the temperature of 30-60 ℃ under reduced pressure to 1/5-1/100 of the original volume, and drying the extracting solutions at the temperature of 30-60 ℃ under reduced pressure for 5-18 hours to obtain the compound.
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